Objective:To investigate the effect and safety of recombinant human brain natriuretic peptide in the treatment of heart failure and respiratory failure.Methods:A retrospective analysis of 78 patients with heart failure and respiratory failure who were treated in our hospital from April 2019 to April 2021 was conducted.According to the different medication regimens,they were divided into experimental group(41 cases)and control group(37 cases).Both groups were given drugs in strict accordance with the requirements of the Chinese guidelines for the diagnosis and treatment of heart failure.The experimental group added recombinant human brain natriuretic peptide on this basis.The therapeutic effect,serum index,adverse reactions and follow-up results were compared between the two groups.Results:The total effective rate of treatment in the experimental group was 90.24 % ,which was higher than 72.97 % in the control group(P<0.05).The level of NT-proBNP in peripheral serum of the experimental group was lower than that of the control group,and the left ventricular ejection fraction and 24 h urine volume were higher than those of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the experimental group and the control group(P>0.05).After 1 year of follow-up,the incidence of adverse events in the experimental group was lower than that in the control group(P<0.05).Conclusion:Recombinant human brain natriuretic peptide is effective in the adjuvant treatment of heart failure complicated with respiratory failure,which can improve serum indexes and reduce the risk of adverse events.The combination of drugs does not increase the incidence of adverse reactions,and the application safety is high.
Objective:To investigate the relationship between the expression of hepatocyte growth factor(HGF)and drug resistance of targeted therapy in non-small cell lung cancer.Methods:A total of 128 patients with non-small cell lung cancer who were treated with epidermal growth factor receptor tyrosine kinase inhibitors(EGFR-TKIs)for targeted therapy in our hospital from June 2017 to June 2021 were selected as the research objects.According to whether EGFR-TKIs resistance was produced,the patients with drug resistance were set as the observation group,and the patients without drug resistance were set as the control group.Univariate and multivariate Logistic regression analysis was used to analyze the factors of targeted therapy resistance in patients with non-small cell lung cancer.Results:Drug resistance occurred in 56 of 128 patients with non-small cell lung cancer.There was no significant difference in gender,age,tumor location,tumor differentiation,tumor size and previous chemotherapy types between the two groups(P>0.05).There were significant differences in lymph node metastasis,HGF and c-MET positive between the two groups(P<0.05).Multivariate Logistic regression analysis showed that HGF positive and c-MET positive were independent risk factors for targeted therapy resistance in patients with non-small cell lung cancer(P<0.05).Spearman correlation analysis showed that HGF and c-MET expression were positively correlated with non-small cell lung cancer targeted therapy resistance(r=0.586,0.374,P=0.013,0.009).Conclusion:The expression of HGF and c-MET is closely related to the drug resistance of non-small cell lung cancer targeted therapy,and HGF positive and c-MET positive are independent risk factors for drug resistance of non-small cell lung cancer targeted therapy.They are expected to become biomarkers for monitoring and predicting drug resistance of non-small cell lung cancer molecular targeted therapy.
Objective:To evaluate the use of analgesics in the early stage of fractures in hospitals and provide reference for rational clinical medication.Methods:Relevant information on the use of analgesic drugs in the early stage of fracture from 2021 to 2022 was collected,and the consumption sum,defined daily dose system(DDDs),defined daily cost(DDC)and druy utilization index(DUI)were analyzed.Results:The proportion of analgesic drugs used in the early stage of hospital fractures from 2021 to 2022,celecoxib capsules,irecoxib tablets,loxoprofen sodium tablets,oxycodone hydrochloride injection,and paracetamol dihydrocodeine tablets ranked the top 5 in order;the DDDs of paracetamol dihydrocodeine tablets,celecoxib capsules,irecoxib tablets,loxoprofen sodium tablets,and tramadol hydrochloride sustained-release tablets ranked top 5.The DDC of oxycodone hydrochloride injection was the highest,and that of loxoprofen sodium tablets was the lowest.Maximum DUI value of celecoxib capsules,hydroxycodone hydrochloride injection has the lowest DUI value.Conclusion:The use of analgesics in the early stage of hospital fractures is basically reasonable,but some drugs have higher costs and are worth paying attention to.
