临床相关剂量的抗癌药物均可以导致恶性肿瘤及细胞系发生细胞衰老和凋亡。衰老逃逸是细胞存活和耐药的重要机制，通过逃避凋亡和死亡，细胞重新进入到细胞周期的S期。近年来的研究表明多倍体肿瘤巨细胞（polyploid giant cancer cells，PGCC）有助于肿瘤的发生、侵袭、转移和治疗抵抗，这些PGCC的形成是肿瘤细胞发生衰老逃逸的前提，通过去多倍体化的方式，它们能够产生具有增殖活性的子代细胞，进而逃脱细胞衰老。本文就PGCC与细胞衰老和治疗抵抗之间的相关研究进展以及靶向PGCC的治疗策略进行概述，为探索致命性癌症的治疗干预提供一个全新的模式。

Objectives: To study the risk factors for massive intraoperative blood loss in children with biliary atresia who underwent liver transplantation for the first time,and to analyze their impacts on graft survival,hospital stay and postoperative complications. Methods: The data of 613 children with biliary atresia who underwent liver transplantation at Department of Pediatric Organ Transplantation,Tianjin First Central Hospital from January 2015 to December 2018 were collected and analyzed. There were 270 males and 343 females, aged 7.4 (3.9) months (range: 3.2 to 148.4 months), the body weight of the recipients were (7.8±3.5) kg (range: 4.0 to 43.3 kg).According to the 85th quad of estimated blood loss(EBL),they were divided into two groups:massive EBL group(96 cases) and non massive EBL group(517 cases). The age,height,weight and other factors between the two groups were analyzed and compared. Univariate Logistic regression and multiple stepwise regression were used to determine the risk factors of massive EBL. Then,the postoperative complications of the two groups,including portal vein thrombosis and portal vein anastomotic stenosis etc.,were analyzed and compared by chi square test. Kaplan Meier curve and log rank test were used to analyze the recipient and graft survival rate of the two groups. Results: During the study period,713 transplants were performed and 613 patients were enrolled in the study. Ninety-six patients(15.7%) had massive EBL,and the postoperative hospital stay was 21(16) days(range:2 to 116 days),the hospital stay of non-massive EBL group was 22(12)days(range:3 to 138 days)(U=24 224.0,P=0.32). Univariate Logistic regression analysis showed that the recipient's weight,Kasai portoenterostomy,platelet count,operation time and cold ischemia time were the risk factors of massive EBL during biliary atresia transplantation. Multiple regression analysis showed that cold ischemia time ≥10 hours,prolonged operation time(≥8 hours) and body weight<5.5 kg were important independent risk factors for massive EBL.The incidence of portal vein thrombosis,hepatic vein stenosis,intestinal leakage and pulmonary infection in patients with massive EBL were significantly higher than those without massive EBL(3.1% vs. 0.8%,9.4% vs. 2.1%,6.3% vs. 0.8%,30.2% vs. 20.1%,all P<0.05). The 3-year overall graft and recipient survival rate were significantly lower in patients with massive EBL than those without massive EBL(87.5% vs. 95.7%,P=0.001;84.4% vs. 95.4%,P<0.01,respectively). Conclusions: In children with biliary atresia who underwent liver transplantation for the first time,the effective control of intraoperative bleeding should shorten the operation time and reduce the cold ischemia time as far as possible,on the premise of ensuring the safety of operation. For children without growth disorder,the weight of children should be increased to more than 5.5 kg as far as possible to receive the operation. Reducing intraoperative bleeding is of great significance to the prognosis of children.

