We present the findings of a large linkage study of bipolar affective disorder (BPAD) that involved genomewide analysis of 52 families (448 genotyped individuals) of Spanish, Romany, and Bulgarian descent and further fine mapping of the 1p34-p36, 4q28-q31, and 6q15-q24 regions. An additional sample of 56 German families (280 individuals) was included for this fine-mapping step. The highest nonparametric linkage scores obtained in the fine mapping were 5.49 for 4q31 and 4.87 for 6q24 in the Romany families and 3.97 for 1p35-p36 in the Spanish sample. MOD-score (LOD scores maximized over genetic model parameters) analysis provided significant evidence of linkage to 4q31 and at least borderline significance for the 1p and 6q regions. On the basis of these results and previous positive research findings, 4q31 and 6q24 should now be considered confirmed BPAD susceptibility loci, and 1p35-p36 is proposed as a new putative locus that requires confirmation in replication studies.
Radka Kaneva合作论文数Department of Medical Chemistry and Biochemistry, Medical University -Sofia;Molecular Medicine Center, Medical University – Sofia9
C Kostov合作论文数8
Vesela Stoyanova合作论文数Institute of Physical Chemistry, Bulgarian Academy of Sciences8
Georgi Onchev合作论文数Department of Psychiatry, Medical University Sofia8
Ivo Kremensky合作论文数Laboratory of Molecular Pathology, Medical University7Vihra Milanova合作论文数7S. Krastev合作论文数First Psychiatric Clinic, Medical Academy6A Nikolova合作论文数5R Gaidarova合作论文数4
Johannes Schumacher合作论文数Institut für Humangenetik, Philipps-Universität Marburg;Institute for Human Genetics, University of Bonn;National Institute of Health in Bethesda4
Assen Jablensky合作论文数School of Psychiatry and Clinical Neurosciences, University of Western Australia4
Sven Cichon合作论文数Department of Biomedicine, University of Basel3Peter Propping合作论文数3Amelia Nikolova-Hill合作论文数3
Markus Nöthen合作论文数Institut für Humangenetik, Universitätsklinikum Bonn;Institute of Human Genetics, University of Bonn2C Windemuth合作论文数1Y-A Lee合作论文数1K Strauch合作论文数1Francisco del Rio合作论文数1MJ Gonzalez合作论文数1S Georgiev合作论文数1
Thomas F. Wienker合作论文数1Guillermo Orozco Diaz合作论文数1F. Rivas合作论文数1
David Porteous合作论文数Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh1
Georg Wolfgang Josef Auburger合作论文数Interdisciplinary Center for Neuroscience, Goethe-Universität Frankfurt am Main1
Marcella Rietschel合作论文数Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University1
Peter Nürnberg合作论文数Cologne Center for Genomics, University of Cologne1Robert Fuerst合作论文数1
Wolfgang Gaebel合作论文数Department of Psychiatry and Psychotherapy, LVR-Klinikum, Heinrich-Heine-University1Fermin Perez合作论文数1Mariana G. Ivanova合作论文数1Alexandre A. Todorov合作论文数1
Kathryn Louise Evans合作论文数1Stephanie Ohlraun合作论文数1Vanio Mitev合作论文数1
Fermin Mayoral合作论文数Hospital Regional Universitario Carlos Haya1T. Milenska合作论文数1Antonia Flaquer合作论文数1
Ansgar Klimke合作论文数Department of Psychiatry, Heinrich-Heine-University Duesseldorf1
Thomas G. Schulze合作论文数Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University;Institut für Psychiatrische Phänomik und Genomik, Ludwig-Maximilians-Universität, München1
Susana Maria Gil合作论文数Facultad de Ciencias Veterinarias, Universidad de Buenos Aires1Markus M Noethen合作论文数1
Rami Abou Jamra合作论文数Leipzig University;Universitätsklinikum Leipzig AöR;Institute of Human Genetics, University of Leipzig Medical Center1Eudoxia Gay合作论文数1Francisco Cabaleiro合作论文数1Luba Kalaydjieva合作论文数1
