Something as simple as the use of lateral bracing for a steel I-girder bridge should be consistent across the globe. However, an investigation into the bridge standards of different countries in Europe and North America revealed little to no consistency in how and why lateral bracing is specified or detailed. Most design codes recognize that adding lateral bracing-the diagonal bracing between the bottom flanges of a typical I-girder bridge superstructure-changes the load path of an I-girder bridge sufficiently to mimic the increased stiffness and fatigue life performance of a much more expensive steel box beam superstructure. Still, lateral bracing is rarely used or, if used, not accounted for in the structural capacity of the structure. This is often because the maximum benefit is found with superstructures with few deep girders in the cross section, and far less benefit is seen for shallower multigirder cross sections. Additionally, accounting for the structural benefit of the lateral bracing increases the complexity of the bridge analysis model and precludes the use of simplified line-girder methods. For these reasons, the investigation showed that even when lateral bracing is used for reasons such as construction stability, it is rarely accounted for as a primary load carrying member in new structures. Since the inclusion of lateral bracing provides no structural benefit but also adds dead load and structural analysis complexity, most agencies attempt to eliminate lateral bracing from their structures and simply increase the capacity of the I-girders. However, for existing two-girder composite bridges, an approach is presented in which the careful addition of a new or structural consideration of existing bottom lateral bracing on an existing two I-girder superstructure could improve the live load distribution and reduce fatigue live load stress ranges sufficiently enough for the structure to remain in service without further structural strengthening.

Bridges face increasing demands due to higher traffic loads and more load cycles, which might require strengthening actions. In the Nordic countries, many existing steel girder bridges have non- composite concrete decks. A rational strengthening approach is to install shear connectors, enabling composite action between the deck and the girders for a more efficient use of the structural components. Installing shear connectors in a new steel structure is inexpensive but installing them in existing bridges can be costly. Instead of placing connectors along the entire bridge, they can be strategically installed where they give the most impact, using only as many as needed to get an adequate composite action. Case studies show that selective placement of shear connectors can significantly improve load-bearing capacity while reducing installation efforts. This paper describes two case studies, one single span bridge and one continuous steel-concrete bridge, where the impact from the position of the shear connectors has been evaluated.

Today, steel girder bridges with an overlaying concrete deck are typically designed and constructed as composite structures. This approach optimizes the utilization of materials and structural components. However, many existing steel-concrete bridges were originally designed without shear connectors at the steel-concrete interface. With the increasing demands of heavier traffic loads and a greater number of heavy load cycles, these bridges may sometimes require strengthening. One effective method to enhance their bending moment capacity is to develop composite action by installing shear connectors. One type of connector that is well-suited for postinstallation is the coiled spring pin. These coiled spring pins are inserted from beneath the bridge, passing through holes drilled in both the top flange of the steel structure and the concrete deck. This installation process can be executed seamlessly during ongoing traffic without causing traffic disruptions. This stands in contrast to postinstallation of welded-headed studs, where the pavement, water insulation, and concrete must be removed before the connectors are welded to the steel flange, followed by the application of new concrete and surface protection. This paper presents a monitoring project on a bridge strengthened with postinstalled shear connectors. The measurements were done both before and after the strengthening, which made it possible to evaluate the behavior of the nonstrengthened and strengthened structures. A verification with an finite-element model of the bridge with and without the shear connectors was made. The result from the measurements indicates that the steel girder and the concrete deck act as a composite section both before and after the strengthening at the tested load levels. The evaluation of the results also includes the vertical and longitudinal displacements between the concrete slab and the steel top flange, where the latter displacement is also denoted slip. The slip for the nonstrengthened bridge also indicates a full composite behavior. Due to the lack of shear connectors, other interlocking phenomena are most likely sufficient to achieve composite behavior at the tested load levels. Therefore, after the installation of the shear connectors, only a small reduction of the slip is noticed. Nevertheless, shear connectors significantly enhance the connection at the steel-concrete interface and are more reliable and robust, especially for heavier loads in the ultimate limit state.