Objective: To investigate the etiology,clinical features and prognosis of pediatric liver retransplantation. Methods: The data of 1 024 cases of pediatric liver transplantation (<18 years old) from January 2014 to December 2019 operated at Tianjin First Central Hospital were collected,retrospectively. Retransplantation was performed in 26 cases,among which 25 cases received secondary liver transplantation and 1 case received a third liver transplantation. There were 13 male and 12 female patients among the 25 patients. The median age was 12.9(20.5) months(range: 5.8 to 134.8 months), the body weight was 8.0(5.6) kg(range: 5.0 to 30.0 kg) at the time of retransplantation. The pediatric end-stage liver disease(PELD) score was 17.0(21.3) (range: 0 to 45) before retransplantation. The etiology of retransplantation was biliary complications in 7 cases,primary nonfunction of liver graft in 5 cases,antibody-mediated rejection in 4 cases,hepatic artery thrombosis in 3 cases,portal vein thrombosis in 3 cases,concomitant hepatic artery and portal vein thrombosis in 2 cases,thrombogenesis of inferior Vena Cava in 1 case and sinusoidal obstruction syndrome in 1 case. The patients were divided into two groups according to the time interval(30 days) between two liver transplantations,8 patients were classified into early-retransplantation(≤30 days) group and 18 patients were classified into late-retransplantation (>30 days) group. The etiology of liver retransplantation,pre-transplant score,time interval between two transplantations,surgical aspects,major complications and survival rates were compared between the two groups. Continuous variables with normal distribution were compared with t test,while Mann-Whitney U test was applied to compare variables without normal distribution. Categorical variables were compared with chi-square test. The survival curves were created by Kaplan-Meier method and compared by Log Rank test. Results: The median follow-up time was 26.8(30.2) months(range: 1 day to 85.7 months), and the incidence of retransplantation was 1.9%. In the early-retransplantation group,the duration of surgery was (439.8±151.0)minutes,the graft-to-recipient weight ratio was 5.0(1.8)%(range:3.6% to 6.1%),the main cause for retransplantation were primary nonfunction and vascular complications. In the late-retransplantation group,the duration of surgery was (604.4±158.0)minutes,the graft-to-recipient weight ratio was 3.4(2.1)%(range:1.4% to 5.3%),the main cause for retransplantation were biliary complications,antibody mediated rejection and vascular complications.The 3-month,1-year and 2-year recipient survival rates in the early-retransplantation group were all 62.3%,while the recipient survival rates in the late-retransplantation group were 100%,93.8% and 93.8%,respectively. The difference of recipient survival rates was significant between the early-retransplantation group and the late-retransplantation group(P=0.019). The overall 3-month,1-year and 3-year recipient survival rates after the primary liver transplantation were 97.1%,95.4%,94.1%,respectively. Conclusions: The vascular complications,biliary complications,primary nonfunction and antibody-mediated rejection are the main causes of liver retransplantation.The PELD score is higher in patients receiving early retransplantation,while the surgery is relatively more complex in patients receiving late retransplantation,which is reflected by longer duration of surgeries. Patients in the late-retransplantation group showed similar recipient survival rates with primary liver transplantation recipients,and the survival rates are superior to those of patients in the early-retransplantation group. Infection and multiple organ failure are the most common fatal causes after retransplantation.

Compatibility between a new LIMIT-style FLiLi and high confinement plasmas in EAST device G. Z. Zuo1, J. S. Hu1.2, D. Andruczyk3, C.L. Li1.4, X. C. Meng1.5, Z. Sun1.6, W. Xu1.5, Y.Z. Qian1.4, M. Huang1, R. Maingi6 and EAST team 1Institute of Plasma Physics, Chinese Academy of Sciences 2CAS key Laboratory of Photovoltaic and energy conservation materials 3Center for Plasma Material Interactions, University of Illinois Urbana-Champaign 4University of Science and Technology of China 5Advanced Energy Research Center, Shenzhen University 6Princeton University Plasma Physics Laboratory Princeton zuoguizh@ipp.ac.cn

