ObjectiveChronic pain, a major global public health burden, is primarily driven by altered central pain processing, which conventional treatments rarely target directly. This systematic review and meta-analysis synthesized RCT evidence to quantify acupuncture’s modulatory effects on brain networks associated with altered central pain processing, validate its clinical efficacy/safety, and explore brain network-clinical outcome associations.MethodsComprehensive searches of English/Chinese databases (2016–2025) identified RCTs of acupuncture for chronic pain with neuroimaging. Two researchers independently performed study selection, data extraction, and bias assessment. Meta-analysis used RevMan 5.4; heterogeneity was evaluated via I2/Q test, with correlation analysis and GRADE evidence quality assessment.ResultsSeventeen high-quality RCTs comprising 750 patients, with osteoarticular pain and migraine as main subtypes, were included. Acupuncture significantly improved neuroimaging indicators in the anterior cingulate cortex (ACC) and insula (MD = 0.27, p < 0.00001), primary somatosensory cortex (S1) and thalamus (MD = 0.30, p < 0.00001), and default mode network (DMN) (MD = 0.29, p < 0.00001). Clinically, acupuncture reduced Visual Analogue Scale (VAS) scores (MD = -2.31, p < 0.00001) and increased pain relief rate (OR = 4.30, p < 0.00001), with only mild adverse events reported. Osteoarticular pain demonstrated more pronounced efficacy. No significant publication bias was detected. The GRADE assessment rated the evidence for pain relief rate as high.ConclusionAcupuncture exerts dual effects by alleviating clinical pain - exceeding the minimal clinically important difference (MCID) for VAS - and modulating brain networks implicated in altered central pain processing. It is a safe and valuable non-pharmacological intervention, with standardized protocols and subtype-specific application recommended. However, the evidence is constrained by a limited number of studies, heterogeneity in pain subtypes and neuroimaging modalities, and short follow-up durations. Larger RCTs and multimodal neuroimaging studies are needed for further validation.Systematic review registrationRegistered in PROSPERO (CRD420261290299); URL: https://www.crd.york.ac.uk/prospero/.

Aim: This study endeavors to explore the temporal alterations in the disability-adjusted life years (DALYs) of depressive disorders (DD) attributable to childhood sexual abuse (CSA) in China and India, and to predict the future trends of DALYs from 2024 to 2040. Methods: Using the Global Burden of Disease (GBD) Study 2023, we evaluated the impact of CSA on DD, scrutinizing DALYs per 100,000 population. Our analysis incorporated age, sex, and temporal trends in age-standardized rates (ASR), and an age-period-cohort (APC) analysis was conducted to differentiate the effects of age, period, and cohort on the observed temporal trends. BAPC analysis was employed to forecast the DALYs rates and numbers for different sexes from 2024 to 2040. Results: The number of DALYs for DD attributable to CSA increased by 50.7% in China and by 122% in India from 1990 to 2023. Notable gender disparities emerged, with females demonstrating higher ASR of DALYs in both countries. The highest burden was observed in the 40-44 age group for both sexes in India, and for males in China, while females in China peaked at 35-39 age group. The ASR of DALYs attributable to CSA is projected to increase moderately for both sexes in China, while it will increase sharply in India, especially among females. Conclusions: CSA-attributable DD burden remains stable in China but rises significantly in India. Targeted interventions for ages 40-44 and full-cycle strategies covering children/adolescents and adult survivors are essential. Our study will help the government formulate more targeted and effective preventive and intervention strategies for CSA-attributable DD.

