This study reviewed relevant literature to summarize clinical research on the treatment of adult amblyopia with transcranial magnetoelectric stimulation（TMS） from aspects of improving visual functions such as contrast sensitivity, vision, contour integration, and discrimination ability, as well as the effect of sensory perception training, in order to provide reference for clinical treatment of adult amblyopia.At present, the application of transcranial magnetoelectric stimulation in the treatment of adult amblyopia is relatively limited, and there is no consensus on the optimal treatment plan for transcranial magnetoelectric stimulation in the treatment of adult amblyopia.In the future, a large number of studies need to be conducted to determine the optimal treatment parameters and formulate the optimal treatment plan.
This article reviews the relevant literature and systematically summarizes the name, etiology, pathogenesis, syndrome and treatment classification, and prevention taboos of asthma and clarifies the development of all the above. On this basis, the paper points out the difficult questions in the theoretical research of asthma in modern medicine, providing new ideas for the formulation and clinical treatment of asthma in the future, as well as expanding the approaches of researching on asthma in modern biology.
Objective To observe the clinical efficacy of consciousness-restoring resuscitation acupuncture combined with pregabalin in the treatment of post stroke thalamic pain.Methods 200 patients with post stroke thalamic pain were randomly divided into a control group and a treatment group with 100 patients each. The control group was treated with oral pregabalin, and the treatment group was treated with consciousness-restoring resuscitation acupuncture based on the treatment method in the control group. After 8 weeks of continuous treatment, the clinical efficacy, visual analogue scale（VAS） scores, clinical symptom scores, Pittsburgh sleep quality index（PSQI） scores, and life quality scores of the two groups were compared before and after treatment.Results The total effective rate was 98%（98/100） in the treatment group and 89%（89/100） in the control group, with a statistically significant difference between the two groups（P＜0.01）. After treatment, the VAS score, clinical symptom score, and PSQI score in the two groups were significantly reduced, while the life quality scores were significantly increased, with a statistically significant difference compared to the same group before treatment（P＜0.01）.Moreover, the improvement in the treatment group was more significant, with a statistically significant difference compared to the control group after treatment（P＜0.01）.Conclusion Consciousness-restoring resuscitation acupuncture combined with pregabalin has a significant effect on the treatment of post stroke thalamic pain, which can significantly improve the clinical symptoms, sleep, and life quality of patients.
Pharmacology of traditional Chinese medicine is a bridge discipline connecting traditional medicine and modern medicine, as well as an important supporting discipline for the inheritance and innovative development of traditional Chinese medicine.Its teaching reform is related to the cultivation of high-quality talents and innovative development of traditional Chinese medicine.According to the characteristics of the professional knowledge of pharmacology of traditional Chinese medicine and following “golden course”criteria—advancement, innovation and challenging, teachers should optimize and reorganize the teaching content, comprehensively improve the teaching metho-ds, and change the evaluation methods; by flipping the classroom, change the focus from form to content, from theory to practice, and from process learning to effect feedback.By such teaching reform and practice, the study found that the students of Grade 2019 majoring in Chinese pharmacy in Gansu University of Chinese Medicine showed a signi-ficant improvement in their participation and enthusiasm in the course learning, and the teaching objectives of the course have been mostly achieved.The teaching effect has significantly improved.Compared with Grade 2018,the failure rate of students in Grade 2019 in the final exam decreased from 20.5% to 2.3%;The final average score increased to 78.5 points, an increase of 22.0%;the overall average score of the course increased to 82.0 points, an increase of 15.0%;in addition to significant changes in performance, students’ “soft power” in learning has significantly enhanced.
