目的 比较使用TiLOOP网片的协和式前盆底重建术与自体组织修复术的临床疗效及对患者生活质量的影响.方法 盆腔器官脱垂(POP)62例患者,随机分为TiLOOP网片组32例,自体组织修复组30例,比较两组围术期参数、临床疗效及生活质量的影响.结果 两组围术期参数中的手术时间及出血量比较差异有统计学意义(P<0.05),术后两组前中盆腔相关的Ba、Bp、C点值及生活质量问卷评分较术前均显著改善(P<0.05,P<0.001),术后两组盆底功能障碍问卷(PFDI-20)、盆镀功能影响问卷(PFIQ-7)评分比较差异有统计学意义(P<0.05).结论 使用TiLOOP网片可提高经阴道前盆腔重建手术成功率,表明TiLOOP网片在植入盆底修复POP方面是安全有效的.

目的 探讨微RNA-93(miR-93)介导转化生长因子-β1(TGF-β1)调节Ⅲ型胶原蛋白在压力型尿失禁(SUI)中的表达意义.方法 2014年1月至2018年1月,选取无锡市妇幼保健院收治的SUI病人(SUI组53例)以及同期行妇科良性肿瘤治疗且术前检查无SUI及其他盆腔器官脱垂临床症状的病人(无SUI组53例)为研究对象.取受试者阴道壁组织,以RT-PCR测定miR-93的表达,以蛋白印迹法测定TGF-β1及Ⅲ型胶原蛋白的表达,结合荧光素酶报告分析测定miR-93与TGF-β1的相关性.结果 miR-93在SUI病人阴道壁组织中的表达低于无SUI组(0.63±0.18)比(1.12±0.23),TFG-β1及CollagenⅢ在SUI病人阴道壁组织中的表达亦低于无SUI组[TFG-β1(0.49±0.12)比(0.67±0.15),CollagenⅢ(0.22±0.05)比(0.31±0.09)].SUI组与无SUI组相比,miR-93表达降低[(0.26±0.04)比(1.05±0.12)],TFG-β1及CollagenⅢ在SUI原代成纤维细胞中的表达均降低[TFG-β1(0.92±0.20)比(1.15±0.07);CollagenⅢ(0.32±0.05)比(1.02±0.13)].miR-93基因可与TFG-β1基因结合,并且通过结合提高了TFG-β1的表达.进一步研究证实miR-93过表达的情况下可以提高TFG-β1的表达,而当miR-93的表达被抑制时,TFG-β1的表达亦下调(t=6.590,P=0.007).结论 SUI病人中,miR-93表达降低,介导TGF-β1表达下调,最终导致胶原Ⅲ含量降低.

目的 探究影响卵巢癌复发风险的危险因素并构建预测模型,改善患者预后情况.方法 选取2017年1月至2018年10月在无锡市妇幼保健院妇科确诊的109例卵巢癌患者作为研究对象.经过手术治疗后对患者进行为期2年的随访,根据随访结果将患者分为复发组和未复发组.比较两组的基线资料,通过Cox回归分析影响卵巢癌复发的危险因素,构建卵巢癌复发风险Nomogram预测模型,并采用受试者工作特征(ROC)曲线比较单一指标、卵巢恶性肿瘤风险评估(ROMA)指数、哥本哈根指数(CPH-I)和预测模型对患者复发风险的诊断效能.结果 年龄≥56岁、肿瘤大小≥53mm、国际妇产科联盟(FIGO)分期为Ⅲ期、血清人附睾蛋白4(HE4)≥182.50pmol/L、糖类抗原125(CA125)≥37U/mL为卵巢癌患者术后复发的独立危险因素.根据以上因素构建预测卵巢癌复发风险的Nomogram模型,ROC曲线分析结果显示,预测模型对卵巢癌复发风险的预测价值大于HE4、CA125单独的预测价值,优于ROMA指数和CPH-I指数.结论 以患者年龄、肿瘤大小、FIGO分期、HE4和CA125水平等因素构建的Nomogram预测模型,对卵巢癌患者术后复发风险有较好的诊断效能,对改善患者预后有重要参考价值.

