Wound infections caused by drug-resistant bacteria pose a great threat to human health, and the development of non-drug-resistant antibacterial approaches has become a research priority. In this study, we developed Cu2O-SnO2 doped polydopamine (CSPDA) triple cubic antibacterial nanoenzymes with high photothermal conversion efficiency and good Fenton-like catalase performance. CSPDA antibacterial nanoplat-form can catalyze the generation of hydroxyl radical ( center dot OH) from H2O2 at low concentration (50 mu g .mL-1) under 808 nm near-infrared (NIR) irradiation to achieve a combined photothermal therapy (PTT) and chemodynamic therapy (CDT). And the CSPDA antibacterial nanoplatform displays broad-spectrum and long-lasting antibacterial effects against both Gram-negative Escherichia coli (100 %) and Gram-positive Staphylococcus aureus (100 %) in vitro . Moreover, in a mouse wound model with mixed bacterial infection, the nanoplatform demonstrates a significant in vivo bactericidal effect while remaining good cytocompatible. To conclude, this study successfully develops an efficient and long-lasting bacterial infection treatment system. This system provided different options for future studies on the design of synergis-tic antimicrobial therapy. Hence, the as-synthesized synergetic photothermal therapy and chemodynamic therapy nanoenzymes have rapid and long-term bactericidal ability, well-conglutinant performance and effectively preventing wound infection for clinical application.

The Fenton/Fenton-like reaction is of significant importance in biomedical and environmental remediation applications. However, the use of Fenton/Fenton-like catalysts is limited due to incomplete light absorption, low energy conversion efficiency, and a narrow pH range. To address these issues, we have developed a photothermal-driven heterogeneous Fenton system using Cu2O-SnO2-Polydopamine (PDA) triple cubic heterostructures, which exhibit strong photothermal capabilities in the NIR region. The macromolecular PDA acts as a heat source for higher degradation efficiency due to its excellent photothermal conversion performance. Furthermore, our results show that the system significantly improves the energy conversion efficiency of Cu2O and exhibits excellent catalytic activity over a wide pH range by using Rhodamine B (RhB) as the model dye. This study offers a novel approach for environmental remediation through the synergistic effect of photocatalysis and photothermal processes.

In order to enhance the photostability of Cuprous oxide and improve the photocatalytic activity, this study was the first to prepare polydopamine (PDA) coated Cu2O@SnO2 Fenton heterostructured catalyst (HCs) for pho-tothermal synergistic enhanced pollutant dye degradation. HCs reduced the Cu2O electron-hole pair filling group rate by Cu/Sn heterostructures, and the PDA shell layer protection greatly improved the stability of Cu2O. The developed Cu2O@SnO2@PDA-HCs could generate heat rapidly under near infrared (NIR) laser irradiation, which greatly improved the catalytic efficiency of the catalyst by a typical photothermal enhanced Fenton-driven degradation process. All the results indicate that Cu2O@SnO2@PDA-HCs have great potential applications in dye wastewater treatment.

目的 探讨不同浓度铂基纳米药物载体的近红外光热性能及其光热疗法抗肿瘤作用.方法 利用热溶剂法制备具有近红外光吸收特性的铂基纳米药物载体,系统研究其形貌、粒径、表面电荷等理化性能,考察其在980 nm处的近红外吸光特性及循环产热性能,调查其对人食管鳞状细胞癌细胞TE-1的光热杀伤效果,并采用va-riance(ANOVA)方差分析和独立样本t检验进行统计.结果 铂基纳米载体具有较强的近红外光吸收特性(OD=1.28)、近50℃的光热转换性能以及>95％的光热消融Te-1肿瘤细胞的能力.结论 铂基纳米载体介导的光热疗法具有潜的临床治疗应用价值.

The dye degradation method based on Fenton-like heterogeneous nanostructures has gained significant attention in recent years. We have developed a Copper-Stannum-Polypyrolle-Heterogeneous (Cu-Sn oxide-PPy Heterogeneous, CSPHGs) catalytic system. The system uses a PN junction formed by two oxide semiconductors (Cu2O and SnO2) as the core, which is then coated with polypyrolle (PPy) on the outer layer. Under near-infrared (NIR) light irradiation (500.0 mu g ml(-1), 1.2w center dot cm(-2)), the temperature rapidly reached approximately 45 degrees C within 5 min, demonstrating excellent photothermal performance. We have overcome the limitation of traditional Fenton reactions that require weak acidic conditions for effective operation. Moreover, we have increased the photo-stability of Cu2O monomers by incorporating them into a three-layer heterostructure. The Rhodamine B (RhB) degradation experiment revealed that the generated reactive oxygen species (center dot OH), effectively catalyze the decomposition of dyes. Within 120 min, the degradation rate exceeded 99%. This research provides a new option for environmental remediation through the combination of photo-Fenton and photothermal processes.