The ways of designing and building steel girder bridges with a composite concrete deck vary much between different parts of the world. A bridge system with twin steel I‐girders or a concept with multiple (more than two) girders can be used. The design and use of details and secondary systems also vary a lot. In order to give horizontal stabilization and distribute horizontal loads, bracing between the I‐girders bracings are often used. Although not so common, the bracing can also be used to distribute vertical loads between the main girders. To describe and to analyze the possible impact from using a lateral bracing, this paper describes the design of a curved bridge in Guatemala City and its challenges. The new Bridge over the Pinula River is designed as a steel‐concrete composite bridge with multiple steel girders with a concrete deck on top and has lateral bracing between the girders. The bridge is used as a case study to analyze the impact from a lateral bracing system on the vertical load distribution between the longitudinal girders. The bridge was designed with lateral bracing between the top flanges along the whole bridge and with bracing between the lower flanges near the supports. The case study shows that the distribution of eccentric vertical loads between the longitudinal girders can be improved by using lateral bracing between the lower flanges for multiple girders. In some cases, it may not be beneficial to use lateral bracings along the whole bridge length, like for example this bridge. In this case due to the governing design cases in the construction stages where these bracings influenced the torsional stiffness of the bridge in such way that an unfavorable distribution of the support reactions between the six girders at some supports was achieved.

Supplementary Figure 1A. Effect of Frondanol A5 treatment on small intestine polyps (SIPs) cell proliferation

Supplementary Figure 2A. CD163 protein expression in the control and Frondanol A5-treated colon

Supplementary table 1 : Primers and PCR conditions

Supplementary Figure 1C. Proliferative index in SIPs and CTs from control and treated groups

Supplementary Figure Legends

Some old bridges have a truss between the bottom flanges not intended for torsional effects but for transferring horizontal forces. This paper describes the effects of the truss on torsion for a Norwegian three span bridge from 1967, without composite action. Furthermore, the effects of post-installed shear connectors are investigated. For composite bridges without intended composite action in bending, the effects of the slab preventing the top flanges from moving laterally should not be ignored, since this is important for the deformations of the girders under eccentric loading. Furthermore, the load distribution between the girders for an eccentric load is significantly enhanced if the horizontal truss is considered. The paper also investigates and presents the effects of post-installed shear connectors, with respect to bending stresses in the bottom flanges (moderate effects) and the top flange (large effects).

Inflammatory bowel diseases (IBDs) are chronic inflammatory disorders that include Crohn's disease (CD) and ulcerative colitis (UC). The incidence of IBD is rising globally. However, the etiology of IBD is complex and governed by multiple factors. The current clinical treatment for IBD mainly includes steroids, biological agents and need-based surgery, based on the severity of the disease. Current drug therapy is often associated with adverse effects, which limits its use. Therefore, it necessitates the search for new drug candidates. In this pursuit, phytochemicals take the lead in the search for drug candidates to benefit from IBD treatment. β-myrcene is a natural phytochemical compound present in various plant species which possesses potent anti-inflammatory activity. Here we investigated the role of β-myrcene on colon inflammation to explore its molecular targets. We used 2% DSS colitis and TNF-α challenged HT-29 adenocarcinoma cells as in vivo and in vitro models. Our result indicated that the administration of β-myrcene in dextran sodium sulfate (DSS)-treated mice restored colon length, decreased disease activity index (DAI), myeloperoxidase (MPO) enzyme activity and suppressed proinflammatory mediators. β-myrcene administration suppressed mitogen-activated protein kinases (MAPKs) and nuclear factor-κB (NF-κB) pathways to limit inflammation. β-myrcene also suppressed mRNA expression of proinflammatory chemokines in tumor necrosis factor-α (TNF-α) challenged HT-29 adenocarcinoma cells. In conclusion, β-myrcene administration suppresses colon inflammation by inhibiting MAP kinases and NF-κB pathways.

This paper treats the use of horizontal trusses between the bottom flanges of new I-girder bridges, to create a box-like behaviour. In contrast to the general vertical cross frames of an I-girder bridge, the horizontal trusses bring along substantial torsional stiffness of the cross section of a bridge. The concept gives large advantages when it comes to fatigue caused by eccentric loading, since the I- girders will share the load more equally. The concept is exemplified by bridges in Finland, Guatemala and France, and some design aspects as well as practical aspects are discussed.

Slussen is situated in the inner city of Stockholm just south of the world heritage site Gamla Stan and the royal castle. This historical site and also second biggest traffic and transportation hub in Stockholm is at the moment undergoing a complete refurbishment due to new demands and requirements and due to the fact that the former traffic plant was in a very bad shape with severe settlements and outworn concrete structures. The old traffic structure from the 1930´s is replaced by a modern urban space and transportation node designed by Foster + Partner and Berg arkitekter, adopted to demands and requirements of the future i.e. increased capacity for pedestrians and cyclists, heavily increased discharge capacity for Lake Mälaren, attractive areas for the public close to the water and several restaurants and cafés.This mega project (€ 1.4 Billion) cannot be described completely in a single paper so therefore two objects of special technical interest have been chosen and are described below: the water regulation system as well as the unique 3.400 Tons steel bridge, transported in one piece from China.

