Todesf & auml;lle durch Opioid-& Uuml;berdosierung stellen trotz der Verf & uuml;gbarkeit wirksamer Medikamente weiterhin die h & auml;ufigste Todesursache bei Menschen unter 45 Jahren dar. D'Onofrio et al. verglichen die 7-t & auml;gige Behandlung mit injizierbarem Buprenorphin mit verz & ouml;gerter Freisetzung mit der Behandlung mit sublingualem Buprenorphin hinsichtlich der Therapietreue.
Tricuspid valve disease encompasses a spectrum of conditions, among which tricuspid regurgitation is the most prevalent and clinically significant. Affected patients are typically elderly and present with systemic congestion, impaired renal and hepatic function, and reduced quality of life. Echocardiography enables mechanistic classification, severity grading, and assessment of right ventricular function. While medical therapy remains foundational, transcatheter interventions - including edge-to-edge repair and valve replacement - have emerged as options for high-risk patients. Randomized trials demonstrate improvements in symptoms and quality of life, with emerging evidence for reductions in heart failure hospitalizations. This article provides a practice-oriented overview of diagnosis, management, and referral pathways for tricuspid valve disease, including rarer entities such as tricuspid stenosis, endocarditis, and carcinoid heart disease.
Obgleich zur Abkl & auml;rung eines Myokardinfarkts ohne Obstruktion der Koronararterien (MINOCA) die multimodale Bildgebung empfohlen wird, bleibt es bis heute unklar, bei welchen Patient*innen am ehesten pathologische Befunde zu erwarten sind. Reynolds et al. wollten daher die Mechanismen von MINOCA, Pr & auml;diktoren f & uuml;r Auff & auml;lligkeiten in der Bildgebung sowie geschlechtsspezifische Unterschiede erforschen und haben eine prospektive Studie initiiert.
Background Neoplasms greatly increase the risk of infection- the main causes of death are pneumonia and influenza infection. Streptococcus pneumoniae, the most common pathogen causing community-acquired pneumonia, is of great significance in patients suffering from hematological neoplasms, which have a 30 times higher incidence of invasive pneumococcal disease than the general population. Vaccination plays a key role in prevention. The Standing Committee on Vaccination (STIKO) recommends vaccination for adults over 60 and immunosuppressed adults. Only about 20% of these individuals are vaccinated. Objectives Relevance of pneumococcal vaccination in cancer patients and challenges in practical implementation. Materials and methods Case study of the clinical course of a hematologic patient with recurrent pneumococcal infections. Results Invasive pneumococcal diseases are associated with high morbidity and mortality in cancer patients and are potentially preventable by vaccination. There are adapted recommendations for this group. Conclusion Increased awareness of the risk of pneumococcal disease in cancer patients can help to increase vaccination rates. Coordination between health care sectors is essential in order to implement the recommendations.
Immunoglobulin A nephropathy (IgAN) is the most common form of primary glomerulonephritis and has undergone a therapeutic revolution in just a few years that is unprecedented in nephrology. For the first time, the guidelines define remission as a realistic treatment goal and solidify the so-called "dual-pillar" approach. This educational article summarizes the current recommendations and developments and evaluates the clinical evidence.
