Fragmentation of the titanacyclopentane ring in [(Ar"O)2Ti(CH2)4] (Ar"O = 2,6-diphenylphenoxide) occurs upon addition of PMe3 to yield the eta-2-ethylene complex [(Ar"O)2Ti(eta-2-C2H4)(PMe3)] (1). The reactivity of 1 and its eta-2-propene analogue toward Ph2C=O has been investigated.

The dimolybdenum hexa-alkyl compound [Mo2(CH2SiMe3)6] reacts rapidly with greater-than-or-equal-to four equivalents of Bu(t)NC in hydrocarbon solvents to produce the eta2-iminoacyl compound 1,2-[Mo2R2(eta2-ButNCR)4] (1; R = CH2SiMe3). The solid-state structure of 1 consists of two five-coordinate molybdenum atoms connected by an unbridged metal-metal triple bond, d(Mo=Mo) = 2.2581(8) angstrom. Each molybdenum atom is bonded to the carbon and nitrogen atoms of two iminoacyl groups as well as the carbon atom of an Mo-CH2 SiMe3 group. The environment about each metal centre is best described as pentagonal planar with the iminoacyl carbon atoms mutually cis. The spectroscopic data of 1 indicate that the iminoacyl groups remain eta2-bound in solution, while metal-metal bond rotation is facile. Compound 1 does not react further with Bu(t)NC or CO (1 atm) at 25-degrees-C, but at temperatures above 50-degrees-C the compound undergoes thermolysis to produce unidentified products.

A new series of titanacyclopentane compounds have been isolated by reaction of the titanacyclopentadiene complex [Ti(OAr")2(C4Et4)] (OAr" = 2,6-diphenylphenoxide) with ethylene, propene, and 1-butene.

The desmosomal adhesive core is formed by four major components: desmoglein (Mr, 165,000), desmocollins I and II (Mr, 120,000 and 110,000, respectively), and a Mr 22,000 protein. Here, we report the cloning and sequencing of cDNAs encoding a bovine desmocollin. The open reading frame found in the longest cDNA, 5 kilobases, contains a region encoding a protein of 839 amino acids. The features of the deduced amino acid sequence imply that the mature 707-amino acid desmocollin is a type I transmembrane protein that is produced by proteolytic cleavage of an 810-amino acid precursor. The ectodomain of desmocollin contains repeats that show extensive sequence similarity to members of the cadherin family of calcium-dependent cell adhesion molecules. A comparison of the amino acid sequences of desmocollin, desmoglein, and the cadherins shows that although these intercellular junctional adhesion molecules share a consensus sequence in their adhesive domains that defines them as a family, several features, including the divergence in the sequence of their cytoplasmic tails, divide them into three distinct subtypes.

Der η2‐Iminotitan‐Komplex 1 reagiert mit Azobenzol in Gegenwart von Pyrrolidinopyridin py] unter Ligandenaustausch zum Komplex 2, der sich bei 100°C innerhalb mehrerer Tage in den Phenylimidotitan‐Komplex 3 umwandelt. Die Ti‐N‐Bindung in 3 ist 171.9(3) pm lang, und der Ti‐N‐C‐Winkel beträgt 173.1(3)°. Anders als Imidozirconium‐Verbindungen, die leicht unter C‐H‐Aktivierungen reagieren, ist 3 ein „toter Hund”︁ – selbst bei 110°C keine Reaktion in Benzol! Ar′ = 2,6‐iPr2C6H3, R′ = tBu.magnified image

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFormation and characterization of .eta.2-imine and .eta.2-azobenzene derivatives of titanium containing ancillary aryloxide ligationLoren D. Durfee, John E. Hill, Phillip E. Fanwick, and Ian P. RothwellCite this: Organometallics 1990, 9, 1, 75–80Publication Date (Print):January 1, 1990Publication History Published online1 May 2002Published inissue 1 January 1990https://pubs.acs.org/doi/10.1021/om00115a012https://doi.org/10.1021/om00115a012research-articleACS PublicationsRequest reuse permissionsArticle Views380Altmetric-Citations83LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts

Desmoglein is a major adhesive component of the desmosome. It is also at least one of the antigenic targets of pathogenic antibodies circulating in the sera of patients with the blistering disease Pemphigus foliaceus. To examine the molecular basis of desmosomal adhesion and to further our understanding of its disruption in various bullous disorders we have cloned cDNAs encoding four of the extracellular domains of desmoglein. The predicted amino acid sequence of these clones shows extensive homology with the cadherin class of calcium-dependent cell adhesion molecules. Desmoglein represents a novel subtype of this family.

