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1Effect of different timing of pregnancy termination and mode of delivery on maternal and infant outcomes in patients with early onset severe preeclampsia

张波,张珂,杨一新

目的探讨早发型重度子痫前期患者不同终止妊娠时机、分娩方式对母婴结局的影响.方法回顾性分析2014年1月至2020年6月江苏省无锡市妇幼保健院收治86例早发型重度子痫前期患者的临床资料,根据不同的终止妊娠时间分为A组(27例、终止妊娠时间<32周),B组(31例、终止妊娠时间32～34周),C组(28例、终止妊娠时间>34周);根据分娩方式将其分为阴道分娩组(35例)及剖宫产组(51例).比较各组孕期并发症以及围生儿结局.结果 B、C组发病孕龄大于A组,C组发病孕龄大于B组,差异有统计学意义(P<0.05);C组保守治疗时间短于B组,B组保守治疗时间长于A组,差异有统计学意义(P<0.05).三组孕期并发症总发生率比较,差异无统计学意义(P>0.05).B、C组围生儿死亡率、新生儿窒息率低于A组,Apgar评分高于A组,差异有统计学意义(P<0.05);C组出生体重高于A、B组,B组出生体重高于A组,差异有统计学意义(P<0.05).剖宫产组围生儿死亡、胎儿窘迫及新生儿窒息发生率低于阴道分娩组,Apgar评分高于阴道分娩组,差异有统计学意义(P<0.05).结论在保障安全的前提下延长早发型重度子痫前期患者孕龄至34周以上对母婴结局较好,并提高新生儿存活质量.另外合理采用剖宫产分娩方式能有效降低围生儿死亡率和新生儿窒息发生率.

2021China Medical Herald（2021）引用：4

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2Efficacy of labetalol combined with nifedipine for patients with gestational hypertension and its effect on serum vWF and Apelin levels

Yu-xia SHI,Yi-xin YANG,Min ZHAO

目的探讨拉贝洛尔联合硝苯地平治疗妊娠高血压患者的疗效及对患者血清血管性血友病因子(vWF)、血管活性肽Apelin水平的影响.方法将100例妊娠高血压患者随机分为观察组和对照组,每组50例.对照组采用拉贝洛尔治疗,观察组采用拉贝洛尔联合硝苯地平治疗.比较两组患者治疗后1周、治疗后2周的血压及血清vWF、Apelin水平,比较两组患者治疗后2周的治疗效果.结果治疗后1周及治疗后2周,观察组收缩压和舒张压均低于对照组,两组收缩压、舒张压均有随时间变化的趋势,时间与分组有交互作用(均P<0.05);观察组vWF和Apelin水平均低于对照组,两组血清vWF和Apelin水平均有随时间变化的趋势,时间与分组有交互作用(均P<0.05).观察组患者疗效优于对照组(P<0.05).结论与单用拉贝洛尔相比,拉贝洛尔与硝苯地平联合应用治疗妊娠高血压患者降压效果更好,并可以改善患者血清vWF、Apelin水平.

2019Guangxi Medical Journal（2019）引用：6

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3The clinical efficacy of Marvelon and Mifepristone in the treatment of dysfunctional uterine bleeding in perimenopausal period and the effect on sex hormone concentrations

Yanhua ZHU,Yixin YANG,Yan SUN,Hong ZHANG,Yan TANG,Jiajun WANG

Objective:To compare the clinical efficacy of Marvelon and Mifepristone in the treatment of dysfunctional uterine bleeding in perimenopausal period and the effect on sex hormone concentrations.Methods:124 patients diagnosed with perimenopausal dysfunctional uterine bleeding were collected from our hospital and divided into the observation group and control group randomly,64 cases in each group.The observation group was treated with Marvelon,and the control group was treated with Mifepristone.The endometrial thickness and sex hormone levels before and after the treatment,complete hemostasis time,clinical efficacy between the two groups were compared.Results:After treatment,the endometrial thickness of the two groups was smaller than that before treatment,and the endometrial thickness in the observation group was smaller than that in the control group after treatment;complete hemostasis time was shorter than that in the control group;the total effective rate (98.4％) in the observation group was higher than that in the control group (88.7％),all with significant difference (P ＜ 0.05).The levels of E2,LH and FSH in the observation group were lower than that in the control group after treatment,besides the levels of E2,LH and FSH in the observation group after treatment were lower than that before treatment,all with significant difference (P ＜ 0.05).Conclusions:The clinical efficacy of Marvelon on dysfunctional uterine bleeding in perimenopausal period is better than Mifepristone,which is more effective in reducing the level of sex hormone and worth recommending in clinical application.

