Objective To observe the effect of trimetazidine on angina and high sensitive C reactive protein(hs-CRP) after percutaneous coronary intervention(PCI) in coronary atherosclerosis heart disease.Methods 96 cases of angina pectoris after PCI due to coronary atherosclerosis heart disease were randomly divided into the treatment group and the control group.The control group(48 cases) were treated with aspirin,nitrates,calcium antagonists,beta blockers,statins,low molecular weight heparin,etc;while on this base the treatment group(48 cases) was combined with using trimetazidine.Both groups were treated for 4 weeks.hs-CRP was detected before treatment and on 7,30 d after treatment.Urine routine,blood glucose,liver and kidney function,blood coagulation time and myocardial enzymes were determined before and after medication.The improvement status of angina symptoms,adverse cardiovascular events,adverse drug reactions and hs-CRP level were observed.Results The total effective rate of the treatment group was significantly better than that of the control group(P<0.01).After treatment,hs-CRP level in the treatment group was decreased more obviously than that in the control group(P<0.05).There was no obvious adverse reaction happened in both groups.Conclusion Combination with trimetazidine can improve the clinical symptoms of angina pectoris in the patients after PCI,reduce hs-CRP level,which is safe and reliable with less adverse reactions,and deserves to be promoted.

Objective To observe the effect of clopidogrel combined with Guanxin Shutong capsule on angina pectoris after percutaneous coronary intervention(PCI) for acute coronary syndromes(ACS)and its influence on the high sensitive C reactive protein(HS-CRP) and low density lipoprotein cholesterol(LDL-C).Methods 70 cases of ACS patients with angina pectoris after PCI were randomly divided into 2 groups.The control group were treated with aspirin,nitrates,beta blockers,statins,and low molecular heparin.The united group based the treatment on the use of clopidogrel combined with Guanxin Shutong capsule.The course of treatment was 4 weeks.HS-CRP and LDL-C were detected 14d and 30d before and after the treatment respectively.Blood and urine routines,PT,APTT,and liver and kidney functions were tested before and after the meditation.All the patients were observed in terms of symptoms,cardiovascular events,adverse reactions,HS-CRP and LDL-C level.Results The total treatment efficacy for the united group and the control group was 94.29% and 77.14% respectively,the former significantly better than the latter(P<0.01).After the treatment,HS-CRP and LDL-C in the united group reduced more obviously than in the control group(P<0.05).There were no obvious adverse reactions in the two groups.Conclusion The united method can improve patients' clinical symptoms of angina pectoris after PCI,reduce the HS-CRP and LDL-C levels,and increase no chance of bleeding.It is a safe and effective method for the assistant treatment of angina pectoris after PCI.

Objective To explore the clinical significance of brain natriuretic peptide,cardiac troponin Ⅰ and hypersensitive C-reactive protein in acute myocardial infarction.Method The plasma levels of brain natriuretic peptide,cardiac troponin Ⅰ and hypersensitive C-reactive protein parallelly detected in 50 cases of acute myocardial infarction group and other 30 cases of the contrasting group.The contrastive analysis and correlation of them were conducted and analyzed the relationship with acute myocardial infarction.Results ①The levels of BNP,cTnⅠ,Hs-CRP in acute myocardial infarction group were significantly higher than those in the contrasting group(P0.01).②In acute myocardial infarction group,significant positive correlation was found between plasma BNP,cTnⅠ,and Hs-CRP.Conclusion Brain natriuretic peptide,cardiac troponin Ⅰ and hypersensitive C-reactive protein combined detection of acute myocardial infarction(AMI)predict favorable diagnosis and prognosis.

