Sheikh Sayera Khatun Medical College (Bengali: শেখ সায়েরা খাতুন মেডিকেল কলেজ) is a government medical college in Bangladesh, established in 2011. It is located in Gopalganj. The college is affiliated with Dhaka University as a constituent college.Sheikh Sayera Khatun Medical College was named after Sheikh Sayera Khatun, mother of Bangabandhu Sheikh Mujibur Rahman, the "Father of the Nation", and grandmother of Prime Minister Sheik Hasina.Sheikh Sayera Khatun Medical College began with only 50 students and few infrastructure facilities. The first step in its creation and expansion was the training of undergraduate students.
Sodium-glucose cotransporter-2 (SGLT2) inhibitors have emerged as a novel therapeutic approach for managing type 2 diabetes mellitus (T2DM), offering benefits that extend beyond glycaemic control. This systematic review aims to examine the effects of SGLT2 inhibitors on metabolic syndrome in individuals with prediabetes and obesity. We conducted a comprehensive search across PubMed, EMBASE, Cochrane Library, Web of Science (Core Collection), and Scopus. Title and abstract screening, data extraction, and risk of bias (ROB) assessment were performed independently by two reviewers. ROB was assessed using the Cochrane Risk of Bias tool. A meta-analysis was conducted using a random-effects model.Our meta-analysis did not show statistically significant reductions in body weight (mean difference: –3.05 kg; 95 % CI: –8.18 to 2.09), BMI (mean difference: –1.43 kg/m²; 95 % CI: –4.11 to 1.25), systolic blood pressure (mean difference: –2.12 mmHg; 95 % CI: –7.39 to 3.16), or diastolic blood pressure (mean difference: –1.04 mmHg; 95 % CI: –5.07 to 2.99) with dapagliflozin. However, a reduction was observed in fasting plasma glucose (mean difference: –0.47 mmol/L; 95 % CI: –0.90 to –0.05).Although current findings suggest that SGLT2 inhibitors (dapagliflozin) may have little to no impact on individual components of metabolic syndrome, the evidence remains limited. Further well-powered clinical trials are warranted to validate these observations. Future research should focus on comparing the efficacy of different SGLT2 inhibitors and exploring their potential synergistic effects when combined with other pharmacological agents in the treatment of metabolic syndrome.
•About 56.76% of the students had provisional PTSD.•Female students were more likely to suffer from PTSD symptoms than male students.•Being a victim of social media bullying (AOR= 1.57; 95% CI: 1.17 to 2.11), having relationship problems (AOR= 2.25; 95% CI: 1.82 to 2.79), feeling own self as a burden to their families (AOR= 2.84; 95% CI: 2.27 to 3.56) had a significant association with a higher possibility of suffering from PTSD symptoms in this outbreak.•Financial crisis, limited access to healthcare facilities, experience of COVID-19 symptoms, losing family members or relatives due to COVID-19 had a higher likelihood of developing PTSD symptoms.•Students who talked to their friends or family had curtailed possibility of developing PTSD symptoms.
Background and Objectives: Free fatty acids (FFA) significantly influence the relationship between obesity, insulin resistance, and type 2 diabetes. Elevated plasma FFA levels, common in obese individuals, inhibit insulin-stimulated glucose uptake in muscle tissue, indicating peripheral insulin resistance. This study examines the levels of non-esterified free fatty acids (NEFAs) in type 2 diabetes patients in Bangladesh to understand their role in the disease and inform management and treatment strategies. Materials and Methods: In this cross-sectional study, 134 participants were involved: 100 had previously been diagnosed with type-2 diabetes and 34 served as a non-diabetic control group. Among the diabetic individuals, 60% were newly diagnosed with type-2 diabetes mellitus, 28% had been previously treated but had uncontrolled diabetes, and 11% had been treated and had controlled diabetes and 0.75% had gestational diabetes. The sample included 42.5% males and 57.5% females. Sociodemographic and health data, including BMI, hypertension, cardiovascular history, and lifestyle habits, were collected through questionnaires. Blood pressure was measured per ACC/AHA guidelines. Blood samples were analyzed for glucose, NEFA, and lipid profiles using automated analyzers. NEFA estimation followed specific reagent procedures, while lipid profiling assessed total cholesterol, HDL, LDL, and triglycerides per ADA guidelines. Data were analyzed using Excel and SPSS, with significance set at p<0.05. Results: NEFA levels were significantly higher in diabetic patients (647 µM/L) compared to healthy controls (331.5 µM/L). Significant associations were found between NEFA levels, insulin resistance, and diabetes. Controlled diabetics had lower NEFA levels than uncontrolled ones. Lifestyle factors like work hours and exercise habits correlated with NEFA levels, highlighting their importance in diabetes management. Conclusion: Elevated NEFA levels are common among diabetic patients in Bangladesh, influenced by disease control status and lifestyle factors. Effective diabetes management requires comprehensive strategies targeting NEFA levels through medical and lifestyle interventions Key words: Non-esterified free fatty acids (NEFAs), type 2 diabetes, insulin resistance, atherosclerosis and cardiovascular disease.