2018Chinese Journal of Human Sexuality（2018）引用：25

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4盐酸左氧氟沙星注射液对盆腔炎患者的疗效及安全性评价

杨一新,孙磊,朱燕华

目的:评价盐酸左氧氟沙星注射液对盆腔炎患者的临床疗效及安全性.方法:选取2014年3月-2015年3月间医院收治的盆腔炎患者120例,将其分为观察组和对照组(每组60例);观察组患者给予盐酸左氧氟沙星注射液治疗,对照组患者给予氧氟沙星注射液治疗,比较两组患者职后的临床疗效、腹痛缓解时间、白细胞计数复常时间、妇检复常时间和不良反应的发生情况等.结果:观察组患者治疗后总有效率为95.00％,显著高于对照组为80.00％(P＜ 0.05);观察组患者的腹痛缓解时间为(3.21±0.52)d、白细胞计数恢复正常时间为(1.14±0.16)d和妇检恢复正常时间为(3.59± 1.45)d,优于对照组腹痛缓解时间为(5.37±1.23)d、白细胞计数恢复正常时间为(2.68±1.38)d和妇检恢复正常时间(6.07±1.53)d(P＜0.05);观察组患者不良反应的发生率为8.33％,低于对照组为26.67％ (P＜ 0.05).结论:盐酸左氧氟沙星注射液治疗盆腔炎患者的临床疗效优于氧氟沙星,且不良反应发生少,安全性好.

2015Anti-Infection Pharmacy（2015）引用：1

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5Application value of cervical liquid based cell combined colposcope in examination of cervical lesions

Yan-hua ZHU,Jian-xia WANG,Ke XU,Yi-xin YANG,Ying-jie GU

目的探讨宫颈液基细胞检查联合阴道镜检查在宫颈病变中的应用价值.方法收集无锡市妇幼保健院妇产科2013年3月至2014年3月门诊就诊疑似宫颈病变的妇科患者150例,按照随机数字表法分为联合组和阴道镜组,每组75例,阴道镜组实行单纯的阴道镜检查,联合组首先经过液基细胞学染色检查,再将筛出的阳性结果行阴道镜检查,将检查的结果和病理组织检查金标准比较,评价液基细胞检查联合阴道镜检查的临床的价值.结果联合组和阴道镜检查组总的阳性检出率为34.0％,联合组的阳性率为54.67％,明显的高于阴道镜组的阳性率13.33％,两组阳性率之间的差异具有显著的统计学意义(P＜0.05);经过计算联合组诊断宫颈病变的符合率为53.33％(40/75),对于CIN I的符合率为54.05％(20/37),对于CIN Ⅱ诊断的符合率为41.17％(7/17).结论宫颈液基细胞联合阴道镜检查与病理组织检查具有一定的符合率,并且检查方法简单易行,值得临床上采纳使用.

2014Journal of Medical Forum（2014）引用：2

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6Expression and significance of AMP-activated protein kinase in ovarian tumor

YANG Yixin,ZHAO Min,XU Junying

Objective To investigate the expression and significance of AMP-activated protein kinase in ovarian tumors.Methods Immunohistochemical staining was used to examine the expressions of AMPKα1,AMPKα2and p-AMPK in 30patients with ovarian carcinoma(group A),20 cases with ovarian cystadenoma(group B)and 6normal ovarian tissue samples(group C).Results The AMPKα1and AMPKα2 were expressed in the cytoplasm and AMPKα2 was expressed in the nucleus in a small amount as well.The positive expression rate of AMPKα1protein in group A was 30%,which was similar to 35%in group B and 33%in group C(P>0.05).The positive expression rate of AMPKα2protein in group A was 80%,which was significantly higher than 45%in group B and 33%in group C(P<0.05).The positive expression of p-AMPK in group A was lower than that in groups of B and C(P<0.05).The positive expressions of AMPKα1and AMPKα2 were not correlated to the clinicopathological parameters.Conclution AMPKα2is overexpressed in ovarian cancer,suggesting that AMPK signal pathway plays an important role in the development of ovarian cancer.

2013Jiangsu Medical Journal（2013）

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