To comprehensively evaluate the human body's respiratory, circular metabolism and other functions, and to diagnose lung disease, an accurate and reliable pulmonary function test (PFT) is developed. The system is divided into two parts:hardware and software. It realizes the collection of respiratory, pulse oxygen, carbon dioxide, oxygen and other signals, and draws flow-volume curve (FV curve), volume-time curve (VT curve), respiratory waveform, pulse wave, carbon dioxide and oxygen waveform in real time on the upper computer of the PFT system, and conducts signal processing and parameter calculation for each signal. The experimental results prove that the system is safe and reliable, it can accurately measure the basic functions of human body, and provide reliable parameters, and has good application prospects.

目的 探讨进展期胃癌D2根治术中No.8p淋巴结转移与临床病理参数的相关性.方法 回顾性分析安徽医科大学附属六安医院2018年1月至2020年12月70例进展期胃癌患者的临床资料,采用多因素logistic回归分析肿瘤大小、发生部位、组织类型、组织学分级、Borrmann分型、浸润深度、肿瘤N分期、No.8a组淋巴结转移情况与No.8p组淋巴结转移的关系.结果 No.8p组淋巴结转移率为11.43％.单因素分析显示,病灶位于胃大弯侧和小弯侧、低分化和高中分化、浸润型和局限型、No.8a组淋巴结转移与否之间,No.8p组淋巴结转移情况差异存在统计学意义(P<0.05).logistic多因素分析显示,肿瘤位于小弯侧、低分化、No.8a组淋巴结转移,No.8p组淋巴结转移的危险因素(P<0.05).结论 进展期胃癌No.8p组淋巴结转移率较高,肿瘤位于小弯侧、低分化、No.8a组淋巴结转移时需重视No.8p组淋巴结转移.

探讨胃蛋白酶原和4种肿瘤标志物CEA、CA50、CA199、CA242联合检测对胃癌诊断的临床意义.102例胃癌患者(胃癌组)、87例胃部良性病变患者(胃良性病变组)和71例健康体检患者(对照组).应用全自动电化学发光免疫分析仪,测定不同临床分期患者血清肿瘤标志物含量水平,分析检测结果.结果 显示,胃癌组血清胃蛋白酶原Ⅰ和CEA、CA50、CA199、CA242水平高于良性病变组和对照组患者(P＜0.05),良性病变组上述指标高于对照组(P＜0.05);胃癌Ⅲ、Ⅳ期组患者血清胃蛋白酶原Ⅰ和CEA、CA50、CA199、CA242含量明显高于胃癌Ⅰ、Ⅱ期组;指标联合检测的阳性率高于单项检测阳性率(P＜0.05).结果 表明,胃癌患者血清胃蛋白酶原Ⅰ和CEA、CA50、CA199、CA242含量较高,转移后上述指标血清含量增加,联合检测比单一检测更具诊断价值.

目的：探讨乳腺结节增生的手术治疗的临床效果。方法：选取我院收治的乳腺结节增生患者76例，根据治疗方法不同随机分为两组，手术治疗的38例设为观察组，药物保守治疗的39例设为对照组，对两组的临床治疗效果进行比较。结果：观察组治疗后痊愈者26例，有效者10例，失败者2例，总有效率为94．7％；对照组治疗后痊愈者19例，有效者12例，失败者7例，总有效率为81．6％。两组乳腺结节增生患者在不同治疗后的疗效结果差异具有统计学意义（P＜0．05）。结论：与药物保守治疗方法相比，手术治疗方法能明显降低乳腺结节增生复发率，具有满意的临床效果。

目的:探讨经胃造瘘管放置空肠营养管治疗上消化道穿孔老年患者的可行性及治疗价值.方法:将我院普外科2008-02/2012-07收治的38例消化道穿孔患者,根据其肠内营养方式分为2组,A组患者术后采用鼻饲管进行肠内营养,B组患者采用经胃造瘘放置空肠营养管术后予肠内营养.分析比较两组患者术后出现呼吸道、消化道及其他各类不适的比例.结果:B组患者术后排斥引流管心理、鼻咽部不适、异物感、置管营养期间恶心、呕吐、早起（＜3d）下床活动及置管后严重咳嗽、咳痰、合并肺炎等发生率与A组患者比较有明显统计学意义（P=0.036）;营养改善方面,两组手术后第9天与第1天比较白蛋白,前白蛋白等指标均明显升高（P=0.024;0.044）,但二者第9天之间比较无明显差异（P＞0.05）.结论:采用经胃造瘘管置空肠营养管,术后早期行肠内营养,患者耐受性好,并发症低,尤其适合老年上消化道穿孔患者.

