Background/Objectives: Acne vulgaris is a prevalent dermatological condition, yet clear, region-specific management guidelines, particularly for India’s diverse population, remain limited. Effective acne management extends beyond pharmacologic therapy, emphasizing proper skincare, patient education, and adherence strategies. This consensus aims to provide tailored, evidence-based recommendations for optimizing acne treatment in the Indian context. Methods: A panel of 14 dermatology experts with ≥15 years of experience reviewed literature, real-world clinical practices, and patient-centric factors relevant to acne management in India. Using a modified Delphi process with two virtual voting rounds, 61 statements across seven clinical domains were evaluated. Consensus was defined as ≥75% agreement. Results: Topical retinoids remain the first-line therapy, with combination regimens (benzoyl peroxide or topical antibiotics) preferred to enhance efficacy and minimize antibiotic resistance. Hormonal therapies, including combined oral contraceptives and spironolactone, are recommended for females with resistant acne. Guidance includes individualized treatment plans, baseline investigations, and selection of appropriate topical and systemic agents. Special considerations for pregnancy and lactation prioritize maternal and fetal safety. Conclusions: This expert consensus provides practical, evidence-based recommendations for acne management in India, integrating pharmacological and non-pharmacological approaches. The tailored guidance supports individualized care, antibiotic stewardship, and improved treatment adherence, aiming to enhance patient outcomes nationwide.

Introduction:Tinea capitis (TC) is a common fungal infection of the scalp, especially in children. Trichoscopy is a noninvasive technique that allows rapid and magnified in vivo observation of the hair with the visualization of morphologic features that are often imperceptible to the naked eye. Aim:This study aimed to evaluate the usefulness of trichoscopy in clinical diagnosis and to study various clinico-morphological patterns of TC. Materials and Methods:This cross-sectional, observational study included 140 clinically diagnosed cases of TC seen during a period of 1 year (April 2021 to March 2022). All patients were evaluated using a dermoscope (DermLite DL4 Multispectral 3 Gen, San Juan Capistrano, CA, USA,10×). Results:The prevalence rate of TC in this study was 2.69 per thousand population. The most common clinical variant was gray patch followed by kerion and black dot, and the most common etiological agent was Trichophyton tonsurans. The characteristic trichoscopic features were as follows: comma hairs (80%), followed by corkscrew hairs (68.6%), bent hairs (54.2%), zigzag hairs (35.7%), and morse code-like hairs (15%). Other findings included scaling (89.2%), followed by black dot (67.1%), broken hairs (42.8%), and crusting and pustules (32.1% each). Comma and corkscrew-shaped hairs were most common in the black dot type, whereas zigzag, bent hairs, and morse code hairs were common in the gray patch type of TC. There was a significant association between trichoscopic findings and type of TC. Conclusion:Trichoscopy can be considered a novel tool for rapid diagnosis and selection of the appropriate therapy and in the monitoring of treatment efficacy in TC.

Background: Pemphigus is a potentially life-threatening autoimmune blistering disease which characteristically affects skin and mucosae. Pulse therapy for the treatment of pemphigus has been in vogue for several years and considered better than conventional corticosteroids. Aims and objectives: This study was conducted to evaluate the efficacy and safety of pulse therapy in pemphigus patients treated over a period of 10 years. Materials and Methods: This retrospective study was based on medical records of Pemphigus patients treated at Department of Dermatology from January 2008 to December 2017. Diagnosis of pemphigus was made on clinical ground, Tzanck smear and histopathology of skin/mucous membrane lesions. Patients were put on DCP/DAP depending on the completion of family. Results: A total of 124 patients were included in the study. Age of patients ranged from 18 years to 72 years with mean of 41.21±12.71 years. Amongst 124 patients, 114 (92%) had pemphigus vulgaris and 10 (8%) had pemphigus foliaceous. 89 patients received DCP and 35 patients received DAP therapy. Number of pulses received by patients in phase I ranged from 4 to 27, average being 8.16±4.63. 106 patients completed the phase I of which 83 completed the phase II. 54 patients had successfully completed phase III of which 22 are currently in phase IV and 28 patients have completed their five year follow up period and considered as cured. Conclusion: Pulse therapy is a cheap and easily available mode of therapy in treatment of pemphigus in India even in the present era of modern molecules like Rituximab. With pulse therapy, it is now possible to induce and maintain remission, and achieve cure, provided the patients strictly adhere to the prescribed schedule.