The compound [(2,6-Ph 2 C 6 H 3 O) 2 Ti(μ-Cl) 2 Ti(OC 6 H 3 Ph 2 -2,6) 2 ] which is formed by sodium amalgam reduction of Ti(OC 6 H 3 Ph 2 -2,6) 2 Cl 2 (OC 6 H 3 Ph 2 -2,6 = 2,6-diphenylphenoxide) contains a relatively short TiTi distance of 2.9827(7) Å and acute Ti(μ-Cl)Ti angles of 77.79(3) and 78.05(3)°. Crystal data at −130°C: space group P 1 ; a = 13.342(4), b = 13.808(4), c = 16.057(3) Å, α = 97.35(2), β = 104.63(2), γ = 91.64(2)°, Z = 2; ϱ calc = 1.346 g cm −3 .

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and structure of bis(2,6-diisopropylphenoxo)tris(4-phenylpyridine)titanium: a compound containing both reduced and nonreduced 4-phenylpyridine ligands bound to titaniumLoren D. Durfee, John E. Hill, Judith L. Kerschner, Phillip E. Fanwick, and Ian P. RothwellCite this: Inorg. Chem. 1989, 28, 16, 3095–3096Publication Date (Print):August 1, 1989Publication History Published online1 May 2002Published inissue 1 August 1989https://pubs.acs.org/doi/10.1021/ic00315a006https://doi.org/10.1021/ic00315a006research-articleACS PublicationsRequest reuse permissionsArticle Views61Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts

AbstractThe title compound (IV) (space group C2/c, Z = 8) is formed by hydrolysis of the η2‐iminoacyl‐Ti(IV) compound (I) in the presence of 4‐pyrrolidinopyridine (III) and characterized by X‐ray analysis.

AbstractThe trigonal bipyramidal title complex (IV) is obtained according to the scheme.

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIsolation and characterization of bis(2,6-diisopropylphenoxo)bis(4-pyrrolidinopyridine)oxotitanium: a mononuclear aryloxide compound containing a terminal titanium(IV)-oxo groupJohn E. Hill, Phillip E. Fanwick, and Ian P. RothwellCite this: Inorg. Chem. 1989, 28, 18, 3602–3604Publication Date (Print):September 1, 1989Publication History Published online1 May 2002Published inissue 1 September 1989https://pubs.acs.org/doi/10.1021/ic00317a041https://doi.org/10.1021/ic00317a041research-articleACS PublicationsRequest reuse permissionsArticle Views149Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts

To detect the frequency of left axis deviation (LAD) in isolated perimembranous ventricular septal defects (VSD) we retrospectively analyzed electrocardiograms of 59 patients, aged 8 months to 15 years. Patients were grouped into those having ventricular septal aneurysm (VSA) formation (n:20) and those who did not have VSA (n:39). Patients with VSA were then stratified into 2 groups according to the presence of left ventricular-to-right atrial (LV-RA) shunt. Four hundred healthy children served as the control group. We found that 12 (20.3%) of 59 patients with isolated perimembranous VSD had a LAD. Five of 6 patients with perimembranous outlet VSD and 6 with perimembranous inlet VSD had abnormal LAD with a qR pattern in I and aVL and rS in aVF. Abnormal LAD was more prevalent in patients with VSA (40%) than without VSA (7.7%) (P < .01). We also found that mild right ventricular hypertrophy (RVH) with the rsR ̀ or rSR ̀ pattern in V1 was more frequent in patients with VSA, especially those who had LV-RA shunt. However, we could not find significant difference between patients with or without LV-RA shunt for the incidence of abn LAD and mild RVH. Localization of perimembranous VSD was not found to have an effect on frequency of abnormal LAD and mild RVH in this patient group. In patients with clinical findings of VSD, the existence of abnormal LAD especially if it is associated with mild RVH, should raise the possibility of perimembranous VSD with VSA formation.

Ventricular paced rhythm is thought to obscure the electrocardiographic diagnosis of acute coronary occlusion myocardial infarction. Our primary aim was to compare the sensitivity of the modified Sgarbossa criteria (MSC) to that of the original Sgarbossa criteria for the diagnosis of occlusion myocardial infarction in patients with ventricular paced rhythm.In this retrospective case-control investigation, we studied adult patients with ventricular paced rhythm and symptoms of acute coronary syndrome who presented in an emergency manner to 16 international cardiac referral centers between January 2008 and January 2018. The occlusion myocardial infarction group was defined angiographically as thrombolysis in myocardial infarction grade 0 to 1 flow or angiographic evidence of coronary thrombosis and peak cardiac troponin I ≥10.0 ng/mL or troponin T ≥1.0 ng/mL. There were 2 control groups: the “non-occlusion myocardial infarction-angio” group consisted of patients who underwent coronary angiography for presumed type I myocardial infarction but did not meet the definition of occlusion myocardial infarction; the “no occlusion myocardial infarction” control group consisted of randomly selected emergency department patients without occlusion myocardial infarction.There were 59 occlusion myocardial infarction, 90 non-occlusion myocardial infarction-angio, and 102 no occlusion myocardial infarction subjects (mean age, 72.0 years; 168 [66.9%] men). For the diagnosis of occlusion myocardial infarction, the MSC were more sensitive than the original Sgarbossa criteria (sensitivity 81% [95% confidence interval [CI] 69 to 90] versus 56% [95% CI 42 to 69]). Adding concordant ST-depression in V4 to V6 to the MSC yielded 86% (95% CI 75 to 94) sensitivity. For the no occlusion myocardial infarction control group of ED patients, additional test characteristics of MSC and original Sgarbossa criteria, respectively, were as follows: specificity 96% (95% CI 90 to 99) versus 97% (95% CI 92 to 99); negative likelihood ratio (LR) 0.19 (95% CI 0.11 to 0.33) versus 0.45 (95% CI 0.34 to 0.65); and positive LR 21 (95% CI 7.9 to 55) versus 19 (95% CI 6.1 to 59). For the non-occlusion myocardial infarction-angio control group, additional test characteristics of MSC and original Sgarbossa criteria, respectively, were as follows: specificity 84% (95% CI 76 to 91) versus 90% (95% CI 82 to 95); negative LR 0.22 (95% CI 0.13 to 0.38) versus 0.49 (95% CI 0.35 to 0.66); and positive LR 5.2 (95% CI 3.2 to 8.6) versus 5.6 (95% CI 2.9 to 11).For the diagnosis of occlusion myocardial infarction in the presence of ventricular paced rhythm, the MSC were more sensitive than the original Sgarbossa criteria; specificity was high for both rules. The MSC may contribute to clinical decisionmaking for patients with ventricular paced rhythm.