Objective To analyze the stroke predictive Instrument-Ⅱ（SPI-Ⅱ） score and its risk factors in cerebral infarction convalescents with different TCM syndromes.Methods The clinical data of 415 convalescents with cerebral infarction admitted to the inpatient department of Neurology, Affiliated Hospital of Gansu University of Chinese Medicine from January 2017 to December 2021 were retrospectively analyzed, and the syndrome differentiation of the patients was divided into four types: hyperactivity of liver-yang, interjunction of phlegm-stasis, qi deficiency and blood stagnation, phlegm-dampness covering orifices.SPI-Ⅱ was used to analyze the recurrence risk and risk factors of cerebral infarction convalescents with different TCM syndromes.Results In 415 cases of cerebral infarction convalescents, the main TCM syndrome type was hyperactivity of liver-yang, accounting for 51.08%.There were statistically significant differences in stroke risk scores between the syndrome of hyperactivity of liver-yang and the other two syndromes, namely, interjunction of phlegm-stasis and phlegm-dampness covering orifices（P＜0.01）.There was statistical significance in the high recurrence risk of hyperactivity of liver-yang compared with the other three syndrome types（P＜0.01）. SPI-Ⅱ score of cerebral infarction convalescents with hyperactivity of liver-yang syndrome were positively correlated with age, hypertension, diabetes and triglyceride（TG）（P＜0.01）.SPI-Ⅱ score of convalescents with phlegm-stasis interjunction syndrome was positively correlated with age, TG and hypertension（P＜0.05 or P＜0.01）.The score of SPI-Ⅱ in convalescents with qi deficiency and blood stagnation was positively correlated with age and TG（P＜0.01）.There was a positive correlation between SPI-Ⅱ score and TG in patients with phlegm-dampness covering orifices syndrome（P＜0.01）.Conclusion The syndrome of hyperactivity of liver-yang is common type of high risk of recurrence in patients with cerebral infarction. Age, hypertension, diabetes and TG are the main factors affecting SPI-Ⅱ score stratification.
Objective To optimize the processing technology of ginger-roasted Amomum villosum Lour.. Me-thods The content of camphor, borneol, and bornyl acetate in ginger roasted Amomum villosum Lour. was determined by gas chromatography（GC） using a DB-WAX capillary column（50.00 m×0.32 mm×1.00 μm）,detector temperature 280 ℃,split flow injection, split flow ratio 5∶1,flow rate 1.0 mL/min, injection port temperature 230 ℃,injection amount 1.0 μL.Using the content of camphor, borneol, and bornyl acetate in Amomum villosum Lour. as the evaluation index, a single factor experiment was conducted to investigate the effects of stir-frying frequency, processing temperature, spraying time of ginger juice, and stir-frying time after spraying ginger juice on the content of camphor, borneol, and bornyl acetate in Amomum villosum Lour.. The Box-Behnken response surface method was used to optimize the optimal processing technology for ginger roasted Amomum villosum Lour.. Results Camphor, borneol, and bornyl acetate had good linear relationships within their respective linear ranges, and their precision, repeatability, and stability met the test requirements. The average sample recovery rates were 97.96%,98.26%,and 98.68%,respectively. The RSDs were 1.65%,1.57%,and 1.54% respectively. Response surface optimization showed that the optimal processing technology for ginger-roasted Amomum villosum Lour. was as follows: stir frying frequency 85 times per minute, spraying ginger juice for 2.7 minutes, processing temperature 138 ℃,spraying ginger juice for 1.7 minutes, and the predicted comprehensive score was 97.76%. Conclusion The optimized processing technology of ginger-roasted Amomum villosum Lour. is simple, stable, and reliable, which can better guarantee the quality of ginger roasted Amomum villosum Lour..
By reviewing relevant literature, this paper summarizes the basic characteristics of KKAy mice with type 2 diabetes and the intervention effect of single and compound Chinese medicine on KKAy mice, and analyzes the hypoglycemic effect of Chinese medicine on KKAy mice with type 2 diabetes.It is believed that KKAy mice would develop the symptoms of polydipsia, polyphagia, polyuria, often suffering from obesity, hyperglycemia, hyperinsulinemia, pancreatic islet dysfunction, liver and kidney damage and other complications.Its mechanism of occurrence and development is very close to human type 2 diabetes, which can be widely used in the experimental study of type 2 diabetes.Some progress has been made in the research on the hypoglycemic effect and complications of single Chinese medicine and compound Chinese medicine on type 2 diabetes model KKAy mice, but still more in-depth research is needed on its mechanism.