Objective:To explore the effectiveness of high quality nursing during drug therapy for newborns in the intensive care unit.Methods:A total of 280 neonates diagnosed and treated in the intensive care unit of the hospital from January 2022 to April 2023 were selected as subjects.According to the principle of 1∶1 random coin toss,the children were divided into high quality group(140 neonates)and reference group(140 neonates).The reference group was given routine medication and nursing,and the high quality group was given high quality nursing on the basis of the reference group.The physical development,medication compliance,neurobehavioral function and intelligence of the two groups were compared.Results:The medication compliance of the high-quality group was higher than that of the reference group at the second and third weeks of nursing(P<0.05).The body weight and body length of the high-quality group were higher than those of the reference group at the second and third weeks(P<0.05).The neurobehavioral function score,mental development index and psychomotor development index of the high-quality group at the third week of nursing were higher than those of the reference group(P<0.05).Conclusion:High quality nursing can improve medication compliance,promote physical development,and improve neurobehavioral function,intellectual development index,and psychomotor development index of newborns during drug treatment in the intensive care unit.
Objective:To observe the clinical effect of Liangxue Quyu prescription combined with western medicine in the treatment of children with Henoch-Schonlein Purpura(blood heat rash syndrome).Methods:Sixty children with Henoch-Schonlein Purpura(blood heat rash syndrome)who were hospitalized in the pediatric ward of Songxian Hospital of Traditional Chinese Medicine from January 2019 to December 2021 were selected as the research objects.They were randomly divided into treatment group and control group,with 30 cases in each group.The control group was given conventional western medicine treatment,and the treatment group was given oral modified Liangxue Quyu prescription treatment on the basis of the control group.The clinical efficacy and TCM symptom scores of the two groups were compared.Results:The total effective rate of treatment group was higher than that of control group(P<0.05).After treatment,TCM syndrome scores of the two groups were lower than before treatment,and the treatment group was lower than the control group(P<0.05).Conclusion:The prescription of Liangxue Quyu prescription combined with western medicine in the treatment of children with Henoch-Schonlein Purpura(blood heat rash syndrome)can effectively improve the clinical symptoms,the curative effect is accurate,and has clinical application value.
Objective:To analyze the clinical distribution characteristics and drug resistance changes of Stenotrophomonas maltophilia,and to provide reference for clinical anti-infection treatment.Methods:The distribution and drug sensitivity of Stenotrophomonas maltophilia isolated from inpatients in a tertiary general hospital from January 2018 to December 2022 were retrospectively analyzed,and statistical analysis was performed by Whonet 5.6.Results:A total of 438 strains of Stenotrophomonas maltophilia were isolated from 2018 to 2022,and the isolation rate increased from 4.09 % to 6.42 % ,showing an increasing trend year by year.The isolated strains were mainly from elderly patients over 60 years old,accounting for 84.47 % .The main sources of samples were sputum and alveolar lavage fluid,accounting for 89.95 % and 5.71 % ,respectively.The top three clinical departments with the highest isolation rate were respiratory department(162 strains,36.98 % ),intensive care unit(69 strains,15.75 % )and geriatrics department(38 strains,8.68 % ).The results of in vitro drug sensitivity test showed that the resistance rates of Stenotrophomonas maltophilia to minocycline,cotrimoxazole,levofloxacin and chloramphenicol were low,which were 2.13 % ,8.22 % ,11.45 % and 17.12 % ,respectively.There was no significant change in the resistance rate during the five years(P>0.05).The resistance rate of Stenotrophomonas maltophilia to ceftazidime was high(39.01 % ),and it showed an upward trend from 2021 to 2022,and the fluctuation of resistance rate was statistically significant(P<0.01).Conclusion:The isolation rate of Stenotrophomonas maltophilia increased year by year,and the resistance rate to some antibiotics fluctuated.The prevention and control of Stenotrophomonas maltophilia should be strengthened in clinical treatment,and antibiotics should be reasonably selected according to the results of drug sensitivity test.