目的 应用免疫组化和实时荧光定量PCR(real-time fluorescence quantitative PCR,qRT-PCR)技术检测结直肠癌中BRAF V600E突变,比较这两种技术在结直肠癌中的应用价值.方法 总结113例结直肠癌标本BRAF V600E免疫组化和qRT-PCR的结果 ,以测序为金标准,评价这两种技术在结直肠癌BRAF V600E突变检测中的应用价值.结果 113例结直肠癌标本中,免疫组化检测阳性19例,阴性82例,不确定诊断12例.其中19例阳性标本经测序确认BRAF V600E突变6例,未突变13例;12例不确定诊断病例经测序确认1例突变,11例未突变.免疫组化阳性检出率为16.81％,阴性检出率为72.57％,不确定诊断例数占检测例数的10.62％.113例结直肠癌标本同时行qRT-PCR检测,结果 突变7例,未突变106例,阳性检出率为6.19％,阴性检出率为93.8％,无不确定诊断,与测序结果 一致,符合率达100％.以测序为金标准,比较这两种技术在结直肠癌检测BRAF V600E中的应用价值,免疫组化和qRT-PCR技术的灵敏度、特异度、阳性预测值、阴性预测值、假阴性率、假阳性率、准确率分别为100％、86.32％、31.58％、100％、0、13.68％、87.13％和100％、100％、100％、100％、0、0、100％.经配对χ2检验这两种检测方法差异有显著性(P<0.00001).结论 在结直肠癌BRAF V600E检测中,qRT-PCR较免疫组化有更高的准确性.

目的 探究固肾安胎丸联合黄体酮对先兆流产患者的保胎效果及作用机制.方法 将98例先兆流产患者按照随机数字表法均分为对照组和治疗组,各49例,对照组患者给予黄体酮肌肉注射;治疗组患者在对照组治疗的基础上加用固肾安胎丸口服.对比2组的保胎效果,治疗前后监测血清绒毛膜促性腺激素(β-HCG)、孕激素(P)水平、T淋巴细胞亚群CD4+、CD8+和CD4 +/CD8+水平及血清中血管内皮生长因子(VEGF)、白细胞介素-10(IL-10)和一氧化氮(NO)水平变化,追踪患者的分娩情况.结果 对照组的有效率(77.6％)明显低于治疗组(93.9％)(P＜0.05);治疗后治疗组患者的β-HCG、P、CD4+、CD4+/CD8+、VEGF和IL-10水平显著高于对照组(P＜0.05);而CD8+和NO水平显著低于对照组患者(P＜0.05);治疗组的分娩结局明显优于对照组(P＜0.05).结论 固肾安胎丸联合黄体酮肌肉注射能通过调节T淋巴细胞亚群、VEGF、IL-10和NO水平产生保胎效果,提高激素水平,保胎成功率高.

目的:探讨稽留流产患者实施身心协调舒适性护理的临床效果.方法:选择2016年4月至2017年10月接诊的86例稽留流产患者,随机分为研究组和对照组各43例.对照组予以传统护理干预,研究组予以身心协调舒适性护理.通过SAS和SDS量表对两组患者在干预前和干预后第14 d末的心境感知状态进行评估;通过自制的认知水平问卷比较两组患者对稽留流产的认知水平;对两组患者的护理满意率进行比较.结果:研究组干预后的焦虑和抑郁得分低于对照组,稽留流产认知度、生殖健康知识掌握率、再次妊娠信心率、满意率均高于对照组差异有统计学意义(P＜0.05).结论:身心协调舒适性护理应用于稽留流产女性,能改善其心境状态,且能提高其对疾病的认知水平.

目的:探析妊娠晚期产前出血对母婴结局的影响.方法:选择妊娠晚期孕产妇110例作为研究对象,根据是否出现产前出血分为对照组(82例,产前未出血)和观察组(28例,产前出血).对2组临床资料进行分析,并对孕产妇发生妊娠晚期产前出血的原因进行统计,比较2组孕产妇及新生儿的妊娠结局.结果:观察组28例孕晚期出血原因为前置胎盘、胎盘早剥、宫颈疾病及其他,发生率分别为50.00％、32.14％、14.29％和3.57％.2组孕产妇产后出血发生率比较差异无统计学意义(P>0.05),观察组阴道分娩率低于对照组(P<0.01),剖宫产率和子宫切除率均高于对照组(P<0.01和P<0.05);观察组早产和新生儿窒息率均高于对照组(P<0.05),胎儿窘迫和死胎发生率在2组间差异均无统计学意义(P>0.05).结论:存在妊娠晚期产前出血,孕产妇及新生儿不良结局的发生概率将显著增加,医护人员应根据产妇具体情况,及时对其展开针对性临床干预措施.

