目的 比较阈下微脉冲激光与多点扫描激光治疗糖尿病性黄斑水肿的临床疗效.方法 回顾性分析2015年3月至2018年5月,糖尿病视网膜病变增生期Ⅳ期合并黄斑水肿患者50例100只眼的临床资料,分为微脉冲激光组和多点扫描激光组,每组患者25例50只眼.微脉冲激光组,黄斑区采用微脉冲激光治疗;多点扫描激光组,黄斑区采用多点扫描激光治疗.术后随访6个月,比较两组患者治疗前后患眼的最佳矫正视力(Best corrected visual acuity,BCVA)、黄斑中心区视网膜厚度(Central macular thickness,CMT)和视网膜平均光敏感度(Mean sensitivity,MS).结果 治疗后2个月,微脉冲激光组CMT较多点扫描激光组明显降低(P＜0.05);治疗后6个月,两组的CMT比较,差异无统计学意义(P＞0.05).治疗后2个月,两组BCVA比较,差异无统计学意义(P＞0.05);治疗后6个月,微脉冲激光组BCVA显著优于多点扫描激光组(P＜0.05).治疗后2和6个月,微脉冲激光组MS均优于多点扫描激光组(P＜0.05).两组不良反应发生率分别为2％和4％,差异无统计学意义(P＞0.05).结论 两种激光手术方法均可减轻糖尿病性黄斑水肿,降低黄斑中心区视网膜厚度,但相较而言,微脉冲激光疗法BCVA和MS改变更明显,术后视功能恢复效果更佳.

AIM:To evaluate the clinical effects of fasudil therapy on nonarteritic anterior ischemic optic neuropathy ( NAION) . <br> METHODS:Seventy eyes of 70 patients with NAION in our hospital were collected and randomly divided into treatment group ( 35 patients ) which was intravenously injected fasudil, and control group ( 35 patients ) which was intravenously injected composite salvia miltiorrhiza injection.At the 4wk of follow-up, the best corrected visual acuity ( BCVA) and visual field were observed and compared. <br> RESULTS:The total effective rate of BCVA in treatment group was 86%, in control group was 57%.The difference in two groups had statistical significance (P<0.05).The improvement rate of visual field in treatment group was 83%and in control group was 57%.The difference in two groups had statistical significance ( P<0.05) <br> CONCLUSION:The clinical effects of fasudil on NAION are better than conventional medication.

目的 探讨小切口非超声乳化术与超声乳化术治疗年龄相关性白内障的临床效果及其对生活质量的影响.方法 选取2012年2月至2013年3月我院收治的年龄相关性白内障患者62例(62眼),依据手术方式不同分为非超声乳化组(28例)和超声乳化组(34例).比较分析两组患者术后2周视力、手术前后角膜内皮变化以及术后2周生活质量评分情况.结果 与超声乳化组相比,非超声乳化组患者术后2周视力≤0.1的比率(7.14％)明显降低,视力≥0.5的比率(75.00％)明显提高,差异有统计学意义(P＜0.05).与术前相比,两组患者术后角膜内皮细胞数、细胞密度及六角形细胞比例均明显下降,差异均有统计学意义(均为P＜O.05);与超声乳化组相比,非超声乳化组患者术后角膜内皮细胞数、细胞密度及六角形细胞比例均较高,差异均有统计学意义(均为P ＜0.05).与超声乳化组相比,非超声乳化组患者术后2周生活质量评分均较高,但差异均无统计学意义(均为P＞0.05).结论 小切口非超声乳化术更适于基层医院在年龄相关性白内障患者的治疗中广泛推广应用.

OBJECTIVE To analyze the distribution and drug susceptibility of pathogenic bacteria causing infections in patients of ophthalmology department so as to guide the reasonable medication.METHODS A total of 120cases of patients with eye infections who were treated in the hospital from 2011 to 2012in the hospital were enrolled in the study,then the isolation and identification of the pathogens isolated from the patients were performed by referring to the clinical routine identification procedures for microorganism and the national clinical laboratory procedures,the automatic identification and drug susceptibility analyzer VITEK-32of BioMérieux,France was employed,finally the drug susceptibility was determined by referring to the standards of Committee for Clinical Laboratory Standards.RESULTS A total of 94strains of pathogens were isolated from the eye secretions from 2011to2012,including 44(46.81%)strains of gram-positive bacteria,27(28.72%)strains of gram-negative bacteria,and 23(24.47%)strains of fungi;the Staphylococcus epidermidis,Pseudomonas aeruginosa,Staphylococcus aureus,Haemophilus influenzae,and Aspergillus spp ranked the top 5species of pathogens,accounting for28.72%,14.89%,13.83%,12.77%,and 11.70%,respectively.The detection rate of the gram-positive bacteria was significantly higher than that of the gram-negative bacteria or fungi(P<0.05).The drug susceptibility rates of the S.aureus and S.epidermidis to vancomycin and linezolid were 100.00%;the drug susceptibility rates of the P.aeruginosato piperacillin and amikacin were 100.00%.CONCLUSIONDrug resistance of the pathogens causing the eye infections is increasingly severe,it is necessary for the hospital to understand to the distribution of the pathogens causing eye infections,grasp the drug susceptibility of the common species of pathogens,and reasonably use antibiotics based on the result of drug susceptibility testing so as to relive the patients′suffering and control the eye diseases.

目的:探讨四君子汤保留灌肠治疗新生儿窒息后喂养不耐受的临床疗效及其对血清一氧化氮的影响.方法:将我院收治的窒息后喂养不耐受的52例患儿随机分为对照组和治疗组,每组各26例.对照组在患儿出现喂养不耐受后立即停止经口喂养,并以静脉高营养的形式以保证水份和营养物质的摄入;治疗组在此基础上加用四君子汤保留灌肠.比较两组临床疗效,并动态观察其血清一氧化氮的变化.结果:与对照组相比,治疗组经四君子汤保留灌肠治疗后,患儿在症状消失时间、恢复至出生体重时间以及肠道营养达418.4 kJ/(kg·d)时间均有所缩短[(3.78±0.42)d vs (5.12±1.42)d;(7.63±1.22)d vs (9.35±1.87)d;(10.16±1.38)d vs (11.50±1.66)d](均P＜0.01).同时血清一氧化氮更快地趋于正常,治疗后96 h,治疗组患儿血清NO明显低于对照组[(78.41±10.63) μmol/L vs (94.23±11.08) μmol/L](P＜0.01).结论:在窒息后发生喂养不耐受的新生儿中,通过四君子汤保留灌肠的方法能够有效地调整胃肠道激素分泌水平,从而促进疾病的康复.

喂养不耐受是窒息后新生儿较为常见的胃肠道功能紊乱.对此,我们在胃肠外营养的基础上采用四君子汤保留灌肠的方法对其进行干预,取得了较好的临床疗效,同时通过分阶段对患儿血浆胃动素(MOT)水平进行测定,从而深入验证其有效性.