• No significant correlation between genetically predicted β-blockers and the risk of developing psoriasis • European populations with genetic proxies of loop diuretics exhibited an increased risk of psoriasis East • Asians with genetic proxies of loop diuretics exhibited a reduced risk of psoriasis

Objective: This study aimed to evaluate the effectiveness of midnight-noon ebb-flow (MNEF) theory guided moxibustion therapy for ankylosing spondylitis (AS) in terms of physical function, disease activity, health-related quality of life, inflammatory cytokines, and immune function biomarkers. Methods: 135 AS patients in Changzhou No. 2 hospital affiliated to Nanjing Medical University were randomly allocated to the control group, Moxibustion I group or the Moxibustion II group. AS patients in the control group received conventional intervention alone, while AS patients in the Moxibustion I group and Moxibustion II group received 4-week conventional moxibustion and MNEF theory-guided moxibustion therapy, respectively. Physical function, disease activity, health-related quality of life, inflammatory cytokines, and immune function biomarkers were assessed at baseline and at the endpoint week. Results: After moxibustion intervention, only performance of physical function measured by Bath Ankylosing Spondylitis Functional Index (BASFI) (F = 17.1, P < 0.01), and disease activity by the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) (F = 17, P < 0.01) were statistically significant differences between the three groups, and the Bath Ankylosing Spondylitis Metrology Index (BASMI) score were no group differences (F = 3.15, P = 0.07). The effect of MNEF-theory based moxibustion was shown to be better than conventional moxibustion therapy in the level of erythrocyte sedimentation rate (ESR) (2.67, 95% CI, 0.15 to 5.18; P = 0.04) and the radio of CD4 + CD25 + CD127 low (-2.83, 95% CI, -4.68 to -0.98; P < 0.01). However, with the use of the Tukey multiple comparisons test, compared with the conventional moxibustion therapy alone, MNEF-theory based moxibustion therapy had no statistically significant improvement in the serum levels of interleukin-6 (IL-6), interleukin-17 (IL-17), tumor necrosis factor α (TNF-α) ( P > 0.05). Conclusion: Overall, MNEF-theory guided moxibustion therapy significantly improved physical activity and health-related quality of life, reduced disease activity, and decreased systemic inflammation for AS patients.

As an important part of traditional Chinese medicine (TCM) nursing technology, moxibustion plays a unique role in improving the symptoms of ankylosing spondylitis (AS). The research on the mechanism of moxibustion intervention in AS mainly focuses on anti-inflammatory effects, immune regulation, bone metabolism regulation, intes-tinal flora regulation, and so on. Molecular medicine is of great significance to further clarify the mechanism of moxibustion intervention in AS. However, there are still some problems in the research on the molecular mechanism of moxibustion intervention in AS:the existing biomedical research methods only explore from a specific field and lack the exploration of moxibustion-targeted molecules based on biomedical network. In the future, the molecular network effect of moxibustion on AS can be discussed comprehensively and systematically with the help of omics technology and the construction of biological information interaction network between omics. The effect of moxibustion on upstream osteogenic transcription factors and related signaling pathways such as WNT,β-catenin, and BMP/Smads is not yet clear. Future research can focus on the relevant signal targets of bone reconstruction and clarify the mechanism of moxibustion against the new bone formation. In addition, there is a lack of research on the molecular mechanism of moxibustion in the treatment of AS from the perspective of metabolites. It is necessary to further explore the mechanism of moxibustion in the treatment of AS with the help of metabonomics technology.

综述慢性心力衰竭病人再入院的影响因素,并分析未来研究趋势.以便在此基础上构建风险模型,筛选高危病人,并为高危病人制订综合的疾病管理计划以及治疗和随访方案,从而降低慢性心力衰竭病人的再住院率.

Objective To explore the therapeutic effects of trimetazidine (TMZ) on diabetic patients with coronary heart diseases.Methods We conducted a comprehensive electronic search of PubMed, EMBASE, and Cochrane databases between the inception dates of databases and May 2019 (last search conducted on 30 May 2019) to identify randomized controlled trials. The evaluation method recommended by Cochrane Collaboration for bias risk assessment was employed for quality assessment. Random or fixed models were used to investigate pooled mean differences in left ventricular function, serum glucose metabolism, serum lipid profile, myocardial ischemia episodes and exercise tolerance with effect size indicated by the 95% confidence interval (CI).Results Additional TMZ treatment contributed to considerable improvement of left ventricular ejection fraction (WMD=4.39, 95%CI: 3.83, 4.95, P<0.00001), left ventricular end diastolic diameter (WMD=-3.17, 95%CI: -4.90, -1.44, P=0.0003) and left ventricular end systolic diameter (WMD=-4.69, 95%CI: -8.66, -0.72, P=0.02). TMZ administration also significantly decreased fasting blood glucose (SMD=-0.43, 95%CI: -0.70, -0.17, P=0.001), glycosylated hemoglobin level (WMD=-0.59, 95%CI: -0.95, -0.24, P=0.001), serum level of total cholesterol (WMD=-20.36, 95%CI: -39.80, -0.92, P=0.04), low-density lipoprotein cholesterol (WMD=-20.12, 95%CI: -32.95, -7.30, P=0.002) and incidence of myocardial ischemia episodes (SMD=-0.84, 95%CI: -1.50, -0.18, P=0.01). However, there were no significant differences in serum triglyceride level, high-density lipoprotein cholesterol, exercise tolerance between the TMZ group and the control group. Conclusion TMZ treatment in diabetic patients with coronary heart disease is effective to improve cardiac function, serum glucose and lipid metabolism and clinical symptoms.