Background:Branched-chain amino acids (BCAAs), including isoleucine (Ile), leucine (Leu), and valine (Val), are substrates for synthesising nitrogenous compounds and signalling molecules involved in regulating immunity. To date, data on the role of BCAAs in autoimmune thyroiditis (AIT) are lacking; therefore, this study aimed to determine the causality using two-sample Mendelian randomisation (MR) and explored the role of BCAAs in the cGAS-STING-NLRP3 pathway in vitro. Methods:The causal relationship between BCAAs and the pathogenesis of AIT were identified using a two-sample MR study. The anti-inflammatory effects of BCAAs and their role in the cGAS-STING-NLRP3 pathway were investigated in lipopolysaccharide (LPS)- induced thyroid follicular cells (TFCs). Results:Our findings indicate that BCAAs are a pathogenic factor for AIT (IVW OR = 4.960; 95 % CI = (1.54,15.940); P = 0.007). Leu significantly exacerbated the inflammatory response of thyroid cells, as evidenced by the up-regulation of tumour necrosis factor-alpha (TNF-α) and interleukin (IL)-6 and down-regulation of TGF-β1; simultaneously aggravated cellular injury and oxidative stress; significantly increased the expression of Sestrin2/p-mTOR and cGAS/STING/NLRP3 in AIT cells. Furthermore, the expression of IL-18 and IL-1β was significantly increased. Conversely, Leu deprivation induced cell injury, decreased oxidative stress, and inhibited Sestrin2/p-mTOR and cGAS/STING/NLRP3 pathways. Conclusion:Our findings suggest a potential causal effect of genetically predicted Leu on AIT; Leu significantly exacerbated the inflammatory response and cellular damage in AIT cells. The mechanism by which Leu induces inflammation involves activating the promoted Sestrin2/mTOR and cGAS-STING-NLRP3 signalling pathways. Our study proposes a novel mechanism for the contributions of Leu in AIT and potential therapeutic strategies involving Leu deprivation in treating AIT.

Obstructive sleep apnea (OSA) is associated with metabolic disorders such as insulin resistance and liver fat accumulation. However, the specific mediating role of liver-related metabolic indicators in this association has not been fully studied. The purpose of this study was to investigate the relationship between Metabolic Score for Insulin Resistance (METS-IR) and OSA, focusing on the mediating effects of liver fat percentage (PLF) and hepatic steatosis index (HSI). Understanding these mechanisms may provide insights into targeted interventions for OSA. A total of 12,655 participants from the National Health and Nutrition Examination Survey (NHANES) were included in this analysis. Obstructive sleep apnea (OSA) was assessed using the NHANES questionnaire. Weighted multivariate logistic regression was employed to assess the relationship between METS-IR and OSA, with a mediation model constructed to explore the mediating roles of key liver and metabolic markers, including PLF, HSI, SII and OBS. Among 12,655 subjects, 31.04% had OSA. METS-IR was closely related to the increased risk of OSA, and the highest quartile group of METS-IR had a significantly increased risk of OSA (OR = 2.36, 95% CI 1.73-3.23). Mediating effect analysis showed that PLF and HSI mediated 6.95% and 17.87% of the effects, respectively, while systemic immunity-inflammation index (SII) and oxidative balance score (OBS) had no significant mediating effect. METS-IR is an important predictor of OSA risk, primarily mediated by hepatic lipid accumulation. Addressing insulin resistance and hepatic metabolic health is crucial for the effective management of OSA and provides valuable guidance for clinical risk assessment in susceptible populations.

Nanotechnology has great potential and advantages in the treatment of hepatocellular carcinoma (HCC), but the research trends and future directions are not yet clear. Analyze the development trajectory, research hotspots, and future trends of nanotechnology and HCC research globally in the past 20 years, providing a more comprehensive and intuitive reference for researchers in this field. Retrieve relevant literature on nanotechnology and HCC research in the Web of Science (WOS) Core Collection database, and conduct bibliometric analysis using software such as CiteSpace, VOSviewer, and SCImago Graphica. A total of 852 English publications meeting the criteria were retrieved from the WOS database, with an overall increasing trend in the number of publications and citation frequency over the years. China leads in the number of publications and international collaborations, followed by the USA and India. The most influential research institution is the Chinese Academy of Sciences, the most influential scholar/team is the Rahman, Mahfoozur team, and the journal with the most publications is the International Journal of Nanomedicine. A comprehensive analysis reveals that the current main research directions include new types of nanoparticles, targeted drug delivery systems, photothermal/photodynamic therapy, gene delivery systems, diagnostics, and imaging. It is anticipated that further collaboration among scholars, institutions, and countries will accelerate the development of nanotechnology in the field of HCC research. This study provides an in-depth analysis of the research status and development trends of nanotechnology in treating HCC from a bibliometric perspective, offering possible guidance for researchers to explore hot topics and frontiers, select suitable journals, and partners in this field.

