With the widespread application of percutaneous coronary intervention(PCI)in patients with coronary heart disease(CHD),the mortality of patients with CHD has gradually decreased.However,there is an increased risk of major adverse cardiovascular events after PCI.Therefore,early and accurate risk stratification is crucial for the postoperative management of CHD patients after PCI.Age,creatinine and ejection fraction(ACEF)score includes age,creatinine,and left ventricular ejection fraction,the data are easy to obtain,and its accurate predictive ability has been widely verified in a variety of clinical practices.This article will review the application of the ACEF score and its derivative scores in patients with CHD after PCI.
Absent in melanoma 2(AIM2)recognizes double-stranded DNA from pathogenic microorganisms or the host itself,causing activated caspase-1 to shear pro-interleukin(IL)-1 β and pro-IL-18 and mediating the maturation and secretion of the inflammatory factors IL-1β and IL-18 to elicit an intrinsic immune response.In addition,AIM2 inflammasome can convert Gasdermin D(GSDMD)to GSDMD-N,which promotes the release of cytokines and various cytoplasmic contents,causing cell membrane rupture and leading to pyroptosis.An increasing number of studies have shown that the development process of cardiovascular diseases,such as atherosclerosis,myocardial infarction and heart failure,is associated with AIM2 inflammasome,IL-1[3 and pyroptosis.This paper reviews the possible mechanisms of the role of AIM2 inflammasome in the development of cardiovascular diseases based on the current available studies,with the aim of providing new ideas for the targeted therapy of cardiovascular diseases.
Patient-reported outcomes(PROs)are any reports on the patient's health status that comes directly from the patient,providing the most direct and realistic efficacy evaluation indicators for clinical research and practice from the patient's perspective.With the development of individualized medicine model and the promotion of patient-centered medicine concept,PROs are receiving increasing attention and have been promoted by more and more researchers.Understanding the application of PROs in clinical trials is a necessary step to further improve the quality of clinical research.Taking the cardiovascular field as an example,this paper elaborates and summarizes the application status of PROs in clinical trials,in order to provide reference and suggestions for the application and development of PROs in domestic clinical trials.
Acute myocardial infarction is a serious type of coronary heart disease,which is the main cause of death and disability.In recent years,nanomaterials,as a new therapeutic method,have shown great potential in the diagnosis and treatment of clinical diseases.This article describes the progress of nanomaterials in the treatment of myocardial infarction from the aspects of reactive oxygen species scavenging,inflammatory reaction,myocardial cell apoptosis,myocardial fibrosis,cardiac vascular regeneration,and anti-myocardial infarction related arrhythmia,aiming to provide new ideas for the treatment of myocardial infarction.
Myosin phosphatase targeting subunit(MYPT)family includes five members.They can influence the activity of myosin light chain phosphatase(MLCP)and cell function,regulating Rho/ROCK pathway and NO/cGMP/PKG pathway through their own phosphorylation,thus playing an important role in the occurrence and development of cardiovascular disease.This article reviews the structure of MYPT family members,their relationship with cell function and signaling pathways,and their mechanism of action in cardiovascular disease,so as to provide a theoretical basis for the research and treatment of cardiovascular disease.
