Kidwai Memorial Institute of Oncology (Kannada: ಕಿದ್ವಾಯಿ ಸ್ಮಾರಕ ಗಂಥಿ ಸಂಸ್ಥೆ ) is a cancer care hospital in Bangalore Karnataka state, India. It is an autonomous institution of the Government of Karnataka and a Regional Cancer Centre funded by the Government of India. It was granted Regional Cancer Centre status on 1 November 1980. The Indian Council of Medical Research has recognised this referral Institution as a research organization.
Additional Cytogenetic Abnormalities (ACAs) are common in blast phase of CML (Chronic Myeloid Leukemia). This study analyzed an array of additional cytogenetic abnormalities (ACA) in CML blast phase, along with their clinical presentation, prevalence, complexity, and lineage specificity. 58 subjects in the CML Blast phase were studied between January 2023 and July 2024, for their demographics, clinical presentation, lineage assessment and ACAs. Their survival rates were evaluated prospectively. Conventional cytogenetic and karyotypic analyses were performed in all cases. Among 58 subjects, 67.24
Introduction Multiple primary malignancies (MPMs) are increasingly being detected with improved survival and diagnostics. However, Indian data remain limited. This study evaluated the epidemiology of MPMs in a tertiary cancer center. Objective To analyze the clinicopathological profile, survival outcomes, and etiological factors of patients with MPMs at a South Indian cancer center. Materials and Methods This is a retrospective observational study of patients with MPMs analyzed between March 2023 and July 2025. Patients were identified using the Warren-Gates criteria. Data on demographics, tumor sites, histology, stage, treatment, and outcomes were collected. The overall survival (OS) was estimated using the Kaplan-Meier method. Results Sixty-five patients were included: 37 metachronous (56.9%), 27 synchronous (41.5%), and 1 triple primary (1.5%). The median age at diagnosis was 54 years for synchronous malignancy, while for metachronous cases, index cases are usually diagnosed at a median age 48 years and second primary cancer diagnosed on a median age of 51 years, with a median interval of 20 months. Male more common for synchronous, while female common in metachronous. Breast cancer was most common among metachronous index and second primary cases, and gastrointestinal tumors were predominant among synchronous cases, and adenocarcinoma was the most common histology. Molecular testing was performed whenever feasible. Index metachronous tumors were mostly nonmetastatic (86.5%), whereas second primaries metastatic (40.5%) burden was increased. Treatment completion was highest for first primaries (89%), followed by second (43%) and synchronous tumors (56%). The etiological links were mainly tobacco-related (45%) and genetic (35%). Median OS was 86.0 months for metachronous, 29.0 months for synchronous, and 10.0 months for triple primaries; overall cohort median OS was 43.0 months. Conclusions MPMs in this Indian cohort showed distinct patterns of breast and gastrointestinal predominance, limited molecular testing, and a survival advantage for metachronous disease. These findings support long-term surveillance, tobacco-control measures, and integration of genetic counselling and molecular profiling in low- and middle-income country settings.
BACKGROUND:Hepatitis B virus (HBV) is well established to be lymphotropic with replicative intermediates of the virus found in the mononuclear cells and B cells. HBV is also known to persist indefinitely in the form of occult infection (HBsAg negative but HBV DNA positive). Serological and molecular studies and meta-analyses have found a significant association of HBV with diffuse large B-cell lymphoma (DLBCL). Whether the HBV is in the malignant cells or not remains unclear. AIM:To localize viral HBS gene sequences within the malignant cells of DLBCL. SETTINGS AND DESIGN:The study was conducted in the Department of Microbiology on archived lymph node tissue sections sourced from the Department of Histopathology in a tertiary care cancer center. MATERIALS AND METHODS:Non-isotopic in situ hybridization (NISH) was performed on lymph node sections from 40 formalin-fixed paraffin-embedded tissues of DLBCLs using a digoxigenin-labeled HBVS gene probe. All patients were incidentally HBsAg negative. RESULTS:Eleven of the 40 lymph nodes from DLBCL patients were HBV NISH positive. However, the positive signals were non-uniformly distributed mainly in the nucleus of the large malignant lymphoid cells, despite all cases being seronegative for HBsAg. CONCLUSION:Nearly 28% of the patients' lymph nodes showed evidence of HBV DNA. A possible explanation for NISH positivity in seronegative DLBCLs could be due to occult HBV infection. Future studies on HBsAg seropositive and seronegative DLBCL cases using more sensitive assays like polymerase chain reaction ISH may elucidate the causal association of HBV with DLBCLs more precisely and define the magnitude of the association.
INTRODUCTION:Total mesorectal excision has significantly improved oncologic outcomes in rectal cancer; however, post-operative urinary and sexual dysfunction remain important concerns due to inadvertent pelvic autonomic nerve injury. Intraoperative identification of these nerves is particularly challenging following neoadjuvant chemoradiotherapy. This study evaluated the feasibility of indocyanine green (ICG)-guided fluorescence imaging for the selective visualisation of pelvic autonomic nerves during minimally invasive TME. PATIENTS AND METHODS:In this prospective pilot feasibility study, 24 patients undergoing minimally invasive TME for rectal adenocarcinoma were included. Twelve patients underwent conventional nerve-preserving TME guided by anatomical landmarks, whereas twelve received intravenous ICG (0.5 mg/kg) 12 h preoperatively. Near-infrared imaging was used intraoperatively. Short-term post-operative outcomes assessed included the day of urinary catheter removal, need for recatheterisation and incidence of urinary tract infection. RESULTS:The median age was 57 years, and baseline characteristics were comparable between groups. In the fluorescence-guided group, autonomic nerves appeared as distinct non-fluorescent structures against a fluorescent background. Earlier catheter removal was observed in the ICG group (predominantly post-operative day 2 vs. day 3). Recatheterisation was required in one patient in the fluorescence-guided group compared with three in the conventional group. One UTI occurred in the conventional group, whereas none were observed in the fluorescence-guided group. No adverse reactions to ICG were recorded. CONCLUSION:Pre-operative low-dose ICG administration is feasible and safe for real-time intraoperative visualisation of pelvic autonomic nerves during minimally invasive TME and may improve early post-operative urinary outcomes. Larger prospective studies are warranted.