目的 探究盆底肌训练结合生物反馈电刺激在产后盆底功能康复中的应用效果.方法 选取2016年10月至2018年10月于盱眙县人民医院住院分娩并于产后42 d复查确诊为盆底功能障碍性疾病的产妇200例,按随机数表随机分为两组,各100例.对照组给予常规康复训练干预;观察组给予盆底肌训练结合生物反馈电刺激干预.对比两组盆底肌张力、性生活质量及尿失禁发生率.结果 干预3个月后测评,观察组盆底肌张力优于对照组,性生活质量高于对照组,压力性尿失禁程度也轻于对照组,差异均有统计学意义(均P<0.05).结论 盆底肌训练结合生物反馈电刺激应用于产妇产后盆底功能康复中,可显著改善产妇盆底肌张力,提高其性生活质量,降低产后压力性尿失禁程度.

急性盆腔炎的发生,除了患者原有的基础疾病外,还与患者的日常生活方式以及自我认知有关,从患者的自我效能层面着手,充分调动起主观能动性,使其积极参与到自我生活护理,可以提高院外生活质量[1]. 故有学者提出了动机访谈干预,该项新型的护理模式实则是由美国Miller学者首次倡议,即将患者视为一个独立的个体,以交谈的形式深入其矛盾内心,进而帮助其开展自我剖析,提高自我内在的主观能动性,敦促自我改变不良的生活方式与行为习惯,最终促进病情的正面转归. 由于该项照护模式涉及心理学技巧与方法,目前临床护士尚缺少这方面技能与理论培训,所以该项新型的护理手段尚未得到全面推广与普及. 本研究旨在剖析动机访谈干预应用于急性盆腔炎患者所产生的临床效果. 现报告如下.

目的 探讨裸花紫珠片治疗慢性盆腔炎的临床效果及对患者血清白细胞介素-1β(IL-1β)、单核细胞趋化蛋白-1(MCP-1)和粒细胞-巨噬细胞集落刺激因子(GM-CSF)水平的影响.方法 以我院124例慢性盆腔炎患者为研究对象,其中给予头孢曲松钠、左奥硝唑氯化钠注射液静脉滴注治疗的62例为对照组;加用裸花紫珠片治疗的62例患者为观察组.通过主要症状的消失时间及中医证候积分变化评价其临床效果,监测用药前后血清IL-1β、MCP-1、GM-CSF水平.结果 观察组患者的有效率(91.9％)明显高于对照组患者77.4％(P<0.05);经治疗后,观察组患者的体温降至正常、下腹痛消失、白带正常时间较对照组明显缩短(P<0.05);治疗后两组患者的主要中医症候积分、血清IL-1β、MCP-1、GM-CSF水平显著低于治疗前,以观察组的下降更为明显(P<0.05).结论 裸花紫珠片利于促进慢性盆腔炎患者临床症状的消退,其机制可能在于调控血清IL-1β、MCP-1、GM-CSF水平而发挥抗炎作用,值得临床推广运用.

目的:探讨金刚藤咀嚼片辨治湿热瘀结证慢性盆腔炎性包块的临床效果.方法:选取200例湿热蕴结证慢性盆腔炎性包块患者,随机分为对照组和观察组各100例.对照组给予抗生素治之;观察组联合给予金刚藤咀嚼片口服,连续治疗2周.治疗前后对比两组的有效率,评价中医证候积分,观察盆腔包块直径大小变化,检测血液流变学指标,监测血清细胞因子CRP、TNF-α、IL-6水平及宫颈黏液中sIgA水平变化.结果:观察组的有效率为90％,较对照组的79％明显增高,差异具有统计学意义(P＜0.05);治疗后观察组患者的中医证候积分与对照组相比显著降低,差异具有统计学意义(P＜0.05);观察组的盆腔包块直径相比对照组明显缩小,差异具有统计学意义(P＜0.05);观察组的血液流变各指标显著低于对照组,差异具有统计学意义(P＜0.05);治疗后观察组患者的血清CRP、TNF-α、IL-6水平均显著低于对照组,而宫颈黏液中sIgA水平经治疗后则显著高于对照组,差异具有统计学意义(P＜0.05).结论:金刚藤咀嚼片辨治湿热瘀结证慢性盆腔炎性包块疗效确切,利于改善临床症状,促进盆腔包块的消退,其机制与改善血液流变学指标以利于血液微循环及调控因子水平以提高宫颈黏膜对病原微生物反复上行感染的防御能力、减轻免疫损伤有一定相关性,值得深入进一步探究.