A 24-year-old man presented with multiple asymptomatic pigmented lesions on neck, trunk, and upper limb for 6 months duration. On dermatological examination, multiple hyperpigmented, coalescent macular to papular lesions with scaling at few places are present over the neck, trunk and upper limb in a reticulate pattern [Figures 1 and 2]. Potassium hydroxide mount from scrapings did not show fungal hyphae. Skin biopsy from the papule revealed moderate hyperkeratosis, preserved granular layer, acanthosis, and papillomatosis [Figure 3]. The upper dermis showed scant perivascular lymphocytic infiltration. Periodic acid Schiff (PAS) stain was negative for fungal elements. Except for obesity, his general physical and systemic examination did not reveal any findings. None of the family members had similar lesions. The patient was started on oral minocycline 100 mg daily, with a complete clearing of lesions in 15 days.Figure 1: Hyperpigmented scaly macules and papules on anterior aspect of chest and neckFigure 2: Hyperpigmented macules and papules on the posterior trunk and neckFigure 3: Photomicrograph showing moderate hyperkeratosis, acanthosis, and papillomatosis. The upper dermis exhibits scant perivascular lymphocytic infiltration (H&E, 10x)Question What is the diagnosis? Answer Confluent and reticulated papillomatosis (CRP) of Gougerot and Carteaud. Discussion Gougerot and Carteaud originally described CRP in 1927. It is a rare disease typically affecting young persons. CRP was primarily thought to be caused by Malassezia furfur. The current infectious theory is that CRP is caused by bacteria, Dietzia papillomatosis, an anaerobic gram-positive coccus/rod actinomycete. There are noninfectious causes also that include diabetes, obesity, ultraviolet light, amyloidosis, and K16 mutation. There is an association between confluent and reticulated papillomatosis, diabetes mellitus, and obesity because hyperinsulinemia has mitogenic and antiapoptotic effects. Increased levels of insulin-like growth factor 1, tyrosine kinase receptor superfamily, epidermal growth factor, and fibroblast growth factor induce epidermal proliferation. Changes in confluent and reticulated papillomatosis with changing weight and diabetes control support this theory.[1,2] Familial cases of confluent and reticulated papillomatosis could be due to overexpression of keratin-16.[3] The disease preferentially involves intermammary and interscapular regions with potential extension to other sites. It typically manifests as multiple subcentimeter brown to hyperpigmented papules that may coalesce centrally to form plaques while demonstrating reticulation peripherally. The hallmark of these papules is that they exhibit epidermal changes of scaling, hyperkeratosis, or even atrophy.[1] Dermoscopic features of brownish pigmentation with overlying white scales and a pattern of “sulci and gyri” have been reported.[4] Davis et al[5] proposed a set of criteria for the diagnosis of CRP which are as follows: 1) clinical findings include scaly brown macules and patches, at least part of which appear reticulated and papillomatous, 2) involvement of the upper trunk and neck, 3) fungal staining of scales is negative for fungus, 4) no response to antifungal treatment, and 5) excellent response to minocycline. There is a wide array of dermatoses that may resemble CRP. The closest mimic in terms of distribution and appearance is acanthosis nigricans. Reticulated hyperpigmentation without papules or plaques may occur in Dowling–Degos disease, Galli–Galli disease, and dyskeratosis congenita. If the patient complains of pruritus in addition to reticulated hyperpigmentation, prurigo pigmentosa has to be suspected. If a patient presents with dirt-like, slightly verrucous plaques that are resistant to ordinary cleansing over the distribution of CRP, terra firma-forme dermatosis should be considered.[1] Therapeutic options are many and varied due to unknown pathogenic mechanisms: Antimycotics, oral antibiotics, derivatives of vitamin A (retinoids) and vitamin D. Minocycline was first used for the treatment of CRP in 1965 by Carteaud and is reported as a drug of choice. They possess anti-proliferative and anti-inflammatory action, and they also inhibit Propionibacteriumacnes lipase activity, collagenase activity, and complement activation system.[5] It was effective in clearing lesions in our patients too. However, the exact duration for which minocycline should be used is not clear. Recurrence after stopping medications is also common despite a good initial response to treatment. Declaration of patient's consent The authors certify that they have obtained all appropriate patient consent forms. In the form, the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed. Financial support and sponsorship Nil. Conflicts of interest There are no conflicts of interest.

