The University for International Integration of the Afro-Brazilian Lusophony (Portuguese: Universidade da Integração Internacional da Lusofonia Afro-Brasileira, UNILAB) is a public federal university located in Redenção, Ceará, Brazil. The city was chosen because it was the first Brazilian city to abolish slavery. The major courses offered are preferentially the ones included in the mutual interest of all countries in the Community of Portuguese Language Countries. They are: Brazil, Angola, Cape Verde, Guinea Bissau, Sao Tome and Principe, Mozambique, Portugal and East Timor. Looking for international integration, 50% of the seats in the University are for international students from those countries.According to Paulo Speller, the president of the commission that was responsible for creating the university, "in the first year (2010) the University had about 350 students from 8 different countries. In total the University might have more than 10.000 students when it is fully structured.".Currently, the Unilab has 4 campuses: The Liberdade Campus in Redenção, the Auroras Campus in Redenção, the Palmares Campus in Acarape and the Malês Campus in São Francisco do Conde..
Cashew apple bagasse (BAC) is a by-product obtained from the production of beverages based on the pseudo-fruit. Although it is commonly used for human and animal food or as a fertilizer, it adds very little economic value and is often wasted. Therefore, this study aims to carry out a systematic review of the applicability of BAC as a raw material for pharmaceutical and/or biotechnological products. This review was carried out according to the PRISMA© 2020 Checklist methodology. PubMed and ScienceDirect databases were used to collect and peer-review papers, using the following descriptors: “(cashew apple OR cashew)” AND (“bagasse” OR “biomass” OR “by-product”), considering the interval between 2019 and 2025. We excluded review articles, out of scope papers that and undergraduate academic productions. A total of 168 papers were found. After excluding duplicates, the titles and abstracts were peer-reviewed. Of these, 147 were excluded because they were not suitable for the research, even after 7 papers were re-screened. Finally, 11 full texts were peer-reviewed according to eligibility criteria and only one of these was excluded from the final count (n = 10). The raw material was described in terms of its phytochemical and nutritional composition and its physicochemical and lignocellulosic characteristics. It was possible to highlight the potential application of this by-product as an intermediate or final product in the industrial production of cosmetic, biopharmaceutical and biotechnological products. Despite promising findings, logistical, economic, and manufacturing constraints remain, and further in vivo studies are required to confirm biosafety comprehensively.
Magnetic nanoparticles functionalized with diethylenetriaminepenta(methylene phosphonic acid) and activated with glutaraldehyde were designed as a heterofunctional support for immobilizing Eversa Transform 2.0 lipase. Structural characterization by X-ray diffraction, transmission and scanning electron microscopies, X-ray fluorescence, Fourier-transform infrared spectroscopy, thermogravimetry, and vibrating-sample magnetometry confirmed preservation of the magnetite spinel phase, spherical primary nanoparticles of approximately 16 nm, progressive organic coating, and magnetic responsiveness after enzyme loading. Molecular docking suggested that glutaraldehyde can act as an interfacial bridge between accessible lysine residues of the lipase and the phosphonate-functionalized surface, with calculated interaction energies of − 6.0 to − 3.6 kcal mol−1 for lysine-glutaraldehyde contacts and − 5.4 to − 3.2 kcal mol−1 for the phosphonate-glutaraldehyde-lysine complex. A Taguchi L9 design identified protein loading and ionic strength as the most influential immobilization variables, and the optimized condition was 6 h, 5 mM buffer, 5 mg enzyme per g support, and 40 °C.Under these conditions, the immobilized biocatalyst reached 60.5 ± 1.4
Mimosa caesalpiniifolia is a native legume commonly used in agroforestry systems, degraded land recovery, and timber production in semiarid regions. Although this species is naturally hardy, its seedlings are highly sensitive to water deficit during early growth stages, limiting their establishment under drought conditions. This study investigated the effects of Bacillus aryabhattai inoculation and silicon (Si) application on seedling growth, physiological performance, and soil microbial and enzymatic activity under two water regimes (50
The co‐immobilization process of lipases in kaolin enhances industrial processes, making them more efficient, sustainable, economical, and innovative. This study aims to optimize the co‐immobilization of CALB and Eversa Transform 2.0 lipases in functionalized kaolin, envisioning the subsequent computational analysis of enzyme‐support interactions. The statistical tool applied for process optimization was the Taguchi L9 method, which enabled the identification of the ideal conditions for enzyme immobilization (time: 24 h, pH 9, buffer concentration: 5 mM, and enzyme load: 6 mg g −1 of support) in modified kaolin. Subsequently, the produced biocatalyst was characterized by X‐ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, thermogravimetry (TGA), and scanning electron microscopy (SEM). The KCBG/Eversa‐CALB biocatalyst showed superior thermal stability, with a half‐life 2 to 3 times longer than soluble enzymes between 50 °C and 80 °C, in addition to resistance to pH and solvent variations. After 180 days, it maintained more than 85% of the initial activity. In addition, it demonstrated high enantio, regio‐, and stereoselectivity for secondary alcohols and retained 50% of its activity after five cycles. In summary, the co‐immobilization of CALB and Eversa in kaolin improved the operational stability of the enzymes, increasing the efficiency and sustainability of industrial processes.
Objetivo: Desenvolver e avaliar, por meio de estudo metodológico, um protótipo de aplicativo móvel para familiares e cuidadores sobre efeitos adversos em crianças em tratamento oncológico. Métodos: Estudo metodológico baseado nas etapas do Double Diamond Process, seguindo as fases do Design Instrucional Contextualizado. A construção do conteúdo foi subsidiada por revisão integrativa e benchmarking de soluções tecnológicas. A avaliação de conteúdo ocorreu entre julho e setembro de 2022, com sete enfermeiras especialistas, utilizando a escala Likert e o Índice de Validade de Conteúdo. A usabilidade foi avaliada entre outubro e novembro de 2022, com sete cuidadores, em unidade pediátrica de hospital privado em Fortaleza, Ceará, por meio do Smartphone Usability questionnaiRE. Resultados: A revisão da literatura identificou quatro dimensões temáticas: sensorial, nutricional, imunológica e conforto. A prototipagem resultou em 48 telas e 65 ilustrações. O Índice de Validade de Conteúdo global foi de 0,85. Na avaliação de usabilidade, o protótipo obteve escore de satisfação de 66%. Conclusão: O protótipo “Três, três, passará” apresentou validade de conteúdo e boa aceitação pelos usuários, configurando-se como tecnologia educacional promissora para apoiar cuidadores informais de crianças em tratamento oncológico.
