Les parents d’enfants en bas-âge sont particulièrement inquiets au sujet de la sécurité des aliments et questionnent fréquemment le corps médical. La réglementation européenne sur les aliments infantiles permet d’assurer des niveaux de sécurité très élevés et plus sévères que pour l’alimentation courante. La limite appliquée à la teneur en pesticides illustre le niveau élevé d’exigence. Celle-ci ne doit jamais dépasser le seuil de détectabilité de 10ppb, quelle que soit la molécule utilisée. D’autres contaminants tels que les nitrates font aussi l’objet d’une attention plus grande en alimentation infantile. La maîtrise des risques alimentaires requiert une expérience et un savoir faire spécifique que les industriels de l’alimentation infantile ont su développer, notamment la contractualisation avec des producteurs de matières premières de très haute qualité.

Food safety is a concern for parents of infants, and healthcare professionals are often questioned by them about this topic. Baby food European regulation ensures high levels of safety and is more rigorous than common food regulation. Maximal limit for pesticides in baby food demonstrates the high level of requirements. This limit must be below the 10 ppb detection threshold, whatever the chemical used. Other contaminants such as nitrates are also the subject of greater expectations in baby food. Food safety risks control needs a specific know-how that baby food manufacturers have acquired and experienced, more particularly by working with producers of high quality raw material.

Objectives. The purpose of this open multicenter study was to evaluate the value of a new starch-thickened formula in infants with regurgitations in ambulatory pediatric practice.Population and methods. The study population comprised fullterm infants with an age at inclusion of 1-90 days, who were bottle-fed and presented regurgitations. The formula tested was an infant formula-thickened with starch (2 g/100 mL). The primary endpoint was the frequency of bottles regurgitated, expressed in percentage of meals per clay after 15 days of feeding with the preparation studied. Secondary endpoints were the assessment. of regurgitations using the Vandenplas' score, as well as the daily increase in weight, height, and cranial circumference, overall and gastrointestinal tolerance, and formula acceptability.Results. Sixty-four infants presenting regurgitation were included. The frequency of bottles regurgitated estimated at 80.3% at inclusion significantly decreased at D3, D15, and D30 to 40.1, 40.2 and 37.2% (P < 0.0001), respectively. Thirty percent of infants (lid not present regurgitations at all at D30. Similarly, a significant decrease in the Vandenplas' score was observed from 1.9 at D0 to 0.9 at D30 (P < 0.0001). Infant growth was similar to the French and European growth curves.Conclusion. The results showed rapid and lasting improvement in decreasing the frequency of feeding-bottles regurgitated by 50% from the first 3 clays of using this new starch-thickened formula (2 g/100 mL). These satisfying results encourage the use of the tested formula in cases of infant regurgitation, in line with the European Society of Gastroenterology, Hepatology and Nutrition (ESPGHAN) recommendations. (c) 2009 Elsevier Masson SAS. All rights reserved.

20 à 50 % des nourrissons présentent des régurgitations ; à l’âge d’un an 5 % en souffrent encore, celles-ci peuvent alors être évocatrices de RGO (Reflux Gastro-Oesophagien). Nous avions observé dans un travail précédent qu’une préparation infantile contenant 2g d’amidon pour 100mL chez des nourrissons de moins de 3 mois présentant des régurgitations permettait une diminution rapide de la fréquence des régurgitations et une persistance de l’effet dans le temps. L’objectif de cette étude observationnelle était de suivre ces mêmes nourrissons, ayant bénéficié d’une prise en charge diététique pour régurgitations durant 1 mois, jusqu’à l’âge d’un an et d’évaluer la persistance des régurgitations et leur étiologie. Les nourrissons avaient au préalable été inclus dans une étude ouverte et multicentrique. Ces enfants devaient avoir moins de 3 mois au moment de l’inclusion et présenter des régurgitations. Ils ont reçu un lait infantile épaissi à l’amidon (2g/100mL) et contenant des lipides structurés durant 30 jours consécutifs, à l’issue desquels la fréquence des régurgitations avaient diminué de plus de 50 %. L’évolution des régurgitations a ensuite été évaluée dans le cadre d’une visite à l’âge d’un an. 52 nourrissons ont été revus à l’âge de 12,09 (+/−0.51) mois. Ils étaient tous diversifiés depuis l’âge de 5.51 (+/−0.69) mois et la moitié de la population avait déjà effectué ses premiers pas. 8 nourrissons ont pris un traitement médicamenteux anti-reflux pour RGO suite à la première étude, mais sans qu’aucune exploration n’ait été réalisée. Seuls 4 nourrissons (soit 8 %) régurgitaient encore à l’âge d’un an, dont deux présentaient un score de « Vandenplas » d’une valeur de 2 (sur une échelle de 0 à 6, le score 0 correspondant à « pas de régurgitation » et le score 6 à « régurgitation complète à la fin de chaque repas ») et deux d’une valeur de 1. Cette première étude observationnelle a permis de confirmer la possible persistance chez certains nourrissons jusqu’à l’âge d’un an de régurgitations, sans diagnostic de RGO. Ce travail invite à recommander la réalisation d’études avec un suivi prolongé afin de mieux évaluer l’effet de la prise en charge diététique et médicamenteuse et l’épidémiologie en termes d’exploration.

