目的 分析吉非替尼致药品不良反应(ADR)的相关因素,为临床安全用药提供参考.方法 检索2020年1—12月无锡市上报国家ADR监测系统吉非替尼致ADR报告,记录患者性别、年龄、原患疾病、用药情况、ADR发生时间、累及的系统/器官及临床表现、转归和关联性评价等信息进行统计分析.结果 共提取49例报告,其中男16例,女29例,4例患性别不详;年龄24～85(60±13)岁;主要ADR累及胃肠系统损害24例次,表现为呕吐、腹泻、便秘等,皮肤及其附属器损害19例次,主要为皮疹、痤疮、瘙痒等,呼吸系统损害18例次,表现为间质性肺炎、肺部感染、鼻咽炎;49例吉非替尼片致不良反应患者中痊愈10例,好转21例,未好转12例,死亡1例,其他5例转归信息不详.结论 通过对49例吉非替尼致不良反应分析可知,严重甚至危及生命的不良反应发生比例较高.故应加强吉非替尼在抗肿瘤治疗中的不良反应监测和处理,加强其上市后的安全性研究工作.

氨氯地平是第三代二氢吡啶类钙拮抗剂，1992年7月31日获美国食品药品监督管理局(FDA)批准上市，于1993年在中国上市，为高血压、稳定型心绞痛和/或变异型心绞痛治疗的一线药物。该药能阻滞钙离子跨膜进入心肌和血管平滑肌细胞，直接松弛血管平滑肌而起到降压作用，通过扩张外周小动脉和冠状动脉，减少总外周血管阻力，解除冠状动脉痉挛，降低心脏的后负荷，减少心脏能量消耗和对氧的需求，从而缓解心绞痛。氨氯地平在10 mg/d的剂量范围内有良好的耐受性，大多数不良反应是轻中度的。常见的不良反应有潮红、疲劳、水肿、眩晕、头痛、腹痛，恶心、心悸、嗜睡等，其特殊的不良反应为牙龈增生[1-2]。为了解氨氯地平致牙龈增生相关研究情况以及其临床表现、严重程度、预后、发生机制及防治措施，本研究应用文献计量学方法对国内外关于氨氯地平致牙龈增生的有关文献进行分析，为临床安全用药提供参考。

目的：探讨氨氯地平过量中毒的特点。方法对1989年1月至2013年12月国内外医药学期刊中公开发表的有关氨氯地平过量中毒的报道进行分析。结果国内外氨氯地平过量中毒的报道共计34例，主要表现为心脏功能抑制、肾功能衰竭、水肿等，严重者可引发多器官衰竭和猝死。结论氨氯地平过量中毒的死亡率较高，可达20.59%，救治工作困难。

Objective: To establish a gas chromatography method for the determination of pyridine in cetylpyridinium chloride ophthalmic solution. Methods: The separation was performed on a capillary column which was a copolymer of 5% diphenyl-95% diphenyl siloxane as stationary phase.Column temperature was 35℃for 5 minutes.Then it increased to 115℃in rate of 8℃per minute.Carrier gas was nitrogen. Injector and detector were set at 120℃and 260℃respectively. Results:Pyridine and contamination could be completely separated with the established method. It was a linear correlation between the peak area and the concentration in concentration range of 0.492~9.84μg/ml.The recovery was 99.8%(n=9).RSD is 4.9%(n=6). Conclusion: The established method was accurate, simple and is suitable for determination of pyridine in cetylpyridinium chloride ophthalmic solution.