The Anatomical RecordVolume 92, Issue 3 p. 305-358 American Association of AnatomistsFree Access American Association of Anatomists. Proceedings, officers and list of members R. R. Bensley, R. R. BensleySearch for more papers by this authorB. F. Kingsbury, B. F. KingsburySearch for more papers by this authorGeorge L. Streeter, George L. StreeterSearch for more papers by this authorH. E. Jordan, H. E. JordanSearch for more papers by this authorJ. E. Kindred, J. E. KindredSearch for more papers by this authorC. C. Speidel, C. C. SpeidelSearch for more papers by this authorWilbur C. Smith, Wilbur C. SmithSearch for more papers by this authorHarold Cummins, Harold CumminsSearch for more papers by this authorRudolph Matas, Rudolph MatasSearch for more papers by this authorOliver P. Jones, Oliver P. JonesSearch for more papers by this authorR. R. Humphrey, R. R. HumphreySearch for more papers by this authorF. E. Emery, F. E. EmerySearch for more papers by this authorStacy R. Guild, Stacy R. GuildSearch for more papers by this authorGeorge B. Wislocki, George B. WislockiSearch for more papers by this authorWilliam K. Gregory, William K. GregorySearch for more papers by this authorFranz Weidenreich, Franz WeidenreichSearch for more papers by this authorJohn E. Hill, John E. HillSearch for more papers by this authorPhilip B. Armstrong, Philip B. ArmstrongSearch for more papers by this authorWalter F. Greene, Walter F. GreeneSearch for more papers by this authorTheodore Snook, Theodore SnookSearch for more papers by this authorEarl W. Count, Earl W. CountSearch for more papers by this authorCharles A. Woerner, Charles A. WoernerSearch for more papers by this authorJames W. Benjamin, James W. BenjaminSearch for more papers by this author R. R. Bensley, R. R. BensleySearch for more papers by this authorB. F. Kingsbury, B. F. KingsburySearch for more papers by this authorGeorge L. Streeter, George L. StreeterSearch for more papers by this authorH. E. Jordan, H. E. JordanSearch for more papers by this authorJ. E. Kindred, J. E. KindredSearch for more papers by this authorC. C. Speidel, C. C. SpeidelSearch for more papers by this authorWilbur C. Smith, Wilbur C. SmithSearch for more papers by this authorHarold Cummins, Harold CumminsSearch for more papers by this authorRudolph Matas, Rudolph MatasSearch for more papers by this authorOliver P. Jones, Oliver P. JonesSearch for more papers by this authorR. R. Humphrey, R. R. HumphreySearch for more papers by this authorF. E. Emery, F. E. EmerySearch for more papers by this authorStacy R. Guild, Stacy R. GuildSearch for more papers by this authorGeorge B. Wislocki, George B. WislockiSearch for more papers by this authorWilliam K. Gregory, William K. GregorySearch for more papers by this authorFranz Weidenreich, Franz WeidenreichSearch for more papers by this authorJohn E. Hill, John E. HillSearch for more papers by this authorPhilip B. Armstrong, Philip B. ArmstrongSearch for more papers by this authorWalter F. Greene, Walter F. GreeneSearch for more papers by this authorTheodore Snook, Theodore SnookSearch for more papers by this authorEarl W. Count, Earl W. CountSearch for more papers by this authorCharles A. Woerner, Charles A. WoernerSearch for more papers by this authorJames W. Benjamin, James W. BenjaminSearch for more papers by this author First published: July 1945 https://doi.org/10.1002/ar.1090920312AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Volume92, Issue3July 1945Pages 305-358 RelatedInformation