Journal of Gastroenterology and HepatologyVolume 22, Issue 2 p. 283-284 Successful surgical resection of a huge gastrointestinal stromal tumor of the third portion of the duodenum Akihiko Takeda, Akihiko Takeda Division of Digestive Surgery and Clinical Pathology, Funabashi Municipal Medical Center,Search for more papers by this authorYoshiji Watanabe, Yoshiji Watanabe Division of Digestive Surgery andSearch for more papers by this authorToshitaka Uehara, Toshitaka Uehara Department of Academic Surgery, Graduate School of Medicine, Chiba University, Chiba, andSearch for more papers by this authorTakashi Maruyama, Takashi Maruyama Division of Digestive Surgery andSearch for more papers by this authorHajime Tanaka, Hajime Tanaka Division of Digestive Surgery andSearch for more papers by this authorHiroshi Matsuzaki, Hiroshi Matsuzaki Division of Digestive Surgery andSearch for more papers by this authorHideaki Arima, Hideaki Arima Division of Digestive Surgery andSearch for more papers by this authorToshiyuki Natsune, Toshiyuki Natsune Division of Digestive Surgery andSearch for more papers by this authorHidehiro Kudo, Hidehiro Kudo Division of Digestive Surgery andSearch for more papers by this authorAtsutaka Sakama, Atsutaka Sakama Division of Digestive Surgery andSearch for more papers by this authorNoriyuki Tohnosu, Noriyuki Tohnosu Division of Digestive Surgery andSearch for more papers by this authorHideaki Shimada, Hideaki Shimada Division of General and Gastroenterological Surgery, Saitama Medical University, Saitama, JapanSearch for more papers by this authorHirotoshi Sato, Hirotoshi Sato Division of Digestive Surgery andSearch for more papers by this author Akihiko Takeda, Akihiko Takeda Division of Digestive Surgery and Clinical Pathology, Funabashi Municipal Medical Center,Search for more papers by this authorYoshiji Watanabe, Yoshiji Watanabe Division of Digestive Surgery andSearch for more papers by this authorToshitaka Uehara, Toshitaka Uehara Department of Academic Surgery, Graduate School of Medicine, Chiba University, Chiba, andSearch for more papers by this authorTakashi Maruyama, Takashi Maruyama Division of Digestive Surgery andSearch for more papers by this authorHajime Tanaka, Hajime Tanaka Division of Digestive Surgery andSearch for more papers by this authorHiroshi Matsuzaki, Hiroshi Matsuzaki Division of Digestive Surgery andSearch for more papers by this authorHideaki Arima, Hideaki Arima Division of Digestive Surgery andSearch for more papers by this authorToshiyuki Natsune, Toshiyuki Natsune Division of Digestive Surgery andSearch for more papers by this authorHidehiro Kudo, Hidehiro Kudo Division of Digestive Surgery andSearch for more papers by this authorAtsutaka Sakama, Atsutaka Sakama Division of Digestive Surgery andSearch for more papers by this authorNoriyuki Tohnosu, Noriyuki Tohnosu Division of Digestive Surgery andSearch for more papers by this authorHideaki Shimada, Hideaki Shimada Division of General and Gastroenterological Surgery, Saitama Medical University, Saitama, JapanSearch for more papers by this authorHirotoshi Sato, Hirotoshi Sato Division of Digestive Surgery andSearch for more papers by this author First published: 29 January 2007 https://doi.org/10.1111/j.1440-1746.2006.04484.xCitations: 5Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. References 1 Uehara K, Hasegawa H, Ogiso S. Diagnosis and treatment of gastrointestinal stromal tumor of the duodenum (Japanese). Geka 2001; 63: 1058–61. 2 Akkus MA, Kismet K, Erel S, Adibelli MA, Pulat H. Case report: duodenal stromal tumor. Acta Gastroenterol. Belg. 2005; 68: 95–7. 3 Takahashi T, Noguchi T, Takeno S, Uchida Y, Shimoda H, Yokoyama S. Gastrointestinal stromal tumor of the duodenal ampulla: report of a case. Surg. Today 2001; 31: 722–6. 4 Sakamoto Y, Yamamoto J, Takahashi H et al. Segmental resection of the third portion of the duodenum for a gastrointestinal stromal tumor: a case report. Jpn J. Clin. Oncol. 2003; 33: 364–6. 5 Lin SC, Huang MJ, Zeng CY, Wang TI, Liu ZL, Shiay RK. Clinical manifestation and prognostic factors in patients with gastrointestinal stromal tumors. World J. Gastroenterol. 2003; 9: 2809–12. 6 Nowain A, Bhakta H, Pais S, Kanel G, Verma S. Gastrointestinal stromal tumors. Clinical profile, pathogenesis, treatment strategies and prognosis. J. Gastroenterol. Hepatol. 2005; 20: 818–24. Citing Literature Volume22, Issue2February 2007Pages 283-284 ReferencesRelatedInformation

Background: Recently, esophageal microcancers have been frequently diagnosed and are receiving increasing attention as initial findings of cancer. We examined whether the clinicopathological features and microvascular patterns of esophageal microcancers on magnifying endoscopy are useful for diagnosis.Methods: Magnifying endoscopy was performed to examine the histopathological features of 55 esophageal cancers measuring ≤10 mm in diameter (34 small cancers, 16 microcancers, and five supermicrocancers).Results: Although some lesions were detected only on iodine staining, most were detected on conventional endoscopic examination. Most small cancers and microcancers were m1 or m2; some were m3 or sm2. Supermicrocancers were dysplasia or m1 cancer. As for the microvascular pattern, most m1 and m2 cancers showed type 3 vessels, while most submucosal cancers showed type 4 vessels.Conclusions: Microvascular patterns on magnifying endoscopy are useful for the differential diagnosis of benign and malignant esophageal cancers and for estimating the depth of tumor invasion. The shape of small lesions is often altered considerably by biopsy. Residual tumor may persist unless the basal layer of the lesion is included in biopsy specimens, even in microcancers. Consequently, endoscopic mucosal resection, without biopsy, is being performed in increasing numbers of patients with lesions suspected to be cancer on the basis of their microvascular patterns.