目的：探讨针对原发性腹膜后肿瘤（PRT）患者，对其进行外科治疗后获得的效果表现。方法：选取我院2010年12月-2012年12月PRT患者64例，对其诊断与治疗情况进行回顾性分析。结果：通过病理检查最终证明患者出现了腹膜后肿瘤的情况。在所有的患者中，有42例患者检查后证实为恶性，有22例患者检查后证实为良性。对患者进行CT检查诊断，最终诊断的准确率大于80%，而对患者采用B超诊断，诊断准确率大于50%。将患者患有的良性肿瘤全部切除的概率为81.82%（18/22），将患者患有的恶性肿瘤全部切除的概率为71.43%（30/42）。结论：对P R T患者实施影像学检查能有效准备对患者进行手术之前进行正确诊断，有效确定对患者进行手术切除的具体范围。针对此类患者将所患肿瘤全部切除，关键时刻配合切除脏器是主要的治疗手段，对PRT患者采取手术治疗能够发挥显著效果。

Objective: To establish a stable mouse model of paraquat poisoning induced pulmonary fibrosis by a single intraperitoneal injection of paraquat.Methods: 60 healthy female C57BL/6J mice were randomly divided in to six groups according to the paraquat dosage: the saline control group,and the 30,40,50,60 and 80 mg/kg paraquat group,each group of 10 mice.The mice were sacrificed on day 28 for pathological examination(HE stain ing).The LD50 was calculated and the sections after HE staining were evaluated for the formation of lung fibrosis by using Ashcroft scoring system.Results: The LD50 of intraperitoneal paraquat of 28 days was 55.1923 mg/kg.All the paraquat dosage could induce some degrees of pulmonary fibrosis.The severity and early mortality in creased with the dosage.Conclution: We successfully established a mouse model of pulmonary fibrosis by single intraperitoneal injection of paraquat.The optimal paraquat dosage is 40 or 50 mg/kg.

腺样囊性癌是生长缓慢但恶性度高的上皮性肿瘤,好发于腮腺、颌下腺、舌下腺、腭腺等小涎腺及皮肤等组织,其具有局部侵袭性强、远处转移率高、长期预后较差等典型生物学特征.目前,治疗腺样囊性癌主要是采用以手术为主,辅以术后化学治疗、放射治疗和基因分子治疗等综合治疗手段,能显著提高患者疗效及改善患者预后.我们近期诊断皮肤腺样囊性癌1例,现报道如下.

患儿,女,5岁.因进行性阵发性腹痛1个月余,伴呕吐1 d入院.患儿1个月前在无明显诱因下出现阵发性腹痛,以脐周为主.当时未予特殊处理,后患儿症状逐渐加重,入院前一日患儿开始出现持续腹痛伴呕吐,呕吐物为胃内容物,就诊于当地医院输液治疗后未见明显好转,后转至我院,检查发现患儿盆腔可及包块,故拟盆腔包块收住,病程中,患儿无发热,有轻度咳嗽,咳痰。

小儿颈部大血管损伤临床少见,本院近期收治1例,现报道如下. 临床资料 2例均为男性,年龄分别为8岁和5岁,均为玩耍时不慎绊倒,手中所持锐器刺中颈部致伤,均表现为大量出血(当地医院未敢处理),于伤后约1 h入院.

Objective To compare accuracy and surgery time between C-arm X-ray and 3D-CT in guiding thoracolumbar pedicle screw fixation.Methods98 and 104 pedicle screws were placed under the guidance of C-arm X-ray and 3D-CT respectively.Record the surgery time and after the operation,the position of the pedicle screw was evaluated with CT using the Richter grading system.ResultsGuided by C-arm X-ray navigation,accuracy of pedicle screw placement was 96.9% and surgery time was (75.0±15.0)min;with the guidance of 3D-CT,accuracy was 100%(P>0.05) and surgery time was (101.5±21.0) min(P<0.01).ConclusionsC-arm X-ray and 3D-CT navigation system both can accurately guide the thoracolumbar pedicle screw implants.However,the surgery time was longer under the guidance of 3D-CT because the operation was more complex.