Background and objectivesMajor Depressive Disorder (MDD) is one of the most prevalent and debilitating health conditions worldwide. Previous studies have reported a link between metabolic dysregulation and MDD. However, evidence for a causal relationship between blood metabolites and MDD is lacking.MethodsUsing a two-sample bidirectional Mendelian randomization analysis (MR), we assessed the causal relationship between 1,400 serum metabolites and Major Depressive Disorder (MDD). The Inverse Variance Weighted method (IVW) was employed to estimate the causal association between exposures and outcomes. Additionally, MR-Egger regression, weighted median, simple mode, and weighted mode methods were used as supplementary approaches for a comprehensive appraisal of the causality between blood metabolites and MDD. Pleiotropy and heterogeneity tests were also conducted. Lastly, the relevant metabolites were subjected to metabolite function analysis, and a reverse MR was implemented to explore the potential influence of MDD on these metabolites.ResultsAfter rigorous screening, we identified 34 known metabolites, 13 unknown metabolites, and 18 metabolite ratios associated with Major Depressive Disorder (MDD). Among all metabolites, 33 were found to have positive associations, and 32 had negative associations. The top five metabolites that increased the risk of MDD were the Arachidonate (20:4n6) to linoleate (18:2n6) ratio, LysoPE(18:0/0:0), N-acetyl-beta-alanine levels, Arachidonate (20:4n6) to oleate to vaccenate (18:1) ratio, Glutaminylglutamine, and Threonine to pyruvate ratio. Conversely, the top five metabolites that decreased the risk of MDD were N6-Acetyl-L-lysine, Oleoyl-linoleoyl-glycerol (18:1 to 18:2) [2] to linoleoyl-arachidonoyl-glycerol (18:2 to 20:4) [2] ratio, Methionine to phosphate ratio, Pregnanediol 3-O-glucuronide, and 6-Oxopiperidine-2-carboxylic acid. Metabolite function enrichment was primarily concentrated in pathways such as Bile Acid Biosynthesis (FDR=0.177), Glutathione Metabolism (FDR=0.177), Threonine, and 2-Oxobutanoate Degradation (FDR=0.177). In addition, enrichment was noted in pathways like Valine, Leucine, and Isoleucine Biosynthesis (p=0.04), as well as Ascorbate and Aldarate Metabolism (p=0.04).DiscussionWithin a pool of 1,400 blood metabolites, we identified 34 known metabolites and 13 unknown metabolites, as well as 18 metabolite ratios associated with Major Depressive Disorder (MDD). Additionally, three functionally enriched groups and two metabolic pathways were selected. The integration of genomics and metabolomics has provided significant insights for the screening and prevention of MDD.