总结柳刚主任医师通过针灸治疗轻度认知障碍的经验.其认为,轻度认知障碍病位在脑,与五脏相关,尤其与脾肾密切相关,基本病机为脾肾亏虚、髓海失养,或痰瘀互结、蒙蔽清窍.其临证善于灵活运用"通督调神"针刺结合辨证选穴及"化瘀通络"灸,辅以电针、记忆训练等方法治疗轻度认知障碍,临床疗效显著.附典型病案1则以验证.
Objective To observe the clinical efficacy of myofascial release combined with proprioceptive neuromuscular facilitation（PNF） in the treatment of patellofemoral pain syndrome（PFPS）.Methods 64 patients with PFPS were randomly divided into a control group and a treatment group, with 32 patients in each group.The control group was treated with ultrashort wave combined with PNF,while the treatment group was treated with myofascial release combined with PNF.Both groups were treated 4 times a week for 6 consecutive weeks.The visual analogue scale（VAS）score, the knee joint Lysholm function score, and the surface electromyographic median frequency（MF） values of the gluteus maximus, medial femoral, and lateral femoral muscles were compared between the two groups before treatment, 6 weeks after treatment, and 1 month of follow-up.Results After 6 weeks of treatment and 1 month of follow-up, the VAS score of the two groups significantly decreased, while the Lysholm knee function score, the MF values of the gluteus maximus, medial femoral muscle, and lateral femoral muscle significantly increased, with a statistically significant difference compared to the same group before treatment（P＜0.05）,and the treatment group improved more significantly, with a statistically significant difference compared to the control group after treatment（P＜0.05）.Conclusion Myofascial release combined with PNF can alleviate pain in patients with PFPS,improve knee function, and maintain a good short-term effect.
目的 观察妇康丸联合中药穴位敷贴对剖宫产术后子宫复旧的影响.方法 将123例剖宫产术后产妇采用随机数字表法分为对照组58例和治疗组65例,对照组产妇术后给予常规护理、静脉滴注缩宫素,并口服益母草胶囊;治疗组在对照组治疗方法的基础上口服妇康丸,并选取关元和子宫穴进行中药穴位敷贴,每贴8～10h.2组共服用药物5 d.比较2组术后24 h出血量,术后第3天、第5天宫底高度,术后第10天子宫前后径、长径及横径,以及恶露持续时间.结果 治疗组术后24 h出血量,术后第3天及第5天宫底高度,术后第10天子宫长径、横径及前后径均小于对照组,恶露持续时间均短于对照组,2组比较差异有统计学意义(P＜0.05).结论 妇康丸联合中药穴位敷贴可促进剖宫产术后产妇子宫复旧,减少出血量.
目的 观察脾胃培源方治疗慢性萎缩性胃炎脾胃虚弱证的临床疗效.方法 将80例慢性萎缩性胃炎脾胃虚弱证患者采用随机数字表法分为对照组和治疗组,各40例.对照组给予胃复春口服,治疗组给予脾胃培源方治疗,2组均连续治疗3个月.观察2组的临床疗效,以及治疗前后中医症候积分,胃镜病理积分,血清超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GAH-PX)、丙二醛(MDA)、胃泌素17(G17)、胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)水平,PG Ⅰ和PGⅡ的比值(PGR).结果 治疗后2组胃脘疼痛、胃脘胀满、胃脘痞闷、食少、神疲乏力、气短懒言、便溏积分,胃镜病理积分,血清MDA、G17、PGⅡ水平明显降低,血清PGⅠ、SOD、GSH-PX水平及PGR明显升高,与同组治疗前比较差异均有统计学意义(P＜0.05),且治疗组改善更明显,与对照组治疗后比较差异均有统计学意义(P＜0.05);治疗组总有效率为92.5％(37/40),对照组为75.0％(30/40),2组比较差异有统计学意义(P＜0.05).结论 脾胃培源方可改善慢性萎缩性胃炎脾胃虚弱证患者的临床症状、病理学改变、胃功能及氧化应激指标,促进胃黏膜细胞的损伤修复.
