Objective To analyze the clinicopathologic characteristics of remnant gastric cancer(RGC).Methods The clinical data of 114 patients with RGC treated in The Second Affiliated Hospital of Northern Sichuan Medical College and The General Hospital of Chinese People’s Liberation Army from March 2000 to May 2008 were reviewed and analyzed retrospectively.The clinicopathologic characteristics between the patients with primary benign diseases and those with malignant diseases were evaluated.Results A total of 114 cases,the age was(62.6±11.3)years,and the males versus females was 4.7∶1.0.Most patients(76.2%,64/84)were diagnosed at advanced stages(consistent with pT),and the proportion of pT1 stage cases was only 23.8%(20/84),tumor invasion pT4 was 60.7%(51/84).It was more common that tumor directly invaded adjacent organs or structures(27.4%,23/84),lymph nodes positive(42.9%,36/84),and distant metastasis(27.2%,31/114).The location of distant metastasis was usually confined in the abdominal cavity(93.5%,29/31),and the peritoneum disseminated was the most commonly structures(67.7%,21/31).Histologically,the incidence of poorly differentiated adenocarcinoma(76.7%,79/103)was the mostly histologic grade as well as the diffuse type(78.6%,81/103)was the mostly Lauren classification.Between the patients with primary benign diseases and those with initial malignant disease,the initial gastrectomy or the methods of reconstruction had significantly differences(both P=0.000).The median time from initial resection to development of RGC was 30.0 years in the patients with original benign disease,contrary to 3.3 years in those with previous malignant disease(P=0.000).Both primary diseases(benign or malignant)and the age at initial gastrectomy were the major influencing factors for the time of RGC developed(P0.05).For pathohistology characters,except signet-ring cell carcinoma(P=0.045),pT4b(P= 0.049),pN stage(P=0.025),and Borrmann classification(P=0.005),there were no significant differences between the patients with previous benign diseases and those with original malignant disease,as well as the resectability rate,curative resection(R0)rate,and overall survival rate(P 0.05).Conclusions It is almost unaffected by original benign diseases or malignant diseases for clinicopathologic characteristics including the treatment option and prognostic factors.It is necessary and feasibility to form a pattern of endoscopic follow-up for RGC.

Ovarian tumor is one of the three common malignant tumors in reproductive apparatus of females,which seriously threatens women′s health,as well as occurs and develops in negligence.Because there is no symptom in the early stage and lack of effective screening medium,80% of people who are diagnosed ovarian cancer is in mid-term and late period.Therefore,it′s very important for the sufferers to find out the ovarian cancer earlier.With the application of combined measurement of tumor markers,it can assist ovarian cancer diagnosis in the early stage and increase the rate of subsistence.At the same time,the combined measurement is good to the monitoring of the patients′condition,the evaluation of the curative effect and the determination of the prognosis.

Objective To summarize and analyze the treatment options and prognostic factors of gastric stump carcinoma(GSC).Methods The clinical data of 114 patients with GSC treated in The Second Affiliated Hospital of Northern Sichuan Medical College and The General Hospital of Chinese People's Liberation Army from Mar.2000 to May. 2008 were reviewed,and influencing factors of surgical resection and prognosis were analyzed.Results For all patients, the ratios of surgical resection and curative resection(R0 resection) were 57.0%(65/114) and 54.4%(62/114),respectively.The ratios of total gastrectomy,distal gastrectomy,proximal gastrectomy,endoscopic mucosal resection(EMR), and endoscopic submucosal dissection(ESD) were 73.8%(48/65),16.9%(11/65),3.1%(2/65),4.6%(3/65),and 1.5%(1/65)in resection cases,and were 75.8%(47/62),16.1%(10/62),3.2%(2/62),4.8%(3/62),and 0 in R0 resection cases,respectively.Seventy-five patients were followed-up for 0.3-79 months(median 12 months),the median survival time was 19.5 months,and 1-,3-,and 5-year overall survival rates were 61.8%,42.3%,and 30.1%,respectively.The results of multivariate analysis showed that resection rate was higher in patients with initial distal gastrectomy(P=0.002),kps score≥80(P=0.016),lower macroscopic type(P=0.013),and cM0(P=0.000).R0 resection(P=0.000),macroscopic type(P=0.005),and cT stage(P=0.006) were the independent prognostic factors.There were both no significant difference on survival between the patients with previous benign disease and those with original malignant disease when analyzed with univariate or multivariate method(P>0.05).There were no significant difference on overall survival curve among patients treated with palliative resection,palliative chemotherapy,simple laparotomy,and best supportive care(P>0.05).Conclusion sThe treatment options and prognosis of GSC were not influenced by the primary benign diseases or malignant diseases,and R0 resection is the most important prognostic factor.Removal of total remnant stomach is the best surgical procedure for GSC,and palliative laparotomy should be avoided.

<正>根治性手术是胃癌最有效的治疗手段,但术后复发率高仍是目前胃癌治疗的难题之一。局部晚期的病人无法一期行根治性手术,可以通过新辅助化疗或者化疗联合放疗后使癌块局限达到手术目的。转移性胃癌病人没有手术机会,只能通过化疗

芳香化酶是细胞色素P450酶家族中一个成员,在体内将睾酮、雄烯二酮、16-α-羟雄烯二酮转化成雌酮和雌二醇。绝经后妇女外周循环中的雌激素水平明显下降,但乳腺癌组织里有高表达的芳香化酶,可能导致乳腺癌局部的高雌激素环境而促使肿瘤增殖。临床上根据这一特有的病理生理学改变,应用芳香化酶抑制剂抑制乳腺癌组织内高表达的芳香化酶活性,减少雌激素的合成,治疗乳腺癌。

芳香化酶是细胞色素P450酶家族中一个成员,在体内将睾酮、雄烯二酮、16-α-羟雄烯二酮转化成雌酮和雌二醇.绝经后妇女外周循环中的雌激素水平明显下降,但乳腺癌组织里有高表达的芳香化酶,可能导致乳腺癌局部的高雌激素环境而促使肿瘤增殖.临床上根据这一特有的病理生理学改变,应用芳香化酶抑制剂抑制乳腺癌组织内高表达的芳香化酶活性,减少雌激素的合成,治疗乳腺癌.