Chernivtsi National University (full name Yuriy Fedkovych Chernivtsi National University, Ukrainian: Чернівецький національний університет імені Юрія Федьковича) is a public university in the City of Chernivtsi in Western Ukraine. One of the leading Ukrainian institutions for higher education, it was founded in 1875 as the Franz-Josephs-Universität Czernowitz when Chernivtsi (Czernowitz) was the capital of the Duchy of Bukovina, a Cisleithanian crown land of Austria-Hungary. Today the university is based at the Residence of Bukovinian and Dalmatian Metropolitans building complex, a UNESCO World Heritage Site since 2011.
A stochastic model is considered for processes described by systems of nonlinear stochastic partial functional differential equations of a special form, accounting for both Brownian-type diffusion perturbations and Poisson switching. The existence of a solution to the Cauchy problem for such systems is proved. The results obtained can be used to study the asymptotic stability of solutions of similar systems.
Acetaminophen (APAP) overdose is a major cause of acute liver failure and can be fatal, often without early symptoms. Protein deficiency, arising from illness or inadequate diet, impairs growth, immunity, and tissue repair. Both conditions can harm the kidneys, yet the impact of energy imbalance on renal physiology remains unclear. In this study, APAP toxicity and a low-protein diet induced behavioral suppression and tissue damage, as evidenced by reduced whole-body, liver, and kidney weights in rats. In kidney mitochondria of rats exposed to only toxic APAP doses, ATP levels declined sharply while ADP and AMP increased. AMP deaminase and ATPases' activities rose about twofold and 1.5-fold, respectively, whereas cytosolic 5'-nucleotidase activity fell nearly threefold, suggesting compensatory responses to disrupted energy balance. The strongest reductions in ATP and the greatest increases in AMP and ATPase activity occurred in APAP-intoxicated rats fed a low-protein diet. This combination also intensified lipid peroxidation and oxidative protein damage, evidenced by elevated TBARS, reduced protein SH-groups, and increased protein carbonyls. Overall, APAP intoxication with protein deficiency disrupts renal energy metabolism, leading to mitochondrial dysfunction and structural kidney injury. Nutritional status therefore critically influences drug-induced nephrotoxicity, and antioxidant strategies may help prevent damage under metabolic stress.
This study investigated the performance optimization of photovoltaic system (PV) systems installed on an ellipsoidal rooftop at the Politeknik Balikpapan Building, addressing the unique challenges posed by curved surfaces, such as uneven irradiance distribution and shading effects. This research aims to evaluate and compare the performance of monocrystalline and polycrystalline PV modules using Helioscope software, with a focus on two key metrics: Performance Ratio (PR) and Energy Density Ratio (EDR). Simulations were conducted by segmenting the rooftop into distinct areas based on azimuth angles, allowing a detailed analysis of the shading impact. The results showed that monocrystalline PV modules achieved a PR of 71.5
A metric space is plastic if all its non-expansive bijections are isometries. We prove three main results: (1) every countable dense subset of a normed space is not plastic, (2) every k-crowded separable metric space contains a plastic dense subspace, and (3) every strictly convex separable metric abelian group contains a plastic dense subgroup. (c) 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
Introduction: Seven new 4-[2-(dichloromethyl)pyrazolo[1,5-a][1,3,5]triazine derivatives were investigated for anticancer activity, possible molecular mechanisms of anticancer action, and ADMET properties. Methods: The 4-benzenesulfonamide derivatives of pyrazolo[1,5-a][1,3,5]triazine were synthesized using the condensation of N-(2,2-dichloro-1-cyanovinyl)-amides IV with 1H-pyrazol-5-amine. Compound antitumor activities were evaluated using the NCI-60 human cancer cell line. AutoDockTools and AutoDock Vina software were used for molecular modeling. Using the ADMETlab 3.0 and pkCSM web sources, the ADMET properties of compounds 4, 5, and 7 were calculated. Results: Seven new pyrazolo[1,5-a][1,3,5]triazine derivatives were synthesized. The compounds 4, 5, and 7 exhibit high activity >1 μM against leukemia, colon, and renal cancer. Compound 4 exhibited the most potent activity, with IC50 values of 0.32 μM against leukemia, 0.49-0.89 μM against colon cancer, and 0.92 μM against renal cancer. Molecular modeling has demonstrated a potential antitumor mechanism involving CDK. The predicted ADMET profile of compounds 4, 5, and 7 is favorable. Discussion: The seven novel pyrazolo[1,5-a][1,3,5]triazines, as purine bioisosteres, were developed, synthesized, and investigated by in vitro and in silico methods. Conclusion: Seven novel pyrazolo[1,5-a][1,3,5]triazine derivatives exhibited anticancer activity against the NCI-60 cancer cell lines. The compounds 4, 5, and 7 demonstrated strong anticancer activity, with growth inhibition (GI) values exceeding 50% across all nine cancer types tested. The most active compound, 4, is against leukemia, colon cancer, renal cancer, and lung cancer. All compounds exhibit low toxicity, with LC50 values of 100 μM or greater. The molecular docking of compounds 4, 5, and 7 revealed the potential to inhibit cancer-associated cyclin-dependent kinases. The predicted ADMET profiles of their compounds are favorable, providing a basis for further improvement of their anticancer activity.
