Hong Bang International University (HIU) is a private university in Ho Chi Minh City.HIU has faculties of law, economics, fine arts, foreign languages. The university has been accredited by three US educational organizations as meeting American education standard.
Insomnia and anxiety disorders have become increasingly prevalent in modern society. The formulation study of MECS hard capsules composed of the medicinal herbs Mimosa pudica, Erythrina variegata, Cinnamomum iners, and Scoparia dulcis in an optimized weight ratio (%) of 40:12:16:32 represents a traditional Vietnamese pharmaceutical preparation. These medicinal plants have long been utilized in traditional medicine for the supportive treatment of insomnia and anxiety. This study aimed to evaluate the safety, sedative, and anxiolytic effects of MECS capsules in Swiss albino mice, while also investigating the interaction affinity of bioactive compounds from the four herbal components through in silico approaches, including molecular docking, ADMET prediction, QSAR modeling, and molecular dynamics (MD) simulations. A total of 11 potential bioactive compounds were identified through a multicriteria decision-making system. Among these, 9 compounds were confirmed in the MECS capsule using UPLC-QToF-MS chromatographic profiling, supporting the in silico screening results. Subchronic toxicity and anxiolytic effects were assessed using the light-dark box (LDB) and elevated plus maze (EPM) behavioral models, with MECS capsules administered at doses of 346 and 692 mg/kg. A sleep recovery model using diazepam was applied to evaluate the sedative properties. Toxicological assessment indicated no adverse effects at the maximum tested dose (D max) of 39 g/kg of body weight. Furthermore, no deleterious effects were observed during the 60 day subacute toxicity evaluation at either dosage level. Behavioral assessments using the LDB and EPM models demonstrated that MECS capsules reduced anxiety-related behaviors. Diazepam significantly prolonged the sleep duration and shortened sleep onset latency at both doses, confirming the sedative effect of MECS capsules. The combined evidence from docking analysis, ADMET prediction, MDs simulations, and in vivo experimentation in S. albino mice showed the MECS hard capsulesformulated from medicinal herbs with a favorable safety profileexhibited pronounced sedative and anxiolytic activities. These findings suggest that MECS capsules hold promise as a natural-origin therapeutic agent for the treatment of anxiety disorders and insomnia.
Background Pediatric necrotizing pneumonia (PNP) is a rare but life-threatening complication of pneumonia. This study aimed to describe the clinical characteristics, paraclinical features, interventional treatments, and outcomes of PNP. Methods This was a retrospective study of PNP identified from hospitalized pneumonia cases at a tertiary center. Diagnosis was based on clinical presentation and imaging findings (CXR, ultrasound, or CT). Demographic, clinical, microbiological, laboratory, treatment, and outcome data were analyzed. Associations between clinical variables and outcomes were analyzed, with statistical significance set at p < 0.05. Results Among 963 pediatric pneumonia hospitalizations, 15 patients (1.6%) were diagnosed with PNP, with a median age of 3 years. At admission, respiratory failure (SpO2 < 94%) was present in 73.3% of patients. Respiratory support was administered to all patients and categorized according to the highest level of support received: invasive mechanical ventilation (40.0%), nasal continuous positive airway pressure (NCPAP) (33.3%), and low-flow oxygen via nasal cannula (26.7%); no patients received high-flow nasal cannula (HFNC) or bilevel positive airway pressure (BiPAP). No patients received corticosteroids or nebulized therapy before admission, whereas corticosteroids and nebulized therapy were administered during hospitalization in 13.3% and 20.0% of patients, respectively. Streptococcus pneumoniae was the predominant pathogen (53.3%), followed by Staphylococcus aureus (13.3%), and polymicrobial infections were identified in 46.7% of cases. PCR showed a higher pathogen detection rate than conventional culture (64.7% vs. 20.3%), particularly in respiratory and pleural specimens. Pleural effusion or empyema was identified in 73.3% of patients, and surgical intervention was required in 53.3%, primarily involving video-assisted thoracoscopic surgery (VATS) with pleural drainage. Initial antimicrobial therapy mainly consisted of β-lactams combined with vancomycin (60 mg/kg/day), with dose escalation to 80 mg/kg/day required in 60.0% of patients. Median durations of hospitalization and antibiotic therapy were 25 and 28 days, respectively. Overall survival was 93.3%, with one death attributed to septic shock and multi-organ failure. Elevated C-reactive protein was the only factor significantly associated with treatment outcome (p = 0.011). Conclusion Persistent fever, respiratory failure, or prolonged pneumonia after 72 h of antibiotics warrants evaluation for complications. Diagnosis relies on chest imaging (CXR, ultrasound, or CT), with prolonged intravenous antibiotics targeting Streptococcus pneumoniae and Staphylococcus aureus. Therapeutic drug monitoring is essential for vancomycin. Surgical intervention (debridement, pleural drainage) is indicated for persistent infection, significant pleural effusion, or extensive necrosis leading to uncontrolled sepsis or respiratory failure.
