Objective: This study aimed to investigate the Chinese norms for the Symptom Checklist 90 (SCL-90) scale and its application. Methods: In total, 7,489 adults from Tianjin and Qingdao in China were included. Their data were compared with the norm data of 1,388 people published by Jin et al., the combined norms published by Tang et al., the data of 2,808 adults published by Chen and Li, and the data of 1,890 adults from Tong in China. Results: In five different periods, notable changes were observed in each factor of the SCL-90 that significantly differed from the previous norms. The scores of each factor showed an increasing annual trend. Compulsion consistently obtained the highest scores, and phobia consistently obtained the lowest scores. The scores tended to decrease from compulsion to anxiety, and psychosis scored lower than paranoia. There was a significant difference in the detection rate between the critical screening value of two points and the standard score. Using the standard score as the critical value, the detection rate ranged between 13 and 16% and was relatively concentrated. Using two points as the critical value, the detection rate ranged between 38 and 50%. Conclusion: The usual model in China is not consistent with social development. Using two points as the critical value is no longer suitable for the SCL-90. New Chinese norms and measurement standards should be developed. The mean value plus one standard deviation could be used as the new measurement standard.

针对传统MMP I量表中题目数量过多,许多应用场景下受试者依从性差的问题,提出使用机器学习算法对MMP I量表中的临床量表进行简化的方法,对6种经典机器学习算法的简化效果进行了比较,并在受试者测评数据上对原始和简化后测评结果的敏感度与特异度进行了对比分析.实验结果表明,使用最小绝对收缩和选择算子(LASSO)的算法在保持相近准确率的同时简化效果最好,平均减少了37.3％的男性和39.1％的女性受试者题目数量,并且简化后测评结果的敏感度与特异度仍能保持在原始测评结果的85％,缩短了测评时间,适用于更多的应用场景.

目的 使用机器学习算法对明尼苏达多相个性调查表(MMPI)中的临床量表进行简化.方法 将7410例测试者的测评数据针对不同人群进行划分,通过机器学习算法进行建模分析以实现动态删减部分题组.结果 将动态删减后的结果保持删减前结果75％的敏感度与特异度为阈值,男性的癔症(Hy)为阴性且精神衰弱(Pt)、精神分裂(Sc)为阳性的分组,癔症(Hy)、抑郁(D)为阴性且精神衰弱(Pt)、精神分裂(Sc)为阳性的分组,精神分裂(Sc)、精神衰弱(Pt)、妄想(Pa)、男性-女性倾向(Mf)、病态人格(Pd)、社会内向(Si)为阴性且癔症(Hy)、抑郁(D)为阳性的分组,均可缩减8.3％的题目;抑郁(D)、精神衰弱(Pt)、精神分裂(Sc)、社会内向(Si)、轻躁狂(Ma)、男性-女性倾向(Mf)为阴性且疑病(Hs)为阳性的分组可缩减15.0％的题目;精神分裂(Sc)为阴性且抑郁(D)为阳性的分组可缩减12.0％的题目.女性的精神分裂(Sc)、抑郁(D)、病态人格(Pd)、社会内向(Si)、疑病(Hs)、妄想(Pa)、轻躁狂(Ma)、男性-女性倾向(Mf)为阴性且癔症(Hy)为阳性的分组可缩减12.0％的题目;抑郁(D)、社会内向(Si)、癔症(Hy)为阴性且精神分裂(Sc)、妄想(Pa)、精神衰弱(Pt)为阳性的分组可缩减11.5％的题目.结论 简化后的版本实现了筛查与辅助诊断的功能,更适用于体检场景.基于本研究提出的机器学习模型,继续扩大数据量,能够挖掘出更多的可简化分组.

目的 研究大学生心理健康状况以及SCL-90常模.方法 利用临沂市某大学8221名在校大学生测评的症状自评量表(SCL-90)、抑郁症筛查量表(PHQ-9)结果数据,分析SCL-90信效度,并与2010年全国范围数据以及2020年体检中心人群数据常模对比分析.结果 8221名大学生SCL-90各因子分均低于2020年常模(P<0.01);SCL-90躯体化、抑郁、敌对、偏执、精神病性因子分低于2010年常模(P<0.05),强迫、人际敏感、焦虑、恐怖因子分高于2010年常模(P<0.05).强迫、人际敏感两个维度以2分作为临界值的检出率大于标准分临界值的检出率(P<0.01);躯体化、焦虑、恐怖、精神病性四个维度以2分作为临界值的检出率小于标准分临界值的检出率(P<0.01).研究中SCL-90量表的信度较高,总量表和各分量表的信度均在0.8以上;抑郁分量表与PHQ-9的一致性在0.529,其一致性与2010年常模一致,高于2020年体检常模.结论 针对大学生群体使用的常模不同于一般群体,不同的分量表应该制定不同的临界值.