Objective To assess the accuracy of computer navigation technology used in thoracolumbar pedicle screw fixation.Methods 15 cases with thoracolumbar lesions underwent orthopaedic operations.72 pedicle screws were inserted with the computer navigation.After the operation,the position of the pedicle screw was evaluated with CT and X-ray using the Richter grading system.Results All cases succeeded with assistance of computer navigation.15 cases were followed up for 6 to 24 months.No pedicle screw loosening or breakage was found.According to the location of the screw in X-ray and CT results,there was no vessel,nerve or spinal cord complication.According to Richter grading system,the results were excellent in 68 cases(94.4%) and good in 4(5.6%).It obviously reduced the radiation exposure to C-arm fluroscopy and the time that spend on surgery.It obviously improved the success rate of surgery.Conclusions C-arm navigation can obviously reduce error in thoracolumbar pedicle screw fixation and improve the accuracy of it.

目的:探讨三维CT导航系统在胸腰椎椎弓根螺钉内固定中的应用价值.方法:三维CT导航系统辅助下.对导航组13例患者植入胸腰椎椎弓根螺钉65枚,其中胸椎骨折4例、腰椎骨折7例、腰椎滑脱症2例;在x线透视下对传统组14例患者植入胸腰椎椎弓根螺钉70枚,其中胸椎骨折3例、腰椎骨折7例、腰椎滑脱症2例、腰椎间盘突出症2例.术后均行CT扫描,按Richter分类法评估螺钉的位置.结果:术后按Richter分类法评估,导航组螺钉位置优62枚(95.4%),良3枚(4.6%),差0枚;传统手术组优57枚(81.4%),良10枚(14.3%),差3枚(4.3%).两组置钉准确性差异有统计学意义(P＜0.05).两组术后均无神经、脊髓损伤.24例随访0.5-1.0 a,复查X线片和CT.无螺钉松动和断裂钉,无迟发性脊髓损伤.结论:三维CT导航系统可以准确引导胸腰椎椎弓根螺钉的植入,手术精度高,并发症少.

Objective To study the multidetector CT (MDCT) features of soft tissue hemangiomas.Methods Plain CT,contrast-enhanced CT and CT angiographic findings of 20 patients with soft tissue hemangiomas confirmed by clinical,operative and pathologic data were retrospectively analysed.Results The lesions appeared as soft tissue density on CT and 5 cases with patchy calcification.There were various enhancement after administration of contrast media,net-like vessel enhancement intratumor both arterial and venous phase(12/20),the large supplying arteriae including simple feeding artery(4/12) and multiple feeding arteriae(8/12) could be seen,and varix within the tumors(6/12),no or mild enhancement in other cases(8 cases) on arterial phase,and homogeneous enhancement on venous phase also presented.Conclusion The imaging findings such as shape,size,supplying artery of soft tissue hemangiomas can be showed clearly by MDCT angiography.

Objective To evaluate the diagnostic value of 3-dimensional reconstruction for hip joint trauma. Methods 35 patients with hip joint trauma which diagnosed with spiral CT were reconstructed with 3 dimensional CT(including mutilplanar reformation-MPR,Shadow surface display-SSD,and volume rendering-VR) in ADW 4.2 workstation.Results Imaging findings including fracture,dislocation,the bone fragment in the joint space and swelling around the joint were displayed clearly in the axial imaging as well as MPR,SSD VR. Conclusion It plays an important role in the diagnosis of hip trauma and in the surgical plan designing.

目的探讨小婴儿(≤3个月)嵌顿疝发病特点及治疗.方法总结36例小婴儿嵌顿疝发病及治疗情况,其中急诊手术33例,自然复位后择期手术3例.急诊手术33例中肠坏死4例,睾丸坏死1例,回盲部嵌顿伴阑尾炎1例.结果28例冬季(头年10月～来年3月)发病,其中包括4例小肠坏死和1例睾丸坏死患儿.全组均治愈,随访23例,无并发症及复发,无对侧疝发生.结论小婴儿嵌顿疝多发生在冬季;易产生肠坏死和睾丸坏死,均应急诊手术,术中应探查患侧睾丸;伴发结肠坏死能否Ⅰ期行肠切除吻合,值得关注和研究;急诊手术时探查是否存在对侧潜在疝意义不大.