OBJECTIVE:This study evaluated the association between intestinal anatomical characteristics-including the resected bowel segment, residual small bowel length (RSBL), and preservation of the ileocecal valve (ICV)-and treatment outcomes in children with short bowel syndrome (SBS). METHODS:A retrospective study was conducted of 35 paediatric SBS patients who underwent small bowel resection at the study site from July 2021 to July 2024. SBS was defined by an RSBL ≤ 25% of the expected length for age or dependence on parenteral nutrition ≥ 60 days. Treatment outcomes were categorised as successful (clinical stabilisation and discharge) or unsuccessful (death or lack of improvement). RESULTS:Most patients underwent surgery during the neonatal period (91.4%). A majority had RSBL > 38 cm (88.6%), preserved ICV (74.2%), and intact colon (67.7%). The overall treatment success rate was 60% (n = 21), while mortality or failure occurred in 40% (n = 14). The mean RSBL in the success group (86.1 ± 28.1 cm) was significantly longer than in the failure group (52.7 ± 24.9 cm; p < 0.001). All patients with very short (15-38 cm) or ultra-short (< 15 cm) RSBL experienced treatment failure or death (p < 0.05). Preservation of both the colon and ICV was significantly associated with treatment success (p < 0.05). Patients without ICV preservation had longer median hospital stays than those with ICV preservation (126 days vs. 100.5 days; p < 0.05). CONCLUSION:Colon and ileocecal valve preservation are key prognostic factors improving outcomes and reducing hospitalisation in paediatric short bowel syndrome.
To translate, cross-culturally adapt, and examine the psychometric properties of the Vietnamese version of the Lower Extremity Functional Scale (LEFS-V) in individuals with knee osteoarthritis (KOA). A cross-sectional study. Two hospitals and two Catholic convents in Vietnam. 174 Vietnamese individuals aged ≥ 45 years with KOA were diagnosed based on clinical examination using the National Institute for Health and Care Excellence (NICE) criteria. Participants completed the baseline assessment and 5-7days retest, which included the LEFS-V, Numerical Pain Rating Scale (NPRS), and Knee Injury and Osteoarthritis Outcome Score (KOOS). Psychometric property testing included content validity (CVI), internal consistency (Cronbach’s α), test–retest reliability (ICC (3,1), standard error of measurement (SEM), minimum detectable change (MDC95), and construct validity. Spearman correlations were used to examine associations with the KOOS subscales and NPRS. Strong content validity with item-CVI from 0.83 to 1.00. LEFS-V demonstrated high internal consistency (Cronbach’s α = 0.942) and excellent test–retest reliability (ICC (3,1) = 0.985; 95
Background:Bilateral sagittal split osteotomy (BSSO) is widely used for mandibular advancement in patients with skeletal Class 2 malocclusion; however, long-term postoperative stability remains an important clinical concern. Purpose:To evaluate long-term skeletal, dentoalveolar, and soft tissue stability following mandibular advancement with BSSO and rigid fixation. Methods:A retrospective cohort study was conducted in 32 patients undergoing mandibular advancement with BSSO and rigid fixation. Cephalometric measurements were obtained at four time points: preoperative, immediate postoperative, 12 months, and long-term follow-up (>3 years). Changes were analyzed using the Wilcoxon signed-rank test. Results:The mean mandibular advancement was 5.42 ± 1.71 mm. Immediately after surgery, significant skeletal correction was achieved, with increased SNB and decreased ANB (both p < 0.001), accompanied by significant improvements in occlusal and soft tissue profile measurements. Most skeletal and occlusal parameters remained stable during the first postoperative year and throughout long-term follow-up, with no statistically significant changes observed between one year and the final evaluation. Soft tissue remodeling continued during follow-up, whereas overall skeletal and dental stability was maintained. Conclusion:Bilateral sagittal split osteotomy with rigid fixation effectively corrected skeletal Class 2 malocclusion and demonstrated favorable long-term skeletal, dental, and soft tissue stability.