Objective To investigate the occupational injuries status among emergency medical staff in Lanzhou and analyze the related risk factors.Methods From March 2022 to July 2022,the researchers used the cluster random sampling method to select medical staff in emergency departments of 11 hospitals in Lanzhou as the study subjects, designed the occupational injury questionnaire on the template of existing questionnaire and carried out this investigation.Results The overall incidence of sub-health among emergency medical staff in Lanzhou was 75.48%,mainly manifested by poor sleep quality（74.52%）,dizziness, brain distention, and muscle pain（74.04%）;the overall incidence of occupation-related injuries was 76.44%（159/208）,dominated by needle-stick injuries（35.10%） and oral ulcers（29.46%）;the overall incidence of occupation-related diseases was 64.90%（135/208）,mainly being neurasthenia（35.10%） and lumbar cervical spondylosis（22.12%）. By univariate and multivariate logistic regression analysis, working years＞10 years, frequent exposure to radiation such as X-rays, frequent exposure to hazardous chemical substances, and frequent exposure to patients with infectious diseases were the main risk factors for the sub-health status among emergency medical staff（P＜0.05 or P＜0.01）;tertiary hospitals, age＞40 years, and frequent breaking of ampoules or use of sharp instruments were risk factors for occupationally related injuries（P＜0.05 or P＜0.01）;years of work＞10 years, low job satisfaction, frequent exposure to light radiation, and frequent facing to death were risk factors for occupationally related diseases（P＜0.05 or P＜0.01）.Conclusion The ratio of incidence of sub-health, occupational-related injuries, and occupational-related diseases among emergency medical staff in Lanzhou is high, and it is recommended to strengthen the training of medical staff in occupational protection, especially the emergency treatment measures after occupational exposure.
Objective To summarize the medication patterns of professor LI Yingdong in the treatment of chronic heart failure（CHF）.Methods 354 prescriptions of professor LI Yingdong for CHF were collected, and the TCM inheritance assistance platform（V2.5） was used for drug frequency analysis, drug association rule analysis, common drug association degree analysis, complex system entropy cluster analysis and entropy cluster analysis of new prescriptions.Results The study found that 26 traditional Chinese medicines were more often used（with a frequency of ≥30）,and the top seven were Ramulus cinnamomi,Fructus Aurantii,Salvia miltiorrhiza, roasted Glycyrrhizae radix,Paeoniae Radix Rubra,fried Atractylodes macrocephala,and Poria cocos. The top seven drug combinations were Ramulus cinnamomi-Fructus Aurantii,Salvia miltiorrhiza-Ramulus cinnamomi,Salvia miltiorrhiza-Fructus Aurantii,Salvia miltiorrhiza-Ramulus cinnamomi-Fructus Aurantii,roasted Glycyrrhizae radix-Ramulus cinnamomi,Glycyrrhizae radix-Fructus Aurantii,and Glycyrrhizae radix-Ramulus cinnamomi-Fructus Aurantii. Twelve groups drug combinations were found, and six new prescriptions for the treatment of CHF were extracted. Conclusion Professor LI Yingdong often uses cold and warm drugs in the treatment of CHF,and herb pairs. The medication pattern conforms to the pathogenesis characteristics of the disease, which can provide a new medication idea for clinical treatment of CHF.
目的 观察加味八正散对慢性肾小球肾炎模型大鼠血清肝细胞生长因子(HGF)及血管内皮生长因子(VEGF)的影响,探讨加味八正散治疗慢性肾小球肾炎的作用机制.方法 将90只SD大鼠适应性饲养7 d后,采用随机数字表法分为空白组,模型组,阳性对照组,加味八正散低、中、高剂量组6组,每组15只.除空白组外,其余各组大鼠均在腹股沟处皮下及尾静脉注射阳离子化牛血清白蛋白溶液,建立慢性肾小球肾炎大鼠模型.造模成功后,加味八正散高、中、低剂量组分别灌胃加味八正散溶液36,18,9 g/(kg·d),阳性对照组灌胃肾炎康复片混悬液0.6 mg/(kg·d),空白组与模型组均灌胃相同体积的蒸馏水,连续灌胃6周.末次给药后,大鼠腹主动脉取血,分离血清,采用酶联免疫吸附法测定各组大鼠血清HGF、VEGF含量.结果 与空白组比较,模型组大鼠血清HGF、VEGF含量明显降低(P＜0.01);与模型组比较,加味八正散各剂量组及阳性对照组大鼠血清HGF、VEGF含量均明显升高(P＜0.01).结论 加味八正散可升高慢性肾小球肾炎模型大鼠血清HGF、VEGF含量,促进肾脏间质血管再生和修复.