Indian Association of Dermatologists, Venereologists and Leprologists is actively involved in providing its members diverse opportunities for academic growth. The residents during post graduation can avail post graduate thesis grants and scholarships. IADVL observerships and trainings are more suitable immediately after completing post graduation. Many awards including the PG thesis based award paper session is an excellent opportunity to present the research work conducted during residency. Apart from this the IADVL digital academy platform is an excellent learning resource.

Background Despite acne being a common dermatological problem, there is a paucity of literature addressing the knowledge, attitude and practice about it. Aims/Objectives To find out what patients know about acne, its cause and treatment, as well as myths, misconceptions and attitude towards it. Methods A cross-sectional, descriptive questionnaire-based study on acne patients at Maharana Bhupal Hospital, RNT Medical College, Udaipur, Rajasthan, India. Results Most (84.8%) patients belonged to the age group of 16-25 years. The majority (63.9%) presented 12 months after the onset of acne. More than half had average knowledge, a positive attitude and good practices, related significantly to gender and education. Limitations A standardized questionnaire suitable for all dialects and regional languages would have yielded more uniform results. Conclusion Study revealed that acne patients still need to acquire accurate, adequate and easily accessible information to seek timely and appropriate treatment, and alleviate their psychological suffering.

AMA Balai M, Meghwal L, Sehgal S, Gupta L. Extensive Mongolian spots in a healthy child. Dermatology Review/Przegląd Dermatologiczny. 2023;110(6):719-721. doi:10.5114/dr.2023.138879. APA Balai, M., Meghwal, L., Sehgal, S., & Gupta, L. (2023). Extensive Mongolian spots in a healthy child. Dermatology Review/Przegląd Dermatologiczny, 110(6), 719-721. https://doi.org/10.5114/dr.2023.138879 Chicago Balai, Manisha, Lavina Meghwal, Sumit Sehgal, and Lalit Kumar Gupta. 2023. "Extensive Mongolian spots in a healthy child". Dermatology Review/Przegląd Dermatologiczny 110 (6): 719-721. doi:10.5114/dr.2023.138879. Harvard Balai, M., Meghwal, L., Sehgal, S., and Gupta, L. (2023). Extensive Mongolian spots in a healthy child. Dermatology Review/Przegląd Dermatologiczny, 110(6), pp.719-721. https://doi.org/10.5114/dr.2023.138879 MLA Balai, Manisha et al. "Extensive Mongolian spots in a healthy child." Dermatology Review/Przegląd Dermatologiczny, vol. 110, no. 6, 2023, pp. 719-721. doi:10.5114/dr.2023.138879. Vancouver Balai M, Meghwal L, Sehgal S, Gupta L. Extensive Mongolian spots in a healthy child. Dermatology Review/Przegląd Dermatologiczny. 2023;110(6):719-721. doi:10.5114/dr.2023.138879.

