The composition of saliva was studied in normal conditions and calculi formation in an oral cavity. It is shown that under conditions of pathogenic mineralization occurs a deviation of saliva parameters from the norm: the shift of pH to the alkaline side; decrease in calcium and protein, the increase in content of phosphorus ions and electrolyte components, which is the result of a breach of its structural and mineralizing properties.

Crystallization of biological fluids genetically based process associated with the presence of certain organic and inorganic components [Martusevich, 2002]. Biological fluids complex polydisperse non-cellular structures with fragile relationships within them components: saliva, blood serum, lymph, etc. The composition of body fluids are lyotropic liquid crystals, the most minor changes in the body's vital functions are manifested in changes in their structural order. Elements in biological fluids reacts immediately change its structure to any impact of external and internal [Zakharova et al., 2005]. The most simple, yet informative way to assess the physical and chemical properties of biomaterials and biological fluids are in particular crystallographic methods based on qualitative and quantitative description and interpretation crystallization of biosubstrates. They allow you to consider the integrative information content of nutrient liquid. It is important that the crystallization a process that brings together objects like a living, and the mineral world [Yushkin et al., 1996], in connection with which it may be a universal method for storing and transmitting information. Currently, the crystallographic method of research used to establish the correct diagnosis for different kinds of diseases as a complement to other diagnostic methods. Its essence is to analyze the shapes of crystallization, resulting in drying of various biological fluids [Selifanova, 2005]. Oral liquid forms a crystalline structure, as in the native state, and by adding crystal-compounds. The morphology of these structures is due to the chemical composition of saliva [Belskaya, 2009]. When you view the resulting crystal structures under low magnification of microscope, it was found [Denisov, 2003] that the crystal pattern is uneven and varies in different areas (zones) of dried droplets (Fig. 1).

Thermodynamic and experimental studies were performed concerning phase formation process in the solution compositionally close to the oral fluid of humans with respect to the mineral and amino acid content. It has been established that amino acids to a considerable extent contribute into the ionic strength of the system promoting an increase in the electrostatic repulsion between the ions of the like charge and inhibiting the deposition of low-soluble calcium phosphates. In this process, the complexation of amino acids with Ca2+ does not result in a decrease of the solution supersaturation level and in changing the sequence of salt preci pitation. The experimental simulation results for hydroxyapatite crystallization process have demonstrated that the inhibiting effect of amino acids is caused by the adsorption interaction between ionized species and the surface of the solid phase.

Elemental composition of 30 samples of oral liquid from four groups of patients living in the Omsk Region was investigated by means of atomic emission spectral analysis with inductively coupled plasma. Comparative analysis of the composition of saliva for patients with different diseases of oral cavity showed that the elemental composition is specific in each case. It was established that the diagnostics of the corresponding diseases may be carried out on the basis of the data on the ratios Ca/P and Na/K. It was discovered with the help of mathematical statistics that the distribution of microelements Zn, Cu, Fe, Mn, Al also has group-related features.