Background Obstructive sleep apnea (OSA) is associated with metabolic disorders such as insulin resistance and liver fat accumulation. However, the specific mediating role of liver-related metabolic indicators in this association has not been fully studied. The purpose of this study was to investigate the relationship between Metabolic Score for Insulin Resistance (METS-IR) and OSA, focusing on the mediating effects of liver fat percentage (PLF) and hepatic steatosis index (HSI). Understanding these mechanisms may provide insights into targeted interventions for OSA. Methods A total of 12,655 participants from the National Health and Nutrition Examination Survey (NHANES) were included in this analysis. Obstructive sleep apnea (OSA) was assessed using the NHANES questionnaire. Weighted multivariate logistic regression was employed to assess the relationship between METS-IR and OSA, with a mediation model constructed to explore the mediating roles of key liver and metabolic markers, including PLF, HSI, SII, and OBS. Results Among 12,655 subjects, 31.04% had OSA. METS-IR was closely related to the increased risk of OSA, and the highest quartile group of METS-IR had a significantly increased risk of OSA ( OR = 2.35, 95% CI : 1.72–3.21 ). Mediating effect analysis showed that PLF and HSI mediated 11.22% and 22.78% of the effects, respectively, while systemic immunity-inflammation index (SII) and oxidative balance score (OBS) had no significant mediating effect. Conclusions METS-IR is an important predictor of OSA risk, primarily mediated by hepatic lipid accumulation. Addressing insulin resistance and hepatic metabolic health is crucial for the effective management of OSA and provides valuable guidance for clinical risk assessment in susceptible populations.

BACKGROUND:Neuroinflammation is involved in the advancement of depression. Du-moxibustion can treat depression. Here, we explored whether Du-moxibustion could alleviate neuroglia-associated neuro-inflammatory process in chronic unpredictable mild stress (CUMS) mice. METHODS:C57BL/6J mice were distributed into five groups. Except for the CON group, other four groups underwent CUMS for four consecutive weeks, and Du-moxibustion was given simultaneously after modeling. Behavioral tests were then carried out. Additionally, Western blot was conducted to measure the relative expression levels of high-mobility group box 1 (HMGB1), toll-like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), and nuclear factor-kappa B (NF-κB). Immunofluorescence was employed to evaluate the positive cells of ionized calcium binding adapter molecule 1 (Iba-1) and glial fibrillary acidic protein (GFAP). Furthermore, interleukin-1 beta (IL-1β) and tumor necrosis factor-alpha (TNF-α) were analyzed using an ELISA assay. RESULTS:We found that CUMS induced depression-like behaviors, such as reduced sucrose preference ratio, decreased locomotor and exploratory activity, decreased the time in open arms and prolonged immobility. Furthermore, versus the CON group, the expression of HMGB1, TLR4, MyD88, NF-κB, positive cells of Iba-1, IL-1β and TNF-α were increased but positive cells of GFAP were decreased in CUMS group. However, the detrimental effects were ameliorated by treatment with CUMS+FLU and CUMS+DM. LIMITATIONS:A shortage of this study is that only CUMS model of depression were used, while other depression model were not included. CONCLUSIONS:Du-moxibustion alleviates depression-like behaviors in CUMS mice mainly by reducing neuroinflammation, which offers novel insights into the potential treatment of depression.

Abstract Background Depression and insomnia often co-occur and have a bidirectional relationship. This review utilized bibliometric and visualized analysis to explore current research hotspots and trends in this field to identify future clinical practice directions. Methods To identify papers on the comorbidity of depression and insomnia, the researchers utilized the Web of Science Core Collection (WoSCC). They employed tools such as CiteSpace, VOSviewer, and Scimago Graphica to visually analyze the knowledge network of authors, institutions, countries/regions, journals, cited authors, cited references, cited journals, and keywords in the field of depression comorbid with insomnia. Results A total of 697 papers were extracted from the Web of Science Core Collection (WoSCC) with Andrew D. Krystal being the most influential author in this area. The University of Pittsburgh and the United States emerged as the most prolific institution and country, respectively. The Journal of Affective Disorders was the most productive journal, with primary keywords including insomnia, depression, anxiety, disorder, and sleep. In terms of co-citation analysis, Morin, Cm led the field. The top-cited journal was Sleep, and the paper titled “Validation of the Insomnia Severity Index as an outcome measure for insomnia research” ranked first. Finally, “Psychiatry”was the most frequent study category. Conclusions This bibliometric analysis provides a comprehensive overview of current research on depression comorbid with insomnia and highlights key areas of focus, offering guidance for clinicians and researchers in selecting research directions.