Objective:To explore the application effect of detail nursing and comfort nursing on children with pneumonia during drug atomization treatment.Methods:A total of 100 children with pneumonia admitted to our department from October 2021 to October 2022 were selected as the research objects.The patients were divided into observation group and control group by random number table method,with 50 children in each group.All patients were treated with budesonide combined with ipratropium bromide.The control group received routine nursing during the treatment,and the observation group received detailed and comfortable nursing during the treatment.The clinical indicators,lung function indicators[peak expiratory flow(PEF),exhaled nitric oxide(FeNO)]and inflammatory factor levels[white blood cell count(WBC,procalcitonin(PCT),high-sensitivity C-reactive protein(hsCRP)],and family satisfaction were compared between the two groups.Results:The disappearance time of lung rales/wheezing rales,cough disappearance time,total fever days,imaging recovery time and hospitalization time in the observation group were shorter than those in the control group(P<0.05).The level of PEF in the observation group was higher than that in the control group,and the levels of FeNO,PCT,hsCRP and WBC were lower than those in the control group(P<0.05).The nursing satisfaction of the observation group was higher than that of the control group(P<0.05).Conclusion:The application of detailed nursing and comfortable nursing on children with pneumonia during drug atomization treatment is effective,which can shorten the duration of clinical symptoms and promote the early recovery of children.Meanwhile,it can further improve the respiratory function of children,assist in reducing the body's inflammatory factor response,and the satisfaction of children's families is high.
Objective:To investigate the characteristics of adverse drug reactions induced by antineoplastic drugs and provide references for the safe and rational clinical use of these medications.Methods:The reports of adverse reactions of anti-tumor drugs reported in the hospital from January 2022 to June 2023 were analyzed.The general data,suspected drug types,combined drugs,organs and systems involved,clinical manifestations,report types and outcomes of related patients were descriptively analyzed.Results:Among the 292 cases of adverse drug reactions,there were 168 male and 124 female cases,with a significant proportion of individuals aged over 65 years(64.38 % ).Cytotoxic agents were the predominant type of drug-induced adverse reactions(25.13 % ),followed by anti-metabolic drugs(22.01 % ).The top five drugs that caused adverse reactions were all traditional antineoplastic medications.Adverse drug reactions mainly affected the blood system(40.91 % ),followed by the digestive system(20.33 % ).The majority of the reported cases were associated with known serious adverse drug reactions(60.96 % ).Conclusion:The incidence of adverse reactions associated with traditional antineoplastic drugs remains high,while novel antineoplastic drugs have been rapidly developed and extensively utilized.Thus,the clinical application monitoring of both types of drugs should be strengthened to promote the rational use of antineoplastic drugs and ensure the safety of patients.
Objective:To compare the effects of hydrocortisone butyrate ointment and desonide cream on the area and severity of eczema.Methods:A total of 150 patients with eczema treated in Longyan Second Hospital of Fujian Province from January 2020 to December 2022 were included in the study.The patients were randomly divided into the reference group(75 cases,treated with hydrocortisone butyrate ointment)and the study group(75 cases,treated with desonide cream).The clinical efficacy,eczema area and severity,improvement of pruritus and adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was higher than that in the reference group(P<0.05).The improvement of eczema area and severity and pruritus score in the study group was better than that in the reference group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The clinical effect of desonide cream in the treatment of eczema is better than that of hydrocortisone butyrate ointment.It is more conducive to shortening the area of eczema,reducing the severity of eczema,and will not increase adverse reactions.
