The active ingredients of traditional Chinese medicine(TCM)generally have poor solubility,low content,and cumbersome extraction and separation methods,which are not conducive to detection and analysis and poor medicinal properties,limiting their clinical application.New nanomaterials such as Graphene oxide(GO)have been gradually used in the extraction,separation and purification of active components of TCM and anti-tumor therapy due to their unique physicochemical properties,which are expected to improve the clinical application limitations of TCM and promote the clinical development of TCM.Based on the structural properties of GO,this paper summarizes the application of GO in the effective components of TCM,including promoting the dissolution of the effective components of TCM and improving the separation and purification efficiency,improving bioavailability,enhancing drug potency,improving tumor targeting,sustained release,and enhancing curative effect.The existing problems and future development of GO are discussed.The purpose of this study is to provide reference for the development of GO and its derivatives in the field of TCM and the clinical application of active components of TCM.
The clinical treatment of skin diseases that affect appearance is more difficult.This article is prescribed by the medical records of skin diseases that damage the appearance by collecting and using flower drugs,select classic medical case and collect relevant literature,and explore flower drugs from the perspective of pharmaceutical thinking and the principle of governance.Existing the advantages in treating skin diseases that damage the appearance.
Drug safety has always been a hot topic in the world.The basis of evaluating drug safety lies in the standardization of terms of adverse drug reactions,which can provide a basis for drug regulators to evaluate drug safety.By means of literature search and web search,this paper summarized and introduced the summary,hierarchical structure and application characteristics of the existing international glossary of adverse reaction terms MedDRA,WHO-ART,CTCAE and OMERACT.At the same time,it also analyzes the practical problems encountered in the use of the existing adverse reaction term set.Based on the characteristics of safety evaluation of traditional Chinese medicine(TCM),this paper discussed the establishment of a glossary of adverse reactions of TCM.
[Objective]To explore the correlation between serum calcium level and disease activity in patients with rheumatoid arthritis(RA)and its distribution in different traditional Chinese medicine(TCM)syndromes.[Methods]A total of 160 outpatients and inpatients with RA in our hospital from October 2020 to October 2022 were enrolled as the study group,and 160 healthy people who underwent routine physical examination in the physical examination center of our hospital were selected as the healthy control group(HC group),and the differences in serum calcium levels between the two groups were compared.According to TCM syndrome differentiation,the study group was divided into four groups:phlegm and stasis syndrome group,cold-dampness obstruction syndrome group,damp-heat obstruction syndrome group,liver and kidney deficiency syndrome group.We compared the distribution of each serum calcium level among different groups of RA patients.Spearman correlation analysis was used to study the relationship between serum calcium level and erythrocyte sedimentation rate(ESR),hypersensitive C-reactive protein(hs-CRP),rheumatoid factor(RF),anti-cyclic citrullinated peptide(CCP)antibody level,antistreptolysin O(ASO)and the course of disease in RA patients.And pearson correlation analysis was used to explore the relationship between serum calcium level and Disease Activity Score 28(DAS28).[Results]The serum calcium level in RA group was lower than that in HC group(P＜0.01).Among the four groups,the serum calcium level in the phlegm-stasis syndrome group and the cold-dampness obstruction syndrome group were significantly higher than that in the damp-heat obstruction syndrome group and the liver and kidney deficiency syndrome group(P＜0.01).The serum calcium level was negatively correlated with DAS28(rs=-0.398,P＜0.01),and negatively correlated with ESR(rs=-0.289,P＜0.01).It was negatively correlated with hs-CRP(rs=-0.351,P＜0.01),and negatively correlated with the course of disease(rs=-0.423,P＜0.01),but had no significant correlation with RF,anti-CCP antibody and ASO.[Conclusion]Serum calcium level in RA patients is significantly lower than that in healthy people,which was negatively correlated with disease activity and disease course.The distribution of serum calcium level in TCM syndrome types of RA is regular,which provides objective reference value for TCM syndrome differentiation.
Vascular Parkinson's syndrome is a secondary Parkinson syndrome caused by cerebrovascular diseases.With the aging of the population,the incidence rate of this disease is increasing with the increase of cardiovascular and cerebrovascular diseases.However,there is no effective treatment method yet,and acupuncture therapy has obvious advantages and characteristics.This paper introduces a case of Treating Vascular Parkinson's syndrome with Taiji Liuhe acupuncture method.Taiji Liuhe acupuncture method adopts"four step regulation"acupuncture method to form the meridian regulation system of Taiji and Eight Trigrams.It has less acupoints and less pain stimulation.It can regulate qi and blood meridians of the whole body,balance viscera and yin and yang,and drive away diseases.