Malignant tumors are the most important killer of human health worldwide, posing a great danger to human life and health. Traditional tumor treatment methods such as surgery, chemotherapy and radiation therapy have drawbacks such as insufficient targeting and causing certain damage to the organism. Therefore, researchers are exploring new safe, effective and low-cost methods for tumor treatment. With the development of bionics, molecular science, gene technology and nanoscience, tumor bionic therapy solutions based on bionic micro-nano technology have become a hot topic in current research and treatment. Researchers have developed various bionic materials inspired by nature for use in developing new anti-tumor strategies. These materials have good biocompatibility, excellent anti-tumor effect, lower cost and greener than traditional tumor treatments. This paper introduces four types of tumor bionic therapeutic strategies from the perspective of improving the tumor microenvironment and their application advantages; it also analyzes the therapeutic effects of bionic anti-tumor materials. The manuscript summarizes the problems faced by its development and provides an outlook on its subsequent applications.

Engineered hydrogels with excellent mechanical properties and multi-functionality have great potential as soft electronic skins, tissue substitutes and flexible robotic joints. However, it has been a challenge to construct multifunctional hydrogels, especially when integrating high stretchability, toughness and strength, low hysteresis, good self-healing and adhesion abilities into a hydrogel system simultaneously. Here, we successfully developed a structural hydrogel composed of a reversible covalently cross-link-based poly-N-(2-hydroxyethyl)acrylamide (PHEMAA) network and available plastically deformable casein micelles. Such a design enabled the reversible covalent cross-links and casein micelles to enhance energy dissipation and toughen the PHEMAA/casein hybrid hydrogel synergistically. More importantly, the hydrogel could respond to the imposed strains reversibly by cross-link and micelle deformation induced-network reconstitution, which led to low hysteresis of the hydrogels. The recoverable gel networks still exhibited their effects on energy dissipation at the stress-focused area, endowing the hydrogels with fatigue resistance. As a result, the hydrogels exhibited a compressive strength of 36.5 MPa, high stretchability (1460%), high toughness (∼5.98 MJ m-3), low hysteresis (<30%) and fatigue resistance with almost completely overlapped hysteresis curves during 10 loading cycles. In addition, the introduction of casein micelles and reversible covalent bonding endowed the elastomer hydrogels with high adhesivity, self-healing abilities and biocompatibility.

Hypoxia regulation by drug delivery nanocargo is an unprecedented strategy for overcoming inherent vices of traditional tumor treatments. Particularly, stimuli-responsive nanomaterials which are sensitive to external physical stimuli (light, ultrasound, magnetic field, etc.) are greatly desired to realize controllable drug release at tumor lesion and to avoid undesirable drug leakage during delivery process. Herein, a photothermal mediated ROS self-enhanced CDT nanoplatform is developed as anti-tumor nanoagents by Vitamin C (VC) loaded concave octahedral PtCu nanoframes (COPtCu-Ns). Typically, VC has been proved to be a promising pro-oxidant for generation of H 2 O 2 and causing selective toxicity to tumor cells rather than normal cells. Simultaneously, the COPtCu-Ns possess Fenton-like catalytic activity in acidic tumor microenvironment and generate the advanced ROS substance (hydroxyl radical, •OH) subsequently, which causes more serious damage to tumor cells. The as-designed system show good biocompatibility and bloodcompatibility, quick elimination, and no obvious tissue toxicity both in vitro and in vivo for synergistic PTT and CDT tumor therapy.

Phase change materials (PCMs) are materials that are stimulated by the external enthalpy change (temperature) to realize solid-liquid and liquid-solid phase transformation. Due to temperature sensitivity, friendly modification, and low toxicity, PCMs have been widely used in smart drug delivery. More often than not, the drug was encapsulated in a solid PCMs matrix, a thermally responsive material. After the trigger implementation, PCMs change into a solid-liquid phase, and the loading drug is released accordingly. Therefore, PCMs can achieve precise release control with different temperature adjustments, which is especially important for small molecular drugs with severe side effects. The combination of drug therapy and hyperthermia through PCMs can achieve more accurate and effective treatment of tumor target areas. This study briefly summarizes the latest developments on PCMs as smart gate-keepers for anti-tumor applications in light of PCMs becoming a research hot spot in the nanomedicine sector in recent years.

In this study, Fe 3+ was polymerized on the surface of melamine foam by polypyrrole, and then through a series of reactions with ammonia and Fe 2+ , polypyrrole and Fe 3 O 4 , functionalized hollow melamine foam (MF@PPy-Fe 3 O 4 ) was successfully prepared and observed through scanning electron microscope (SEM). The catalytic degradation of methylene blue (MB) by MF@PPy-Fe 3 O 4 catalyst in aqueous solution was studied under 808nm NIR laser. The catalytic degradation of MB by MF@PPy-Fe 3 O 4 was investigated. Compared with the traditional Fe 3 O 4 nanocatellates, MF@PPy-Fe 3 O 4 perform good Fenton catalytic activity in the degradation of organic dyes such as MB. Fenton reaction rate in the organic dyes degraded like MB. This study pioneered the use of photothermal synergetic Fenton catalytic effect to degrade MB, which has never been done before. Beside, MF@PPy-Fe 3 O 4 has good photothermal stability and can be easily separated from the reaction medium. The results show that MF@PPy-Fe 3 O 4 has good latent using value on the treatment of industrial wastewater.