The pharmacokinetics of maquindox in control and pathological groups of rabbits were analyzed and given references for clinical treatment.12 rabbits were randomly divided into 2 groups.Group A was the control group,and group B was tested group with experimental renal injury.24 h before the experiment,rabbits in group B were treated with a hypodermic injection of HgCl2(1.5 mL/kg).Both group of rabbits were treated with a rapid single-dosage intravenous injection of Maquindox(20 mg/kg).The blood samples were collected from heart 8 times within 6 hours after injection.The mass concentrations of Maquindox in serum were detected by HPLC.The results showed that the disposition of Maquindox in rabbits matched with non-absorption one-compartment open model.The optimal concentration-time equations of the three groups were:ρcontrol group=25.564 2e-0.371 6t,ρrenal injury=20.026 6e-0.099 8t.Compared with the control group,t1/2 renal injury prolonged by 276.16%;kel renal injury decreased by 73.14%;CLB renal injury decreased by 69.91%;AUC renal injury increased by 187.57%.It can be concluded that the pharmacokinetics parameters of Maquindox in rabbit pathological model have changed apparently,so it is necessary to lengthen the dosing interval or lessen the dosage of Maquindox on the pathological occasions.

【Objective】 The study compared the pharmacokinetics of Maquindox in control(healthy rabbits) and treated(rabbits with hepatic injury) groups to provide materials and references for clinical therapy.【Method】 12 rabbits were randomly and averagely divided into 2 groups.One was the control group,and the other one was treated with a hypodermic injection of CCl4(0.4 mL/kg) 24 h before the experiment for the replication of hepatic injury model.24 h later,rabbits were treated with a rapid single-dosage intravenous injection of Maquindox(20 mg/kg).The blood samples were collected from heart 8 times within 6 hours after injection.The concentrations of Maquindox in serum were detected by HPLC.【Result】 The results showed that the disposition of Maquindox in rabbits matched with non-absorption one-compartment open model.And the optimal concentration-time equations of the 2 groups were:Ccontrol group=25.564 2 e-0.371 6 t,Chepatic injury=24.308 9 e-0.144 t.Compared with control group,t1/2 hepatic injury prolonged by 166.49%;kel hepatic injury decreased by 61.25%;CLB hepatic injury decreased by 54.95%;AUC hepatic injury increased by 155.87%.【Conclusion】 It can be concluded that Maquindox distributed in vivo abroad,and eliminated rapidly.The pharmacokinetics parameters of Maquindox in rabbit pathological model changed apparently,so it is necessary to lengthen the dosing interval or lessen the dosage of Maquindox on the pathological occasions.