The alkaloids of a number of Aspidosperma species were isolated and identified. In one species the lignanes (−)-lirioresinol-C and (+)-O,O-dimethyllirioresinol-B were also encountered.
Abstract The alkaloids of a number of Aspidosperma species were isolated and identified. In one species the lignanes (−)-lirioresinol-C and (+)-O,O-dimethyllirioresinol-B were also encountered.
The results of a survey of Brazilian Aspidosperma species are reported and the structures of seven new alkaloids described. Of these, two have the carbon-nitrogen skeleton of aspidospermatidine (LV) and four that of aspidofractinine (LXV). The last is olivacine-N-oxide (XXII). In addition the chemistry of compactinervine, (VI) an alkaloid with the strychane skeleton, is presented.
A total synthesis of penduletin was achieved, conclusively proving the proposed structure for this substance.
The structure of a new flavone called penduletin (II), isolated as its glucoside (pendulin I) from Brickelia pendula , was established to be the 4′,5-dihydroxy-3,6,7-trimethoxy flavone. In pendulin, a glucose molecule is attached at the 4′ position.