肺癌是临床最常见的原发性恶性肿瘤之一,常伴淋巴结、骨、脑、肝、肾上腺及消化道等部位的转移.临床上由肺癌转移至口腔且均为表皮生长因子受体突变的病例并不多见.本文回顾报道2例以牙龈肿物为首发症状就诊于河北医科大学第四医院·河北省肿瘤医院口腔科的患者,总结分析2例患者的诊疗过程,并对其临床表现、病理诊断与治疗进行讨论.

垂体和鞍区肿瘤约占所有脑肿瘤的15％.目前最常见的肿瘤是垂体腺瘤,即局限于鞍区的良性神经内分泌肿瘤.累及鞍区的肿瘤种类较多,反映了其复杂的解剖结构(表1).本文重点讨论第4 版即WHO(2017)垂体肿瘤分类的主要变化,包括垂体神经内分泌肿瘤新分类的命名和分子遗传学,主要是垂体腺瘤,同时介绍一些垂体非神经内分泌肿瘤.

头颈部发生的肿瘤,其原发部位和病理类型之多,居全身肿瘤之首.由于头颈部的解剖关系比较复杂,集中了一些重要的器官,衍生出了相应的类型众多的肿瘤和肿瘤样病变,治疗方式各异.所以WHO(2017)头颈部肿瘤分类更新了对头颈部肿瘤系统的讨论.该文将简要阐述这一更新的主要内容.

Objective To study the effects of Rhizoma Drynariae on proliferation and differentiation of human gingival fibroblast(HGF).Methods HGFs were inclubated with different concentrations of Rhizoma Drynariae respectively,alkaline phosphatase(ALP) were measured by MTT assay to search for the best concentration.Effects of Rhizoma Drynariae at this best concentration on cell cycle was studied by flow cytometer.Results Rhizoma Drynariae at selected concentrations increased ALP expression(P0.05),especially at 100 μg/mL.At 100 μg/mL,G1 period cells were decreased,S and G2M periods' cells were increased,the proliferation index was higher than that of the control group(P0.05).Conclusion Proper concentrations of Rhizoma drynariae may promote ALP expression of HGFs and more cells entered proliferation state.

AIM:To study the biological activity of human periodontal ligament cells(PDLCs) and gingival fibroblasts(GF).METHODS: Isolated human periodontal ligament cells and gingival fibroblasts were cultured according to the method of tissue-explant.Their growth curve were draw.ALP activity were detected.The expression of collagen Ⅰ、collagen Ⅲ and BMP were determined by immunohistochemistry dyeing and FCM,in purpose of comparing characteristics of those two kinds of cells.RESULTS: The primary culture achievement ratio and proliferation activity of gingival fibroblasts were obviously higher than the periodontal ligament cells.The expression of collagen Ⅰ,Ⅲ and BMP were strongly positive in gingival fibroblast, but was weakly positive in periodontal ligament cells.CONCLUSION: Periodontal ligament cells showed stronger bone formation ability,and could be regarded as ideal seed-cells in periodontal tissue engineering.The gingival fibroblasts were easily to be cultured with high success rate,also may be regarded as the ideal seed cells in periodontal tissue engineering.

Objective To study the effects of rhizoma drynariae on the ultramicrostructure and the activity of alkaline phosphatase(ALP)of human gingival fibroblast(HGF)cultured in vitro.Methods HGFs were inclubated with different concentrations of rhizoma drynariae respectively and ALP was measured by MTT assay to search for the best concentration.Effects of rhizoma drynariae by this best concentration on ultramicrostructure was studied by electron microscope.Results Rhizoma drynariae at selected concentrations increased ALP expression(P<0.05),especially at 100 μg/mL.At 100 μg/mL,the cell apparatus increased in number and was reinforced in function.Conclusion Proper concentrations of rhizoma drynariae may promote ALP expression of HGFs,increasing the number of cell apparatus and reinforcing its function.