黑素细胞痣(melanocytic nevus)又名色素痣,是皮肤的黑素细胞良性增生性病变,可生长于身体的任何部位,且以颜面部多发[1].因现代人们对外貌的要求并担心其恶变,色素痣手术切除逐年增加,成为病理科较常见的组织标本之一.根据痣细胞巢的生长部位可分为交界痣、复合痣、皮内痣.色素痣组织切片经HE染色后可见形状不一的棕黄色、棕褐色或棕黑色的细小颗粒,我们称之为黑色素.这种黑色素颗粒可掩盖细胞的结构和形态,影响观察,而且其颗粒存积的颜色与进一步免疫组化DAB显色的棕黄色难以区别,对疾病的诊断造成障碍.为去除黑色素颗粒对细胞的影响,提高色素痣标本的制片质量,笔者对传统脱黑色素法进行了探索改良,并对脱色素标本免疫组化的处理方法条件优化,现将实验内容介绍如下.

Objective:To compare the clinical efficacy of Marvelon and Mifepristone in the treatment of dysfunctional uterine bleeding in perimenopausal period and the effect on sex hormone concentrations.Methods:124 patients diagnosed with perimenopausal dysfunctional uterine bleeding were collected from our hospital and divided into the observation group and control group randomly,64 cases in each group.The observation group was treated with Marvelon,and the control group was treated with Mifepristone.The endometrial thickness and sex hormone levels before and after the treatment,complete hemostasis time,clinical efficacy between the two groups were compared.Results:After treatment,the endometrial thickness of the two groups was smaller than that before treatment,and the endometrial thickness in the observation group was smaller than that in the control group after treatment;complete hemostasis time was shorter than that in the control group;the total effective rate (98.4％) in the observation group was higher than that in the control group (88.7％),all with significant difference (P ＜ 0.05).The levels of E2,LH and FSH in the observation group were lower than that in the control group after treatment,besides the levels of E2,LH and FSH in the observation group after treatment were lower than that before treatment,all with significant difference (P ＜ 0.05).Conclusions:The clinical efficacy of Marvelon on dysfunctional uterine bleeding in perimenopausal period is better than Mifepristone,which is more effective in reducing the level of sex hormone and worth recommending in clinical application.

目的:探讨抗子宫内膜抗体与抗精子抗体应用于检测不孕者和习惯性流产者的临床价值.方法:选择2013年10月至2015年10月无锡市妇幼保健院收治的不孕者125例作为A组,选择同期收治的习惯性流产者125例作为B组,再选择同期进行常规检查的孕妇100例作为对照组.采用酶联免疫吸附法对三组人员抗子宫内膜抗体、抗精子抗体进行检测,并进行对比分析,总结抗子宫内膜抗体、抗精子抗体与不孕和习惯性流产的相关性.结果:A组患者抗子宫内膜抗体检测阳性率、抗精子抗体检测阳性率和总阳性率均高于对照组人员,其差异均具有统计学意义(均P ＜0.05);B组患者抗子宫内膜抗体检测阳性率、抗精子抗体检测阳性率和总阳性率均高于对照组人员,其差异均具有统计学意义(均P ＜0.05);B组患者孕周＜12周者抗子宫内膜抗体检测阳性率、抗精子抗体检测阳性率和总阳性率均高于孕周≥12周患者,其差异均具有统计学意义(均P＜0.05).结论:对抗子宫内膜抗体和抗精子抗体进行检测对诊断习惯性流产和不孕者具有重要临床价值,为不明原因的习惯性流产和不孕者提供了新的诊断依据,抗子宫内膜抗体和抗精子抗体与早期流产具有显著相关性.