Aim: There are still not enough informations to propose guidelines about post-discharge nutrition. We evaluated growth and bone mineralisation in very low birth weight (VLBW) infants fed preterm formula (PF) or standard term formula (TF).

UNLABELLED Besides assuring growth and development in early infancy, human breast milk plays a key role in preventing infections, in particular by favouring the growth of bifidobacteria. The development of infant formulas containing probiotic agents consequently represents a significant advance in the provision of an optimal alternative to breast feeding when this is not feasible. A further concern is to avoid an excessively high protein content relative to breast milk, potentially favouring obesity in later life. OBJECTIVES The objective of this open Multicenter comparative study was to demonstrate that a new infant formula, characterized by a reduced protein content and the presence of a probiotic agent, was as effective as conventional formulas in assuring growth during the first months of life. POPULATION AND METHODS The study population comprised full-term healthy infants with an age at inclusion of 1-28 days, whose mothers no longer wished to continue breast feeding or were unable to breast feed. The test formula (GE), enriched with Bifidobacterium lactis, had a protein content of 1.5 g/100 ml. The primary end point was daily weight gain from day 0 to day 90. Secondary end points were daily increase in height and cranial circumference, overall and gastrointestinal tolerance and formula acceptability. A total of 203 infants were included in the analysis, 117 receiving GE and 86 the formula habitually prescribed by the paediatrician. RESULTS Daily gains in weight, height and cranial circumference did not differ significantly between the groups. The rates of overall and gastrointestinal adverse events were comparable in the two groups and the acceptability of GE was consistently good, similar to that of the standard formulas. CONCLUSION The results of this study demonstrated that the new probiotic infant formula GE has equivalent efficacy to conventional formulas in achieving growth in early infancy, and is well tolerated.

Outre son rôle sur la croissance et le développement du nourrisson, le lait maternel participe à la prévention des infections, notamment en favorisant la croissance intestinale des bifidobactéries. Le développement de nouvelles formules infantiles contenant des agents probiotiques représente ainsi un concept intéressant en nutrition infantile, lorsque l'allaitement maternel est impossible. En outre, une teneur du lait infantile trop élevée en protéines serait susceptible de favoriser la survenue ultérieure d'une obésité.

OBJECTIVES:To assess the presence and impact of health education messages in pediatricians' waiting rooms.METHODS:In September 2001, 81 pediatricians completed a questionnaire about the furnishings and equipment in their waiting rooms. They also distributed a questionnaire about waiting room health education messages to parents, to be completed at home.RESULTS:The analysis considered 1830 questionnaires. Health education messages were posted in 91% of the waiting rooms and most frequently concerned children's accidents, vaccines, hygiene and nutrition. The best topics that the parents remembered involved child neglect, antibiotic therapy, AIDS and other sexually transmitted diseases, and nutrition. Although memorization of the messages was not influenced by duration of the wait, it was higher among parents who had previously visited the pediatrician. These messages led 14% of the parents to discuss them spontaneously with their pediatrician.CONCLUSION:Health education messages are posted in nearly all the waiting rooms studied; parents remember them in a variable and rather inexplicable order. Posting these messages demonstrates the pediatricians' willingness to be involved - beyond the simple consultation - in the health education of children and families. Identifying the real impact of these messages would require further study.

