Dasatinib, a therapy for chronic myeloid leukemia, suffers from poor bioavailability. Self-microemulsifying drug delivery systems (SMEDDSs) are used to improve its dissolution. This study aimed to develop and validate a novel reverse-phase high-performance liquid chromatography (RP-HPLC) method for quantifying dasatinib in SMEDDS formulations. The RP-HPLC method utilized a mobile phase of methanol and 0.1% trifluoroacetic acid (55:45, v/v) and identified a peak wavelength for dasatinib at 324 nm. SMEDDS formulations comprised Capryol 90, Transcutol HP, and Tween 40. The method was validated according to ICH guidelines, demonstrating excellent linearity (R 2 = 0.9993), accuracy (recovery between 98% and 101%), and precision (relative standard deviation of 0.73%). It also showed stability and reliability with limits of detection and quantification of 0.17 and 0.50 µg/mL, respectively. This RP-HPLC method meets all validation criteria and provides a robust, cost-effective tool for analyzing dasatinib in SMEDDS formulations.
Colonoscopy remains the gold standard for early detection and prevention of colorectal cancer, with adequate bowel cleansing being pivotal for its success. This systematic review aims to evaluate the efficacy and safety of split-dose ultra-low-volume polyethylene glycol (PEG) with ascorbic acid (Asc) versus sodium picosulfate magnesium citrate for bowel preparation. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we conducted a comprehensive literature search across Embase, PubMed, Web of Science, and Scopus from inception to July 2025. Data analysis was conducted using R version 4.2.2 (31 October 2022) and RStudio version 2022.07.2 (2009-2022, RStudio, Inc.) Our literature search yielded six eligible studies involving 3285 patients. Our findings indicate no significant differences in overall and right-sided colon adequate cleansing rates between the two regimens: risk ratio: 1.05, 95% confidence interval (CI): 0.99-1.12, P = 0.1082; and risk ratio: 1.03, 95% CI: 0.99-1.08, P = 0.1755, respectively. However, PEG + Asc demonstrated a significantly lower rate of vomiting compared to sodium picosulfate magnesium citrate (risk ratio: 2.58, 95% CI: 0.94-2.78, P = 0.0008), suggesting better tolerability. Other secondary outcomes, including nausea, abdominal pain, and overall Boston Bowel Preparation Scale scores, did not show significant differences. The quality of the evidence varied across the outcomes. Our results support the comparable efficacy of both bowel preparation agents while highlighting PEG + Asc's potential advantages in tolerability. Our findings suggest that the choice between these two preparations can be tailored to the specific patient, considering their preferences or previous experiences, although some caution is advised in interpreting these findings.
Brain tumors during pregnancy are rare and pose unique challenges in diagnosis, management, and anesthetic care. This report is novel owing to the rare coexistence of a giant anaplastic oligodendroglioma with an ongoing pregnancy requiring urgent dual surgical interventions. A 27-year-old, right‐handed, Middle Eastern Saudi woman at 35 weeks of gestation presented with neurological symptoms, including partial loss of consciousness, left-sided ptosis, and severe headaches. Imaging revealed a large left temporoparietal mass with significant midline shift, diagnosed as an anaplastic oligodendroglioma. She underwent an emergency cesarean section and craniotomy under general anesthesia. Postoperative recovery was uneventful for both the mother and the newborn. This case highlights the critical importance of multidisciplinary coordination, individualized anesthetic planning, and timely surgical decision-making in managing complex neurosurgical cases during pregnancy. The combined obstetric–neurosurgical approach contributed to a favorable maternal and neonatal outcome.
Foot drop (FD) refers to a clinical picture characterized by the inability to lift the foot against gravity due to weakness of the dorsiflexor muscles. Patients with FD typically present with an abnormal gait marked by exaggerated flexion of the knee and hip joints, along with internal rotation of the foot, which may increase the risk of falls and injuries. Intraneural ganglion cysts are benign, fluid-filled lesions located within the epineurium of peripheral nerves. We report the case of a 22-year-old male who presented with right lower limb pain and numbness and later developed acute weakness of the right foot, resulting in complete FD that persisted for four months. He denied any history of trauma and was otherwise medically healthy. On examination, there was muscle wasting in the anterior and lateral compartments of the right leg, complete FD with 0/5 power in dorsiflexion and eversion, and reduced sensation along the distribution of the right common peroneal nerve (CPN). Local examination revealed a palpable and tender swelling around the neck of the right fibula. Plain X-rays revealed no abnormalities; however, MRI demonstrated a small cystic soft tissue lesion located posterolateral to the proximal fibular head, measuring 5 x 1.5 x 2.5 cm. Surgical exploration of the right CPN was performed with neurolysis and excision of the lesion. Histopathological examination confirmed the diagnosis of a ganglion cyst. Postoperatively, the patient had an uneventful recovery, and after two weeks of physical and occupational therapy, he reported improvement in pain and numbness, although motor function remained unchanged at that time. The association between FD and ganglion cysts is a rare pathology; however, it should be included in the differential diagnosis of FD, particularly in the absence of trauma.