Aducanumab is a novel disease‐modifying anti‐amyloid‐beta (Aβ) human monoclonal antibody specifically targeted to the pathophysiology of Alzheimer's disease (AD). It was granted for treating AD in June 2021 by the United States Food and Drug Administration. We systematically analyzed available trials to evaluate the efficacy and safety of aducanumab treating AD. We followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta‐Analysis) guidelines. We conducted an extensive literature search using the electronic databases MEDLINE through PubMed, EMBASE, Cochrane, Web of Science, and Scopus for suitable studies on aducanumab. We considered human clinical trials of aducanumab, assessing its efficacy and adverse effects in treating AD, excluding any experimental animal studies. We included three randomised controlled trials. Studies reported that aducanumab reduced brain amyloid‐beta plaques in a time‐ and dose‐dependent manner (dose–response, P < 0.05) and a slowed decline in cognition (22% reduction) in the high‐dose treated group, difference of −0.39 versus placebo in Clinical Dementia Rating Scale Sum Boxes (95% CI, −0.69 to −0.09; P = 0.012) along with a reduced amyloid positron emission tomography standard uptake value ratio score (P < 0.001) and plasma p181‐tau (phosphorylated tau) level. Amyloid‐related imaging abnormality was reported as a serious adverse event and was profound in high‐dose treated group (425/1029 in 10 mg/kg). Aducanumab has been reported to affect two main pathophysiologic hallmarks (Aβ and tau) of AD. We suggest future studies addressing aducanumab's efficacy and safety to confirm that the benefit of this drug outweighs the risk.
BACKGROUND:The COVID-19 outbreak spillovers mental health burden where suicide is a common psychological public health issue that affects people all over the world. This study aimed to explore the factors associated with suicidal behavior among university students in Bangladesh after one year of the COVID-19 outbreak. METHODS:An online cross-sectional survey was conducted among 2100 Bangladeshi university students aged ≥18 years from April 29 to May 15, 2021. The survey questionnaire contained socio-demographic information, COVID-19 related physical and psychosocial factors (CRPPF), preventive response to psychological stress, and the Suicidal Behaviors Questionnaire-Revised (SBQ-R) scale. Descriptive statistics along with logistic regression were performed for statistical analysis. RESULTS:About 47.90% of the students were at risk of suicidal behavior, and female students were very likely to be at risk of suicidal behavior than their male counterparts (AOR = 2.28; 95% CI: 1.86 to 2.81). Keeping distance from friends or family (AOR = 1.66; 95% CI: 1.34 to 2.04), having relationship problems (AOR = 2.20; 95% CI: 1.79 to 2.70), feeling own selves as burden to families (AOR = 2.50; 95% CI: 2.02 to 3.11), and being stressed of lockdown (AOR = 1.56; 95% CI: 1.19 to 2.03) were highlighted as some of the significant factors associated with increased risk of suicidal behavior. CONCLUSION:University students were exposed to several factors that impose the risk of developing suicidal behavior. Concerned authorities should design & implement appropriate strategies for ensuring suicidal prevention besides their mental well-being.
