Abstract Introduction: Over the past decade, there has been an increase in renal transplantation among the elderly. However, age-related declines in immune function heighten the risks associated with immunosuppressive therapy, impacting patient survival. This study examines the first year’s immunosuppressive regimen post-kidney transplantation in elderly individuals. Methodology: A singlecenter retrospective cross-sectional study was conducted, categorizing kidney transplant recipients from January 2013 to December 2017 into two groups: a control group (aged 30–50 years) and a seniors group (over 60 years). Results: The study included 59 seniors and 114 controls. Seniorsreceived lower mycophenolate doses (11 ± 7.7 mg/kg/day) compared to controls (15 ± 7.2 mg/kg/day; p = 0.003) and fewer corticosteroids were administered (64.9% vs. 18.6%; p = 0.0001) as maintenance immunosuppression. Seniors also had a higher tacrolimus level-to-dose ratio (p < 0.05). Additionally, seniors experienced more leukopenia (56.5% vs. 35.6%; p = 0.017) and cytomegalovirus infections (44.7% vs. 26.9%; p = 0.034). Conclusion: Despite receiving lower mycophenolate doses and fewer corticosteroids along with a higher tacrolimus level-to-dose ratio, seniors had more adverse events. However, graft survival was not affected. These results suggest that elderly patients may benefit from reduced immunosuppressant exposure, supporting a conservative approach.
Objective To map the scientific production of absenteeism among nursing professionals in teaching hospitals. Methods Scoping review, following the recommendations of the Joanna Briggs Institute. The guiding question was: What are the factors associated with absenteeism among the nursing staff in teaching healthcare institutions? The search was conducted in five databases using the Rayyan application. Study selection was performed by two reviewers, using a data extraction tool. Results Of the 844 publications, 11 articles published between 2017 and 2022 were selected. The intervening factors of absenteeism among nursing staff were: organizational, individual (non-modifiable and modifiable), and external aspects. Conclusion Absenteeism is multifactorial, and social roles related to women are influential factors. Intervention studies are recommended. The need for future analyses is emphasized so that leaders can promote actions to prevent absenteeism.