We examined the current status and diagnostic accuracy of currently available techniques for tumor staging and assessed treatment outcomes in patients with superficial esophageal cancer who received esophaguspreserving therapy, such as endoscopic mucosal resection (EMR) alone or combined with chemoradiotherapy (CRT).

Magnifying endoscopy with dye or acetic acid is useful for evaluating mucosal surface patterns in patients with Barrett's epithelium. Barrett's epithelium can be diagnosed on the basis of the presence of translucent longitudinal vessels. Specialized intestinal metaplasia frequently occurs in villous- or gyrus-type mucosa. Superficial Barrett's adenocarcinoma is associated with irregularities or destruction of mucosal surface patterns. Magnifying endoscopy combined with optical chromoendoscopy by new techniques for enhancement of vascular images, such as narrow-band imaging (NBI) and Fuji intelligent color enhancement (FICE), may further improve diagnostic accuracy. Irregularly arranged abnormal vessels appear in cancerous lesions. However, classification systems for characteristic vascular patterns have not been established. Whether vascular patterns are useful for diagnosing cancers with mild atypia remains an open question.

Endoscopic findings have traditionally been evaluated on the basis of differences in color and changes in surface structure. We examined whether microvascular patterns on magnifying endoscopy could be used to diagnose benign and malignant superficial esophageal lesions and to estimate the depth of tumor invasion.

We report herein the case of a 63-year-old male with hemoperitoneum secondary to exogastric leiomyoma. The patient had been receiving anticoagulation therapy for a cerebral embolism and complained of sudden, severe abdominal pain. A sonogram and computed tomography scan showed an exogastric mass and massive ascites. A peritoneal puncture proved the presence of an intraperitoneal hemorrhage. An emergency laparotomy revealed a pedunculated bleeding tumor, thus confirming the preoperative diagnosis of a ruptured exogastric tumor. A microscopic analysis of the excised tumor demonstrated gastric leiomyoma. Other authors have reported hemoperitoneum secondary to gastric myogenic tumors, but no cases of leiomyomas could be found in the literature.

By statistically analyzing 28,800 cells of arrayed stacked gate transistors, for the first time, we examine the effectiveness of nitric oxide (NO) and nitrous oxide (N2O) nitridation in the suppression of the microscopic stress-induced leakage current (mSILC) observed in devices on the order of square microns in size. We have found that NO nitridation is more effective in suppressing the mSILC than N2O nitridation and is very promising for the reduction of bit failures. The difference between the SILC observed in devices on the order of square millimeters in size and the mSILC observed in devices on the order of square microns in size is also discussed.

The high performance of 0.25 µm dual gate complementary metal oxide semiconductor with an ultrathin gate oxide of 2 nm is demonstrated for low-voltage logic applications. Boron penetration can be effectively suppressed by the nitrogen implantation technique, even if the gate oxide film is reduced to 2 nm. It is confirmed that N-channel and P-channel metal oxide semiconductor field effect transistors (MOSFETs) with high current drivability can be realized by the thin gate oxide, although the transconductance is not inversely proportional to the gate oxide thickness due to the increase in the effect of the inversion capacitance and the gate depletion. The inverter delay time with the aluminum interconnect load is markedly improved by the highly drivable MOSFETs with thin gate oxide, especially at low-voltage operation. Furthermore, hot carrier degradation of N-channel MOSFETs can be suppressed by reducing the gate oxide thickness. However, it was found that the hot carrier degradation of P-channel MOSFETs is enhanced in the thin gate oxide region under channel hot hole injection.

In this paper an experimental study of the scalability of a gate/N - overlapped lightly doped drain (OL-LDD) structure in the deep-submicrometer regime is presented. Devices were optimized for processes with a design rule down to 0.15 µm. The allowable power supply voltage is obtained by investigating the time-dependent dielectric breakdown reliability, the minimum operating voltage, the gate-induced-drain-leakage current, the drain-induced-barrier-lowering effect and the DC hot carrier reliability. It was found that the maximum allowable supply voltage is mainly limited by the DC hot carrier reliability even in the deep-submicrometer range. A higher current-driving ability in the OL-LDD structure is achieved in comparison to that in a single drain (SD) structure when V Dmax is applied as a supply voltage. The OL-LDD structure has a smaller C GD in the inversion region as well as in the accumulated region, as compared with the SD structure, especially with smaller L G . Consequently, the performance of complementary metal-oxide-semiconductor (CMOS) devices with the OL-LDD structure is superior to that with the SD structure in the deep-submicrometer regime. It is also confirmed that the OL-LDD structure has a scaling merit even for 0.15 µm CMOS devices.