International Journal of DermatologyVolume 61, Issue 12 p. e461-e463 Correspondence Erythromelanosis follicularis faciei et colli: a clinicoepidemiological study Ankita Srivastava MD, Corresponding Author Ankita Srivastava MD [email protected] Department of Dermatology, All India Institute of Medical Sciences, Nagpur, IndiaSearch for more papers by this authorLalit Gupta MD, Lalit Gupta MD Department of Dermatology, RNT Medical College, Udaipur, IndiaSearch for more papers by this authorAshok Kumar Khare MD, Ashok Kumar Khare MD Department of Dermatology, RNT Medical College, Udaipur, IndiaSearch for more papers by this authorManisha Balai MD, Manisha Balai MD Department of Dermatology, RNT Medical College, Udaipur, IndiaSearch for more papers by this authorAsit Mittal MD, Asit Mittal MD Department of Dermatology, RNT Medical College, Udaipur, IndiaSearch for more papers by this author Ankita Srivastava MD, Corresponding Author Ankita Srivastava MD [email protected] Department of Dermatology, All India Institute of Medical Sciences, Nagpur, IndiaSearch for more papers by this authorLalit Gupta MD, Lalit Gupta MD Department of Dermatology, RNT Medical College, Udaipur, IndiaSearch for more papers by this authorAshok Kumar Khare MD, Ashok Kumar Khare MD Department of Dermatology, RNT Medical College, Udaipur, IndiaSearch for more papers by this authorManisha Balai MD, Manisha Balai MD Department of Dermatology, RNT Medical College, Udaipur, IndiaSearch for more papers by this authorAsit Mittal MD, Asit Mittal MD Department of Dermatology, RNT Medical College, Udaipur, IndiaSearch for more papers by this author First published: 05 May 2022 https://doi.org/10.1111/ijd.16250 Conflict of Interest: None. Funding source: None. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article. References 1van Geel N, Speeckaert R. Acquired pigmentary disorders. In: R Chalmers, J Barker, C Griffiths, T Bleiker, D Creamer, (eds), Rook's Textbook of Dermatology. 9th edn. John Wiley & Sons, West Sussex: 2016; 88: 14– 15. 2Rather S, Yaseen A, Mukhija M. Erythromelanosis follicularis faciei et colli - a cross-sectional, descriptive study. Indian J Dermatol 2016; 61: 308– 313. 3Arif T, Adil M, Amin SS, et al. Erythromelanosis follicularis faciei et colli: A clinicoepidemiologic study. Pediatr Dermatol 2018; 35(1): e70– e71. 4Yañez S, Velasco JA, González MP. Familial erythromelanosis follicularis faciei et colli-an autosomal recessive mode of inheritance. Clin Exp Dermatol 1993; 18: 283– 285. 5Augustine M, Jayaseelan E. Erythromelanosis follicularis faciei et colli: Relationship with keratosis pilaris. Indian J Dermatol Venereol Leprol 2008; 74: 47– 49. 6Maouni S, El Anzi O, Sqalli A, et al. Erythromelanosis follicularis faciei et colli: Dermoscopy and dermatopathology correlates. JAAD Case Rep 2019; 5(6): 535– 536. 7Rather S, Shah AA, Shah FY. Dermoscopy as a noninvasive diagnostic modality in Erythromelanosis follicularis Faciei et Colli: A case series. Dermatol Pract Concept 2021; 11(2): e2021020. 8Thielmann CM, Sondermann W. Erythromelanosis follicularis Faciei et Colli: A case report in a Caucasian male and brief review of the literature. Case Rep Dermatol 2020; 12(3): 231– 235. 9Tsunoda K, Watanabe A, Amano H. Erythromelanosis follicularis Faciei et Colli treated with intense pulsed light. Dermatol Surg 2022 https://doi.org/10.1097/DSS.0000000000003382. Epub ahead of print. Volume61, Issue12December 2022Pages e461-e463 ReferencesRelatedInformation

The present study was designed to examine the effects of Aloe vera on whole body X-ray exposure induced injury to heart, lung, and bone of male balb/c mice. Animals were divided into four groups: control, Aloe vera (50 mg/kg body weight on alternate days for 30 days), X-ray (2Gy) and Aloe vera+ X-ray. X-ray irradiation led to enhanced lipid peroxidation level associated with decline in reduced glutathione concentration in pulmonary tissue of mice. Moreover, lipid peroxidation level and reduced glutathione content in cardiac tissue remained unaltered after radiation exposure. In addition, X-ray exposure caused poor and delayed uptake of 99mTc-mebrofenin as observed in hepatobiliary clearance study. Dual energy X-ray absorptiometry scan revealed a significant decrease in bone mineral density after X-ray irradiation. Aloe vera administration to radiation exposed animals restored pulmonary reduced glutathione content and lipid peroxidation level along with significantly improved bone mineral density and hepatobiliary clearance profile as compared to irradiated counterparts. The current observations suggest that Aloe vera plays vital role in modulating deleterious effects caused by X-ray exposure in various organs of mice, which may attributed its free radical scavenging ability and strengthening of antioxidant defense system.