Objective:To observe the effect of propranolol on serum myocardial injury markers and adverse events in patients with angina pectoris before percutaneous coronary intervention(PCI).Methods:A total of 142 patients with angina pectoris of coronary heart disease admitted to our hospital as the research objects between August 2020 and February 2022.They were divided into observation group(n=72)and control group(n=70).PCI was performed in both groups.The control group was given routine drug treatment before and after the operation.The observation group was given propranolol before the operation.The clinical efficacy,myocardial injury markers and adverse events of the two groups were compared.Results:The total effective rate of the observation group was 94.44 % ,which was higher than 81.43 % of the control group(P<0.05);The levels of CK-MB,LDH and cTnT in the two groups after operation were lower than those before operation,and the levels of CK-MB,LDH and cTnT in the observation group were lower than those in the control group(P<0.05).The incidence of adverse events in the observation group was 4.17 % ,lower than 14.29 % in the control group(P<0.05).Conclusion:The application of propranolol before PCI can effectively improve postoperative curative effect,reduce myocardial injury induced by PCI and prevent the occurrence of postoperative adverse events in patients with angina pectoris of coronary heart disease.
Objective:To investigate the current situation of drug use in elderly patients with diabetes mellitus,to investigate the compliance of medication and to analyze the related factors.Methods:A total of 78 elderly patients with type 2 diabetes mellitus who were diagnosed and treated in our hospital from January 2021 to December 2022 were selected as the research objects.The drug use,demographic sociological characteristics and medication compliance of all patients were investigated and the correlation analysis was carried out.Results:Among the 78 patients,42 patients used one hypoglycemic drug,28 patients used two hypoglycemic drugs,and 8 patients used three or more hypoglycemic drugs.Usage frequency:40 patients were once a day,18 patients were twice a day,20 patients were three times a day.There were 60 patients of medication compliance,and the medication compliance was 76.92 % .Univariate analysis showed that there were statistically significant differences in medication compliance among different medical insurance,education level,marital status,income status and smoking population(P<0.05).Multivariate linear regression analysis showed that medical insurance,education level,marital status,income and smoking were important factors affecting the medication compliance of elderly diabetic patients(P<0.05).Conclusion:There are many types and frequencies of drug use in elderly diabetes patients,and drug compliance needs to be improved.Medical insurance,education,marital status,income,smoking,etc.can affect drug compliance in elderly diabetes patients.
Objective:To investigate the clinical efficacy of Chaihu Shugan Powder combined with Tongxie Yaofang in the treatment of irritable bowel syndrome with diarrhea(IBS-D)with liver depression and spleen deficiency.Methods:A total of 80 patients with diarrhea-predominant irritable bowel syndrome with liver depression and spleen deficiency syndrome admitted to the Third People's Hospital of Fujian University of Traditional Chinese Medicine from January 2021 to March 2023 were selected as the research objects.They were divided into observation group and control group by random number table method,with 40 patients in each group.The control group was treated with pinaverium bromide,and the observation group was treated with Chaihu Shugan Powder combined with Tongxie Yaofang on the basis of the control group.The IBS-SSS score,clinical efficacy,TCM syndrome score and recurrence rate were compared between the two groups.Results:After treatment,the IBS-SSS score and TCM syndrome score of the observation group were lower than those of the control group,and the clinical treatment and TCM markedly effective rate and total effective rate were higher than those of the control group(P<0.05).After 4 weeks of follow-up,the recurrence rate of the observation group was lower than that of the control group(P<0.05).Conclusion:Chaihu Shugan Powder combined with Tongxie Yaofang has a good effect on IBS-D with liver stagnation and spleen deficiency syndrome,which can improve the clinical symptoms of patients and improve their quality of life,and the curative effect is stable and persistent.