As the second most common neurodegenerative disease globally, Parkinson's disease (PD) affects millions of people worldwide. In recent years, the scientific publications related to PD biomarker research have exploded, reflecting the growing interest in unraveling the complex pathophysiology of PD. In this study, we aim to use various bibliometric tools to identify key scientific concepts, detect emerging trends, and analyze the global trends and development of PD biomarker research.The research encompasses various stages of biomarker development, including exploration, identification, and multi-modal research. MOVEMENT DISORDERS emerged as the leading journal in terms of publications and citations. Key authors such as Mollenhauer and Salem were identified, while the University of Pennsylvania and USA stood out in collaboration and research output. NEUROSCIENCES emerged as the most important research direction. Key biomarker categories include α-synuclein-related markers, neurotransmitter-related markers, inflammation and immune system-related markers, oxidative stress and mitochondrial function-related markers, and brain imaging-related markers. Furthermore, future trends in PD biomarker research focus on exosomes and plasma biomarkers, miRNA, cerebrospinal fluid biomarkers, machine learning applications, and animal models of PD. These trends contribute to early diagnosis, disease progression monitoring, and understanding the pathological mechanisms of PD.

Abstract Post-stroke depression (PSD) is a common neuropsychiatric consequence of stroke that can negatively impact cognitive function, somatic function recovery, and patient survival. This paper utilized bibliometric and visualized analysis to explore current research hotspots and trends in this field to identify future clinical practice directions. Researchers utilized the Web of Science Core Collection (WoSCC) to extract papers on PSD and employed tools such as CiteSpace, VOSviewer, and Scimago Graphica to visually analyze the knowledge network of authors, institutions, countries/regions, journals, cited authors, cited references, cited journals, and keywords. A total of 850 papers were extracted from WoSCC, with Robinson, RG being identified as the most influential author in this area. The most prolific institution was Wenzhou Medical University, and China emerged as the leading country in producing research on PSD. Journal of Affective Disorders was found to be the most productive journal, with the primary keywords including poststroke depression, stroke, depression, and symptom. Co-citation analysis identified Robinson, RG as the leading researcher in PSD. The top-cited journal was Stroke, and the paper titled “Poststroke Depression: A Review” was ranked the most cited. Finally, “Neurosciences & Neurology” emerged as the most frequent study category. This study provided valuable information on the hotspot and frontier in PSD research, including potential partners and institutions, as well as reference points for future research topics and development directions.

BackgroundAnkylosing spondylitis (AS) is a rheumatic and autoimmune disease associated with a chronic inflammatory response, mainly characterized by pain, stiffness, or limited mobility of the spine and sacroiliac joints. Severe symptoms can lead to joint deformity, destruction, and even lifelong disability, causing a serious burden on families and society as a whole. A large number of clinical studies have been published on AS over the past 20 years. This study aimed to summarize the current research status and global trends relating to AS clinical trials through a bibliometric analysis.MethodsThe Web of Science Core Collection database was searched for publications related to AS clinical trials published between January 2003 and June 2023. Bibliometric analysis and web visualization were performed using CiteSpace, VOSviewer, and a bibliometric online analysis platform (https://bibliometric.com), which included the number of publications, citations, countries, institutions, journals, authors, references, and keywords.Results1,212 articles published in 201 journals from 65 countries were included in this study. The number of publications related to AS clinical trials is increasing annually. The United States and the Free University of Berlin, the countries and institutions, respectively, that have published the most articles on AS, have made outstanding contributions to this field. The author with the most published papers and co-citations over the period covered by the study was Desiree Van Der Heijde. The journal with the most published and cited articles was Annals of the Rheumatic Diseases. The keywords: “double-blind,” “rheumatoid arthritis,” “efficacy,” “placebo-controlled trial,” “infliximab,” “etanercept,” “psoriatic arthritis” and “therapy” represent the current research hotspots regarding AS.DiscussionThis is the first study to perform a bibliometric analysis and visualization of AS clinical trial publications, providing a reliable research focus and direction for clinicians. Future studies in the field of AS clinical trials should focus on placebo-controlled trials of targeted therapeutic drugs.

