IntroductionBronchopulmonary dysplasia (BPD) is the most common morbidity after premature birth.Severe BPD is defined as a requirement for invasive mechanical ventilation at 36 weeks postmenstrual age, and these infants experience prolonged hospitalizations with frequent care team and provider changes.We hypothesized that a multidisciplinary care team would improve severe BPD clinical outcomes and provide useful input for primary care teams in our quaternary care center.Methods:An inpatient multidisciplinary BPD consultation team was created at Seattle Children's Hospital, including providers from Neonatology, Pulmonology, Pediatric Critical Care, Cardiology, respiratory therapy, nutrition, and occupational/physical therapy.Weekly BPD rounds included primary care teams and reviewed longitudinal information for discussion and documentation of consensus care plans.Two years after our BPD team inception, a provider experience survey was sent to NICU, PICU, Cardiology, and Pulmonary providers.Descriptive statistics include mean +/-standard deviation.Results:Between January 2018 and November 2020, 115 patients were included in BPD rounds, with an average gestational age of 26.8 (+/-4.1 weeks) in 2018, 26.6 (+/-3.5 weeks) in 2019, and 26.4 (+/-2.7 weeks) in 2020.Average birth weights were 880.4g (+/-534g) in 2018, 903.2g (+/-502g) in 2019, and 823.1g (+/-287g) in 2020.At the time of referral to the BPD team, 65.6% of patients in 2018, 57.4% in 2019, and 38.9% in 2020 required invasive mechanical ventilation.34.3% of patients in 2018, 23.4% in 2019, and 22.2% in 2020 required tracheostomy and chronic ventilation.Survival rates for patients followed by the BPD team were 93.8% in 2018, 87.2% in 2019, and 91.2% in 2020.Of the 115 patients, 89 (77.4%) had a significant co-morbidity (NEC, IVH, complex congenital heart disease, or hemodynamically significant PDA).Of 38 BPD provider experience survey responses (14 from NICU, 11 from PICU, 6 from pulmonary, and 7 from cardiology providers), 79% stated that BPD team recommendations were helpful (16% neutral, 5% unhelpful).66% felt the BPD team communication was good (26% neutral, 8% poor).79% felt the BPD team helped the primary team provide better care (13% did not, 8% N/A).Conclusions:We developed a multidisciplinary team to advise on management of severe BPD patients throughout their hospital course.Most providers who care for patients with BPD felt the BPD team was helpful and improved care.Future studies will determine if multidisciplinary BPD rounds improves clinical outcomes such as tracheostomy rates, length of stay, and family experience.

A case of enterococcal meningitis in a toddler is presented. The organism was highly resistant to all drugs previously used for pediatric Gram-positive meningitis. She was successfully treated with intraventricular and intravenous daptomycin and intravenous tigecycline. The organism was characterized as a member of CC17, a notorious emerging nosocomial clone of Enterococcus faecium.

Fluorescent molecularly imprinted polymers (MIPs) have attracted increasing attentions in recent years due to their high selectivity and sensitivity for target molecules. In this study, two cholic acid imprinted fluorescent polymers, i.e., MIP1 and MIP2, were prepared using 4-dimethylamino-N-allylnaphthalimide (F1) and 4-piperazinyl-N-allylnaphthalimide (F2) as the fluorescent functional monomers, respectively. The fluorescence intensity of MIP1 decreased linearly with the increase of the template concentration in the range of 1.50–120.0 μM, while the fluorescence intensity of MIP2 increased linearly with the increase of the template concentration in the range of 0.40–110.0 μM. The detection limits of MIP1 and MIP2 for cholic acid were 0.42 and 0.083 μM, respectively. The mechanisms of the fluorescence responsive of the imprinted polymers were discussed. The results of fluorescence measurement and binding experiments demonstrated that both imprinted polymers have high recognition abilities and binding affinities for the template. The imprinted polymers have been successfully applied to the determination of cholic acid in human serums. The present study indicated that 1,8-naphthalimide can be used as a modular building block for design and construction of various fluorogenic molecularly imprinted materials for practical sensing and separation.