Experimental studies of primarily Western participants have suggested that musical synchrony facilitates social bonding. Critics question the validity and cross-cultural generality of synchrony-bonding relationships, as well as the causal role of music. Drawing on new data from large-scale Registered Reports co-designed and implemented with over 100 collaborators (“Many Voices”), we show that group singing enhances social bonding significantly more than speaking, across 901 participants speaking 30 languages. We share lessons from this collaboration regarding evolutionary hypotheses about the origins of music and language, as well as the importance of collaborating with Indigenous and non-Western researchers. By making the psychology of music research more inclusive, we may broaden our understanding of music and social bonding in humans and beyond. Indigenous knowledge does not oppose science: it improves science.
Despite invasive methods are the gold standard for intracranial pressure (ICP) measurement, several non-invasive techniques (nICP) have been proposed as surrogate, although their use remains insufficiently recognized in clinical practice. These include transcranial Doppler blood flow velocity assessment (arterial or venous), optic nerve sheath diameter (ONSD), automated pupillometry, measurement of skull expansion and compliance, brain imaging, double-depth ophthalmic artery blood flow velocity, and ultrasound time-of-flight. The main limitations of all indirect methods are calibration and zeroing, which constrain the absolute accuracy of non-invasive ICP monitoring. For transcranial Doppler-based methods, the 95
BackgroundAtopic dermatitis (AD) is a common chronic inflammatory skin disease in children, often preceding or coexisting with other atopic conditions. Severe AD significantly impacts quality of life and is associated with mental health disorders and sleep disturbances. Dupilumab is approved for moderate-to-severe AD in children aged 6 months and older. However, limited studies have evaluated its efficacy in diverse populations, especially in Latin American children. MethodsWe conducted a multicenter, retrospective study in Colombia, including children aged <= 18 years with moderate-to-severe AD who began dupilumab treatment between January 1, 2018, and January 1, 2024. Data collected included demographics, disease characteristics, treatment history, adverse events (AEs), and disease severity scores. Statistical analyses were performed using R software (p < 0.05). ResultsNinety-two patients were included, with a median age of 14 years at dupilumab initiation. The most common comorbidities were allergic rhinitis (75%) and asthma (34%). Significant improvements in disease severity were observed, with a median reduction of 72% in EASI and 55% in SCORAD between Weeks 10 and 22, and 81% and 69%, respectively, by Weeks 46-58. Ocular AEs were the most frequent (23%), and paradoxical head and neck dermatitis occurred in 15% of patients. No serious AEs were reported, and 94% of patients remained on treatment. ConclusionsDupilumab showed significant clinical improvements in Latin American children with moderate-to-severe AD. AEs were mild and transient. These findings underscore the need for evaluating dupilumab's efficacy in diverse populations for personalized treatment strategies.
Dorsocervical fibro-lipodystrophy, commonly known as “buffalo hump,” presents a challenging deformity often associated with HIV-related lipodystrophy or idiopathic etiologies. Although various surgical techniques have been reported, a comprehensive evaluation of their safety, efficacy, and recurrence rates remains lacking. This systematic review and meta-analysis aimed to evaluate outcomes of surgical interventions, particularly suction-assisted lipectomy, in managing dorsocervical fibro-lipodystrophy. A systematic review with meta-analysis was conducted using PubMed and ScienceDirect. Eligible studies reported surgical outcomes of dorsocervical fibro-lipodystrophy managed with suction-assisted or excisional lipectomy. Meta-analyses used a random-effects model, with heterogeneity and publication bias assessed. Sensitivity analysis was performed. Twenty-two studies encompassing 218 patients were included. Most cases were associated with HIV-related lipodystrophy, and the average patient age was 47.4 years. Suction-assisted lipectomy was the most common approach. The pooled recurrence rate with liposuction was 10.6 www.springer.com/00266 .