Objective:To identify and determine the impurities in amlodipine beslyate tablets.Methods:The main impurities in amlodipine beslyate tablets were identified with LC-MS,NMR and chromatographic methods.Then the main impurities were determined with C18 column as stationary phase and buffer(pH 3.0)-methanol-acetontrile 50∶35∶15 as mobile phase.Results:The main impurity in amlodipine beslyate tablets was proved to be the dehydration product of amlodipine(Impurity A,IM A).IM A could be completely separated with the established method.It was a linear correlation between the area and the concentration in the range of 0.5~10.0 μg / ml.The Limit of Quantification of the method was 10 ng / ml,recovery was 98.2%(n = 9) and the RSD of the method was 0.2%(n = 6).Conclusion:The main impurity in amlodipine beslyate tablets was IM A.The established method is accurate,simple and is suitable for determination of IM A in amlodipine beslyate tablets.

>喉罩通气道（LMA）简称喉罩,作为一种新型通气道,既可以让患者自主呼吸,又能施行正压通气,是介于气管插管与面罩之间的通气工具 [1] 。喉罩是英国麻醉医师Brain在1981年发明的,1988年正式投入生产,1991年获FDA批准用于临床,使用患者数已超过2亿例次。SLIPA（streamlined liner of the pharynx air-way）喉罩是一种新型喉上通气装置,由南非麻醉科医师Don Miller针对传统喉罩的缺点而发明,具有反流误吸保护、密封性佳、无需充气、插入快速方便、不

Desorption Electrospray Ionization(DESI),a newly developed ionization method,is the combination of electrospray and desorption ionization.Samples can be determinated without pretreatment and under ambient conditions.Therefore,DESI is an efficient,selective,and sensitive method.The present paper reviewed the ionization mechanisms,latest instrument development,characteristics and applications of DESI.

Objective: To develope a rapid liquid chromatography tandem mass spectrometry method for the quantification of terbinafine in human plasma.Methods: Separation was performed using a C18 column(4.6 mm×150 mm,5 μm)maintained at 30℃ and the mobile phase consisting of a mixture of methyl alcohol and water(containing 20 mmol·L-1 ammonium acetate)(95∶5) was delivered at a flow rate of 1.0 mL·min-1.The analytes were analyzed by electro-spray ionization(ESI) in a multiple reaction monitoring(MRM) mode.The precursor to product ion transition of m/z 292.00→141.10 and m/z 530.95→82.10 were used to measure terbinafine and the internal standard(ketoconazole),respectively.Results: The linearity ranged from 10.3 to 2054 ng·mL-1(r=0.9978);the limit of quantification of terbinafine in human plasma was 10.3 ng·mL-1.The intra-and inter-assay precisions,accuracy and absolute recovery met the requirement of a bioanalytical method,the method was absent of matrix effects.Conclusion: The method is selective and suitable for the clinical quantification of terbinafine in human plasma.

Objective To observe the efficacy of gabapentin in treating residual neuralgia of herpes zoster.Methods Fourty-six patients with residual neuralgia of herpes zoster were randomly divided into two groups.The patients in group A(24 cases)were treated with gabapentin plus conventional therapy and those in group B with carbamazepine plus conventional therapy.Visual analogue scale(VAS)was used to evaluate the efficacy.Results Clinical efficacy was better in group A than that in group B.Conclusion Gabapentin is effective and better than carbamazepine in treating the residual neuralgia of herpes zoster.

目的:探讨丹皮酚(Paeonol)对实验性高脂血症大鼠的体质量、血脂和血糖的影响.方法:将70只幼龄SD大鼠随机分为6组,即正常对照组、高脂模型组、丹皮酚干预组(高、中、低剂量)和安慰剂对照组,高脂饲料喂养建立高脂血症大鼠模型.分别于4、8、12 w检测大鼠的体质量变化及血清中血脂(TC、TG、VLDL)和血糖的水平.结果:与正常对照组比较,高脂模型组大鼠体质量及血清中TC、TG、VLDL和血糖均显著升高(P<0.05);与高脂模型组比较,丹皮酚各剂母组大鼠体质量及血清中TC、TG、VLDL、血糖均显著降低(P<0.05).结论:丹皮酚能降低高脂血症大鼠体质量、血脂(TC、TG、VLDL)和血糖,其作用呈一定的剂量依赖性.