Objective:To explore the effect of staged intensive education in sufentanil patient-controlled epidural labor analgesia(PCEA).Methods:A total of 82 parturients who gave birth in our hospital from January 2020 to January 2023 were randomly divided into control group and observation group,with 41 parturients in each group.Both groups received sufentanil combined with ropivacaine PCEA.The control group was given routine nursing,and the observation group was given staged intensive education on the basis of the control group.The duration of labor and maternal and infant outcomes of the two groups were counted,and the amount of bleeding,pain and the first urination time after delivery were recorded.Results:The first,second and third stages of labor in the observation group were shorter than those in the control group(P<0.05).The amount of bleeding at 2 hours after delivery in the observation group was less than that in the control group(P<0.05).The proportion of pain grade 0 and grade I in the observation group was higher than that in the control group,and the proportion of pain grade Ⅱ and grade Ⅲ in the observation group was lower than that in the control group(P<0.05).The first time of postpartum urination in the observation group was earlier than that in the control group(P<0.05).The vaginal delivery rate of the observation group was 73.17 % ,which was higher than 48.78 % of the control group(P<0.05).The incidence of neonatal complications in the observation group was 4.88 % ,which was lower than 19.52 % in the control group(P<0.05).Conclusion:Sufentanil PCEA intervention combined with staged intensive education can effectively shorten the maternal labor process,reduce bleeding,relieve maternal pain,promote the recovery of postpartum urinary function,and optimize maternal and infant outcomes.
Objective:To explore the efficacy of Qianlie Shutong capsules combined with finasteride tablets in treating patients with benign prostatic hyperplasia.Methods:A total of 90 patients with benign prostatic hyperplasia admitted to the Department of Urology,Huaihe Hospital of Henan University from August 2021 to August 2022 were selected and divided into control group and observation group by random number table method,with 45 patients in each group.The control group was treated with finasteride tablets,and the observation group was treated with Qianlie Shutong capsules.The therapeutic effect,urination function,inflammatory factors,IPSS score,QOL score and incidence of adverse reactions were compared between the two groups.Results:After 2 weeks of treatment,the total effective rate of the observation group was higher than that of the control group(P<0.05).The PVR level in the observation group was lower than that in the control group,while the Qmax level was higher than that in the control group(P<0.05).The IPSS score and QOL score of the observation group were lower than those of the control group(P<0.05).The level of IL-10 in the observation group was higher than that in the control group,while the levels of IL-17 and TNF-α were lower than those of the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups during treatment(P>0.05).Conclusion:The combination of Qianlie Shutong capsules and finasteride tablets has a good effect on the treatment of patients with benign prostatic hyperplasia,which can strengthen the regulation of inflammatory factor levels,alleviate prostate symptoms,improve urination function,and improve quality of life,with high safety.
Objective:To explore the clinical effect of compound ferrous sulfate granules combined with high-dose blood transfusion in the treatment of neonatal severe anemia.Methods:Sixty neonates with severe anemia who were treated in our hospital from May 2019 to May 2022 were selected as the research objects.The patients were divided into study group and control group according to the random number table method,with 30 cases in each group.The control group received high-dose blood transfusion,and the study group received compound ferrous sulfate granules combined with high-dose blood transfusion.The red blood cell index level,hemoglobin index level,total effective rate of clinical treatment,serum ferritin level,serum iron level,total iron binding capacity level and total incidence of adverse reactions were compared between the two groups.Results:After treatment,the levels of red blood cells and hemoglobin in the study group were higher than those in the control group(P<0.05).The total effective rate of clinical treatment in the study group was 96.67 % ,which was higher than 80.00 % in the control group(P<0.05).The levels of serum ferritin and serum iron in the study group were higher than those in the control group,and the level of total iron binding capacity was lower than that in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The clinical efficacy of compound ferrous sulfate granules combined with high-dose blood transfusion in neonates with severe anemia is significantly better than that of high-dose blood transfusion alone.It can improve the red blood cell,hemoglobin level and iron metabolism index of children without increasing the incidence of adverse reactions.
