目的 探讨他克莫司联合盐酸氨酮戊酸光动力(ALA-PDT)治疗外阴硬化萎缩性苔癣(LS)的临床疗效.方法 选择2018年1月1日—2020年2月1日在我院接受诊治的LS患者64例,按照随机数字表法分为对照组和观察组各32例.对照组采用他克莫司治疗,观察组采用ALA-PDT联合他克莫司治疗.比较2组患者临床疗效、症状评分、皮损面积,并对2组复发情况、不良反应发生情况进行比较.结果 观察组治疗总有效率明显高于对照组(P<0.05).治疗后,2组萎缩、白斑、瘙痒症状评分均明显低于治疗前,且观察组明显低于对照组(P<0.05).治疗后,2组皮损面积积分明显低于治疗前,且观察组明显低于对照组(P<0.05).观察组不良反应发生率、3个月复发率均明显低于对照组(P<0.05).结论 采用ALA-PDT联合他克莫司治疗LS患者,可有效改善LS患者临床症状,减小阴部皮损面积,提高临床疗效,并降低患者疾病复发率,效果安全可靠.

目的 探讨积雪苷霜结合卤米松乳膏对女性外阴硬化萎缩性苔藓疗效、皮损面积及瘙痒评分的影响.方法 回顾性分析2017年1月-2019年1月于嘉兴市妇幼保健院和嘉兴市荣军医院收治的68例行外阴硬化萎缩性苔藓患者,分为观察组与对照组各34例.给予对照组患者卤米松乳膏用药治疗,给予观察组患者卤米松乳膏与积雪苷霜联合用药治疗.比较两组患者的临床疗效、皮损面积、瘙痒、白斑评分及复发率.结果 治疗后,观察组的总有效率明显高于对照组,皮损面积、瘙痒、白斑评分及停药2个月、6个月后的复发率均明显低于对照组,差异均有统计学意义(均P＜0.05).结论 积雪苷霜软膏联合卤米松乳膏治疗女性外阴硬化萎缩性苔藓患者效果显著,可明显减少皮损面积,缓解瘙痒症状,减少白斑,降低复发率.

目的 观察液氮冷冻孕妇宫颈尖锐湿疣的疗效及对分娩结局的影响,旨在为患者提供安全有效的治疗方法.方法 选取2016年12月-2018年10月嘉兴市妇幼保健院收治并确诊的宫颈尖锐湿疣孕妇106例为研究对象,分为对照组和观察组,每组53例.对照组予以聚甲酚磺醛溶液治疗,观察组予以液氮冷冻治疗,治疗结束后评估两组疗效及分娩结局.结果 观察组痊愈率(79.25％)明显高于对照组(39.62％),差异有统计学意义(P＜0.05);对照组复发率(22.64％)明显高于观察组(5.66％),差异有统计学意义(P＜0.05);观察组剖宫产率(18.87％)明显低于对照组(58.49％),自然分娩率(81.13％)明显高于对照组(22.64％),两组分娩结局比较差异均有统计学意义(均P＜0.05);对照组新生儿窒息率(13.21％)、胎儿宫内感染发生率(16.98％)明显高于观察组(1.89％、3.77％),差异均有统计学意义(均P＜0.05);观察组新生儿Apgar评分(8.92±2.05)分明显高于对照组(6.17±1.24)分,差异有统计学意义(P＜0.05);两组好转率(32.08％ vs.20.75％)、胎膜早破发生率(13.21％ vs.5.66％)比较差异均无统计学意义(均P＞0.05);观察组不良反应发生率(13.21％)与对照组(7.55％)比较差异无统计学意义(P＞0.05).结论 液氮冷冻法治疗孕妇宫颈尖锐湿疣,有助于提高患者治愈率,降低复发率,有效改善孕妇分娩结局及新生儿状况,安全性高,值得临床推广应用.

目的 探究聚甲酚磺醛洗剂联合激光对女性生殖器尖锐湿疣的治疗效果及对患者免疫功能的影响.方法 选取2016年12月-2018年5月于该院接受治疗的女性生殖器尖锐湿疣患者120例,按照完全随机法分为激光治疗组、联合治疗组,各60例,激光治疗组患者使用CO2激光进行治疗,联合治疗组患者使用聚甲酚磺醛洗剂联合CO2激光进行治疗.统计两组患者创面愈合时间,酶联免疫吸附试验法检测血清白细胞介素-6(IL-6)、白细胞介素-10 (IL-10)、肿瘤坏死因子-α (TNF-α)、缺氧诱导因子-1 α(HIF-1α)、血管内皮生长因子(VEGF)水平,对两组患者免疫球蛋白水平进行检测,对比两组患者治疗效果和不良反应发生情况.结果 联合治疗组患者创面结痂、愈合时间均短于激光治疗组(P＜0.05).、治疗后联合治疗组血清IL-6、IL-10、TNF-α水平均低于激光治疗组(P＜0.05).治疗后联合治疗组患者血清HIF-1α、VEGF水平均低于激光治疗组(P＜0.05).治疗后联合治疗组患者血清IgA、IgM、IgG水平均低于激光治疗组(P＜0.05).联合治疗组患者治疗总有效率高于激光治疗组(P＜0.05).联合治疗组患者不良反应率略高于激光治疗组,但两组比较差异无统计学意义(P＞0.05).结论 使用聚甲酚磺醛洗剂联合激光对女性生殖器尖锐湿疣患者进行治疗,能够加快患者创面愈合,抑制患者炎症反应以及疣体发展,改善患者免疫功能,治疗效果显著.

Objective To observe the clinical efficacy of desloratadine citrate disodium combined with Yupingfeng Granule in the treatment of chronic urticaria.Methods 86 patients of chronic urticaria (CU) were divided into the control group and treatment group according to random number table,43 cases in each group.The control group was orally treated with desloratadine citrate disodium,and the treatment group was orally treated with Yupingfeng Granule based on the treatment for the control group,with a course of 4 weeks.The clinical efficacy was observed,the disease severity was evaluated by urticarial activity scale (UAS),the life quality was assessed by dermatology life quality index(DLQI),and the changes of serum interleukin-4 (IL-4),interferon-γ(IFN-γ) and immunoglobulin E (IgE)were detected.Results ①The total effective rate was 72.09％ in the control group and 90.70％ in the treatment group.The clinical efficacy of the treatment group was obviously better than that of the control group (P ＜ 0.05).②After treatment,the symptom scores of pruritus and wheal were decreased in both groups (P ＜ 0.01),and the scores of the treatment group were lower than those of the control group (P ＜ 0.01).③Mter treatment,the DLQI was significantly decreased in both groups(P ＜0.01),and the DLQI of the treatment group was lower than that of the control group (P ＜0.01).④After treatment,the levels of IL-4 and IgE were decreased and the IFN-γ level was increased in both groups(P ＜0.05),and the improvement in the treatment group was better than that in the control group(P ＜ 0.05).Conclusion Desloratadine citrate disodium combined with Yupingfeng Granule shows definite clinical efficacy in the treatment of chronic urticaria,which can enhance the life quality and improve the immune state of patients.