The Coimbatore Medical College is a state government-run medical college recognized by the Medical Council of India. It is located in the city of Coimbatore, in Tamil Nadu, India. The hospital attached to the college is located near the railway station and harbours departments like Gastroenterology, Microbiology, Anatomy, Biochemistry, Pharmacology, Pathology, Physiology, Ophthalmology, ENT, SPM, Obstretics and gynecology, Orthopeadics, Pediatrics, Respiratory medicine, Radiology, Diabetology, Surgery, Medicine, Dermatology, Psychiatry, FM etc.
Oral cavity malignancies causing full thickness cheek defects constitute a special group which require meticulous reconstruction post resection in resource limited settings where free flaps are not routinely feasible. We aimed to study the post operative outcome of patients in whom the bipaddled pectoralis major myocutaneous flap was used to reconstruct through and through defects.of the oral cavity. This is a retrospective study in which we analysed data of patients undergoing bipaddled pectoralis major myocutaneous flap reconstruction for full thickness cheek defects in our institute during the period from April 2022 to April 2024. A total of 44 patients with T4a disease underwent bipaddled PMMC flap reconstruction during the two year period. Women constituted 72.7
A polyvinyl alcohol (PVA) film loaded with Centella Asiatica (CA) extracts was made for wound healing applications. The film was produced using solvent casting and analysed for its phytochemical, chemical compositions, morphology, mechanical properties, drug release, and biocompatibility. The HPLC showed that quercetin and other active ingredients were present, and FTIR confirmed strong hydrogen bonding between CA and PVA. The degrees film displayed a contact angle of 86.60 , indicating hydrophilicity crucial for cellular attachment and moisture retention. Mechanical testing revealed a tensile strength of 3.54 MPa and an elongation of 17.09 %, confirming the film's durability and flexibility. The film demonstrated 91 % wound healing at a concentration of 100 mu g/mL, and cell toxicity tests revealed that more than 88 % of the cells remained alive, indicating high compatibility with living tissue. In vivo confirmation showed rapid wound contraction, whereas histological investigation revealed substantial collagen deposition and fibroblast proliferation in the treated groups. The drug release profile demonstrated a biphasic pattern characterised by anomalous (non-Fickian) diffusion behaviour. These results highlight the CA-PVA film as a promising wound dressing with suitable biological activity, biocompatibility, and mechanical strength.
Large language model (LLM) agents deployed in clinical settings often exhibit abrupt, threshold-driven behavior, offering little visibility into accumulating risk prior to escalation. In real-world care, however, clinicians act on gradually rising concern rather than instantaneous triggers. We study whether explicit state dynamics can expose such pre-escalation signals without delegating clinical authority to the agent. We introduce a lightweight agent architecture in which a memoryless clinical risk encoder is integrated over time using first- and second-order dynamics to produce a continuous escalation pressure signal. Across synthetic ward scenarios, stateless agents exhibit sharp escalation cliffs, while second-order dynamics produce smooth, anticipatory concern trajectories despite similar escalation timing. These trajectories surface sustained unease prior to escalation, enabling human-in-the-loop monitoring and more informed intervention. Our results suggest that explicit state dynamics can make LLM agents more clinically legible by revealing how long concern has been rising, not just when thresholds are crossed.
Background: Existing regression models for determining intimate partner violence (IPV) against women include characteristics of women and men individually but evidence lacking on couple characteristics and best fit models. We aimed to compare regression models in predicting IPV using characteristics of women and her partner separately and as a dyad. Methods: We used couple data from National Family Health Survey-5 containing data from both women and her partner. IPV considered as positive response for any of the questions on domestic violence. Multiple logistic regression models were built separately for characteristics of women and men and couple characteristics. Best fit models identified through r-squared value and AIC and BIC statistics. Results: We included 46445 couple data for final analysis. R-squared value for models including female characteristics were similar to models with couple characteristics and higher than the models with male characteristics. Odds Ratio were also higher for women characteristics compared to their counterparts’ characteristics. Family history of IPV among women, women’s attitude towards wife beating and controlling behavior of partner were associated with higher IPV. Conclusions: Individual characteristics of women in a couple alone can be an effective determinant of IPV than the traditional view of power relations between men and women in household.
