Fruit of Styphnolobium japonicum (L.) Schott (syn. Sophora japonica L.) afforded the flavonoids known for this plant genistein, sophoricoside, genistin, genistein 4′-O-α-L-rhamnopyranoside, and kaempferol 3-O-sophoroside and the new genistein 4′-O-rutinoside [genistein 4′-O-(6′′-α-L-rhamnopyranosyl)-β-D-glucopyranoside], which was isolated for the first time. The chemical structures of the isolated phenolic compounds were studied using UV, 1H and 13C NMR spectroscopy; mass spectrometry; and chemical transformations.
Medical deepfakes are AI-generated synthetic medical images that convincingly replicate real scans. They compromise diagnostic integrity and emphasize the need for dependable algorithmic protections in AI-driven medical imaging. Building upon our earlier conference paper, "A Hybrid Approach for Medical Deepfake Detection Using Depth-Wise Convolutions in Vision Transformer and Frequency Domain Analysis [1]" this work extends and refines that framework to develop a more robust medical deepfake detection model. The proposed hybrid architecture incorporates a modified ConvNeXtV2-Tiny backbone augmented with a Triplet Attention Mechanism, specifically designed to enhance spatial, channel-wise, and cross-dimensional feature interactions. This design enables the model to detect subtle forensic inconsistencies often overlooked by traditional CNN and transformer architectures. Evaluated on the ISIC 2019 skin cancer dataset comprising real images along with StyleGAN-and diffusion-generated fakes, the model achieves 96.3 % accuracy under 5-fold cross-validation. Experimental results demonstrate consistent improvements across accuracy, precision, recall, F1-score, and AUC, surpassing existing medical deepfake detection approaches. Despite the limited dataset size, the model exhibits strong generalization, supported by its multimodal input representation and attention-guided feature refinement.
Thyroid cancer is one of the most common endocrine malignancies worldwide. Surgical resection remains the standard care; however, minimally invasive approaches are increasingly being investigated for patients with low-risk cases, particularly papillary thyroid microcarcinoma (PTMC). This review summarizes current evidence on the use of radiofrequency ablation (RFA) in the management of differentiated thyroid carcinoma, with a primary focus on papillary thyroid carcinoma. 27 key publications were analyzed, including international guidelines, meta-analyses, and prospective and retrospective studies. Available data indicate that RFA achieves local tumor control and recurrence-free survival rates comparable to those of surgical management in appropriately selected low-risk patients, while significantly reducing procedure-related morbidity and preserving thyroid function. The technique demonstrates particular efficacy in patients with solitary tumors of up to 1 cm (T1aN0M0) without evidence of metastasis. This review provides a comprehensive evaluation of accumulated clinical data, direct comparison between RFA and thyroid surgery, and an analysis of long-term outcomes as reflected in major guidelines from 2022–2025. Current evidence suggests that RFA represents an emerging organ-preserving strategy that maintains oncologic efficacy in low-risk papillary thyroid carcinoma. Further randomized trials are required to define its role within standardized treatment algorithms.
HPLC techniques for quantitative determination of myricitrin (myricetin-3-O-α-L-rhamnopyranoside) in extracts from leaves of common myrtle (Myrtus communis L.) were developed. The contents of myricitrin in tincture, infusion, and thick extract of myrtle leaves were determined as 0.68 ± 0.02; 0.17 ± 0.01 and 12.75 ± 0.05
Цель настоящего исследования: выявить потенциальные источники катехинов среди порубочных остатков сезонной обрезки отдельных древесных и кустарниковых форм лекарственных растений семейства розоцветные. Объектами исследования служили почки и молодые одревесневшие побеги аронии черноплодной, боярышника однопестичного, шиповника колючейшего, шиповника собачьего и шиповника коричного, заготовленные в результате плановой осенней обрезки крон деревьев и кустарников. Проведенные исследования позволили установить, что содержание суммы восстановленных флавоноидов в пересчете на катехин в изученных образцах сырья составляет от 14,4 до 25,3 % (для почек) и от 7,3 до 20,7 % (для одревесневших побегов). Наиболее высокое содержание суммы восстановленных флавоноидов в пересчете на катехин выявлено в почках шиповника коричного (Rosa cinnamomea L.) (25,29 ± 1,26 %). Показано, что одревесневшие побеги и почки изученных видов лекарственных растений могут служить перспективными источниками катехина для медицинской и фармацевтической промышленности. Полученные нами результаты могут служить основой для создания безотходных схем производства отечественных ЛРП на основе ресурсосберегающих технологий. The purpose of this study is to identify potential sources of catechins among the felling residues of seasonal pruning of individual woody and shrubby forms of medicinal plants of the Rosaceae family. The objects of the study were buds and young lignified shoots of Aronia melanocarpa Elliot., Crataegus monogyna Jacq., Rosa spinosissima L., Rosa canina L. and Rosa cinnamomea L., harvested as a result of planned autumn pruning of tree crowns and shrubs. The conducted studies allowed us to establish that the content of the amount of reduced flavonoids calculated on catechin in the studied raw material samples ranges from 14.4 to 25.3 % (for buds) and from 7.3 to 20.7 % (for lignified shoots). The highest amount of reduced flavonoids in terms of catechin was found in the buds of Rosa cinnamomea L. (25.29 ± 1.26 %). It has been shown that the lignified shoots and buds of the studied medicinal plant species can serve as promising sources of catechin for the medical and pharmaceutical industries. The results we have obtained can serve as a basis for creating waste-free production schemes for domestic HM based on resource-saving technologies.
