It was originally established by Mohammad Manal in Dehradun in 1930. It produces health care products under the name Himalaya Herbal Healthcare whose products include ayurvedic ingredients. It is spread across locations in India, United States, Middle East, Asia, Europe and Oceania, while its products are sold in 106 countries across the world. The company has more than 290 researchers that utilise ayurvedic herbs and minerals. A hepatic drug, named Liv.52, is its flagship product, first introduced in 1955.Himalaya Global Holdings Ltd. (HGH), is the parent of The Himalaya Drug Company worldwide. It is also the global headquarters of all Himalaya subsidiaries.
Background: Oral contraceptives are very widely used agents to check unwanted pregnancies. They contain synthetic analogues of estrogen and progesterone hormones. Estrogen is an important hormone that plays a significant role in menstrual cycle, ovulation, fertilization and implantation. Estrogen receptor α (ERα) can modulate the ovulation, fertilization or receptivity of the uterus. Oral contraceptives pose mild to severe adverse effects such as menstrual cycle disorders, metabolic alterations and increased risk of cancers. It is essential to identify and screen alternative contraceptives that are safer to use. The present study was aimed at identifying the compounds from Cissampelos pareira that is traditionally used for antifertility activity. Methods: The compounds reported from the plant are collected and prepared using the protein preparation wizard. The protein, ERα was selected from protein data bank (1G5O) and prepared. The ligands were docked with the protein and the hits were selected for further screening of free energy calculation, induced fit docking and molecular dynamics simulations based on the respective scores and various interactions. Results: Among various compounds, Coclaurine and Norruffscine have been identified to interact with ERα and possess similar interactions as that of the endogenous ligand, estradiol. The compounds also showed drug-like properties in Qikprop analysis and promising result in the molecular dynamics simulation studies. Conclusion: Considering the dock scores, molecular interactions with the ERα receptor and energy calculations, the compounds Coclaurine and Norruffscine were found to have good binding properties. Further in vitro and in vivo evaluation are warranted for confirmation.
The pool of primordial follicles formed in the ovaries during early development determines the span and quality of fertility in the reproductive life of a woman. As exposure to occupational and environmental toxicants (ETs) has become inevitable, consequences on female fertility need to be established. This review focuses on the ETs, especially well-studied prototypes of the classes endocrine disrupting chemicals (EDCs), heavy metals, agrochemicals, cigarette smoke, certain chemicals used in plastic, cosmetic and sanitary product industries etc that adversely affect the female fertility. Many in vitro, in vivo and epidemiological studies have indicated that these ETs have the potential to affect folliculogenesis and cause reduced fertility in women. Here, we emphasize on four main conditions: polycystic ovary syndrome, primary ovarian insufficiency, multioocytic follicles and meiotic defects including aneuploidies which can be precipitated by ETs. These are considered main causes for reduced female fertility by directly altering the follicular recruitment, development and oocytic meiosis. Although substantial experimental evidence is drawn with respect to the detrimental effects, it is clear that establishing the role of one ET as a risk factor in a single condition is difficult as multiple conditions have common risk factors. Therefore, it is important to consider this as a matter of public and wildlife health.
Background: Curcumin and quercetin are the two important flavonoids that are being used as food ingredients across the globe. They also possess many pharmacological activities such as anti-inflammatory, anticancer and antidiabetic activity. The combination of both these phytoconstituents is available in the market. However, there is lack of any suitable analytical method reported for their simultaneous estimation in food as well as pharmaceutical products. Hence, there is a need to develop a simultaneous method for them. Objectives: The study aims to develop and validate a simple high-performance liquid chromatography (HPLC) method for the simultaneous determination of curcumin and quercetin. Method: Gradient elution was carried out in ACN and GAA (2% v/v) for 15 min wherein the ratio of ACN and GAA was varied from 40-60 v/v ACN: 60-40 GAA v/v from 0-5 min followed by 60-80 v/v ACN: 40-20 v/v GAA between 7- 10 min followed by 80 % ACN: 20 % GAA between 10-15 min. The flow rate was kept 1 mL/min and detection wavelength at 395 nm. The method has been validated according to International Conference of Harmonization (ICH) Q2 (R1) guidelines with respect to specificity, system suitability, accuracy, precision, and robustness. The developed method was further used for the determination of curcumin and quercetin in different herbal extracts, marketed formulations containing these drugs and developed self-nano emulsifying drug delivery system (SNEDDS). Results: The method was linear in the concentration range of 50-250 ng mL-1 for curcumin and 800-1600 ng mL?1 for quercetin, respectively. The limit of detection (LOD) and limit of quantification (LOQ) were 11.76 and 35.6 ng mL?1 for curcumin, respectively, while LOD and LOQ for quercetin were 32.94 and 99.76 ng/mL?1, respectively. The percentage recovery that was found to be in the range of 95-105% with relative standard deviation less than 2% indicating the accuracy and precision of method for both the drugs. Further, the validated method was found specific to detect presence of both the drugs in extracts, marketed formulations and developed SNEDDS. Conclusions: The developed method showed excellent specificity, linearity, accuracy and precision. Thus, it can be further explored to detect curcumin and quercetin in biological samples as well as other marketed formulations.
This review article delineates the role of chelated minerals and phytogenic feed additives (PFAs) cocktail supplementation in improving the overall health status and production performance of poultry birds and its economic effects in the poultry industry. Organically complexed minerals have many advantages over inorganic sources. It has improved absorption and efficacy, which meets the bird's requirements comfortably with a low-dose level. Hence, inorganic forms can be replaced with lower-dose levels of organic minerals without any adverse effects on production performances in broilers and layers. PFAs possess medicinal properties, such as antimicrobial, antioxidant, adaptogenic, and immunomodulatory, therefore, could be recommended as supplements. They are also growth promoters that enhance the overall health status and augment poultry birds' production performance. Furthermore, the tremendous potential of PFAs could be extracted with the recent advances in science and technology. With the advantages of organically complexed minerals and multiple beneficial applications, there is a resurgence to develop PFAs as a cocktail of organic minerals to improve the overall health status of poultry birds and augment their productivity, which, in turn, helps the poultry industry to grow decisively and economically.
To the article "Synthesis, Characterization and Antiioxidant Activity of Schiff Base Compounds Obtained Using Green Chemistry Techniques," by K. Sunil, T. P. Prasanna Kumara, B. Arun Kumar, and S. B. Patel, Vol. 55, No. 1, pp. 46-53, April, 2021