Dear Editor, Epidermolysis bullosa (EB) refers to a group of inherited mechanobullous disorders. Epidermolysis bullosa pruriginosa (EBP) is a type of dystrophic EB which occurs due to mutation in type VII collagen gene.[1,2] It is characterized by intense pruritus, prurigo nodularis like lesions and occasionally tense blisters. It occurs mostly on shin but other body sites like knees, elbows and hands may also be involved. Scarring, milia formation and nail dystrophy are commonly seen. The lesions showed exacerbation in hot and humid climate. The mode of inheritance can be sporadic or autosomal dominant or recessive.[3] We report EBP occurring in a family across two generations affecting three members. A 25-year-old male presented to dermatology outpatient department with intensely itchy skin lesions over lower limbs for 7–8 years [Figure 1]. Similar lesions were also reported in 20-year-old younger sister [Figure 2] and maternal uncle. There was no history of consanguinity in family [Figure 3]. On examination patient had multiple, excoriated nodules on bilateral lower limbs [Figure 1a] with a few tense clear fluid filled blisters. Few of the lesions healed with scarring and milia [Figure 1b]. All toe nails and right ring finger nail were dystrophic [Figure 1c]. Mucosal, hair and teeth examination was normal. The lesions showed exacerbation during hot and humid weather.Figure 1: 25-year-old man with epidermolysis bullosa pruriginosa who presented with (a) multiple excoriated nodules on bilateral lower limbs. (b) Scarring and milia. (c) Dystrophic toe nails. (d) Subepidermal bulla with mild hyperkeratosis and acanthosis. Mild perivascular lymphocytic infiltration in dermis (Hematoxylin and eosin, x100)Figure 2: 20-year-old female (younger sister of patient) with (a) Scarring over bilateral knees and (b) elbows. (c) Dystrophic toe nails. (d) Tense clear fluid filled bulla over ankleFigure 3: Pedigree chart showing disease across two generations affecting three family membersBased on clinical findings, a differential diagnosis of EBP, prurigo nodularis, hypertrophic lichen planus and lichen amyloidosis was made. Punch biopsy was taken from blister for histological examination and sample from perilesional skin was taken for direct immunofluorescence (DIF). Histological examination revealed subepidermal bulla with mild hyperkeratosis and acanthosis. The bullous cavity was filled with proteinaceous fluid with scattered inflammatory cells. Dermis showed mild perivascular lymphocytic infiltrate [Figure 1d]. DIF study was negative for any immunoreactants. Based on clinical and histopathological findings, a final diagnosis of EBP was made. EB is broadly classified into three types on the basis of splitting in skin—EB simplex (intraepidermal), EB junctional (at the level of lamina lucida) and EB dystrophic (sublamina densa). EBP is a subtype of dystrophic EB.[1] EBP is caused by mutation in COL7A1 gene. Glycine substitution in the triple helical domain of type VII collagen is implicated.[2] The term EBP was coined by McGrath JC in 1994.[4] EBP is characterized by hypertrophic and lichenified excoriated papules and nodules with scarring and milia formation. Intact blister is rarely seen. Nail dystrophy is a consistent finding. Albopapuloid lesions can also be seen. Lesions typically occur on shin but elbows, forearms and dorsal aspect of hands can also be affected. Mucosa, flexures, face and hair are usually spared. It is associated with severe pruritus. The exact cause of pruritus in this disease is not known. It could be due to activation of kinin cascade by type VII collagen. Interaction of bradykinin with other mediators might be responsible for severe pruritus.[3] Age of onset is highly variable. It can present at birth or in adulthood. Mode of inheritance can be autosomal dominant or recessive or sporadic.[5] There is no specific treatment. Management is mostly symptomatic. Pruritus is managed with oral antihistamines and topical or intralesional steroids. Various treatment modalities have been tried with variable success. These include tacrolimus, cyclosporine, naltrexone, thalidomide, etretinate, cryotherapy and surgical treatment in the form of dermabrasion or excision grafting. Genetic counselling and gene therapy are more promising approaches.[6,7] After thorough literature search on PubMed and MEDLINE database with search terms “epidermolysis bullosa pruriginosa,” we found only sixty eight cases have been reported till date and out of that, only eight cases have been documented from India. Although it is very rare condition, it mimics some common skin diseases like prurigo nodularis and hypertrophic lichen planus. Differentiation of EBP from these common diseases is extremely necessary because treatment, prognosis and counseling is quite different as far as EBP is concerned. Thus, a proper clinical examination keeping in mind about this rare entity will help in early diagnosis, better management and counseling of patients. Declaration of patient consent The authors certify that they have obtained all appropriate patient consent forms. In the form, the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed. Financial support and sponsorship Nil. Conflicts of interest There are no conflicts of interest.