Objective:To investigate the quality of life of patients with methadone maintenance treatment(MMT),and to explore its influencing factors,so as to provide evidence for improving the quality of MMT service.Methods:From May to December 2019,197 patients treated in the MMT clinic of the Affiliated Brain Hospital of Guangzhou Medical University were investigated by self-made questionnaire,opioid protracted withdrawal symptom rating scale(OP),heroin craving questionnaire(HCQ),Beck anxiety inventory(BAI),Beck depression inventory(BDI),Pittsburgh sleep quality index(PSQI)and quality of life scale for drug addicts(QOL-DA).Single factor and multi-factor linear regression were used to analyze the quality of life and its influencing factors in four fields.Results:Univariate analysis showed that the number of MMT interruptions and the total scores of OP,HCQ,BAI,BDI and PSQI were important factors affecting the quality of life of patients and their four fields.Whether MMT was interrupted was the influencing factor of physical function.The dose of methadone treatment might affect the quality of life and its physical function,psychological function and social function.Further multivariate linear regression analysis showed that the number of MMT interruptions(in the field of detoxification symptoms and toxic side effects),OP(in 4 fields),HCQ(in 3 fields of psychological,social function,detoxification symptoms and toxic side effects),BAI(in 3 fields of physical,psychological function,detoxification symptoms and toxic side effects),PSQI total score(in 2 fields of physical and social function)were important factors affecting the quality of life of MMT patients.Depression(BDI total score)was the influencing factor of both social function and detoxification symptoms and toxic side effects in the quality of life of MMT patients(P<0.05).Conclusion:The number of MMT interruptions,opioid protracted withdrawal symptoms,craving,anxiety symptoms,and sleep quality are important factors affecting the quality of life of MMT patients.Depression has an important impact on the field of both social function and detoxification symptoms and toxic side effects in the quality of life of MMT patients.
Objective:To investigate the effect of selenium yeast combined with vitamin D and levothyroxine on the expression levels of thyroid autoantibodies in patients with hypothyroidism during pregnancy.Methods:From January 2020 to December 2022,82 patients with hypothyroidism in pregnancy who were diagnosed and treated in the Xincheng Town Community Health Service Center,Binhai New Area,Tianjin were selected.The patients were divided into two groups according to the 1:1 random number table method.The traditional group was given vitamin D combined with levothyroxine treatment,the study group was given selenium yeast treatment on the above basis.Both groups were treated and observed for 8 weeks,and changes in the expression levels of thyroid autoantibodies were detected in both groups.Results:After 8 weeks of treatment,the total effective rate of the study group was 97.56 % ,which was higher than 80.49 % of the traditional group(P<0.05).The levels of thyroid peroxidase antibody and thyroglobulin antibody in the study group were lower than those in the traditional group(P<0.05).The incidence of pregnancy complications and perinatal complications in the study group was lower than that in the traditional group(P<0.05).Conclusion:Selenium yeast combined with vitamin D and levothyroxine is effective in the treatment of patients with hypothyroidism during pregnancy,which can effectively improve the levels of serum thyroid peroxidase antibody and thyroglobulin antibody,and reduce the incidence of pregnancy and perinatal complications.
Objective:To explore the therapeutic effect of atorvastatin in the treatment of patients with diabetes nephropathy.Methods:A total of 101 patients with diabetic nephropathy admitted to our hospital from August 2020 to November 2021 were selected and divided into control group(50 cases)and observation group(50 cases)by drawing lots.All patients were given standardized basic treatment.On this basis,the control group was treated with benazepril,and the observation group was treated with benazepril combined with atorvastatin.The hemorheological indexes[whole blood viscosity,erythrocyte aggregation index(RAI),plasma fibrinogen(FIB)],glomerular filtration function[urinary albumin excretion rate(UAER),β2-microglobulin(β2-MG),cystatin C(CysC)],cellular immunity level(CD4+,CD4+/CD8+,CD8+)and adverse reactions were compared between the two groups.Results:After treatment,the levels of whole blood viscosity,RAI and FIB in the observation group were lower than those in the control group(P<0.05).The levels of UAER,β2-MG and CysC in the observation group were lower than those in the control group(P<0.05).The levels of CD4+ and CD4+/CD8+ in the observation group were higher than those in the control group,and the level of CD8+ was lower than that in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Benazepril combined with atorvastatin can effectively regulate the blood lipid level of patients with diabetic nephropathy,improve hemorheology,improve glomerular filtration function,reduce inflammatory response,and do not increase the incidence of adverse reactions.