目的 构建基于"医院-社区-家庭"模式探究社区护理实践教学方法,评价该实践教学模式教学效果,提升社区护理教学质量.方法 抽取我校2014级护理专业学生36人,2015级38人,2014级学生按照传统的医院-社区实践的模式开展社区护理实践,2015级学生按基于"医院-社区-家庭"模式的延续性护理模式进行实践,实践环节结束后,采用自制的社区护理实践教学评价表对两组护生进行调查,并比较两组学生成绩的差异.结果 两组护生对社区护理实践总体评价上无统计学差异(P>0.05),然而新的社区实践模式组在社区实践收获维度的得分明显高于对照组(P<0.05),同时,该组护生的社区实践考核成绩明显高于传统实践模式组(P<0.05).结论 基于"医院-社区-家庭"探究式社区实践模式对于提高社区护理教学质量有一定效果,然而,持续的社区实践教学改进还需进一步探讨和摸索.

Introduction: Moxibustion is described as a technique that applies heat which is generated by burning herbal preparations containing Artemisia vulgaris to stimulate acupuncture points. The aim of this study is to assess the efficacy and safety of moxibustion treatment for AS. In the future, a larger RCT will be conducted based on preliminary data from this study. Methods: This research is a protocol for an open, assessor- and analyst-blinded, randomized clinical trial with two parallel groups. Participants who meet the modified New York criteria for AS will be randomly allocated to the intervention group or the control group with a 1:1 allocation ratio. The intervention group will receive moxibustion intervention for 3 weeks and follow-up for 6 weeks. The control group will not receive moxibustion intervention and will be followed for 6 weeks. Conventional interventions will be allowed for both groups. Primary outcome measures are BASFI, BASDAI, and BASMI. Secondary outcome measures are SF-36, EQ-5D, ASQoL and serum levels of ESR and CRP. Ethics and dissemination: This protocol has been approved by the Institutional Review Board (IRB) of the Clinical Research Centre (Affiliated Hospital of Nanjing University of Chinese Medicine, IRB No. [2018] YK006-01). In addition, results of this preliminary study will be disseminated through peer-reviewed publications.

Abstract Objective To evaluate the available evidence from randomized controlled trials (RCTs) of auricular acupressure (AA) therapy for preventing constipation in breast cancer patients undergoing chemotherapy. Methods The following databases were searched from their inception until August 2017: Ovid Medline, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), and Allied and Alternative Medieine (AMED). We also searched four Chinese databases: Chinese BioMedical Database (CBM), China National Knowledge Infrastructure (CNKI), WANFANG Data, and Chinese VIP Database. Only the RCTs related to the effects of AA therapy on preventing constipation in breast cancer patients undergoing chemotherapy were included in this study. Quantitative syntheses of data from RCTs were conducted using RevMan 5.3 software. Study selection, data extraction, and validation were performed independently by two authors. Cochrane criteria for risk of bias were used to assess the methodological quality of the trials. Results Four RCTs met the inclusion criteria, and most were of low methodological quality. Study participants in the AA plus routine care group showed significantly greater improvements in the response rate (risk ratio [RR] = 1.27, 95% confidence interval [CI] [1.14,1.42], P < 0.01) with low heterogeneity χ2 = 2.31, P = 0.31, l2 = 14%). In addition, when compared with routine care alone, one RCT suggested favorable statistically significant effects of AA plus routine care on Constipation Assessment Scale (CAS; mean difference [MD] = -5.07,95% CI [-6.86, -3.28], P < 0.01). Furthermore, when compared with routine care alone, one RCT suggested positive statistically significant effects of AA plus routine care on Patient Assessment of Constipation-Quality of Life (PAC-QOL; MD = -1.26,95% CI [-1.59, -0.93], P < 0.01). Conclusions Overall, as a potential safety therapy, only weak evidence can support the hypothesis that AA can effectively prevent constipation in breast cancer patients undergoing chemotherapy.

目的:了解护生应聘焦虑状况,分析应聘焦虑与积极心理资本的关系,为维护心理健康提供相关依据.方法:2014年3月-2015年6月期间,用问卷调查法调查华东地区4所高校502名护理应届毕业生的应聘期间心理焦虑状况,分析其心理焦虑状况与积极心理资本的相关性.结果:护生应聘状态焦虑得分为(47.67±13.42)分;操作考试前焦虑状态尤为严重;应聘焦虑与积极心理资本呈负相关(P＜0.05);积极心理资本中的坚韧性、希望、自我效能是应聘焦虑的影响因素.结论:护生应聘焦虑较为严重,影响其身心健康.应通过构建积极心理资本,给予专业的心理干预等方法维护其应聘期间身心健康.

病理学和病理生理学是高校护理学专业中重要的两门专业基础必修课程。近年来，两门学科逐渐被合并为一门新的二级学科———病理学与病理生理学。如何从高校护理的培养目标出发，组织这门新兴课程的教学是值得护理专业教师研究的问题。作者主要从教学内容优化、教学方法选取、教学媒介选用、双语教学及教学评定几方面浅谈此课程的教学体会。

[目的]探讨护理本科生实习中期考核方法改革，探索适合的护理人才考核机制，为护理人才培养提供相关依据。[方法]创新临床实习护生中期考核方法，在常州大学护理本科生实习中期考核中实行教师标准化病人(TSP)与客观结构化考试(OSCE)考核相结合的方法。[结果]创新的考核方式有利于以评促学，客观全面地考核了护生的知识与技能。[结论]TSP 与 OSCE相结合是一种创新实用的临床中期考核方式。