Journal of Pediatric Gastroenterology and NutritionVolume 39, Issue S1 p. S502-S502 ABSTRACTS: Poster Session Abstracts P1171 DO DIGESTIVE AND NUTRITIONAL TROUBLES CONSTITUTE PROBLEM FOR PAEDIATRICIAN ? RESULTS OF A SURVEY. L. D. Van Egroo, L. D. Van Egroo Medical Department, Nestle, NoisielSearch for more papers by this authorF. Huet, F. Huet Pediatric Department, CHU, DijonSearch for more papers by this authorC. Van Egroo, C. Van Egroo Medical Department, Clin Eval et Com, Clin Eval et Com, FranceSearch for more papers by this authorE. Lachambre, E. Lachambre Medical Department, Nestle, NoisielSearch for more papers by this author L. D. Van Egroo, L. D. Van Egroo Medical Department, Nestle, NoisielSearch for more papers by this authorF. Huet, F. Huet Pediatric Department, CHU, DijonSearch for more papers by this authorC. Van Egroo, C. Van Egroo Medical Department, Clin Eval et Com, Clin Eval et Com, FranceSearch for more papers by this authorE. Lachambre, E. Lachambre Medical Department, Nestle, NoisielSearch for more papers by this author First published: 01 June 2004 https://doi.org/10.1002/j.1536-4801.2004.tb13601.x Submitted by: [email protected] Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume39, IssueS1June 2004Pages S502-S502 RelatedInformation

ABSTRACTObjectivesProbiotics may be useful in preventing acute infectious diarrhea. Bifidobacteria are particularly attractive as probiotics agent because they constitute the predominant colonic flora of breastfed infants and are thought to play a role in the decreased incidence of diarrhea in breastfed infants.MethodsThis was a multicenter, double‐blind, controlled study to evaluate the efficacy of a milk formula supplemented with viable Bifidobacterium lactis strain Bb 12 (BbF) in the prevention of acute diarrhea in infants younger than 8 months living in residential nurseries or foster care centers.ResultsNinety healthy children received either the BbF or a conventional formula (CF) daily. The mean duration of the stay in the residential center was similar (137 v 148 days). At enrollment, there were no differences between the two groups with respect to age (3.7 ± 2.1 months), gender, anthropometric data, history of allergy or gastrointestinal disease, frequency of breast‐feeding in the neonatal period or timing of introduction of solid food. Altogether, 28.3% of the BbF infants had diarrhea during the study compared with 38.7% of controls (NS). There was a statistically insignificant trend for shorter episodes of diarrhea in the BbF group (5.1 ± 3.3 days v 7 ± 5.5 days, NS). The number of days with diarrhea was 1.15 ± 2.5 in the BbF group with a daily probability of diarrhea of 0.84 versus 2.3 ± 4.5 days and 1.55, respectively, in the CF group (P = 0.0002 and 0.0014). Feeding infants with the BbF reduced their risk of getting diarrhea by a factor of 1.9 (range, 1.33–2.6). Analysis of the cumulative incidence of diarrheal episodes showed a trend that the first onset of diarrhea occurred later in the BbF group.ConclusionThese results provide some evidence that viable Bifidobacterium lactis strain Bb 12, added to an acidified infant formula, has some protective effect against acute diarrhea in healthy children.