Objective To synthesize 18F-AlF-1,4,7-triazacyclononane-l,4,7-triacetic acid (NOTA)-c (CGRRAGGSC),which could specifically bind to the α chain of interleukin (IL)-11 receptor (IL-11 R),and evaluate its targeting potential to IL-11 R-positive tumors.Methods Polypeptide c (CGRRAGGSC) was first coupled with NOTA and then labeled with 18F by AlF labeling method.The radiochemical purity and radiochemical yield of 18F-AlF-NOTA-c(CGRRAGGSC) were analyzed by high performance liquid chromatography,and the stability in vitro was evaluated.The tracer biodistribution in tumor-bearing mice (cell line SKOV3) was evaluated by the dynamic imaging with microPET 30 min,1 h,2 h after injection of 18F-AlF-NOTA-c (CGRRAGGSC).The tracer kinetics was performed in normal mice.Pharmacokinetics parameters were calculated using DAS2.0 software.Results The radiochemical purity of 18F-AlF-NOTA-c(CGRRAGGSC) was higher than 95％ and the radiochemical yield was (30.0±7.4)％.It could be stably maintained in phosphatebuffered solution and plasma for at least 2 h.MicroPET imaging showed that 18F-AlF-NOTA-c(CGRRAGGSC)had a good affinity to SKOV3 tumor.The tumor/muscle ratios at 30 min,1 h,2 h after the injection of 18F-AlF-NOTA-c(CGRRAGGSC) were 6.26±2.98,7.19±3.63 and 9.05±4.30,respectively.The tracer was cleared rapidly in blood and mainly excreted by the liver and kidneys.The T1/2α and T1/2β were (0.38±0.14) h and (2.64±0.28) h,respectively.Conclusions 18F-AlF-NOTA-c(CGRRAGGSC) is easy to be synthesized and has a good affinity to IL-11R-positive tumors.It will be a potential IL-11R-targeting imaging agent.

Objectives:To explore the clinical effect and possible mechanism of Kuntai capsule and hormone replacement therapy in the treatment of climacteric syndrome.Methods:106 patients were randomly divided into control group and observation group,with 53 cases in each group.Patients in the control group were given hormone replacement therapy,while the patients in observation group were given Kuntai capsule on the basis of hormone replacement therapy,both for 12 weeks of treatment.The curative effect,levels of hormone,and the living quality with Kupperman scores were evaluated.Results:The efficiency in observation group was 94.3％,which was higher than that of control group (79.2％),with significant difference (P ＜0.05).The levels of FSH and LH in observation group were lower than these in control group,with significant difference (P ＜ 0.05).The level of E2 in observation group were higher than that in control group after treatment (P ＜ 0.05).The Kupperman score in observation group was lower than that in control group,with significant difference (P ＜ 0.05).Conclusion:Treating climacteric syndrome with Kuntai capsule and hormone replacement therapy is good to improve the patients' clinical symptoms,worthy of clinical promotion.The mechanism may be associated with stimulating the ovarian reserve,improving ovarian function and regulating the levels of hormone.

Objective To investigate the expression of IL-11 and IL-11RA in epithelial ovarian cancers (EOCs).Methods The protein expression of IL-11 and IL-11RA in 108 cases of EOCs were assessed by immunohistochemistry.Results The positive rates of IL-11 in ovarian endometrioid carcinoma, ovarian serous cystadenocarcinoma, ovary mucinous cystadenocarcinoma and ovarian clear cell carcinoma were 78.79%, 74.29%, 50.00% and 40.63%, respectively.Compared with benign ovarian neoplasm, the expression of IL-11 was significantly increased in EOCs (P<0.05).The expression of IL-11 showed no statistical correlation with age in EOCs (P>0.05).The expression of IL-11 was significantly correlated with clinical stage of EOCs (P<0.05).The expression of IL-11 was significantly increased in EOCs with peritoneal metastasis (P<0.05).IL-11RA was highly expressed in associated benign ovarian neoplasm and EOCs.Conclusion The expression of IL-11 is significantly correlated with EOCs.The expression of IL-11RA plays a synergistic role in EOCs.The high expression of IL-11 is close relevant to peritoneal metastasis in EOCs, suggesting a potential target for the treatment of ovarian cancers.

