C. Abdul Hakeem College is a government aided private college for arts and science located in Melvisharam, Tamil Nadu, India. It is one of the oldest colleges in Ranipet district, affiliated to Thiruvalluvar University. The National Assessment and Accreditation Council has conferred A grade. Currently it offers 31 Courses at Under-Graduate level, 6 Courses at Post-Graduate level and Ph.D. programs. It was granted autonomous status by University Grants Commission with effect from 2014–2015 to 2019–2020.
The present study evaluated the growth performance and improve production of Asian seabass, Lates calcarifer using bioencapsulated microalgae in the marine cladoceran, Penilia sp. The marine cladoceran, Penilia sp., isolated from Adyar creek, Chennai, was fed four species of microalgae consisting of Chlorella marina, Nannochloropsis oculata, Isochrysis galbana and Tetraselmis suecica. Penilia sp. fed each microalgae species were used as a diet for seabass (Lates calcarifer) larvae and their growth, survival, proximate composition and fatty acids profiles were recorded. The highest fecundity was observed in N. oculata and C. marina (1–3 × 105 cells mL−1) fed Penilia sp. (8 and 10 individuals/broodstock) followed by I. galbana and T. suecica fed Penilia sp. The species attained maturity within 7 days in N. oculata fed Penilia sp. followed by C. marina (7 days), I. galbana (9 days) and T. suecica (9 days) fed Penilia sp. Mass culture of Penilia sp. carried out using microalgae diets revealed a maximum population density 37.3 ± 0.2 individuals mL−1 recorded within 7 days for N. oculata fed Penilia sp. followed by C. marina (35.4 ± 0.18 individuals mL−1) fed Penilia sp. Subsequently, seabass larvae fed with N. oculata encapsulated Penilia sp. exhibited significantly higher (p < 0.05) concentrations of docosahexaenoic acid, oleic acid, and palmitic acid in both 2 13 days of post-hatch larvae, whereas seabass larvae fed with C. marina encapsulated Penilia sp. showed significantly lower docosahexaenoic acid, oleic acid and stearic acid at 2 days 13 days post hatch larvae. Furthermore, N. oculata encapsulated Penilia sp. fed seabass larvae had the highest specific growth rate ( 2.2 ± 0.06
Functionalized multiwalled carbon nanotube (f-MWCNT) was successfully prepared and reinforced in different proportions (0.05
Graphene and its derivatives have been increasingly explored for various biomedical applications. Despite their promising potential, the accelerated development and integration of these materials in medical technologies have raised important questions regarding their biocompatibility, toxicity, and overall safety within physiological systems. Graphene oxide (GO) and graphitic carbon nitride (g-C3N4) nanoparticles are widely studied for their strong adsorption and photocatalytic properties, making them effective materials for removing emerging contaminants from water and wastewater. In this study, we performed a detailed evaluation of the acute (24 h) cytotoxic effects of GO and g-C3N4 nanoparticles on DrG and DrF cells by assessing cell morphology, viability, mortality, and membrane integrity. GO exhibited minimal cytotoxicity under the tested conditions, with only a slight reduction in cell viability observed at 100 µg/mL concentrations due to dose-dependent oxidative stress. In contrast, g-C3N4 nanoparticles demonstrated significant cytotoxicity in both cell types, even at 40 µg/mL concentrations, inducing oxidative stress, elevated ROS production, mitochondrial dysfunction, and a marked decrease in cell viability. These findings underscore the importance of dose consideration in the design of GO-based biomedical applications and highlight the potential limitations of g-C3N4 in similar contexts. Overall, GO showed good biocompatibility, further supported by the favorable growth of cells on GO-coated substrates (50 µg/mL).
The persistent risk of infection and delayed tissue regeneration at wound and implant sites remains a major limitation of current clinical materials. To address these challenges, a multifunctional polymer-based hydrogel film was developed with the dual objectives of effective microbial control and enhanced tissue compatibility. The hydrogel matrix was composed of chitosan (2
Diabetes mellitus is a complex, multifactorial metabolic disorder characterized by chronic hyperglycemia and progressive organ dysfunction. Conventional diagnostic and prognostic markers such as fasting glucose and glycated hemoglobin provide limited insight into disease heterogeneity, early molecular changes, and individualized risk of complications. In recent years, RNA-based biomarkers have emerged as powerful tools for capturing dynamic regulatory processes underlying diabetes onset, progression, and therapeutic response. These biomarkers include messenger RNAs (mRNAs), microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and transfer RNA-derived fragments (tRFs), which collectively orchestrate gene expression, metabolic signaling, immune modulation, and cellular stress responses. This review comprehensively examines the landscape of RNA-based biomarkers in diabetes, highlighting their mechanistic relevance, detection platforms, clinical utility, and translational challenges. We discuss how regulatory RNA networks reflect beta-cell dysfunction, insulin resistance, inflammation, and tissue-specific pathology, and how their integration into liquid biopsy approaches and computational frameworks may redefine precision diagnostics and personalized diabetes care.