Journal of Pediatric Gastroenterology and NutritionVolume 39, Issue S1 p. S551-S551 ABSTRACTS: Satellite Symposia Abstracts ADEQUACY OF A WHEY PREDOMINANT, REDUCED PROTEIN CONTENT INFANT FORMULA WITH A PROTEIN/ENERGY RATIO OF 1.8 G/100 KCAL FOR GROWTH OF TERM INFANTS DURING THE FIRST FOUR MONTHS OF LIFE D Turck, D Turck Jeanne de Flandre Hospital, LilleSearch for more papers by this authorC Grillon, C Grillon La Pitié-Salpetrière Hospital, ParisSearch for more papers by this authorE Lachambre, E Lachambre Nestlé, NoisielSearch for more papers by this authorP Robiliard, P Robiliard ReimsSearch for more papers by this authorL Beck, L Beck Nestlé, NoisielSearch for more papers by this authorJL Maurin, JL Maurin MarseillesSearch for more papers by this authorJP Bernet, JP Bernet LambersartSearch for more papers by this authorJ Marx, J Marx Marcqen-BaroeuilSearch for more papers by this authorF Lebrun, F Lebrun Cochin Hospital, Paris, FranceSearch for more papers by this authorLD Van Egroo, LD Van Egroo Nestlé, NoisielSearch for more papers by this author D Turck, D Turck Jeanne de Flandre Hospital, LilleSearch for more papers by this authorC Grillon, C Grillon La Pitié-Salpetrière Hospital, ParisSearch for more papers by this authorE Lachambre, E Lachambre Nestlé, NoisielSearch for more papers by this authorP Robiliard, P Robiliard ReimsSearch for more papers by this authorL Beck, L Beck Nestlé, NoisielSearch for more papers by this authorJL Maurin, JL Maurin MarseillesSearch for more papers by this authorJP Bernet, JP Bernet LambersartSearch for more papers by this authorJ Marx, J Marx Marcqen-BaroeuilSearch for more papers by this authorF Lebrun, F Lebrun Cochin Hospital, Paris, FranceSearch for more papers by this authorLD Van Egroo, LD Van Egroo Nestlé, NoisielSearch for more papers by this author First published: 01 June 2004 https://doi.org/10.1002/j.1536-4801.2004.tb13724.xRead the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume39, IssueS1June 2004Pages S551-S551 RelatedInformation

Adopted children from foreign countries represent a high risk population for infectious diseases, nutritional problems and neuro-developmental delay. Medical screening including clinical and biological evaluation is recommended after arrival.

The microbiome has emerged as a major determinant of the functioning of host organisms, affecting both health and disease. Here, Han et al. use the workhorse of aging research, C. elegans, to identify specific mechanisms by which gut bacteria influence mitochondrial dynamics and aging, a first step toward analogous manipulations to modulate human aging.

Journal of Pediatric Gastroenterology and NutritionVolume 26, Issue 5 p. 539-539 Abstracts: ESPGHAN-NASPGN 5th Joint Meeting PREVENTION OF DIARRHEA BY FEEDING INFANTS WITH AN ACIDIFIED MILK FORMULA CONTAINING BIFIDOCTERIUM BIFIDUM (Bb). J. P. Chouraqui, J. P. Chouraqui CHU GRENOBLE, FranceSearch for more papers by this authorL. D. Van EGROO, L. D. Van EGROO Lab. DIETINA, FranceSearch for more papers by this authorM. C. Fichot, M. C. Fichot Lab. DIETINA, FranceSearch for more papers by this author J. P. Chouraqui, J. P. Chouraqui CHU GRENOBLE, FranceSearch for more papers by this authorL. D. Van EGROO, L. D. Van EGROO Lab. DIETINA, FranceSearch for more papers by this authorM. C. Fichot, M. C. Fichot Lab. DIETINA, FranceSearch for more papers by this author First published: 01 May 1998 https://doi.org/10.1002/j.1536-4801.1998.tb00908.xCitations: 1Read the full textAbout ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article.Citing Literature Volume26, Issue5May 1998Pages 539-539 RelatedInformation

La tolerance, l'acceptabilite et l'efficacite cliniques d'un lait epaissi a l'amidon de mais precuit ont ete evaluees dans une etude prospective, ouverte, sur une periode d'un mois, chez 95 nourrissons, âges de 2 semaines a 11 mois, presentant des regurgitations simples. Cette etude montre une tres bonne tolerance evaluee sur la survenue eventuelle d'evenements indesirables, la frequence et la consistance des selles, la presence de cris et pleurs en periode postprandiale et de reveils nocturnes inexpliques. On constate d'autre part une diminution significative des regurgitations. Ces resultats tres satisfaisants permettent de recommander l'utilisation de la formule testee en premiere intention, dans le cadre de la prise en charge dietetique des regurgitations, permettant ainsi de ne recourir aux prescriptions medicamenteuses qu'en seconde intention.

An open and prospective study was conducted in 95 infants, aged 2 weeks to 11 months, suffering from simple regurgitations, to assess the safety and efficacy of a milk thickened with maize starch during one-month-period. The results of the intention-to-treat analysis show a very good safety according to the following evaluation criteria : adverse events, frequency and consistance of stools, shouts and cries in postprandial period and unexplained night awakenings. The efficacy results show a significant decrease in regurgitations. These satisfying results on the thickened milk tested can recommand its use in the dietary measures on regurgitations to reduce digestive drugs.