As we were on the road to recovery from the coronavirus disease-19 (COVID-19) pandemic, the world is waking up to yet another potential adversary. Monkeypox (or human monkeypox) caused by monkeypox virus (an orthopox virus) is fast emerging in more than 80 countries worldwide, where it has never been historically reported. We in India, have already seen the advent of this outbreak since July 2022, with a progressive rise in number of cases being seen. Though the virus is not a novel virus; it is presenting with atypical manifestations as compared to our conventional knowledge of the disease. Through this document, the Indian Association of Dermatologists, Venereologists, and Leprologists Academy aims to sensitize dermatologists toward recognizing the clinical features and responding promptly, to contain the outbreak at the earliest. In view of the non-availability of specific antiviral drugs as well as vaccines; early detection, isolation, and prevention of spread form the mainstay of our approach towards the outbreak, which has been declared to be a "Public Health Emergency of International Concern" by the World Health Organization.

Background: An association between lichen planus and systemic disorders such as diabetes mellitus, dyslipidemia and metabolic syndrome has been reported. Aim: To assess the clinico-epidemiological profile of lichen planus, evaluate prevalence of underlying metabolic complications and compare the clinical profile of patients with and without metabolic syndrome. Material and methods: All the patients with lichen planus attending dermatology out patient department of a tertiary care centre in South Rajasthan over a period of one year were studied. Patients with lichenoid drug eruptions and those receiving systemic treatment for lichen planus were excluded from the study. Statistical analysis was done using the chi – square test. A p value < 0.05 was considered significant. Results: A total of 270 patients of lichen planus were enrolled. Male to female ratio was found to be 0.76: 1. Maximum (64; 23.7%) patients belonged to the age group of 31 – 40 years. Classical morphology was the most common (128; 47.4%) cutaneous pattern. Mucosal and nail involvement was seen in 80 (29.6%) and 87 (32.2%) patients respectively. Koebner phenomenon was present in 57 (21.1%) patients. The investigations were completed by 175 (64.8%) patients. Diabetes mellitus and hypertension were found in 12.6% (22/175) and 14.3% (25/175) patients respectively. The diagnostic criteria for dyslipidemia and metabolic syndrome were fulfilled by 39.4% (69/175) and 27.4% (48/175) patients respectively. Majority (81.2%) of the patients with metabolic syndrome belonged to age group 40 years and above, and oral and nail involvement was found to be more common in them. It is recommended that these patients should be screened for complications like diabetes, hypertension, dyslipidemia and metabolic syndrome. Conclusion: Significant numbers of lichen planus patients were found to have dyslipidemia and metabolic syndrome. Patients aged 40 years and above, with oral and nail involvement have higher propensity to be associated with metabolic syndrome and therefore such patients should be screened for metabolic complications. Timely screening and early intervention may reduce the risk of related morbidity and mortality. Limitations: Lack of control group is the drawback of our study. Age and sex matched comparative studies are required for confirmation of the results.

Background: Stevens-Johnson syndrome and toxic epidermal necrolysis are severe, life-threatening mucocutaneous drug reactions with a high morbidity and mortality that require immediate medical care. Several immunomodulatory drugs are used for the treatment but evidence of their efficacy is limited. Cyclosporine has recently been found to have a promising role in SJS/TEN owing to its potent antiapoptotic activity. Aims: This open label prospective study was conducted to determine the efficacy, safety, and tolerability of cyclosporine in patients with SJS/TEN. Methods: This study was conducted at a tertiary care teaching hospital of South Rajasthan during a period of 4 years (August 2015 to July 2019). Data regarding clinical profile, causative drug(s), disease severity, associated comorbidities, treatment received, and outcome were recorded in a predesigned proforma. SCORTEN prognostic score was calculated for each patient at the time of admission. Cyclosporine was administered in a dose of 5 mg/kg body weight in two divided dosage until reepithelization. Results: Out of 16 patients 10 were males and 6 were females. Mean age of patients was 30.62 ± 16.98 years (range: 7–63). Most of the patients, i.e., 8 out of 16 had TEN, 5 patients had SJS, and 3 patients had SJS/TEN overlap. Mean ± SD delay between onset and admission was 3.812 ± 1.377 days (range: 2–7). Among the suspected drugs, antiepileptics (43.7%) formed the major group. Mean duration of reepithelization was 10.5 ± 3.46 days (range: 7–15). Based on the SCORTEN, the expected mortality was 2.55 with mean predicted mortality rate of 16.43% with SD of 19.3. Limitations: 1) Sample size was small. 2) Placebo control trial could not be done due to the severity of the disease. Conclusion: We recommend cyclosporine (5 mg/kg/day) as the first line-specific immunomodulatory agent in SJS/TEN on account of its efficacy, safety, rapid reepithelization, decrease hospital stay, and reduced morbidity and mortality.