The capability of the global, electromagnetic gyrokinetic GENE code interfaced with the transport Tango solver is exploited to address the impact of fusion alpha particles (in their dual role of fast particles and heating source) on plasma profiles and performance at JET in the discharges with the highest quasi-stationary peak fusion power during the DTE2 experimental campaigns. Employing radially global nonlinear electromagnetic GENE-Tango simulations, we compare results with/without alpha particles and alpha heating. Our findings reveal that alpha particles have a negligible impact on turbulent transport, with GENE-Tango converging to similar plasma profiles regardless of their inclusion as a kinetic species in GENE. On the other hand, alpha heating is found to contribute to the peaking of the electron temperature profiles, leading to a 1keV drop on the on-axis electron temperature when alpha heating is neglected in Tango. The minimal impact of alpha particles on turbulent transport in this JET discharge - despite this being the shot with the highest fusion output - is attributed to the low content of fusion alpha in this discharge. To assess the potential impact of alpha particles on turbulent transport in regimes with higher alpha particle density, as expected in ITER and fusion reactors, we artificially increased the alpha particle concentration to levels expected for ITER. By performing global nonlinear GENE standalone simulations, we found that increasing the alpha particle density beyond five times the nominal value lead to significant overall turbulence destabilization.

Periodontitis is an inflammatory disease of the root surface caused by bacterial biofilms, leading to tooth loss and systemic health complications. Current treatment options rely on mechanical biofilm removal and chemical antimicrobial cleansing, which can be ineffective and contribute to tissue damage and bacterial resistance. Cold atmospheric plasma jet is a promising alternative due to its antimicrobial effects, lack of resistance development, and without known side effects. This study investigates the development and efficacy of a bipolar plasma nozzle designed for use on non-conductive surfaces, such as natural teeth. A proof-of-concept experiment was performed using a prototype plasma system (helium + 1 % oxygen used as working gas), with in vitro tests on bacterial agar plates of E. coli and S. aureus. The results demonstrate that plasma treatment effectively reduces bacterial concentration, with inhibition zones increasing with treatment duration, reaching two orders of magnitude reduction at 10 minutes of treatment. These findings support the potential of plasma technology as a novel method for periodontal disinfection, making way for further clinical applications.Clinical Relevance— This work provides proof-of-concept for the disinfection and treatment of inflamed surfaces in periodontology using a novel cold atmospheric plasma jet device.

We demonstrate the first electrically injected AlGaN-based ultraviolet-B resonant-cavity light-emitting diode (RCLED). The devices feature dielectric SiO2/HfO2 distributed Bragg reflectors enabled by tunnel junctions (TJs) for lateral current spreading. A highly doped n++-AlGaN/n++-GaN/p++-AlGaN TJ and a top n-AlGaN current spreading layer are used as transparent contacts, resulting in a good current spreading up to an active region mesa diameter of 120 μm. To access the N-face side of the device, the substrate is removed by electrochemically etching a sacrificial n-AlGaN layer, leading to a smooth underetched surface without evident parasitic etching in the n- and n++-doped layers of the device. The RCLEDs show a narrow emission spectrum with a full width at half-maximum (FWHM) of 4.3 nm compared to 9.4 nm for an ordinary LED and a more directional emission pattern with an angular FWHM of 52° for the resonance at 310 nm in comparison to ∼126° for an LED. Additionally, the RCLEDs show a much more stable emission spectrum with temperature with a red-shift of the electroluminescence peak of about ∼18 pm/K and a negligible change of the FWHM compared to LEDs, which shift ∼30 pm/K and show spectrum broadening with temperature. The demonstration of those devices, where a highly reflective mirror is spatially separated from an ohmic metal contact, opens up a new design space to potentially increase the poor light extraction efficiency in UV LEDs and is an important step toward electrically injected UV vertical-cavity surface-emitting lasers.

