Objective:To explore and analyze the clinical impact of citicoline sodium tablets combined with dopamine hydrazine treatment on patients with Parkinson's disease and mild cognitive impairment.Methods:80 patients with Parkinson's disease and mild cognitive impairment admitted to our hospital from September 2022 to July 2023 were randomly divided into a control group(treated with dopamine,n=40 cases)and an observation group(treated with citicoline sodium tablets and dopamine,n=40 cases)using a random number table method.Explore and analyze the clinical efficacy of two groups.Results:After intervention,the MMSE score,MoCA score,ADL score,clinical effective rate,serum levels of serotonin,norepinephrine,and dopamine in the observation group were higher than those in the control group,and there was a statistical difference between the two groups(P＜0.05);The incidence of adverse events after intervention in the observation group was significantly lower than that in the control group,and there was a statistical difference between the two groups(P＜0.05).Conclusion:The combination of citicoline sodium tablets and dopamine hydrazine in the treatment of mild cognitive impairment patients with Parkinson's disease can significantly improve their cognitive function,enhance their ability to take care of themselves in daily life,regulate and optimize the expression level of neurotransmitters,and has high clinical efficacy and safety,which is worth recommending.
目的:探究头孢哌酮舒巴坦对支气管扩张症者炎症指标、肺功能的影响.方法:选取2020年5月至2022年5月我院收治的80例支气管扩张症患者,按随机数字表法分为两组,各40例.对照组采用乙酰半胱氨酸,观察组在此基础上加用头孢哌酮舒巴坦.比较两组的炎症指标[C-反应蛋白(CRP)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]、肺功能[第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、最大呼气流量(PEF)]、咳痰量及呼吸困难(mMRC)评分、不良反应.结果:两组治疗2周的TNF-α、CRP、IL-6水平比治疗前低,观察组比对照组低(P＜0.05).两组治疗2周的PEF、FEV1、FVC比治疗前高,观察组比对照组高(P＜0.05).两组治疗2周的咳痰量、mMRC评分较治疗前低,观察组较对照组低(P＜0.05).两组不良反应比较,差异无统计学意义(P＞0.05).结论:头孢哌酮舒巴坦可减轻支气管扩张症者的炎症反应,提高其肺功能,减轻病症,且不增加不良反应.
目的:探讨腰椎管狭窄症(DLSS)采取单侧双通道内镜(UBE)下椎板开窗减压术治疗的效果.方法:选择DLSS患者70例进行研究,根据治疗方法不同分为两组,每组35例,包括对照组(传统开放减压术)与观察组(UBE椎板开窗减压术).比较效果.结果:观察组优良率高于对照组,差异显著(P＜0.05);观察组手术时间、手术出血量、术后下床活动时间、住院时间、并发症率均低于对照组,差异显著(P＜0.05);术前,两组疼痛、改良ODI评分无明显差异(P＞0.05),术后1天、术后3个月、术后6个月,观察组疼痛、改良ODI评分均低于对照组,差异显著(P＜0.05);术前,两组生活质量无明显差异(P＞0.05),术后6个月,观察组生活质量评分高于对照组,差异显著(P＜0.05).结论:与传统开放减压术治疗DLSS比较,UBE椎板开窗减压术治疗可缩短手术时间与恢复时间,减少手术出血与并发症发生,同时可更好地缓解术后疼痛,提高患者生活质量,改善腰椎功能,提高临床效果,值得应用.
目的:子宫肌瘤患者于米非司酮治疗基础上,联合桂枝茯苓胶囊行中西医联合治疗,对促进患者子宫肌瘤体积缩小、改善血清激素水平和保证治疗安全性的价值探究.方法:收录2021年1月—2023年1月期间我院子宫肌瘤患者,共计70例,以随机数字表法做分组处理,就不同组别实施差异性治疗方案,展开对比分析.组别命名为对照组、观察组,样本量组间纳入相当,对应给予米非司酮治疗、桂枝茯苓胶囊联合米非司酮治疗.结果:评价两组疗效,观察组为94.29％,明显高于对照组的77.14％,P＜0.05于治疗前后评价两组子宫及肌瘤体积,治疗前组间差异较小,治疗后两组指标均有所改善,且子宫体积参数、肌瘤体积参数均以观察组更低,P＜0.05.于治疗前后评价两组血清激素水平,治疗前组间差异较小,治疗后两组指标均有所改善,且各项指标均以观察组更低,P＜0.05.统计两组并发症发生情况,观察组为8.57％,明显低于对照组28.57％,P＜0.05.于治疗前后评价两组中医证候积分,治疗前组间差异较小,治疗后两组症状均有所好转,且积分值均以观察组更低,P＜0.05.结论:子宫肌瘤患者于米非司酮治疗基础上,联合桂枝茯苓胶囊行中西医联合治疗,对促进患者子宫肌瘤体积缩小、改善血清激素水平和保证治疗安全性的价值显著.
目的:探讨布地奈德联合特布他林治疗儿童喘息性肺炎的应用价值.方法:选择本院2021年1月—2023年3月收治的138例儿童喘息性肺炎患者为研究对象,随机分组,分为观察组(69例)和对照组(69例);对照组患者给特布他林治疗,观察组在对照组基础上给予布地奈德治疗,比较两组治疗效果.结果:观察组治疗总有效率更高(x2=6.900,P=0.009);观察组各项症状缓解时间及住院时间低于对照组(P＜0.05);治疗后,观察组患者的PaO2水平高于对照组(P＜0.05);观察组患者的PaCO2水平低于对照组(P＜0.05);治疗后,观察组患者的CRP、WBC以及EOS指标低于对照组(P＜0.05);两组患者治疗期间的不良反应发生率对比差异不大(x2=0.697,P=0.404).结论:布地奈德联合特布他林治疗儿童喘息性肺炎的效果良好,可在未来临床中加以应用和推广.