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Background: Triple-negative breast cancer (TNBC) is defined as breast cancer that is negative for estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER-2) in cancer tissue. The lack of specific biomarkers makes the diagnosis and prognosis of TNBC challenging. Method: A comprehensive literature review and bibliometric analysis was performed using CiteSpace, VOSviewer and Scimago Graphica. Results: TNBC biomarker research has been growing rapidly in recent years, reflecting the enormous academic interest in TNBC biomarker research. A total of 127 journals published relevant studies and 1749 authors were involved in the field, with developed countries such as the United States, France, and the United Kingdom contributing greatly to the field. Collaborative network analysis found that the research in this field has not yet formed good communication and interaction, and the partnership should be strengthened in the future in order to promote the in-depth development of TNBC biomarker research. A comprehensive analysis of keywords and co-cited literature, etc. found that TNBC biomarker research mainly focuses on immune checkpoint markers, microenvironment-related markers, circulating tumor DNA, metabolic markers, genomics markers and so on. These research hotspots will help to better understand the molecular characteristics and biological processes of TNBC, and provide more accurate biomarkers for its diagnosis, treatment and prognosis. Conclusions: The bibliometric analysis highlighted global trends and key directions in TNBC biomarker research. Future developments in TNBC biomarker research are likely to be in the direction of multi-omics integration, meticulous study of the microenvironment, targeted therapeutic biomarkers, application of liquid biopsy, application of machine learning and artificial intelligence, and individualized therapeutic strategies. Young scholars should learn and collaborate across disciplines, pay attention to new technologies and methods, improve their data analysis skills, and continue to follow up on the latest research trends in order to meet the challenges and opportunities in the field of TNBC biomarkers.

Background Although there is considerable evidence that obstructive sleep apnea (OSA) is associated with cardiovascular and metabolic risks, such as insulin resistance and visceral fat accumulation, limited studies have explored how these risks are mediated by specific metabolic markers. The purpose of this study was to explore the relationship between Cardiometabolic Index (CMI) and OSA, and to pay special attention to the mediating role of insulin resistance metabolic score (METS-IR). Methods Data from 12,703 participants aged 20 and above were analyzed from the National Health and Nutrition Examination Survey (NHANES). CMI was the primary exposure variable, METS-IR served as the mediating variable, and OSA was the outcome. Multivariate logistic regression models were used to adjust for confounders and assess the relationship between CMI and OSA. Mediation analysis determined the proportion of CMI’s effect on OSA explained by METS-IR. Results Among 12,703 subjects, the prevalence of OSA was 30.88%. CMI was significantly associated with increased OSA risk, and participants with the highest quartile of CMI were significantly more likely to have OSA (OR = 2.06, 95% CI : 1.70–2.49). Mediation analysis showed that METS-IR accounted for 89.8% of the association between CMI and OSA, highlighting the key role of insulin resistance in this pathway. Conclusions CMI is a key predictor of OSA risk, which is mainly mediated by its effect on insulin resistance, as shown by METS-IR. These findings highlight the importance of addressing metabolic dysfunction in the prevention and management of OSA, and CMI and METS-IR provide valuable insights into clinical risk assessment in high-risk populations.