Cold atmospheric plasma (CAP) is a promising alternative to antibiotics and chemical substances in dentistry that can reduce the risk of unwanted side effects and bacterial resistance. AmbiJet is a device that can ignite and deliver plasma directly to the site of action for maximum effectiveness. The aim of the study was to investigate its antimicrobial efficacy and the possible development of bacterial resistance. The antimicrobial effect of the plasma was tested under aerobic and anaerobic conditions on bacteria (five aerobic, three anaerobic (Gram +/−)) that are relevant in dentistry. The application times varied from 1 to 7 min. Possible bacterial resistance was evaluated by repeated plasma applications (10 times in 50 days). A possible increase in temperature was measured. Plasma effectively killed 106 seeded aerobic and anaerobic bacteria after an application time of 1 min per 10 mm2. Neither the development of resistance nor an increase in temperature above 40 °C was observed, so patient discomfort can be ruled out. The plasma treatment proved to be effective under anaerobic conditions, so the influence of ROS can be questioned. Our results show that AmbiJet efficiently eliminates pathogenic oral bacteria. Therefore, it can be advocated for clinical therapeutic use.

Experiments on ASDEX Upgrade (AUG) in 2021 and 2022 have addressed a number of critical issues for ITER and EU DEMO. A major objective of the AUG programme is to shed light on the underlying physics of confinement, stability, and plasma exhaust in order to allow reliable extrapolation of results obtained on present day machines to these reactor-grade devices. Concerning pedestal physics, the mitigation of edge localised modes (ELMs) using resonant magnetic perturbations (RMPs) was found to be consistent with a reduction of the linear peeling-ballooning stability threshold due to the helical deformation of the plasma. Conversely, ELM suppression by RMPs is ascribed to an increased pedestal transport that keeps the plasma away from this boundary. Candidates for this increased transport are locally enhanced turbulence and a locked magnetic island in the pedestal. The enhanced D-alpha (EDA) and quasi-continuous exhaust (QCE) regimes have been established as promising ELM-free scenarios. Here, the pressure gradient at the foot of the H-mode pedestal is reduced by a quasi-coherent mode, consistent with violation of the high-n ballooning mode stability limit there. This is suggestive that the EDA and QCE regimes have a common underlying physics origin. In the area of transport physics, full radius models for both L- and H-modes have been developed. These models predict energy confinement in AUG better than the commonly used global scaling laws, representing a large step towards the goal of predictive capability. A new momentum transport analysis framework has been developed that provides access to the intrinsic torque in the plasma core. In the field of exhaust, the X-Point Radiator (XPR), a cold and dense plasma region on closed flux surfaces close to the X-point, was described by an analytical model that provides an understanding of its formation as well as its stability, i.e., the conditions under which it transitions into a deleterious MARFE with the potential to result in a disruptive termination. With the XPR close to the divertor target, a new detached divertor concept, the compact radiative divertor, was developed. Here, the exhaust power is radiated before reaching the target, allowing close proximity of the X-point to the target. No limitations by the shallow field line angle due to the large flux expansion were observed, and sufficient compression of neutral density was demonstrated. With respect to the pumping of non-recycling impurities, the divertor enrichment was found to mainly depend on the ionisation energy of the impurity under consideration. In the area of MHD physics, analysis of the hot plasma core motion in sawtooth crashes showed good agreement with nonlinear 2-fluid simulations. This indicates that the fast reconnection observed in these events is adequately described including the pressure gradient and the electron inertia in the parallel Ohm’s law. Concerning disruption physics, a shattered pellet injection system was installed in collaboration with the ITER International Organisation. Thanks to the ability to vary the shard size distribution independently of the injection velocity, as well as its impurity admixture, it was possible to tailor the current quench rate, which is an important requirement for future large devices such as ITER. Progress was also made modelling the force reduction of VDEs induced by massive gas injection on AUG. The H-mode density limit was characterised in terms of safe operational space with a newly developed active feedback control method that allowed the stability boundary to be probed several times within a single discharge without inducing a disruptive termination. Regarding integrated operation scenarios, the role of density peaking in the confinement of the ITER baseline scenario (high plasma current) was clarified. The usual energy confinement scaling ITER98( p,y ) does not capture this effect, but the more recent H20 scaling does, highlighting again the importance of developing adequate physics based models. Advanced tokamak scenarios, aiming at large non-inductive current fraction due to non-standard profiles of the safety factor in combination with high normalised plasma pressure were studied with a focus on their access conditions. A method to guide the approach of the targeted safety factor profiles was developed, and the conditions for achieving good confinement were clarified. Based on this, two types of advanced scenarios (‘hybrid’ and ‘elevated’ q -profile) were established on AUG and characterised concerning their plasma performance.