(BES Collaboration) J. Z. Bai, Y. Ban, J. G. Bian, X. Cai, J. F. Chang, H. F. Chen, H. S. Chen, Jie Chen, J. C. Chen, Y. B. Chen, S. P. Chi, Y. P. Chu, X. Z. Cui, Y. S. Dai, Y. M. Dai, L. Y. Dong, S. X. Du, Z. Z. Du, J. Fang, S. S. Fang, C. D. Fu, H. Y. Fu, L. P. Fu, C. S. Gao, M. L. Gao, Y. N. Gao, M. Y. Gong, W. X. Gong, S. D. Gu, Y. N. Guo, Y. Q. Guo, Z. J. Guo, S. W. Han, J. He, K. L. He, M. He, X. He, Y. K. Heng, T. Hong, H. M. Hu, T. Hu, G. S. Huang, L. Huang, X. P. Huang, X. B. Ji, C. H. Jiang, X. S. Jiang, D. P. Jin, S. Jin, Y. Jin, Z. J. Ke, Y. F. Lai, F. Li, G. Li, H. H. Li, J. Li, J. C. Li, K. Li, Q. J. Li, R. B. Li, R. Y. Li, W. Li, W. G. Li, X. Q. Li, X. S. Li, C. F. Liu, C. X. Liu, Fang Liu, F. Liu, H. M. Liu, J. B. Liu, J. P. Liu, R. G. Liu, Y. Liu, Z. A. Liu, Z. X. Liu, G. R. Lu, F. Lu, H. J. Lu, J. G. Lu, Z. J. Lu, X. L. Luo, E. C. Ma, F. C. Ma, J. M. Ma, Z. P. Mao, X. C. Meng, X. H. Mo, J. Nie, Z. D. Nie, H. P. Peng, N. D. Qi, C. D. Qian, J. F. Qiu, G. Rong, T. N. Ruan, D. L. Shen, H. Shen, X. Y. Shen, H. Y. Sheng, F. Shi, L. W. Song, H. S. Sun, S. S. Sun, Y. Z. Sun, Z. J. Sun, S. Q. Tang, X. Tang, D. Tian, Y. R. Tian, G. L. Tong, J. Wang, J. Z. Wang, L. Wang, L. S. Wang, M. Wang, Meng Wang, P. Wang, P. L. Wang, W. F. Wang, Y. F. Wang, Zhe Wang, Z. Wang, Zheng Wang, Z. Y. Wang, C. L. Wei, N. Wu, X. M. Xia, X. X. Xie, G. F. Xu, Y. Xu, S. T. Xue, M. L. Yan, W. B. Yan, G. A. Yang, H. X. Yang, J. Yang, S. D. Yang, M. H. Ye, Y. X. Ye, J. Ying, C. S. Yu, G. W. Yu, J. M. Yuan, Y. Yuan, Q. Yue, S. L. Zang, Y. Zeng, B. X. Zhang, B. Y. Zhang, C. C. Zhang, D. H. Zhang, H. Y. Zhang, J. Zhang, J. M. Zhang, J. W. Zhang, L. S. Zhang, Q. J. Zhang, S. Q. Zhang, X. Y. Zhang, Yiyun Zhang, Y. J. Zhang, Y. Y. Zhang, Z. P. Zhang, D. X. Zhao, Jiawei Zhao, J. W. Zhao, P. P. Zhao, W. R. Zhao, Y. B. Zhao, Z. G. Zhao, H. Q. Zheng, J. P. Zheng, L. S. Zheng, Z. P. Zheng, X. C. Zhong, B. Q. Zhou, G. M. Zhou, L. Zhou, N. F. Zhou, K. J. Zhu, Q. M. Zhu, Yingchun Zhu, Y. C. Zhu, Y. S. Zhu, Z. A. Zhu, B. A. Zhuang.

Three kinds of precursor thin films with stacking orders of Cu/Sn/ZnS, Cu/Sn/ZnS/Cu/Sn/ZnS and Cu/Sn/ZnS/Cu/Sn/ZnS/Cu/Sn/ZnS were prepared by magnetron sputtering and annealed with sulfur powder. The microstructure, morphology and optical properties of thin films were investigated by X-ray diffraction, the Raman scattering, scanning electron microscopy and UV-visible spectrophotometer. The increase of cycle number decreases the sulfurizing temperature of the formation of Cu2ZnSnS4 phase. Chemical composition can be controlled by cycle sputtering deposition. After sulfurizing at 500 degrees C, the particle size and the band gap increase with increasing cycle number.