Objective To explore the expressions of high mobility group box B1 (HMGB1),interleukin-6 (IL-6),and transforming growth factor-β1 (TGF-β1) in peripheral blood of patients with severe preeclampsia.Methods ELISA was used to detect the expressions of HMGB1,IL-6,and TGF-β1 in serum of 57 patients with severe preeclampsia and 21 normal late pregnant women (control group).Results Compared with control group,the expressions of HMGB1,IL-6,and TGF-β1 in severe preeclampsia group increased,there were statistically significant differences (P＜0.05).HMGB1 expression in patients with early-onset severe preeclampsia was higher than that in patients with late-onset severe preeclampsia,but there was no statistically significant difference (P＞0.05).IL-6 expression in patients with early-onset severe preeclampsia was higher than that in patients with late-onset severe preeclampsia,TGF-β1 expression in patients with early-onset severe preeclampsia was lower than that in patients with late-onset severe preeclampsia,there were statistically significant differences (P＜0.05).Correlation analysis showed that HMGB1 was positively correlated with IL-6,while HMGB1 was negatively correlated with TGF-β1.Conclusion HMGB1 upregulation may be involved in the pathogenesis of preeclampsia,assessment of cytokines can effectively monitor severe preeclampsia.

While angiotensin II (ang II) has been implicated in the pathogenesis of cardiac cachexia (CC), the molecules that mediate ang II's wasting effect have not been identified. It is known TNF-α level is increased in patients with CC, and TNF-α release is triggered by ang II. We therefore hypothesized that ang II induced muscle wasting is mediated by TNF-α. Ang II infusion led to skeletal muscle wasting in wild type (WT) but not in TNF alpha type 1 receptor knockout (TNFR1KO) mice, suggesting that ang II induced muscle loss is mediated by TNF-α through its type 1 receptor. Microarray analysis identified cholesterol 25-hydroxylase (Ch25h) as the down stream target of TNF-α. Intraperitoneal injection of 25-hydroxycholesterol (25-OHC), the product of Ch25h, resulted in muscle loss in C57BL/6 mice, accompanied by increased expression of atrogin-1, MuRF1 and suppression of IGF-1/Akt signaling pathway. The identification of 25-OHC as an inducer of muscle wasting has implications for the development of specific treatment strategies in preventing muscle loss.

Objective To explore the expressions of CD44 and IMP3 in epithelial ovarian cancer.Methods Fifty-nine patients with epithelial ovarian cancer treated in the hospital from May 2007 to February 2015 were selected as epithelial ovarian cancer group,18 patients with benign ovarian tumors were selected as control group during the same period.Immunohistochemistry was used to detect the expressions of CD44 and IMP3 in the two groups.The data was analyzed by SPSS 19.0 statistical software,inspection level was 0.05.Results The expression scores of CD44 in epithelial ovarian cancer group and control group were (3.78±2.55) points and (1.89±2.91) points,respectively,there was statistically significant difference between the two groups (Z=-2.817,P＜0.05).In epithelial ovarian cancer group,there was no statistically significant difference in the expression score of CD44 between the patients less than 50 years old and the patients aged 50 years old or more than 50 years old (Z=-1.213,P＞0.05);there was no statistically significant difference in the expression score of CD44 between the patients of stage Ⅲ-Ⅳ and the patients of stage Ⅰ-Ⅱ (Z =-1.947,P＞0.05);there was statistically significant difference in the expression score of CD44 between the patients with peritoneal metastasis and the patients without peritoneal metastasis (Z=-2.169,P＜0.05).The expression scores of IMP3 in epithelial ovarian cancer group and control group were (5.45 ±2.75) points and (1.67±1.41) points,respectively,there was statistically significant difference between the two groups (Z=-1.970,P＜0.05).In epithelial ovarian cancer group,there was no statistically significant difference in the expression score of IMP3 between the patients less than 50 years old and the patients aged 50 years old or more than 50 years old (Z=-1.201,P＞0.05);there was no statistically significant difference in the expression score of IMP3 between the patients of stage Ⅲ-Ⅳ and the patients of stage Ⅰ-Ⅱ (Z=-0.622,P＞0.05);there was no statistically significant difference in the expression score of IMP3 between the patients with peritoneal metastasis and the patients without peritoneal metastasis (Z=-1.169,P＞0.05).In epithelial ovarian cancer group,there was no correlation between CD44 expression and IMP3 expression (r =0.188,P＞0.05).Conclusion IMP3 may play a synergistic role in oncogenesis and aggravation of epithelial ovarian cancer,CD44 is important in peritoneal metastasis,which can be used as a new therapeutic target for epithelial ovarian cancer.