Combining the analysis of multiple diagnostics and well-chosen prior information in the framework of Bayesian probability theory, the Integrated Data Analysis code (IDA Fischer et al 2010 Fusion Sci. Technol. 58 675–84) can provide density and temperature radial profiles of fusion plasmas. These IDA-fitted measurements are then used for further analysis, such as discharge simulations and other experimental data analysis. Since IDA considers measurement data, which is frequently fragmentary, with statistical and systematic uncertainties, which are often difficult to quantify, from a heterogeneous set of diagnostics, the fitted profiles and their gradients may be in contradiction to well-established expectations from transport theory. Using the modeling suite ASTRA coupled with the quasi-linear transport solver TGLF, we have created a loop in which simulated profiles and their uncertainties are fed back into IDA as an additional prior, thus providing constraints about the physically reasonable parameter space. We apply this physics-motivated prior to several different plasma scenarios and find improved heat flux match, while still matching the experimental data. This work feeds into a broader effort to make IDA more robust against measurement uncertainties or lack of measurements by combining multiple transport solvers with different levels of complexity and computing costs in a multi-fidelity approach.

This paper presents global gyrokinetic simulations on the transport time scale of an ASDEX Upgrade H-mode discharge showing a pronounced peaking of the on-axis ion temperature profiles. Leveraging the newly developed GENE-Tango tool, which combines the global gyrokinetic code GENE with the transport solver Tango, we investigate the impact of energetic particles and electromagnetic effects on the improved plasma performance observed in the experimental discharge. Our results reveal that a striking agreement between the GENE-Tango simulations and the experimental measurements can be achieved only when energetic particles and electromagnetic effects are simultaneously retained in the modeling. In contrast, when these are neglected we observed a significant underestimation of the on-axis ion temperature, aligning with profiles computed using TGLF-ASTRA. The peaking in the ion temperature profile observed in the simulations can be attributed to the effective suppression of turbulence by high-frequency electromagnetic modes, likely Kinetic Ballooning Modes/Alfv & eacute;n eigenmodes. These modes play a critical role in enhancing zonal flow activity and shearing rate levels which thus lead to a localized increase in the temperature gradient. However, it is crucial to maintain these modes at a state of marginal stability or weak instability to prevent energetic particle turbulence destabilization. Otherwise, the result would be a flattening of all the thermal profiles. Interestingly, we found that global GENE-Tango simulations are required to model correctly the linear dynamics of these high-frequency modes. Additionally, global simulations demonstrate greater tolerance than flux-tube simulations for marginal instability of these high frequency modes while maintaining power balance agreement.

We daily rely upon vertical-cavity surface-emitting lasers (VCSELs) for facial recognition and data communication. These lasers are now experiencing exponential growth and serves in other applications as well such as oxygen monitoring in combustion processes and in anesthetized patients in hospitals and as a source of heating in industry in the form of a large-sized array. The large interest for this laser class is linked to its beneficial qualities such as low threshold current, circular-symmetric low-divergent output beam, high efficiency, compactness, and low fabrication cost due to on-wafer testing. Due to these advantages, there is a strong push to realize VCSELs in other wavelength regimes, beyond the commercially available infrared and red. This would open completely new markets such as flood lights, projectors, sterilization, and medical diagnosis and treatment.

Ultraviolet light-emitting diodes (LEDs) suffer from a low wall-plug efficiency, which is to a large extent limited by the poor light extraction efficiency (LEE). A thin-film flip-chip (TFFC) design with a roughened N-polar AlGaN surface can substantially improve this. We here demonstrate an enabling technology to realize TFFC LEDs emitting in the UVB range (280-320 nm), which includes standard LED processing in combination with electrochemical etching to remove the substrate. The integration of the electro-chemical etching is achieved by epitaxial sacrificial and etch block layers in combination with encapsulation of the LED. The LEE was enhanced by around 25% when the N-polar AlGaN side of the TFFC LEDs was chemically roughened, reaching an external quantum efficiency of 2.25%. By further optimizing the surface structure, our ray-tracing simulations predict a higher LEE from the TFFC LEDs than flip-chip LEDs and a resulting higher wall-plug efficiency.