Evidence has suggested that vascular endothelial growth factor (VEGF), a crucial growth factor in regulating endothelial progenitor cells (EPCs), plays a central role in keloid formation. However, the levels of circulating EPCs in patients with keloid have not yet been explored. The aim of this study was to determine the number of circulating EPCs in patients with keloid. Circulating EPCs (defined as CD45− CD34+CD133+VEGFR2+cells) and VEGF levels from 39 patients with keloid and 22 healthy controls (HCs) were assessed by flow cytometry and ELISA, respectively. EPCs were detectable in the peripheral blood of patients with keloid. The number of circulating EPCs and the levels of plasma VEGF were significantly higher in patients with keloid than in HCs. However, no correlation was found between the number of circulating EPCs and the serum VEGF levels. This study provides the first evidence that EPCs are increased in the peripheral blood of patients with keloid. Understanding the roles of EPCs in keloid fromation may lead to the development of novel therapeutic strategies for keloid.

Amorphous Cu:Zn:Sn:S precursor films were prepared by sol gel and spin-coating with copper chloride, zinc chloride, tin chloride and thiourea solutions as starting materials. A Cu2ZnSnS4 film with kesterite structure and a small amount of chlorine formed when the precursor was annealed under Ar ambient at temperature above 200 degrees C, but its atomic ratios of Cu:Zn:Sn:S far deviated from stoichiometric ratios of the Cu2ZnSnS4. However, when the precursor films were annealed with sulfur powder together at temperatures between 360 and 480 degrees C, the CZTS film containing a very small amount of Cl formed, and its atomic ratio change little for Cu, Zn, and Sn, increases for S and decreases for Cl with increasing temperature. When the temperature is 480 degrees C, a CZTS only has Cu, Zn, Sn, and S element is fabricated, and the atomic ratio of Cu:Zn:Sn:S is near the stoichiometric ratio. The bandgap of the CZTS decreases with increasing annealing temperature. The mechanisms of the formation and the properties of the CZTS are suggested in the present work.

Composition and Bandgap of Cu2ZnSnS4 Thin Films Y.M. Sun, B. Yao, X.C. Meng, D. Wang, D. Long, Z. Hua State Key Lab of Superhard Material and College of Physics, Jilin University, Changchun 130023, P.R. China Key Laboratory of Physics and Technology for Advanced Batteries of Ministry of Education, College of Physics, Jilin University, Changchun, 130012, China Key Laboratory of Functional Materials Physics and Chemistry of the Ministry of Education, Jilin Normal University, Siping 136000, P.R. China

Fe75Co5Zr10B10 amorphous alloy prepared by melt-spinning was annealed at various temperatures. The thermal property and microstructures were investigated by di erential thermal analysis, X-ray di raction, and transmission electron microscopy. The crystallization process of Fe75Co5Zr10B10 amorphous alloy is complex. The α-Fe phase precipitates from the amorphous matrix in the initial stage of crystallization. The α-Mn type (χ) phase precipitates at 570 ◦C, but transforms to α-Fe phase and the Laves C14(λ) phase at higher temperature. In the nal stage of crystallization, Fe3Zr, Fe2Zr, and unknown phases are observed and the λ-phase disappears. The α-Fe phase preferentially nucleates after annealing at 530 ◦C for 10 min and the χ-phase preferentially nucleates after annealing at 600 ◦C for 10 min. The nucleation barrier of χ-phase is larger than that of α-Fe phase. The local structure of χ-phase is more similar to amorphous phase.