Strengthening old bridges is an increasingly relevant strategy for risk prevention and operation continuity in management of infrastructures. Transportation networks are subjected to progressively stricter environmental and load conditions, leading to a growing number of deficient structures, also due to aging and deterioration. However, employable resources are finite, from both economical and environmental points of view. For these reasons, strengthening opportunities should be considered as a viable option, improving bridges behaviour with low economical and environmental impact. With this perspective, a selection of some of the most interesting strengthening techniques for old truss railway bridges is presented. To address effective solutions, the most frequent problems in old truss railway bridges are first presented. Literature analysis and experts’ interviews were conducted and compared to results obtained from a representative bridge cluster. Different solutions addressing highlighted problems are then collected and qualitatively evaluated, in terms of efficacy on structural behaviour and typical construction requirements. Finally, general remarks and recommendations based on collected evidence are presented.

Today, steel girder bridges with concrete deck slabs are generally constructed as steel-concrete composite structures, to utilize the material and the structural parts in an efficient way. However, many existing bridges constructed before the early 1980´s were designed without shear connectors at the steel-concrete interface. With increasing traffics loads and higher amount of load cycles, there is sometimes a need to strengthen these bridges. One way to increase the bending moment capacity is to create composite action by post-installation of shear connectors. The authors have studied the concept of strengthening by post-installed shear connectors, with a focus on a connector called coiled spring pin. This paper presents the results from the first beam tests performed with this kind of shear connector. In line with the previous push-out tests, the test results indicate a very ductile shear connection, with a potential to be a material- and cost-efficient strengthening alternative.

Traffic density and vehicle weight have been increasing over time, which implies that many existing road bridges were not designed for the high service loads and the increased number of load cycles that they are exposed to today. One way to increase the traffic load capacity of non-composite steel- concrete bridges is to use post-install shear connectors and one type of shear connector is the coiled spring pin. This type of connector has advantages for strengthening of existing bridges, since it enables an installation from below while the bridge is still in service and does not bring along removal of concrete and pavement, nor welding to the top flange.This paper describes one ~50 years old Norwegian single span steel-concrete bridge that was strengthened with post-installed coiled spring pins. The strengthening method and the design procedure are presented, along with the results from a field monitoring on Sagstu bridge, performed to evaluate the behaviour of the strengthened structure. The results show that the coiled spring pins counteract the slip and bring along a very good degree of composite action.

Plant-based compounds or phytochemicals such as alkaloids, glycosides, flavonoids, volatile oils, tannins, resins, and polyphenols have been used extensively in traditional medicine for centuries and more recently in Western alternative medicine. Extensive evidence suggests that consumption of dietary polyphenolic compounds lowers the risk of inflammatory diseases. The anti-inflammatory properties of several phytochemicals are mediated through ligand-inducible peroxisome proliferator-activated receptors (PPARs), particularly the PPAR gamma transcription factor. Inflammatory bowel disease (IBD) is represented by ulcerative colitis, which occurs in the mucosa of the colon and rectum, and Crohn's disease (CD) that can involve any segment of gastrointestinal tract. Because of the lack of cost-effective pharmaceutical treatment options, many IBD patients seek and use alternative and unconventional therapies to alleviate their symptoms. PPAR gamma plays a role in the inhibition of inflammatory cytokine expression and activation of anti-inflammatory immune cells. The phytochemicals reported here are ligands that activate PPAR gamma, which in turn modulates inflammatory responses. PPAR gamma is highly expressed in the gut making it a potential therapeutic target for IBDs. This review summarizes the effects of the currently published phytochemicals that modulate the PPAR gamma pathway and reduce or eliminate colonic inflammation.

A requirement for heavier vehicular transport on the Norwegian road network has resulted in a demand for increased bearing capacity for many of the older bridges in the country. Many of the bridges that have been found to have insufficient capacity against present-day demands are steel girder bridges with concrete slabs without a shear connection between steel and concrete. There is a large number of bridges of this type in Norway and the paper presents strengthening of two of those, in Aust-Agder county in the south of the country. These bridges are approximately 30 m long, single span. The bearing capacity has been upgraded by installing composite action between the steel girders and the concrete slab using coiled pins, in conjunction with thickening of the bottom flange of the steel girders. To obtain composite action, the pins are fitted to tightly drilled holes through the top flange of girders up into the concrete slab. Coiled pins have not been used much for bridge applications. In the work presented, the method has been found to have advantages in terms of cost and workability. Furthermore, the method has benefits when viewed from an environmental standpoint, since it allows strengthening of existing non-composite bridges using relatively little new material, and minimizes traffic disruptions.

Many existing bridge structures experience much more significant loads and load cycles than were anticipated when the bridges were originally designed. An effective way to increase the load capacit ...