目的 运用网络药理学方法探究大泻心汤治疗肺癌的作用机制.方法 通过中药系统药理学数据库与分析平台(TCMSP)获取大泻心汤中单味药的活性成分及其靶点.利用疗效药靶数据库(TTD)、Dis-GeNET数据库查找肺癌相关靶点,使用Cytoscape 3.7.2软件确定该复方治疗肺癌的关键靶标,绘制蛋白质-蛋白质相互作用(PPI)图,同时构建"中药-化合物-靶点-疾病"网络构建图.使用DAVID平台对共同靶点进行基因本体(GO)功能分析和京都基因与基因组百科全书(KEGG)信号通路富集分析,并使用Omicshare Tools进行可视化.结果 大泻心汤共筛选获得164个活性成分,与肺癌疾病靶点交集出154个共同靶点,通过筛选共同靶点得到27个关键靶点,主要为信号转导和转录活化因子3(STAT3)、丝氨酸/苏氨酸蛋白激酶1(AKT1)、丝裂原活化蛋白激酶1(MAPK1)及肿瘤抑制基因TP53等.GO功能分析显示与细胞氧化应激反应、核受体、转录因子调节等有关;KEGG信号通路富集分析得到173条信号通路,主要涉及乙型肝炎、糖尿病并发症中的AGE-RAGE信号通路、流体剪切应力与动脉粥样硬化、小细胞肺癌、胰腺癌、人T细胞白血病病毒1感染等多条信号通路.结论 大泻心汤主要通过多成分、多靶点、多通路抑制肿瘤细胞的增殖和生长,从而治疗肺癌.
This study reviewed the relevant literature, summarized the pharmaceutical characteristics of insect drugs and the clinical application characteristics of insect drugs in the treatment of gastrointestinal tumors（esophageal cancer, gastric cancer, colon cancer, liver cancer, pancreatic cancer）,and introduced the usage and taboos of insect drugs.The anti-tumor mechanism of insect drugs is elaborated from the perspectives of inhibiting tumor cell proliferation, inducing tumor cell apoptosis, inhibiting tumor blood vessel and lymphatic vessel regeneration, and immune regulation.It is pointed out that the collateral diseases theory in traditional Chinese medicine can explain the occurrence and development of tumors.It is believed that future research should focus on the pathogenesis of gastrointestinal tumors from the perspective of collateral diseases, as well as the anti-tumor mechanism of insect drugs, providing new ideas for pharmacological research of traditional Chinese medicine in treating tumors and insect drugs.
目的 通过生物信息学分析方法,系统评价miR-125a-5p在胃癌组织中的表达及其与临床病理特征的相关性;通过实验观察miR-125a-5p在胃癌组织中的表达,分析其临床意义,并采用生物信息学方法,进行靶基因和信号通路富集分析.方法 采用实时荧光定量聚合酶链式反应(PCR)法检测miR-125a-5p在胃癌组织和癌旁组织中的表达,并分析其临床意义;采用UALCAN数据库分析miR-125a-5p在胃癌组织中的表达及临床病理特征;采用miRecords数据库的预测软件预测其靶基因,选择至少3个以上软件支持的靶基因,运用DAVID 6.7在线富集分析靶基因参与的信号通路.结果 生物信息学分析和实验研究均发现,相对于癌旁组织,miR-125a-5p在胃癌组织中表达明显下调(P＜0.05),其表达与肿瘤淋巴结转移、浸润深度、肿瘤组织增殖阶段、肿瘤组织类型相关(P＜0.05);生物信息学分析提示,miR-125a-5p与临床病理特征关系密切,其靶基因富集在33个与肿瘤相关的信号通路中.结论 miR-125a-5p是胃癌中下调表达的分子标记物,是潜在的具有临床相关性的抑癌基因,是与临床病理特征关系密切的胃癌标记物.