Fe75Co3Zr10B10 amorphous alloy prepared by melt-spinning was annealed at various temperatures. The thermal property and microstructures were investigated by differential thermal analysis, X-ray diffraction, and transmission electron microscopy. The crystallization process of Fe75Co3Zr10B10 amorphous alloy is complex. The alpha-Fe phase precipitates from the amorphous matrix in the initial stage of crystallization. The alpha-Mn type (chi) phase precipitates at 570 degrees C, but transforms to alpha-Fe phase and the Laves C14(lambda) phase at higher temperature. In the final stage of crystallization, Fe3Zr, Fe2Zr, and unknown phases are observed and the lambda-phase disappears. The alpha-Fe phase preferentially nucleates after annealing at 530 degrees C for 10 min and the chi-phase preferentially nucleates after annealing at 600 degrees C for 10 min. The nucleation barrier of chi-phase is larger than that of alpha-Fe phase. The local structure of chi-phase is more similar to amorphous phase.

J. Z. Bai, Y. Ban, J. G. Bian, X. Cai, J. F. Chang, H. F. Chen, H. S. Chen, J. Chen, J. C. Chen, Y. B. Chen, S. P. Chi, Y. P. Chu, X. Z. Cui, Y. M. Dai, Y. S. Dai, L. Y. Dong, S. X. Du, Z. Z. Du, J. Fang, S. S. Fang, C. D. Fu, H. Y. Fu, L. P. Fu, C. S. Gao, M. L. Gao, Y. N. Gao, M. Y. Gong, W. X. Gong, S. D. Gu, Y. N. Guo, Y. Q. Guo, Z. J. Guo, S. W. Han, F. A. Harris, J. He, K. L. He, M. He, X. He, Y. K. Heng, T. Hong, H. M. Hu, T. Hu, G. S. Huang, L. Huang, X. P. Huang, X. B. Ji, C. H. Jiang, X. S. Jiang, D. P. Jin, S. Jin, Y. Jin, Z. J. Ke, Y. F. Lai, F. Li, G. Li, H. H. Li, J. Li, J. C. Li, K. Li, Q. J. Li, R. B. Li, R. Y. Li, W. Li, W. G. Li, X. Q. Li, X. S. Li, C. F. Liu, C. X. Liu, Fang Liu, F. Liu, H. M. Liu, J. B. Liu, J. P. Liu, R. G. Liu, Y. Liu, Z. A. Liu, Z. X. Liu, G. R. Lu, F. Lu, H. J. Lu, J. G. Lu, Z. J. Lu, X. L. Luo, E. C. Ma, F. C. Ma, J. M. Ma, L. L. Ma, Z. P. Mao, X. C. Meng, X. H. Mo, J. Nie, Z. D. Nie, S. L. Olsen, H. P. Peng, N. D. Qi, C. D. Qian, J. F. Qiu, G. Rong, D. L. Shen, H. Shen, X. Y. Shen, H. Y. Sheng, F. Shi, L. W. Song, H. S. Sun, S. S. Sun, Y. Z. Sun, Z. J. Sun, S. Q. Tang, X. Tang, D. Tian, Y. R. Tian, G. L. Tong, G. S. Varner, J. Wang, J. Z. Wang, L. Wang, L. S. Wang, M. Wang, Meng Wang, P. Wang, P. L. Wang, W. F. Wang, Y. F. Wang, Zhe Wang, Z. Wang, Zheng Wang, Z. Y. Wang, C. L. Wei, N. Wu, X. M. Xia, X. X. Xie, G. F. Xu, Y. Xu, S. T. Xue, M. L. Yan, W. B. Yan, G. A. Yang, H. X. Yang, J. Yang, S. D. Yang, M. H. Ye, Y. X. Ye, J. Ying, C. S. Yu, G. W. Yu, J. M. Yuan, Y. Yuan, Q. Yue, S. L. Zang, Y. Zeng, B. X. Zhang, B. Y. Zhang, C. C. Zhang, D. H. Zhang, H. Y. Zhang, J. Zhang, J. M. Zhang, J. W. Zhang, L. S. Zhang, Q. J. Zhang, S. Q. Zhang, X. Y. Zhang, Y. J. Zhang, Yiyun Zhang, Y. Y. Zhang, Z. P. Zhang, D. X. Zhao, Jiawei Zhao, J. W. Zhao, P. P. Zhao, W. R. Zhao, Y. B. Zhao, Z. G. Zhao, J. P. Zheng, L. S. Zheng, Z. P. Zheng, X. C. Zhong, B. Q. Zhou, G. M. Zhou, L. Zhou, N. F. Zhou, K. J. Zhu, Q. M. Zhu, Yingchun Zhu, Y. C. Zhu, Y. S. Zhu, Z. A. Zhu, B. A. Zhuang, B. S. Zou.