目的 探讨巴戟天寡糖胶囊联合帕罗西汀治疗抑郁症的疗效及对神经递质和炎性因子水平的影响.方法 选取青岛市市立医院2015年2月至2018年12月收治的抑郁症患者143例,按随机数字表法分为对照组(71例)和研究组(72例).两组患者均予帕罗西汀治疗,研究组患者加用巴戟天寡糖胶囊,均治疗8周.结果 研究组总有效率为70.83％,明显高于对照组的54.93％(P<0.05);治疗后,两组患者的去甲肾上腺素(NE)、5-羟色胺(5-HT)、脑源性神经营养因子(BDNF)水平均明显升高(P<0.05),神经生长因子(NGF)及白细胞介素6(IL-6)、白细胞介素12(IL-12)、肿瘤坏死因子-α(TNF-α)水平均明显降低(P<0.05),且研究组均明显优于对照组(P<0.05);研究组不良反应发生率与对照组相当(20.83％比15.49％,P>0.05).结论 巴戟天寡糖胶囊联合帕罗西汀治疗抑郁症,可有效改善患者神经内分泌功能和炎性状况.

目的 观察氟伏沙明联合团体认知行为治疗(GCBT)对强迫症病人的疗效.方法 将按照精神障碍诊断统计手册第4版(DSM-Ⅳ)标准确诊的强迫症病人60例随机分为2组,实验组30例使用氟伏沙明联合GCBT治疗,对照组30例单纯使用氟伏沙明治疗.采用Yale-Brown强迫量表(Y-BOCS)、汉密尔顿焦虑量表(HAMA)、SF-36健康调查简表(SF-36)评定疗效.结果 治疗12周后,实验组和对照组病人平均Y-BOCS、HAMA得分均较治疗前明显下降,但是两组间比较差异无统计学意义(P＞0.05);实验组病人治疗后SF-36评分较治疗前显著升高(t=2.01,P＜0.05),实验组SF-36评分改善优于对照组(F=8.37,P＜0.01).结论 氟伏沙明联合GCBT治疗和氟伏沙明单药治疗均能有效改善强迫症病人的强迫症状和焦虑情绪,但联合治疗能更有效地提高强迫症病人的生活质量.

Objective:To explore the change of cognitive function in first-episode schizophrenia patients after short-term atypical antipsychotic medication. Method:sforty five first-episode schizophrenia patients and 48 demographically matched healthy controls were included. All patients were assessed by brief psychiatry rating scale (BPRS)before and after medication. MATRICS consensus cognitive battery (MCCB)were used to assess the cognitive function of all participants. Results:29 patients had completed8-week atypical antipsy-chotic medication. While 11 patients were medicated with risperidone,9 with olanzapine,9 with aripiprazole. Pa-tients'BPRS scores declined significantly after medication (t=6. 87,P<0. 01). Before medication,the process-ing speed,attention/vigilance,working memory,verbal learning,visual learning and reasoning&problem solving domain scores of schizophrenia patients are significantly lower than healthy controls (t=2. 33-4. 45,all P<0. 05). But after medication,patients'attention/vigilance score and working memory score raised significantly(t=2. 80,t=2. 16,all P<0. 05). Conclusion:The cognitive function of first-episode schizophrenia patients did not change significantly after short-term antipsychotic medication.

OBJECTIVE: To analyse psychological needs of the elderly living in resthome and to provide the basis for improving a-gency services and the quality of the aged. METHODS: 180 old people with normal intelligence living in community nursing home were selected randomly. Psychiatry Needs Inventory for the Elderly was used to learn their psychological needs. The questionnaire was compiled by Fu Shuangxi who was the vice president of Chinese Ageing Development Foundation. SPSS17. 0 statistical software was used to analyse investigation result. RESULTS: The average of each dimension was: physiological needs (1. 58 ± 0. 70), communi-cation needs (1. 89 ± 0. 05), self - actualization needs (2. 52 ± 0. 76) and identification needs (3. 28 ± 0. 82). Post hoc test showed that there were significant different between both of them. The scores of psychological needs of different demographic character-istics were compared. The results showed that cultural difference among groups was significant, [F (3, 150) =3. 807, P <0. 05]; the differences in occupation group were marginal [F (1, 150) =3. 946, P=0. 05]; The psychological demand of manu-al workers (9. 27 ± 0. 29) was more than that at mental workers (9. 61 ± 0. 32). CONCLUSIONS: The study results show that the highest demand is physiological needs, then is communication needs and self - actualization needs, and the last is identification needs. The psychological needs of the elderly may be associated to educational status and vocation. The identification needs of the manual workers are more than those of the brainworker.

Objective To study the psychosocial factors of the effect of medication compliance in patients with depression.Methods Choose 236 depression patients of our hospital as research object, the self-made questionnaire for the investigation and analysis of medication adherence.Results The treatment for complex degree, life work and drug treatment of conflict, disease awareness factors and treatment compliance has significant correlation, P<0.01; And health service convenience, the doctor-patient relationship, social support factor has no significant correlation with medication adherence,P > 0.05.Conclusion The psychosocial factors of medication compliance in patients with depression has the important influence to the medical staff should be reasonable analysis of the actual situation of each patient, thereby improving the service, better improve patient compliance.