目的 探讨卡培他滨不同给药方案用于晚期消化道肿瘤的治疗效果.方法 选取2017年1月～2019年3月陆军军医大学特色医学中心消化内科收治的100例晚期消化道肿瘤患者作为研究对象,按照随机数字表法分为试验组(50例)和对照组(50例).对照组采用2500 mg/m2卡培他滨治疗,试验组采用2000 mg/m2卡培他滨治疗,比较两组患者治疗效果及不良反应发生情况.结果 试验组的总有效率为80.00％,高于对照组的62.00％,差异有统计学意义(P<0.05);试验组不良反应总发生率为22.00％,低于对照组的48.00％,差异有统计学意义(P<0.05).结论 相较于卡培他滨2500 mg/m2治疗,晚期消化道肿瘤患者接受卡培他滨2000 mg/m2治疗,可提高患者的治疗效果,降低不良反应发生率,安全有效.

Objective To investigate the expression of alpha‐fetoprotein(AFP) in various people and situations along with other item of multiple tumor marker protein chip ,and to explore its clinical significance .Methods Totally 25 076 cases detected with multiple tumor markers chip from December 2003 and July 2011 were collected .The expression of AFP and its combination with other item of multiple tumor marker protein chip were analyzed in malignant tumors and other people .Results Elevated AFP in patients with malignant tumors(17 .3% ) was significantly higher than in benign lesions(15 .3% ) and normal persons(12 .1% ) ,a‐mong them ,the AFP rise rate was highest for liver cancer (54 .3% ) ,and the difference was statistically significant (P<0 .01) ,fol‐lowed by ovarian cancer(18 .8% ) and gastric cancer(17 .1% ) .The positive of AFP was commonly combined with other item elevat‐ed in patients with malignant tumors .The most common accompanied item was CA125 ,followed by CA199 ,CEA ,Ferritin ,CA242 , CA15‐3 ,there was no statistically significant between CA242 and CA15‐3(P> 0 .05) .AFP/CA125 was most common pancreatic cancer (60 .5% ) and ovarian cancer (46 .2% ) ,AFP/CA19‐9 was most common in pancreatic cancer (58 .1% ) and liver cancer (43 .7% ) .AFP + CA19‐9 + CA125 was most common in liver cancer (17 .9% ) .Conclusion AFP increase alone was significantly valuable to diagnosis liver cancer ,moreover it combined with CA19‐9 or CA125 may help to improve the positive rate in pancreatic and ovarian cancer .

Objective To evaluate the curative efficacy of compound Kushen injection in preventing hepatic fibrosis formation in patients with chronic hepatitis B(CHB).Methods 90CHB patients were randomly divided into two groups,45case in each group.The patients in the treat group were given the compound Kushen injection(30ml daily)combined with compound glycyrrhizin(160mg daily),and the patients in the control group were only given the compound glycyrrhizin(160mg daily).The hepatic portal vein width and the indexes of hepatic fibrosis were evaluated after the treatment for 8weeks.Results ①After the treatment,the hepatic portal vein width of patients in the treat group diminished obviously(P<0.05),but there was no significant difference in the control group(P> 0.05).②The indexes of hepatic fibrosis,such as HA,LN,PⅢP andⅣ-C,decreased significantly in the treat group after treatment(P<0.05or P<0.01),and each index in the treat group was lower than that in the control group(P<0.05or P<0.01).But the above parameters in the control group altered a little after treatment,and there was no significant difference before and after treatment(P>0.05).Conclusion The compound Kushen injection could prevent hepatic fibrosis formation in patients with chronic hepatitis B(CHB).