Objective To investigate the effects of irbesartan /hydrochlorothiazide for hypertension in patients with early renal damage in urinary albumin(mALB),N-acetyl-β-D-glucosaminidase(NAG enzyme).Methods Randomly divided 80 patients with primary hypertension(grade 1~2)who were with early renal injury also into two groups,one group of 40 patients treated with irbesartan/hydrochlorothiazide,the other of 40 patients with nifedipine,by the sequence of their treatment,medication for 12 weeks.Observed the data and changes in blood pressure,urine mALB,NAG enzymes,kidney function,blood glucose,blood lipids and serum potassium before and after the medication.Results The blood pressure of the two groups was significantly lower than that of before the treatment(P0.01),but when compared the blood pressure of two groups of patients after treatment,the statistically difference was not significant(P0.05);the renal function,blood glucose,blood lipids,serum potassium changes before and after the treatment were not statistically significant(P0.05);the urinary mALB,NAG enzyme of two groups decreased than those of before the treatment(P0.05),but the group of irbesartan /hydrochlorothiazide was significantly better than that group of nifedipine(P0.05).Conclusion Irbesartan/hydrochlorothiazide has a good antihypertensive effect and can reduce the levels of urinary mALB,NAG enzyme at the same time,and improve the renal function.

Objective:To study the clinical significance of serum high-sensitivity C reactive protein(hs-CRP) measurement,and explore the relationships between hs-CRP and immunoglobulin(IgG,IgA and IgM),complement(C3 and C4)in maintenance hemodialysis(MHD) patients.Methods:The level of serum hs-CRP was detected in 93 MHD patients and 40 healthy controls by an automated latex-enhanced immune transmission turbidity method.At the same time,the levels of IgG,IgA,IgM and C3,C4 were determined.According to the normal value(0-10mg/L) of hs-CRP,93 patients were divided into 2 groups:the normal hs-CRP group(63 patients) and the abnormal hs-CRP group(30 patients),and the changes of serum immunoglobulin and complement among the 3 groups were analyzed.Results:The level of hs-CRP in MHD patients was significantly higher than that in healthy controls(P0.01),but C3 was remarkably lower than that in healthy controls(P0.01).IgG in the abnormal hs-CRP group of MHD patients was significantly higher than that in the normal hs-CRP group(P0.01).Conclusions:The increasing of hs-CRP and IgG levels is beneficial to judge the chronic infection of MHD patients,and the decrease of C3 level is the important reason for the decline of humoral immunity in MHD patients.

Objective:To explore the value of serum cystatin C(Cys C) levels in determining the impairment of early renal function.Methods:Serum Cys C in 110 cases with renal function impairment was detected by an automated particle-enhanced turbidimetric immunoassay method,serum creatinine was determined by picricacid method and serum urea by urea enzymatic method,all of which were divided into 5 periods according to the level of glomerular filtration rate(eGFR),and the correlation analysis was carried out.Results:The serum level of Cys C increased with the decrease of the eGFR level in the 110 cases(P<0.01).The Cys C concentration levels had statistical meaning between the 5 periods(P<0.01).The abnormal detection in the 5 periods was 52.94%,64.29%,92.00%,100.00% and 100.00%,respectively.The difference was significant(P<0.01).Conclusions:Serum Cys C is a sensitive indicator reflecting early renal damage,which is of great value in diagnosis of early renal diseases.

目的 探讨同型半胱氨酸(Hcy),脂蛋白(a)[Lp(a)]和血浆纤维蛋白原(Fg)联合检测在急性脑梗死(ACI)诊断中的意义.方法 选择急性脑梗死患者63例,正常对照组43例,分别检测Hcy,Lp(a)和Fg的浓度,并进行比较,分析其与急性脑梗死的关系.结果 急性脑梗死组Hey,Lp(a)和Fg的浓度分别为19.48±8.42 μmol/L,373±182 mg/L和3.7±1.2 g/L,正常对照组三者的浓度分别为10.66±2.61 μmol/L,181±106 mg/L和2.4±1.0 g/L.急性脑梗死组明显高于正常对照组,差异有统计学显著性意义(P<0.01);急性脑梗死组中各项阳性检出率为Hcy 60.3%,Lp(a) 42.9%和Fg 30.0%,而正常对照组三者的阳性率只有6.9%,11.6%和6.9%,急性脑梗死组明显高于正常对照组,差异有统计学意义(P<0.05);三者联合检测阳性率为89%,高于三者任何一个单项阳性率.结论 Hcy,Lp(a)和Fg联合检测有利于急性脑梗死患者的预测、诊断及预后.