Mar Ivanios College is an autonomous educational institution situated in Thiruvananthapuram, Kerala, India. The college is ranked by NIRF as 29th best college in the country by MHRD, Government of India and the institution is located on a small scenic hilltop with a sprawling campus area of hundreds of acres in Bethany Hills, Nalanchira, Thiruvananthapuram. Mar Ivanios College was established in 1949 by Geevarghese Mar Ivanios, the first Archbishop of Trivandrum. It constantly ranked 29th in all India ranking by National Institutional Ranking Framework in 2019.
Recently well designed multifunctional nanoparticles capable of delivering drugs in a controlled manner with low toxicity and high target specificity upheld a significant role in tumour therapy. Here, safe and controlled drug delivery of anti-melanoma drug dacarbazine (DTIC) is attained in malignant melanoma (A375) cells using metal organic frameworks (MOFs) based drug delivery systems. Green fluorescent crystalline fluorescein 5-isothiocyanate (FITC) labelled Zeolitic imidazolate framework-8 (ZIF-8) nanoparticles having a particle size (70 nm) within the biological regime, synthesised through solvothermal approach was employed as the carrier nanoparticles of the anti-melanoma drug dacarbazine. The ZIF-8 carrier nanoparticles were found to be cytocompatible as well as hemocompatible and also possess 62
Praseodymium (Pr3+) doped magnesium aluminate (MgAl2O4) and barium aluminate (BaAl2O4) nanophosphors were synthesised via the sol–gel method. XRD confirmed the formation of single-phase aluminate structures with average crystallite sizes of 18 nm and 15 nm for MgAl2O4: Pr3+ and BaAl2O4: Pr3+, respectively. MgAl2O4: Pr3+ shows irregular, densely packed grains with rough surfaces, while BaAl2O4: Pr3+ consists of smaller, nearly spherical particles with uniform distribution and minimal agglomeration. Absorption studies for both samples exhibited broad bands in the 600–700 nm range, indicating strong coupling with the host lattices. PL spectra demonstrated host-dependent emission characteristics. MgAl2O4: Pr3+ showed intense red emissions with peaks at 650 nm (3P0 → 3F2) and 710 nm (3P0 → 3F3) emissions, while BaAl2O4: Pr3+ exhibited prominent blue emission at 490 nm (3P0 → 3H4) along with weaker green-yellow emissions in the 530–580 nm. These unique emission properties highlight MgAl2O4: Pr3+ as a promising red-emitting phosphor, while BaAl2O4: Pr3+ can be used for blue-emitting applications in solid-state lighting and optoelectronic devices.
A novel organic single crystal 2,4,6-triaminopyrimidine-1,3-diium cyanoacetate monohydrate (TAPCM) was grown effectively by the slow evaporation technique and analysed using FTIR, FT-Raman and UV-Vis spectral analysis. Single crystal XRD revealed the cell parameters and confirmed that TAPCM was crystallized in the monoclinic, centrosymmetric C2/c space group. Quantum chemical computations were conducted by applying the density functional theory (DFT) with B3LYP/6-311G(d,p) and B3LYP/6-311++G(d,p) basis sets. The stability and intermolecular interactions of the TAPCM were examined using the natural bond orbital (NBO) analysis. FT-IR and FT-Raman spectral analyses confirmed the functional groups in TAPCM. The frontier molecular orbital and molecular electrostatic potential (MEP) analyses were employed to illustrate the charge distribution in the TAPCM molecule. UV-Vis spectral analysis was carried out to analyse the optical quality and related characteristics. The intermolecular hydrogen bonding interactions were investigated using topological analysis techniques such as atoms in molecules (AIM) analysis, reduced density gradient (RDG), interaction region indicator (IRI) analyses and electron localization function. Hole-electron analysis was performed to identify the nature of electronic excitations. Fluorescence studies revealed red emission from the TAPCM single crystal at 671 nm. Thermogravimetric and differential thermal analysis (TG-DTA) was utilised to determine the thermal stability of the single crystal. The surface morphology of TAPCM was determined using scanning electron microscopy (SEM). The NLO properties were investigated both experimentally and theoretically using Z-scan and DFT methods. The research findings discovered novel optical limiting behaviour and a high laser damage threshold in the TAPCM.
Magnesium aluminate (MgAl2O4) nanophosphor doped with 10 wt
Abstract Schiff bases and their metal complexes have garnered significant interest as antimicrobial agents, particularly in addressing antimicrobial resistance (AMR). Schiff base-derived metal complexes constitute an important class of compounds that exhibit exceptional biological activity and are therefore promising candidates for drug development, especially in view of the growing threat of AMR and microbial biofilms. This study reports the synthesis and characterization of Cu(II) and Zn(II) complexes, and a Schiff base ligand derived from indole-3-carboxaldehyde and L-tyrosine. The structures of the ligand and its complexes were confirmed using IR, electronic, and NMR spectroscopy. Based on the experimental results, the Cu(II) and Zn(II) complexes were assigned square planar and tetrahedral geometries, respectively. The antimicrobial efficacy of the complexes was evaluated using disc diffusion and minimum inhibitory concentration (MIC) assays. Antibiofilm investigations and fluorescence microscopy revealed that both complexes were effective against P. aeruginosa biofilms, with the Cu(II) complex demonstrating notably greater activity than the Zn(II) complex. Computational studies were performed for target prediction and revealed strong binding affinities with specific P. aeruginosa proteins (PelA, LpxC, AlgL, ExoS, and PslG), thereby supporting the observed biological activity of the synthesized complexes. These synthesized Schiff base complexes efficiently disrupted biofilms, providing a promising approach for managing chronic infections associated with resistant bacteria.