Design and operation of future tokamak fusion reactors using a deuterium–tritium 50:50 mix requires a solid understanding of how energy confinement properties change with ion mass. This study looks at how turbulence and energy transport change in L-mode plasmas in the ASDEX Upgrade tokamak when changing ion species between hydrogen and deuterium. For this purpose, both experimental turbulence measurements and modeling are employed. Local measurements of ion-scale (with wavevector of fluctuations perpendicular to the B-field k⊥< 2 cm−1, k⊥ρs< 0.2, where ρs is the ion sound Larmor radius using the deuterium ion mass) electron temperature fluctuations have been performed in the outer core (normalized toroidal flux ρTor=0.65−0.8) using a multi-channel correlation electron cyclotron emission diagnostic. Lower root mean square perpendicular fluctuation amplitudes and radial correlation lengths have been measured in hydrogen vs deuterium. Measurements of the cross-phase angle between a normal-incidence reflectometer and an ECE signal were made to infer the cross-phase angle between density and temperature fluctuations. The magnitude of the cross-phase angle was found larger (more out-of-phase) in hydrogen than in deuterium. TRANSP power balance simulations show a larger ion heat flux in hydrogen where the electron-ion heat exchange term is found to play an important role. These experimental observations were used as the basis of a validation study of both quasilinear gyrofluid trapped gyro-Landau fluid-SAT2 and nonlinear gyrokinetic GENE codes. Linear solvers indicate that, at long wavelengths (k⊥ρs<1), energy transport in the deuterium discharge is dominated by a mixed ion-temperature-gradient (ITG) and trapped-electron mode turbulence while in hydrogen transport is exclusively and more strongly driven by ITG turbulence. The Ricci validation metric has been used to quantify the agreement between experiments and simulations taking into account both experimental and simulation uncertainties as well as four different observables across different levels of the primacy hierarchy.

In recent years, there has been tremendous improvement in the performance of blue-emitting vertical-cavity surface-emitting lasers (VCSELs) and they are now on the cusp of commercialization. We will summarize state-of-the-art results and outline the main challenges in extending the emission wavelength into the ultraviolet (UV). Our method to simultaneously achieve high-reflectivity mirrors and good cavity length control by selective electrochemical etching has been essential to demonstrate the world’s first UV-B VCSEL. The use of dielectric mirrors, where one material has a negative thermo-optical coefficient, counteracts the inherent red-shift of the resonance wavelength, enabling a temperature-stable emission.

We will give an overview of state-of-the-art results and challenges to achieve high-performing III-nitride vertical-cavity surface-emitting lasers (VCSELs), with a particular focus on the requirements to push the emission wavelength into the ultraviolet (UV). Our method to simultaneously achieve high-reflectivity mirrors and good cavity length control by electrochemical etching enabled the world’s first UV-B VCSEL. The use of dielectric mirrors yielded lasers with a very temperature-stable emission wavelength thanks to the negative thermo-optic coefficient of the mirrors. We have used the same etch methodology to also lift-off fully processed LEDs from their growth substrate to improve the light extraction efficiency.