Objective:To explore the effect of arotinib hydrochloride combined with gemcitabine+cisplatin(GP)chemotherapy regimen in the treatment of advanced lung squamous cell carcinoma based on preference score matching.Methods:The clinical data of 75 patients with advanced lung squamous cell carcinoma treated with GP chemotherapy regimen in the hospital from January 2020 to December 2022 were retrospectively analyzed as the control group,and the clinical data of 69 patients with advanced lung squamous cell carcinoma treated with arotinib hydrochloride combined with GP chemotherapy regimen in the hospital in the same period were collected as the observation group.The baseline data of patients in the two groups were analyzed by propensity score matching method.Patients in the two groups were matched by nearest neighbor method in the ratio of 1:1,the therapeutic effect,serum indexes(vascular endothelial growth factor(VEGF),cancer antigen 125(CA125),cytokeratin 19 fragment antigen(CYFRA)21-1,carcinoembryonic antigen(CEA)and squamous cell carcinoma associated antigen(SCC))and the occurrence of side effects during chemotherapy were compared between the two groups before treatment and after 6 courses of treatment.Results:A total of 50 pairs of propensity scores were successfully matched,There was no significant difference in baseline data between the two groups after matching(P>0.05).After 6 courses of treatment,the disease control rate(DCR)and objective remission rate(ORR)in the observation group were higher than those in the control group(P<0.05).The levels of serum VEGF,CEA,CA125,CYFRA21-1 and SCC in the observation group were lower than those in the control group(P<0.05).There was no significant difference in the incidence of abdominal pain,diarrhea,fever,bone marrow suppression,rash,nausea and vomiting between the two groups during treatment(P>0.05).Conclusion:Allotinib hydrochloride combined with GP chemotherapy regimen can regulate the levels of tumor markers and VEGF in patients with advanced lung squamous cell carcinoma,and the therapeutic effect was significant without increasing toxic and side effects of patients.
Objective:To observe the effect of individualized intervention on children with febrile convulsion caused by severe pneumonia during medication.Methods:A total of 64 children with febrile convulsion caused by severe pneumonia who were treated in our hospital from February 2020 to October 2022 were selected and divided into control group and observation group according to random number method,with 32 children in each group.The children in the control group were given routine nursing intervention,and the children in the observation group were given individualized intervention.The family members'cognition of the disease,the improvement of clinical symptoms,compliance,anxiety and depression scores were compared between the two groups.Results:After intervention,the awareness of disease knowledge among family members of the observation group was significantly higher than that in the control group(P<0.05).After intervention,the time to body temperature recovery,disappearance time of convulsion,lung rales,cough and wheezing in the observation group were significantly shorter than those in the control group(P<0.05).The compliance scoreof observation group was significantly higher than that of the control group(P<0.05).After intervention,the Screen for Child Anxiety Related Emotional Disorders(SCARED)scores and Depression Self Rating Scale for Children(DSRSC)scores of the observation group were significantly lower than those of the control group(P<0.05).Conclusion:Individualized intervention has a significant effect on children with febrile convulsion caused by severe pneumonia.It can enhance the cognitive level of family members of children,improve the compliance of children with treatment,alleviate the adverse psychological state of children,and effectively improve the clinical symptoms and signs of children.
