Bach Mai Hospital is a multi-field medical facility in Hanoi and is considered one of the largest in Vietnam. The hospital was established in 1911 during the French colonial rule. It has played an important role in the health system of Vietnam and is one of three high specialized medical centers, specializing in internal medicine. It is a big center of cadres training and scientific research in the country. The hospital has 3,500 beds and 4,300 staff.During Nixon's Christmas Bombing, Operation Linebacker II, on December 22, 1972 American bombs struck the hospital, obliterating the building and killing 28 hospital staff members and an unconfirmed number of patients.A special rehabilitation unit was opened in 1998 for treating adults and children with disabling conditions (stroke and cerebral palsy). The unit sponsored by Veterans For America has seen more than 1,700 patients and has fitted more than 2,100 plastic braces since its establishment.In 2000, Bach Mai Hospital was partly reconstructed and supplied with up-to-date facilities and equipment under a grant aid project of the Government of Japan.When SARS broke out in Vietnam in 2003, Bach Mai Hospital substantially contributed to putting it under control by providing strict nosocomial infection control, which was implemented by Japanese experts.There is a small speech therapy unit at the Hospital headed by Dr. Vu Thi Bich Hanh.The new spinal unit with 25 patient's beds established with help of Handicap International was opened in May, 2008..
Access to trustworthy artificial intelligence (AI) for clinical applications is uneven, especially in low-resource settings with limited and inconsistent data. Models from high-resource settings often fail to generalize. Transfer learning (TL) can adapt established models to new settings. Using neurological outcome prediction for out-of-hospital cardiac arrest (OHCA) as a proof of concept, we adapted a model trained on a large cohort to Vietnam (243 patients) and Singapore (15,916 patients) using the Pan-Asian Resuscitation Outcomes Study registry. The external model performed poorly on the Vietnam cohort, with an area under the receiver operating characteristic curve (AUROC) of 0.467 (95
Objective Anxiety is associated with decreased functioning and quality of life. Recently, anxiety among university students has been a vital public health concern. Little is known about the prevalence of anxiety, depression, and psychological distress in public health students in Vietnam. This study aims to identify the prevalence of anxiety and its associated factors among students in Hanoi. Methods A cross-sectional study was conducted from April to May 2017 using a self–administered questionnaire amongst 459 public health students. Questions about students’ anxiety were adapted from the Anxiety scale of the standardized Depression Anxiety Stress Scale-21 (DASS-21) to determine psychological anxiety, panic, and fear. The multivariate logistic regression model was utilized to identify the associated factors of students’ anxiety. Results The results showed that the prevalence of anxiety among public health students was 42.3%. The results of the multivariate logistic regression model illustrated that the signs of anxiety in students are strongly correlated with several factors: inadequate financial status of students (OR = 5.0, CI: 1.5–15.7), living in low-income families (OR = 3.06, CI: 1.32–7.11), high learning pressure (OR = 1.78, CI: 1.08–2.91) and having a father as a worker (OR = 2.6, CI: 1.1–6.1). Conclusion This study suggests that public health students experience anxiety; the finding is consistent with previous studies. The study results highlight the need for psychiatric counseling services aimed at vulnerable students in universities in Vietnam.
Mục tiêu: Mô tả đặc điểm lâm sàng, xét nghiệm và hình ảnh cộng hưởng từ của ung thư đường mật trong gan típ ống nhỏ. Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang, hồi cứu, thu thập dữ liệu từ 30 bệnh nhân được chẩn đoán ung thư đường mật trong gan típ ống nhỏ tại Bệnh viện Bạch Mai (1/2021 -11/2025). Kết quả: Tuổi trung bình 57,7 ± 10,7;cao nhất ở nhóm tuổi 50–70 (66,7%), nam chiếm 56,7%. Thường không có triệu chứng (43,3%), đau bụng (33,3%), vàng da (16,7%). CA 19-9 tăng 30,0%, HBsAg dương tính 33,3%. Trên cộng hưởng từ, thể khối chiếm ưu thế (96,7%), kích thước ≥ 5 cm chiếm 53,3%, bờ rõ 73,3%, co kéo bao gan 60,0%. Tổn thương giảm tín hiệu trên T1W (93,3%), tăng tín hiệu trên T2W (96,7%), hạn chế khuếch tán (100%). Dấu hiệu “target sign” gặp ở 36,7% trên T2W và 53,3% trên DWI. Ngấm thuốc đặc trưng gồm ngấm viền thì động mạch (83,3%), tăng dần ở thì tĩnh mạch (93,3%); thì muộn ngấm tăng dần vào trung tâm (76,7%) và ngấm duy trì (20%), thải thuốc hiếm (3,3%). Xâm lấn mạch 3,3% và di căn hạch 30,0%; đa số không giãn đường mật (83,3%). Kết luận: Ung thư đường mật trong gan típ ống nhỏ có biểu hiện lâm sàng nghèo nàn, xét nghiệm không đặc hiệu. Đặc điểm hình ảnh cộng hưởng từ có giá trị trong định hướng chẩn đoán.
Super-enhancers (SEs), characterized by dense clusters of enhancer elements enriched with transcriptional activator binding sites, are involved in cell differentiation. However, little is known about SE-mediated regulation of adipogenic genes. The aim of this study was to elucidate the functional role of the KLF6-proximal SE during the adipogenesis of human adipose-derived stem cells (hADSCs). Adipogenic induction medium (AIM) was used for differentiation of hADSCs into adipocytes, which were evaluated for adipogenic gene expression and adipogenesis using quantitative PCR and Oil Red O (ORO) staining, respectively. The effects of SE inhibitors, locked nucleic acid-mediated enhancer RNA (eRNA) knockdown, and small interfering RNA-mediated knockdown of KLF6 on adipogenesis and adipogenic gene levels were evaluated. Chromatin immunoprecipitation assays were performed to identify transcriptional regulators binding to the promoter regions of KLF6 and the adipogenesis-inhibitory Delta-like non-canonical Notch ligand 1 (DLK1) gene during adipogenesis. In silico screening identified KLF6 as an obesity-susceptibility gene associated with single-nucleotide polymorphisms and located within the domain of SE_00159, which was activated in adipocytes. AIM-cultured hADSCs exhibited time-dependent increases in KLF6 mRNA and protein expression. During adipogenesis, the transcription factor peroxisome proliferator-activated receptor gamma (PPARγ) bound to the KLF6 promoter. Treatment with the SE inhibitor JQ1 resulted in a dose-dependent decrease in KLF6 mRNA expression and reduced ORO staining. Knockdown of eRNA expressed from the SE_00159 domain decreased KLF6 levels during adipogenesis. Consistently, KLF6 knockdown during hADSC adipogenesis downregulated the adipogenic genes PPARG and CEBPA, while upregulating DLK1. Additionally, KLF6 together with histone deacetylase (HDAC)3 bound to the DLK1 promoter and concomitantly caused dissociation of histone acetyltransferase p300 during adipogenesis. SE activation upregulates KLF6 through PPARγ/p300- and eRNA-mediated transcriptional induction during hADSC adipogenesis. KLF6, in turn, represses DLK1 expression through recruitment of HDAC3 to the promoter and p300 dissociation, thereby facilitating adipocyte differentiation. These findings support a working model in which the epigenetic regulation of KLF6 and DLK1 as a potential therapeutic axis in human obesity.
