Atılım University (In Turkish: Atılım Üniversitesi) is a private university, created in 1997. It is located in Ankara, the capital of Turkey. The language of instruction for most courses is English. Education programs are at international standards (e.g. ABET 2000). Atılım University was chosen as one of the best 401-500 universities in the World in 2016 by London-based The Higher Education (THE) and has been highly ranked by many other institutions..
In this paper, we address two open problems posed by Martínez, Gupta and Quoos in [24]. We solve both problems completely and therefore generalize [28, Theorems 3.4 and 3.5]. We study polynomials of the form f(x)=x3g(xq−1) over the finite field F2k such that g(x)=h(x)+xu+xv, where h(x)=ax4+bx3+cx2+bx+a is a self-reciprocal polynomial with a,b,c∈F2k and (u,v)∈{(3,−1),(1,−1),(2,−2),(2,−1)}. The studied classes of polynomials either generalize some existing pentanomials and hexanomials or they are not quasi-multiplicative equivalent to any of the known permutation polynomials in the literature. We find necessary and sufficient conditions on a,b,c∈F2k so that f(x) is a permutation polynomial for F22k. Moreover, we show that some known permutation pentanomials are QM equivalent.
The profust reliability is based on fuzzy state assumption for the system under concern and uses probability measure in reliability evaluation. In this study, the profust reliability of the parallel system that consists of non-identical components is considered by defining an appropriate membership function which depends on the number of failed components. The profust reliability of the system follows a mixture model. Age-based replacement policy is also studied and necessary conditions are obtained for the existence of the finite and unique optimal replacement time.
ABSTRACT In this study, graphene oxide (GO)‐modified poly (phenylene oxide, PPO) anion exchange membranes (F/GO) were developed for application in anion exchange membrane electrolyzers (AEMELs). The incorporation of GO enhanced membrane hydration, ion‐exchange capacity, and hydroxide‐ion conductivity, resulting in an ~15% increase in current density at 2.0 V and 80°C (0.551 A/cm2) compared with the pristine membrane (0.480 A/cm−2). The F/GO membranes also showed enhanced hydrogen production rates and an HHV‐based energy efficiency of 76% at 0.5 A/cm2 and 80°C. These results underscore the potential for F/GO membranes in scalable AEMEL applications. Mechanical and alkaline stability tests confirmed robustness under harsh conditions. These findings demonstrate that the incorporation of GO provides a simple, scalable, and potentially lower‐cost modification strategy compared with highly engineered polymer architectures, while also improving overall electrolyzer performance, highlighting the potential of GO‐modified membranes for practical hydrogen production in AEMEL systems.
BACKGROUND:Hyperglycemia associated with diabetes and its neurological complications is strongly linked to oxidative stress and chronic inflammation; however, the contribution of ferroptosis to this process remains incompletely understood. Ferroptosis is an iron-dependent form of regulated cell death characterized by lipid peroxidation and glutathione depletion and has recently been implicated in neurodegenerative disorders and diabetic neuropathy. Nevertheless, the interaction between ferroptosis and inflammasome signaling in hyperglycemia-induced neuronal injury remains unclear. This study aimed to investigate the role of ferroptosis in hyperglycemia-induced neuronal damage and to evaluate the potential protective effects of the ferroptosis inhibitor UAMC-3203. METHODS:SH-SY5Y cells differentiated with retinoic acid were exposed to normoglycemic or hyperglycemic conditions and treated with UAMC-3203. Expression levels of ferroptosis-related proteins (GPX4, ACSL4), inflammatory mediators (NLRP3, Caspase-1), and the antioxidant transcription factor Nrf2 were analyzed by Western blotting. Lipid peroxidation and antioxidant status were assessed by measuring malondialdehyde (MDA) and glutathione (GSH), while apoptosis was evaluated using Annexin V/PI flow cytometry. RESULTS:Hyperglycemia suppressed GPX4 expression while increasing ACSL4, lipid peroxidation, and NLRP3 inflammasome activation, indicating enhanced ferroptotic and inflammatory stress. UAMC-3203 reduced lipid peroxidation, restored GSH levels, and markedly suppressed NLRP3 expression, particularly at higher concentrations. However, high-dose UAMC-3203 increased apoptotic cell death, suggesting a shift toward alternative cell death pathways when ferroptosis is inhibited. CONCLUSIONS:Collectively, these findings indicate that hyperglycemia induces neuronal injury through a ferroptosis-associated inflammatory signaling axis and that targeting ferroptosis may represent a promising therapeutic strategy for diabetes-related neuronal damage.
The aim of this study is to develop a simulation-based approach for a closed-loop allogeneic whole-cell vaccination method applicable to prostate cancer immunotherapy. To this end, a controller design is required; therefore, this research utilizes Lyapunov's second method of stability. To achieve this objective, a novel mathematical model describing the progression of prostate cancer is employed. The model used in this study incorporates two inputs: the administration rates of allogeneic vaccination and secondary chemotherapy, respectively. Various conditions were examined across all simulations, including low and high initial doses, controlled versus open-loop vaccine administration, and the presence or absence of concomitant low-dose chemotherapy. The simulation results indicate that if only a low initial vaccine dose is administered, the tumor population increases gradually. In the absence of control, significantly higher initial doses are required. Conversely, with the closed-loop approach, complete remission can be achieved within 65 days using a low initial dose. Furthermore, if this regimen is supported by low-dose chemotherapy, the remission period decreases to 11 days.