3 We present the rst measurement of the electron angular distribution parameter 2 in W ! ee events produced in proton-antiproton collisions as a function of the W boson transverse momentum. Our analysis is based on data collected using the DD detector during the 1994{1995 Fermilab Tevatron run. We compare our results with next-to-leading order perturbative QCD, which predicts an angular distribution of (1 1 cos + 2 cos 2), where is the polar angle of the electron in the Collins-Soper frame. In the presence of QCD corrections, the parameters 1 and 2 become functions of p W T , the W boson transverse momentum. This measurement provides a test of next-to-leading order QCD corrections which are a non-negligible contribution to the W boson mass measurement.

Evidence of $\psi(3770)$ decays to a non-${D \bar D}$ final state is observed. A total of $11.8 \pm 4.8 \pm 1.3$ $\psi(3770) \to \PPJP$ events are obtained from a data sample of 27.7 $\rm {pb^{-1}}$ taken at center-of-mass energies around 3.773 GeV using the BES-II detector at the BEPC. The branching fraction is determined to be $BF(\psi(3770) \to \PPJP)=(0.34\pm 0.14 \pm 0.09)%$, corresponding to the partial width of $\Gamma(\psi(3770) \to \PPJP) = (80 \pm 33 \pm 23)$ keV.

The water tank prototype with a dimension of 1m x 1m x 13m was constructed as a building block of the Cerenkov calorimeter for very long baseline neutrino oscillation experiments. The effective attenuation length of the water tank was measured to be (5.74 +/- 0.29)m, and the light collection probability as a function of the incident angle of the particle is studied. Results are compared with a Monte Carlo simulation based on GEANT4 package which incorporates detailed optical processes. A good agreement is achieved and the water tank is feasible for the construction of the Cerenkov calorimeter.

Using a sample of $58\times 10^6$ $J/\psi$ events collected with the BESII detector, radiative decays $J/\psi\to\gamma\gamma V$, where $V=\rho$ or $\phi$, are studied. A resonance around 1420 MeV/c$^2$ (X(1424)) is observed in the $\gamma\rho$ mass spectrum. Its mass and width are measured to be $1424\pm 10(stat)\pm 11(sys)$ MeV/c$^2$ and $ 101.0\pm 8.8 \pm 8.8$ MeV/c$^2$, respectively, and its branching ratio $B(J/\psi\to \gamma X(1424)\to \gamma \gamma \rho)$ is determined to be $(1.07\pm0.17 \pm 0.11)\times 10^{-4}$. A search for $X(1424)\to \gamma\phi$ yields a 95% C.L. upper limit $B(J/\psi\to \gamma X(1424)\to \gamma\gamma \phi) < 0.82 \times 10^{-4}$.

The processes psi(2S)-->gammachi(cJ), chi(cJ)-->p(p) over bar $ (J=0,1,2) are studied using a sample of 14x10(6) psi(2S) decays collected with the Beijing Spectrometer at the Beijing Electron-Positron Collider. Very clear chi(c0), chi(c1) and chi(c2) signals are observed, and the branching fractions B(chi(cJ)-->) (J=0,1,2) are determined to be (27.1(-3.9)(+4.3)+/-4.7)x10(-5), (5.7(-1.5)(+1.7)+/-0.9)x10(-5), and (6.5(-2.1)(+2.4)+/-1.0)x10(-5), respectively, where the first errors are statistical and the second are systematic.