目的 观察针刺辅助治疗轻中度阿尔茨海默病(AD)肾虚髓减证的临床疗效.方法 将90例轻中度AD肾虚髓减证患者采用随机数字表法分为对照组(45例,其中脱落2例、死亡1例)和治疗组(45例,其中脱落1例).对照组给予常规疗法治疗,包括基础治疗(调控血压、降血脂、降血糖、抗血小板聚集、营养脑神经、改善脑局部微循环、抗炎等)和康复训练(运动训练、记忆力训练、专注力训练、注意力训练等);治疗组在对照组治疗方法的基础上给予针刺治疗,主穴取百会、四神聪,配穴取神门、神庭、神通、本神,每日针刺1次,每次留针20 min.治疗4周后比较2组的临床疗效、不良反应发生率,以及治疗前后阿尔茨海默病行为病理评定量表(BEHAVE-AD)评分、日常生活功能量表(ADL)评分,脑血流动力学指标[大脑基底动脉(BA)、中动脉(MCA)血流速度]和血清蛋白[高迁移率族蛋白B1(HMGBl)、髓鞘碱性蛋白(MBP)]水平.结果 治疗组总有效率为90.9％(40/44),对照组为78.6％(33/42),2组比较差异有统计学意义(P＜0.05);治疗后2组BEHAVE-AD评分,血清HMGBl、MBP水平均明显降低,ADL评分,BA、MCA血流速度均明显升高,与同组治疗前比较差异有统计学意义(P＜0.05或P＜0.01),且治疗组改善更明显,与对照组治疗后比较差异均有统计学意义(P＜0.01);2组在治疗期间均未出现明显不良反应.结论 针刺辅助治疗轻中度AD肾虚髓减证疗效显著,可明显改善患者的临床症状,提高日常生活能力,其作用可能与改善患者脑部血流动力学指标及血清蛋白水平有关.
目的 建立敦煌安寐丸的质量标准.方法 参照《中华人民共和国药典(四部)》2020年版通则大蜜丸质量要求,采用薄层色谱(TLC)法对敦煌安寐丸中丹参、首乌藤、远志、黄芩、黄连、枳壳等6味中药进行定性鉴别;采用高效液相色谱(HPLC)法对敦煌安寐丸中的指标性成分斯皮诺素、柚皮苷、黄芩苷及丹参酮ⅡA进行含量测定;建立HPLC指纹图谱并进行相似度分析.结果 TLC法能够有效鉴别6味中药,薄层斑点清晰且阴性对照无干扰.斯皮诺素、柚皮苷、黄芩苷及丹参酮Ⅱ A的回归方程分别为Y=1.6895×107X-5.5407×104(r=0.9999),Y=9.2072×107X-2.0461×104(r=0.9999),Y=1.2132×108X-1.7738×105(r=0.9999),Y=1.2987×107X-9.7682×104(r=0.9999);线性范围分别为 0.006～0.120,0.060～1.200,0.070～1.400,0.002～0.040 mg;平均加样回收率分别为 100.29％,101.42％,99.79％,101.59％;RSD 分别为 1.69％,1.60％,1.53％,1.89％;15批样品中斯皮诺素、柚皮苷、黄芩苷及丹参酮Ⅱ A含量范围分别为0.1087～0.2981,0.0485～0.1258,0.1925～0.5699,0.1214～0.2998 mg/g.建立了15批敦煌安寐丸的HPLC指纹图谱,相似度均大于0.9,共确定了21个共有峰,并指认其中4个共有峰.结论 所建立的质量控制方法专属性强、简便、快捷,可用于该制剂的质量控制.
通过对"中医西传"和"中医西创"相关历史进行探索研究,以"中医西创"为切入点,介绍了部分具有代表性的"中医西创"实例,如针灸西创、中医理论西创及中药西创,并重点介绍针灸西创过程中的代表人物事迹、案例及器物;同时,总结了"中医西创"给现代中医发展带来的思考和启示,以期能在更为广泛的视角下认识中医的传播发展之路,并为现代中医的创新发展提供更多的参考方向,助力中医药更加全面繁荣发展,走向国际舞台.
