Bayreuth Medical Center

To compare treatment patterns and oncologic outcomes of patients with pharyngeal and laryngeal squamous cell carcinoma treated at a tertiary hospital versus three secondary regional hospitals in Franconia, Germany. We retrospectively analyzed 308 consecutive patients (tertiary hospital n = 164; secondary regional hospitals n = 144) diagnosed between 01/2017 and 12/2019 and treated with primary or adjuvant radiotherapy (RT), with or without concomitant chemotherapy. Primary endpoints were overall survival (OS), progression-free survival (PFS), and locoregional recurrence-free survival (LRRFS). Kaplan-Meier estimates, multivariable Cox regression models, and a 1:1 matched-pair analysis were applied. Residual confounding was quantified using E‑values. The cohorts were well balanced, except for a higher prevalence of HPV-negative tumors (52

3D motion capture data of healthy participants is of high value for research groups working in basic research, clinical settings, or the development of medical devices as a reference or for comparison purposes. This dataset provides kinematic and kinetic data from 13 healthy young adults (five women, eight men; mean age 28.2 ± 4.7 years) during ramp walking at three inclinations (0°, 7.5°, and 10°). Using a 3D motion capture system (Vicon Motion Systems Ltd) consisting of 10 infrared cameras, two video cameras and three force plates (Advanced Mechanical Technology, Inc.), data was recorded as participants walked up and down a 6 m instrumented ramp at self-selected speeds. In each trial, two consecutive strides over the force plates are captured. The dataset includes raw data and processes kinematic and kinetic data of the lower limb and upper body based on the Plug-in Gait full body model.

Abstract Background Calcium pyrophosphate deposition (CPPD) disease usually affects peripheral joints in older adults, whereas spinal involvement is rare and intramedullary cases have not been reported. We describe a unique case of intramedullary spinal pseudogout mimicking a tumor. Case presentation A 59-year-old woman presented with chronic cervicothoracic pain. MRI revealed an intramedullary lesion at C7–T2, initially suspected to be a low-grade glioma. Surgical biopsy, however, demonstrated calcium pyrophosphate crystal deposition, confirming CPPD. The patient’s postoperative course was uneventful, with symptomatic improvement under supportive therapy. A literature review identified four previously reported cervical intradural extramedullary CPPD cases (2006–2024), but no intramedullary lesions. Conclusions Intradural CPPD lesions are extremely rare, and this is the first reported intramedullary case. Crystal arthropathies should be considered in the differential diagnosis of spinal cord lesions resembling neoplasms. Further studies are required to better understand the pathophysiology, treatment, and prognosis of spinal pseudogout.