Objective To investigate the relationship between prolonged QRS duration in inferior and lateral leads and short-term outcomes of patients with acute pulmonary embolism(APE).Methods A total of 101 patients with APE diagnosed by pulmonary CT angiography in Ruian People's Hospital from January 2021 to June 2022 were included.According to QRS duration in inferior and lateral leads,the patients were divided into QRS duration≥100ms group(n=42)and QRS duration＜100 ms group(n=59).The past medical history,the results of laboratory examination,electrocardiogram and echocardiography at admission were collected.Cox proportional hazards model was used to analyze influencing factors of death within 30 days after APE.Results The percentage of patients with chronic lung disease was significantly higher in QRS duration≥100 ms group than in QRS duration＜100 ms group(P＜0.05).The proportion of cardiac arrest,syncope,medium to high risk,and high-risk patients,cTnI,and mortality within 30 days in the QRS duration≥100 ms group were higher than those in the QRS duration＜100 ms group,and SpO2 was lower than that in the QRS duration＜100 ms group(all P＜0.05).Cox univariate analysis showed that heart failure,chronic lung disease,cardiac arrest,high-risk,QRS duration≥100 ms were associated with death within 30 days after APE(all P＜0.05).Cox multivariate analysis showed that heart failure and QRS duration≥100 ms were independent predictive factors for the death of APE within 30 days(all P＜0.05).Conclusion APE patients with prolonged QRS duration in inferior and lateral leads have higher mortality rate with 30 days.
描述和综合国内外泛血管疾病(PVD)生物标志物的相关研究,根据范围综述的研究方法,在中国知网、万方数据库、维普网、PubMed、Embase、Web of Science、Cochrane Library等数据库进行系统检索,检索时间为建库至 2023年 1 月17日.2名研究人员依据文献纳入标准和排除标准独立进行文献筛选和数据资料提取.共纳入16篇文献,其中队列研究6篇、病例对照研究5篇、横断面研究4篇、Meta分析1篇.基于动脉粥样硬化形成机制假说对纳入的PVD生物标志物进行分类梳理,并从PVD危险因素以及PVD生物标志物在疾病预测和筛查中的效能进行分析,旨在为未来推广PVD早诊早筛、提升综合防治水平提供参考依据.
急性心肌梗死(下称心梗)是一种严重威胁人类生命健康的心血管急重症,心梗后梗死面积大小与心力衰竭和心律失常等的发生有关.血液生物学标志物(尤其生物学心肌标志物)一直以来在急性心梗的诊断、危险分层、预后评估中备受关注.本文对血液生物学标志物预测心梗面积的研究进展进行综述.
Objective To investigate the detection value of plasma microRNA-195(miR-195),soluble growth stimulation expressed gene 2(sST2),myoglobin(Myo)and cathepsin S(CatS)in patients with acute myocardial infarction(AMI).Methods One hundred and five patients with AMI(observation group)and 94 healthy individuals(control group)were enrolled in this study between April 2019 and October 2020 in Pingyang County People's Hospital.Plasma miR-195,sST2,Myo and CatS were measured.All patients were followed up for 6 months and then were divided into poor outcome group(24 cases)and good outcome group(81 cases)based on the disease prognosis.Plasma miR-195,sST2,Myo and CatS were compared between the two groups.The predictive value of those parameters for the prognosis of AMI patients was analyzed.Results Plasma miR-195,sST2,Myo and CatS were significantly higher in the observation group than in the control group(all P＜0.05).Pearson correlation analysis showed a positive correlation between plasma miR-195,sST2,Myo,and CatS(all P＜0.05).Plasma miR-195,sST2,Myo,and CatS were significantly higher in poor outcome group than in good outcome group(all P＜0.05).Univariate analysis and multivariate Cox regression analysis revealed that abnormally elevated plasma miR-195,sST2,Myo and CatS were the risk factors for poor prognosis of AMI patients(all P＜0.05).The AUC value and sensitivity of a combination of miR-195,sST2,Myo and CatS for predicting prognosis of AMI patients were significantly higher than those of each index(all P＜0.05).Conclusion High expression of plasma miR-195,sST2,Myo and CatS is related to poor prognosis of AMI patients.
目的 探究不同包扎方法对经桡动脉行冠状动脉介入术(TRI)后创口安全性及舒适度的影响.方法 选择2018年12月至2020年12月温州医科大学附属新昌医院心血管内科接受TRI患者220例.采用随机数字表法分为观察组和对照组,各110例.观察组患者采用旋压式止血器压迫板及压迫垫软胶的下方置入纱布止血.对照组患者采用旋压式止血器压迫板下方置入纱布止血.比较两组患者一次止血成功率、止血时间、术后视觉模拟评分法(VAS)评分及并发症发生率,比较两组患者的舒适度评分及舒适度满意度.结果 观察组患者术后VAS评分低于对照组,肿胀、疼痛及皮损发生率低于对照组,差异均有统计学意义(均P＜0.01).观察组舒适度评分低于对照组,舒适度满意度高于对照组,差异均有统计学意义(均P＜0.01).结论 旋压式止血器压迫板可显著提升TRI术后患者的止血效果,舒适度高,且能够降低术后并发症发生率,值得临床推广.