An overview of recent results obtained at the tokamak ASDEX Upgrade (AUG) is given. A work flow for predictive profile modelling of AUG discharges was established which is able to reproduce experimental H-mode plasma profiles based on engineering parameters only. In the plasma center, theoretical predictions on plasma current redistribution by a dynamo effect were confirmed experimentally. For core transport, the stabilizing effect of fast ion distributions on turbulent transport is shown to be important to explain the core isotope effect and improves the description of hollow low-Z impurity profiles. The L–H power threshold of hydrogen plasmas is not affected by small helium admixtures and it increases continuously from the deuterium to the hydrogen level when the hydrogen concentration is raised from 0 to 100%. One focus of recent campaigns was the search for a fusion relevant integrated plasma scenario without large edge localised modes (ELMs). Results from six different ELM-free confinement regimes are compared with respect to reactor relevance: ELM suppression by magnetic perturbation coils could be attributed to toroidally asymmetric turbulent fluctuations in the vicinity of the separatrix. Stable improved confinement mode plasma phases with a detached inner divertor were obtained using a feedback control of the plasma β. The enhanced D α H-mode regime was extended to higher heating power by feedback controlled radiative cooling with argon. The quasi-coherent exhaust regime was developed into an integrated scenario at high heating power and energy confinement, with a detached divertor and without large ELMs. Small ELMs close to the separatrix lead to peeling-ballooning stability and quasi continuous power exhaust. Helium beam density fluctuation measurements confirm that transport close to the separatrix is important to achieve the different ELM-free regimes. Based on separatrix plasma parameters and interchange-drift-Alfvén turbulence, an analytic model was derived that reproduces the experimentally found important operational boundaries of the density limit and between L- and H-mode confinement. Feedback control for the X-point radiator (XPR) position was established as an important element for divertor detachment control. Stable and detached ELM-free phases with H-mode confinement quality were obtained when the XPR was moved 10 cm above the X-point. Investigations of the plasma in the future flexible snow-flake divertor of AUG by means of first SOLPS-ITER simulations with drifts activated predict beneficial detachment properties and the activation of an additional strike point by the drifts.

Cold plasma techniques previously have been shown to be effective in eliminating pathogenic bacteria and biofilm. In this work we focus on the application of a custom-made plasma jet for the in-situ disinfection of dental implants to treat periimplantitis. In order to assess the surface finish in relation to cell behavior, dental implant material was prepared as titanium discs The discs were infected with bacteria in a bioreactor and plasma-treated. Human gingival fibroblasts were seeded, cultivated and stained by conventional immunofluorescence. Differences in cell adhesion and morphology could be observed after only one day of incubation. In particular, plasma-treated discs appeared to have an advanced effect on early cell response and proliferation when compared to conventional dental implant material. Furthermore the disinfection efficancy was testet with natural biofilm with convincing results. The application of a plasma jet can not only successfully remove highly pathogenic bacteria, but also improve implant surface activation as well as accelerate cell adhesion and proliferation. Therefore, it can be considered an innovative means of treating periimplantitis. The device is developed according to medical standards and meets the stipulated requirements. With changeable applicators the device can be customized to different applications.

In this work we performed experiments to compare the efficacy of disinfectants and plasma on biofilms of the bacterial strains E. coli K12 and E. faecalis Symbioflor® grown for 20 h. The disinfecting agents aqueous ethanol (70 %), peracetic acid (PAA) (15 %) and sodium hypochlorite (NaOCl) (3 %) were used and compared to an atmospheric plasma jet. Sterile Mueller-Hinton-1 (MH1) growth medium and deionized (DI) water were used as negative controls to replace the bacterial suspension and/or the disinfectant agent. For these investigations a thermal biofilm sensor was used to detect not only the effectiveness of chemical substances or the plasma jet in removing biofilm, but also possible growth after the treatment. In these experiments the biofilm was grown for 20 h and the different disinfection methods were then applied. The plasma jet and the NaOCl were the most effective treatments whereby the plasma jets effect can be instantly switched on and off while NaOCl is a liquid solution which exerts its effect as long as it remains in place.

The performance of vertical-cavity surface-emitting lasers (VCSELs) is strongly dependent on the spectral detuning between the gain peak and the resonance wavelength. Here, we use angle-resolved photoluminescence spectroscopy to investigate the emission properties of AlGaN-based VCSELs emitting in the ultraviolet-B spectral range with different detuning between the photoluminescence peak of the quantum-wells and the resonance wavelength. Accurate setting of the cavity length, and thereby the resonance wavelength, is accomplished by using doping-selective electrochemical etching of AlGaN sacrificial layers for substrate removal combined with deposition of dielectric spacer layers. By matching the resonance wavelength to the quantum-wells photoluminescence peak, a threshold power density of 0.4 MW/cm2 was achieved, and this was possible only for smooth etched surfaces with a root mean square roughness below 2 nm. These results demonstrate the importance of accurate cavity length control and surface smoothness to achieve low-threshold AlGaN-based ultraviolet VCSELs.