神经性皮炎是一种常见的临床慢性炎症和过敏性皮肤病,具有反复发痒循环的特点[1].神经性皮炎根据皮肤病变的程度分为播散或局部的皮肤病变.临床症状包括干燥,苔藓样(由过度抓伤引起)变厚的皮肤病变,伴有过度发痒.西医治疗神经性皮炎面临严峻挑战,采用局部皮质类固醇、免疫调节剂、抗癫痫药、抗组胺药、抗抑郁药控制病情[2].上述疗法在短期内可以缓解症状,但副作用包括红斑、高发性、灼热和干燥性限制了治疗.神经性皮炎往往复发,因为困难阻碍痒刮循环[3].本案采用刺络拔罐联合雀啄灸治疗,疗效显著,现介绍如下.

Ankylosing spondylitis (AS) is a progressively worsening and disabling form of arthritis that primarily affects the axial skeleton. This disease mainly involves the spine and the sacroiliac joint. Fusion of the spine and the sacroiliac joint may occur in the later stage of the disease, resulting in spinal stiffness and kyphosis, as well as difficulty in walking, which seriously affects the quality of work and daily living activities and imposes a heavy burden on the patient, the family, and society. Increasing attention has been paid to non-pharmacotherapy as an alternative therapy for AS. Moxibustion is an ancient therapeutic technique used in Traditional Chinese Medicine (TCM). Du-moxibustion therapy, a unique and innovative external treatment developed on the basis of ordinary moxibustion, has a definite therapeutic effect on AS. Du-moxibustion skillfully combines the compatible techniques of TCM to integrate meridians, acupoints, Chinese herbal medicine, and moxibustion. This paper describes the operation procedures and precautions to be taken during Du-moxibustion in experimental mice in detail to provide an experimental basis for the study of the mechanism of Du-moxibustion in the treatment of AS.

总结杨继国教授基于"一排二灸三围刺"方法治疗腘窝囊肿的临床经验.腘窝囊肿属于中医学"筋瘤""胶瘤"范畴,因风、寒、湿邪入侵膝关节或外伤使筋脉损伤,局部气血不畅,津液运行失常,湿聚成痰,痰湿凝滞而成.流行病学调查发现胭窝囊肿在35～75岁人群高发,多与膝关节炎性疾病关系密切.杨继国教授认为该病治疗应中西结合,标本兼治,临床采用"一排二灸三围刺"的治疗方法,三者结合临床效果显著.

The sacroiliac joint is an important part of human life behavior and daily activities. With the increase in people's lives and work pressure and the change of travel mode, the incidence rate of sacroiliac joint subluxation is getting higher and higher. The purpose of this study is to explore the relationship between medical choice, health behavior, and health status of patients with sacroiliac joint subluxation and put forward feasible suggestions for promoting the treatment and rehabilitation of patients. The EuroQoL 5 Dimensions 5 Levels health index survey scale was selected to investigate the health status of patients with sacroiliac joint subluxation. T test and analysis of variance were used for univariate analysis of medical choice and health behavior of patients with sacroiliac subluxation, and ordinary least squares was used for multivariate analysis. The elderly patients with subluxation of sacroiliac joint are in poor health. The health status of patients who chose to seek medical treatment for disease diagnosis and prescription was significantly worse. Patients with subluxation of sacroiliac joint with regular defecation have better health status. Patients who travel by bike or bus have worse health. The health status of those who sit still for more than 1 hour a day is significantly better. The health status of patients with sacroiliac subluxation is closely related to their choice of medical treatment and health behavior. It is suggested that rehabilitation therapy such as acupuncture and manipulation should be selected for intervention. Good health behaviors such as abstinence and regular defecation should be shaped. More attention should be paid to the health status of women at risk.

临床实践表明,针刺治疗眼疾疗效显著,在治疗眼疾时往往取眼部穴位,但眼部解剖结构复杂,易发生眼部血肿等针刺意外,这在一定程度上限制了针刺在临床眼科疾病治疗中的应用.为此,眼部血肿的处理及预防成为针灸医师必须掌握的内容.本文从血肿发生的原因、处理应对措施及针刺致血肿预防三方面入手,重点论述针刺致眼区重度出血的临床处理,以期为临床工作者针刺眼区穴位提供有益的参考.