Hepatic osteodystrophy (HOD) is a debilitating metabolic bone disorder inextricably linked to chronic liver disease, with its prevalence surging alongside the global rise of metabolic dysfunction-associated steatohepatitis (MASH). Current clinical interventions remain fragmented, failing to concurrently address the upstream hepatic lipotoxicity and the downstream skeletal deterioration. Herein, we engineer copper-doped bioactive glasses (CuBGs) as a multifunctional ion-therapy nanoplatform that exploits natural hepatic tropism to synchronously rescue MASH-HOD pathology via targeted reprogramming of the liver-bone axis. By delivering localized therapeutic ions, CuBGs orchestrate robust hepatic metabolic recovery: they enhance glucose tolerance and restore mitochondrial oxidative phosphorylation (OXPHOS), thereby effectively halting intrahepatic triglyceride accumulation and quenching ROS-driven inflammation. Crucially, this hepatic rescue reactivates the liver-bone endocrine crosstalk by robustly upregulating the secretion of the hepatokine lecithin-cholesterol acyltransferase (LCAT). Systemic LCAT restoration directly stimulates profound osteoblastogenesis and new bone formation, decisively reversing MASH-induced trabecular bone loss without acting as a conventional anti-resorptive agent. This dual-organ modulation comprehensively ameliorates the interconnected multi-organ microenvironment in MASH-HOD without inducing systemic toxicity. Ultimately, this bioactive glass-mediated copper delivery system establishes a novel, highly scalable strategy for ion-based nanotherapeutics, offering a promising and integrated strategy for complex liver-bone comorbidities.
Manganese based nanoparticles have potential to revolutionize agricultural practices for enhanced nutrient uptake, growth, and yield. In present study, the effect of manganese sulfide (MnS) nanoparticles (NPs) was evaluated on Eruca sativa grown under field condition. Spherical crystals of 8 nm MnS NPs applied at 8 kg/ha through broadcasting method markedly increased agronomic parameters i.e., root length up to 23.52
Additive manufacturing (3D printing) is used to fabricate the complex and customized parts for advanced engineering applications; however, there remains a limited comparative understanding of how different 3D printed parts (core geometries) with the combination of other polymer matrix material (sandwich composite structures) influence under different loading conditions. To address this gap, the present study investigates the mechanical behaviour of sandwich structures incorporating hexagonal, triangular, and tri-hexagonal cores under low velocity impact (LVI) and compression after impact (CAI) loading conditions. The cores were fabricated from polylactic acid (PLA) with a 10
Practical implications arise when Fourier’s law is insufficient and Cattaneo-Christov theory offers a solid basis for simulating transporting heat. In complex thermal processes where thermal and solutal memory effects are of a significant order of magnitude, the Cattaneo-Christov theory provides insights and overcomes important limits. It is an essential approach for studying advanced thermal systems. This paper examines the simultaneous enhancement of non-Fickian mass transfer and non-Fourier heat transport in viscoplastic fluid (Bingham-Papanastasiou fluid) containing hybrid nanoparticles. The mathematical problems describing generalized heat and mass transfer are developed using the rheological model and governing conservation principles. The finite element method (FEM) is used to solve the designed problems numerically. The precision of the numerical solutions is checked, and their grid independence is further examined. The trends in wall heat enhancement fluxes are analyzed using a comprehensive display. Novel predictions are perceived, and the wall shear stresses, the Nusselt number, and the Sherwood number against important factors are studied against related parameters because these quantities are essential to develop and design effective thermal systems. The chemical reactions (generative and destructive) have a remarkable impact on wall mass transport rate. The wall mass transfer rate increases with the rise of destructive chemical reactions. However, opposite observations are recorded for generative chemical reactions. It is concluded that the use of multi-component nanofluids (tri- and di-nanofluids) considerably increases the Nusselt number in comparison to mono-nanofluids, while the thermal memory effect somewhat lowers the temperature of the fluid, and eventually, the Nusselt number increases. Thus, for an optimum heat transfer rate, the Bingham fluids with thermal memory effects are recommended. The wall mass transport (Sherwood number) increases due to an increase in the concentration relaxation time parameter. Thus, the Bingham fluid with thermal memory effects has more capability of transporting solute than the Bingham fluid with zero thermal memory effects. Hence, it is concluded that the Bingham fluid with higher thermal memory effects is an efficient working fluid for efficient.
Lack of psychological wellbeing and deterioration of mental health of the personnel is currently becoming an emerging issue in the corporate sector of Pakistan, due to the exceeding work demands as well as the hostile working environment in most organizations. To cater to this apparent issue, this study investigates the impact of decent work and socially sustainable HRM practices on the psychological wellbeing of workforce, incorporating both hedonic and eudaimonic perspectives, while examining the moderating role of employee voice. A survey was conducted based on the banking sector of Islamabad, Pakistan. A total of 203 responses were collected and analyzed via SPSS and Smart PLS. The findings of this study confirmed decent work to have a positive relationship with psychological wellbeing of employees and socially sustainable HRM to mediate the relationship between decent work and psychological wellbeing. However, the findings of the study did not support employee voice to be playing a moderating role in the relationship. This study educates managers regarding the importance of the protection of psychological wellbeing of their workforce, improves their understanding regarding the concepts of decent work and socially sustainable HRM, and conveys information about how these notions may be incorporated into their organization’s HR policies.