An accurate description of turbulence up to the transport time scale is essential for predicting core plasma profiles and enabling reliable calculations for designing advanced scenarios and future devices. Here, we exploit the gap separation between turbulence and transport time scales and couple the global gyrokinetic code GENE to the transport-solver Tango, including kinetic electrons, collisions, realistic geometries, toroidal rotation and electromagnetic effects for the first time. This approach overcomes gyrokinetic codes' limitations and enables high-fidelity profile calculations in experimentally relevant plasma conditions, significantly reducing the computational cost. We present numerical results of GENE-Tango for two ASDEX Upgrade discharges, one of which exhibits a pronounced peaking of the ion temperature profile not reproduced by TGLF-ASTRA. We show that GENE-Tango can correctly capture the ion temperature peaking observed in the experiment. By retaining different physical effects in the GENE simulations, e.g., collisions, toroidal rotation and electromagnetic effects, we demonstrate that the ion temperature profile's peaking is due to electromagnetic effects of submarginal MHD instability. Based on these results, the expected GENE-Tango speedup for the ITER standard scenario is larger than two orders of magnitude compared to a single gyrokinetic simulation up to the transport time scale, possibly making first-principles ITER simulations feasible on current computing resources.

: Cold atmospheric plasma jets have started to demonstrate their potential in various medical applications. Those devices generate a plasma using noble gases or air and are used to disinfect the inflamed tissues and even trigger natural healing processes. We are developing a plasma jet device with the purpose of depositing in situ a coating on implant materials that reduces bacteria attachment. The coating is not antimicrobial which is regarded as controversial. This new treatment shall offer physicians a possibility to control reinfection caused or triggered by medical implants. In this work, we present the method as well as first evaluation results. They show how the precursor and gas carrier influence the coating properties and allow to tune their surface properties. The adhesion of the coatings to the substrate was excellent, while the adhesion of Escherichia coli on the coated substrate was significantly reduced. Those preliminary results show the potential of this atmospheric plasma jet–based coating technique.

Objective. Microfabricated neuroprosthetic devices have made possible important observations on neuron activity; however, long-term high-fidelity recording performance of these devices has yet to be realized. Tissue-device interactions appear to be a primary source of lost recording performance. The current state of the art for visualizing the tissue response surrounding brain implants in animals is immunohistochemistry + confocal microscopy, which is mainly performed after sacrificing the animal. Monitoring the tissue response as it develops could reveal important features of the response which may inform improvements in electrode design. Approach. Optical coherence tomography (OCT), an imaging technique commonly used in ophthalmology, has already been adapted for imaging of brain tissue. Here, we use OCT to achieve real-time, in vivo monitoring of the tissue response surrounding chronically implanted neural devices. The employed tissue-response-provoking implants are coated with a plasma-deposited nanofilm, which has been demonstrated as a biocompatible and anti-inflammatory interface for indwelling devices. We evaluate the method by comparing the OCT results to traditional histology qualitatively and quantitatively. Main results. The differences in OCT signal across the implantation period between the plasma group and the control reveal that the plasma-type coating of otherwise rigid brain probes (glass) only slightly improve the glial encapsulation in the brain parenchyma indicating that geometrical or mechanical influences are dominating the encapsulation process. Significance. Our approach can long-term monitor and compare the tissue-response to chronically-implanted neural probes with and withour plasma coating in living animal models. Our findings provide valuable insigh to the well acknowledged yet not solved challenge.

III-nitride membranes offer promising perspectives and improved device designs in photonics, electronics, and optomechanics. However, the removal of the growth substrate often leads to a rough membrane surface, which increases scattering losses in optical devices. In this work, we demonstrate membranes with etched surface roughness comparable to that of the as-grown epitaxial material, accomplished by the implementation of a properly designed built-in polarization field near the top of the sacrificial layer from an AlInN interlayer, which is polarization-mismatched to GaN. This leads to a steeper reduction in free carrier density during the electrochemical etching of the sacrificial layer, limiting the etching current and thus causing an abrupter etch stop. As a result, the root mean square roughness is reduced to 0.4 nm over 5 × 5 μm2. These smooth membranes open attractive pathways for the fabrication of high-quality optical cavities and waveguides operating in the ultraviolet and visible spectral regions.